Details for: F2rl1

Gene ID: 14063

Symbol: F2rl1

Ensembl ID: ENSMUSG00000021678

Description: F2R like trypsin receptor 1

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-MMU-373076)
  • G alpha (q) signalling events
    (R-MMU-416476)
  • Gpcr downstream signalling
    (R-MMU-388396)
  • Gpcr ligand binding
    (R-MMU-500792)
  • Peptide ligand-binding receptors
    (R-MMU-375276)
  • Signaling by gpcr
    (R-MMU-372790)
  • Blood coagulation
    (GO:0007596)
  • Cell-cell junction maintenance
    (GO:0045217)
  • Defense response to virus
    (GO:0051607)
  • Early endosome
    (GO:0005769)
  • Establishment of endothelial barrier
    (GO:0061028)
  • G-protein alpha-subunit binding
    (GO:0001965)
  • G-protein beta-subunit binding
    (GO:0031681)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Heterotrimeric g-protein binding
    (GO:0032795)
  • Immune system process
    (GO:0002376)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Leukocyte migration
    (GO:0050900)
  • Leukocyte proliferation
    (GO:0070661)
  • Mature conventional dendritic cell differentiation
    (GO:0097029)
  • Membrane
    (GO:0016020)
  • Negative regulation of chemokine production
    (GO:0032682)
  • Negative regulation of insulin secretion
    (GO:0046676)
  • Negative regulation of jnk cascade
    (GO:0046329)
  • Negative regulation of toll-like receptor 3 signaling pathway
    (GO:0034140)
  • Negative regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010804)
  • Neutrophil activation
    (GO:0042119)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of actin filament depolymerization
    (GO:0030836)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of chemotaxis
    (GO:0050921)
  • Positive regulation of cytokine production involved in immune response
    (GO:0002720)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of eosinophil degranulation
    (GO:0043311)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of glomerular filtration
    (GO:0003104)
  • Positive regulation of gtpase activity
    (GO:0043547)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of leukocyte chemotaxis
    (GO:0002690)
  • Positive regulation of neutrophil mediated killing of gram-negative bacterium
    (GO:0070963)
  • Positive regulation of phagocytosis, engulfment
    (GO:0060100)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of positive chemotaxis
    (GO:0050927)
  • Positive regulation of pseudopodium assembly
    (GO:0031274)
  • Positive regulation of renin secretion into blood stream
    (GO:1900135)
  • Positive regulation of rho protein signal transduction
    (GO:0035025)
  • Positive regulation of superoxide anion generation
    (GO:0032930)
  • Positive regulation of toll-like receptor 2 signaling pathway
    (GO:0034137)
  • Positive regulation of toll-like receptor 3 signaling pathway
    (GO:0034141)
  • Positive regulation of toll-like receptor 4 signaling pathway
    (GO:0034145)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Potassium channel activating, g protein-coupled receptor signaling pathway
    (GO:0099109)
  • Protease binding
    (GO:0002020)
  • Proteinase-activated receptor activity
    (GO:0001648)
  • Pseudopodium
    (GO:0031143)
  • Regulation of blood coagulation
    (GO:0030193)
  • Regulation of canonical nf-kappab signal transduction
    (GO:0043122)
  • Regulation of chemokine (c-x-c motif) ligand 2 production
    (GO:2000341)
  • Regulation of jnk cascade
    (GO:0046328)
  • Signal transduction
    (GO:0007165)
  • T cell activation involved in immune response
    (GO:0002286)
  • Thrombin-activated receptor activity
    (GO:0015057)
  • Thrombin-activated receptor signaling pathway
    (GO:0070493)
  • Vasodilation
    (GO:0042311)

Other Information

Genular Protein ID: 722898760

Symbol: PAR2_MOUSE

Name: Proteinase-activated receptor 2

UniProtKB Accession Codes:

P55086

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 1 ExpressionAtlas 1 GO 63 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7890726

Title: The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression.

PubMed ID: 7890726

DOI: 10.1074/jbc.270.11.5950

PubMed ID: 9918574

Title: Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1.

PubMed ID: 9918574

PubMed ID: 11086091

Title: Delayed onset of inflammation in protease-activated receptor-2-deficient mice.

PubMed ID: 11086091

DOI: 10.4049/jimmunol.165.11.6504

PubMed ID: 11859856

Title: Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear.

PubMed ID: 11859856

DOI: 10.1254/jjp.88.77

PubMed ID: 14519665

Title: Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo.

PubMed ID: 14519665

DOI: 10.1096/fj.02-1112com

PubMed ID: 12821670

Title: A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis.

PubMed ID: 12821670

DOI: 10.1074/jbc.m300573200

PubMed ID: 16081834

Title: Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms.

PubMed ID: 16081834

DOI: 10.4049/jimmunol.175.4.2598

PubMed ID: 15879675

Title: Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin content in protease-activated receptor 2-deficient mice.

PubMed ID: 15879675

DOI: 10.1254/jphs.scz050138

PubMed ID: 15919826

Title: A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.

PubMed ID: 15919826

DOI: 10.1073/pnas.0409535102

PubMed ID: 16476770

Title: Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis.

PubMed ID: 16476770

DOI: 10.1084/jem.20052148

PubMed ID: 17965715

Title: 'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

PubMed ID: 17965715

DOI: 10.1038/ni1525

PubMed ID: 20584806

Title: Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis.

PubMed ID: 20584806

DOI: 10.1136/ard.2010.130336

PubMed ID: 19845798

Title: Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo.

PubMed ID: 19845798

DOI: 10.1111/j.1365-2567.2009.03144.x

PubMed ID: 20215560

Title: PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology.

PubMed ID: 20215560

DOI: 10.1124/mol.109.062018

Sequence Information:

  • Length: 399
  • Mass: 44752
  • Checksum: A93749425ED0B194
  • Sequence:
    • MRSLSLAWLL GGITLLAASV SCSRTENLAP GRNNSKGRSL IGRLETQPPI TGKGVPVEPG 
FSIDEFSASI LTGKLTTVFL PVVYIIVFVI GLPSNGMALW IFLFRTKKKH PAVIYMANLA 
LADLLSVIWF PLKISYHLHG NNWVYGEALC KVLIGFFYGN MYCSILFMTC LSVQRYWVIV 
NPMGHPRKKA NIAVGVSLAI WLLIFLVTIP LYVMKQTIYI PALNITTCHD VLPEEVLVGD 
MFNYFLSLAI GVFLFPALLT ASAYVLMIKT LRSSAMDEHS EKKRQRAIRL IITVLAMYFI 
CFAPSNLLLV VHYFLIKTQR QSHVYALYLV ALCLSTLNSC IDPFVYYFVS KDFRDHARNA 
LLCRSVRTVN RMQISLSSNK FSRKSGSYSS SSTSVKTSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.