Details for: CRY1

Gene ID: 1407

Symbol: CRY1

Ensembl ID: ENSG00000008405

Description: cryptochrome circadian regulator 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.88
    Marker Score: 7848.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.6
    Marker Score: 936
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.54
    Marker Score: 1329
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168002
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.4
    Marker Score: 1691
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.35
    Marker Score: 51129
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.29
    Marker Score: 1869
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.28
    Marker Score: 375
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.26
    Marker Score: 701
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.25
    Marker Score: 504
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.18
    Marker Score: 40239
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17408
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.1
    Marker Score: 346
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.09
    Marker Score: 1205
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.07
    Marker Score: 1442
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.07
    Marker Score: 754.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.04
    Marker Score: 1113
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.03
    Marker Score: 3963
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.03
    Marker Score: 4179
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71711
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47936
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.99
    Marker Score: 590
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.98
    Marker Score: 60157
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.97
    Marker Score: 4002
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.94
    Marker Score: 2308
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.94
    Marker Score: 993
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.94
    Marker Score: 298
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.92
    Marker Score: 1274
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.92
    Marker Score: 552
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2709
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.9
    Marker Score: 285
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.9
    Marker Score: 1082
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.89
    Marker Score: 14227
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.88
    Marker Score: 5670
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.88
    Marker Score: 13182
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.87
    Marker Score: 2061
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.87
    Marker Score: 743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.87
    Marker Score: 1415
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.87
    Marker Score: 8977
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.87
    Marker Score: 6664
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.87
    Marker Score: 669
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.86
    Marker Score: 7428
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.86
    Marker Score: 362
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.85
    Marker Score: 28803
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4858
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.85
    Marker Score: 494
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.85
    Marker Score: 31189
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.84
    Marker Score: 2662
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.84
    Marker Score: 264
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.84
    Marker Score: 5050
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.84
    Marker Score: 284
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.83
    Marker Score: 284
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.83
    Marker Score: 652
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.83
    Marker Score: 481
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.82
    Marker Score: 3529
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.81
    Marker Score: 936
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.81
    Marker Score: 338
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.81
    Marker Score: 324
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.8
    Marker Score: 2831
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.79
    Marker Score: 1950
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.79
    Marker Score: 409
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.79
    Marker Score: 7436
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 602
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.78
    Marker Score: 1121
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.78
    Marker Score: 16592
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.76
    Marker Score: 1665.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.75
    Marker Score: 170
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.75
    Marker Score: 7118
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.74
    Marker Score: 469
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.73
    Marker Score: 347
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 234
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.72
    Marker Score: 260
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.72
    Marker Score: 379
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2993
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.71
    Marker Score: 653
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.71
    Marker Score: 14122
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.71
    Marker Score: 615
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.71
    Marker Score: 1363
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.71
    Marker Score: 267
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.71
    Marker Score: 1043
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.69
    Marker Score: 981
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 621
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.68
    Marker Score: 2321
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.67
    Marker Score: 507
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.67
    Marker Score: 349
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.67
    Marker Score: 166
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.66
    Marker Score: 271
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.66
    Marker Score: 257
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.66
    Marker Score: 166
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.66
    Marker Score: 580
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.66
    Marker Score: 277

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Other Information

**Key characteristics:** - Cryptochrome 1 is a protein with a molecular weight of approximately 120 kDa. - It is a member of the cryptochrome family of photoreceptors. - It is expressed in a variety of cell types throughout the body. - Cryptochrome 1 is a key regulator of the circadian clock, and its expression and activity are tightly synchronized with the light-dark cycle. **Pathways and functions:** - Cryptochrome 1 is involved in the regulation of the circadian rhythm through the blue light photoreceptor pathway. - Blue light exposure stimulates the activation of the cryptochrome 1 protein. - Activated cryptochrome 1 then recruits and activates the cryptochrome-interacting protein, cryptochrome-like 1 (CRY2). - This complex then recruits and activates the clock protein period 1 (PER1) and period 2 (PER2), which are responsible for resetting the circadian clock at night. **Clinical significance:** - Mutations in the CRY1 gene have been linked to a number of human diseases, including circadian disorders, age-related macular degeneration, and cancer. - Cryptochrome 1 is a potential therapeutic target for these diseases. - Drugs that target cryptochrome 1 have been shown to be effective in correcting circadian disorders in animal models.

Genular Protein ID: 3988928960

Symbol: CRY1_HUMAN

Name: Cryptochrome-1

UniProtKB Accession Codes:

Q16526

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 37 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8909283

Title: Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins.

PubMed ID: 8909283

DOI: 10.1021/bi962209o

PubMed ID: 8921389

Title: Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors.

PubMed ID: 8921389

DOI: 10.1006/geno.1996.0539

PubMed ID: 8600518

Title: Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family.

PubMed ID: 8600518

DOI: 10.1126/science.272.5258.109

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10531061

Title: Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.

PubMed ID: 10531061

DOI: 10.1126/science.286.5440.768

PubMed ID: 14672706

Title: A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.

PubMed ID: 14672706

DOI: 10.1016/j.bbrc.2003.11.099

PubMed ID: 16790549

Title: Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

PubMed ID: 16790549

DOI: 10.1073/pnas.0604138103

PubMed ID: 17463251

Title: SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.

PubMed ID: 17463251

DOI: 10.1126/science.1141194

PubMed ID: 20852621

Title: Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis.

PubMed ID: 20852621

DOI: 10.1038/nm.2214

PubMed ID: 21613214

Title: Biochemical analysis of the canonical model for the mammalian circadian clock.

PubMed ID: 21613214

DOI: 10.1074/jbc.m111.254680

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 23133559

Title: Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene.

PubMed ID: 23133559

DOI: 10.1371/journal.pone.0048152

PubMed ID: 22798407

Title: Identification of small molecule activators of cryptochrome.

PubMed ID: 22798407

DOI: 10.1126/science.1223710

PubMed ID: 23303907

Title: Metabolism and the circadian clock converge.

PubMed ID: 23303907

DOI: 10.1152/physrev.00016.2012

PubMed ID: 23916625

Title: Molecular architecture of the mammalian circadian clock.

PubMed ID: 23916625

DOI: 10.1016/j.tcb.2013.07.002

PubMed ID: 26431207

Title: CUL4-DDB1-CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1.

PubMed ID: 26431207

DOI: 10.1371/journal.pone.0139725

PubMed ID: 27565346

Title: Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.

PubMed ID: 27565346

DOI: 10.1016/j.cell.2016.07.027

PubMed ID: 28388406

Title: Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder.

PubMed ID: 28388406

DOI: 10.1016/j.cell.2017.03.027

PubMed ID: 30530698

Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.

PubMed ID: 30530698

DOI: 10.1073/pnas.1816411115

Sequence Information:

  • Length: 586
  • Mass: 66395
  • Checksum: 96A5B09A6364D3B9
  • Sequence:
    • MGVNAVHWFR KGLRLHDNPA LKECIQGADT IRCVYILDPW FAGSSNVGIN RWRFLLQCLE 
DLDANLRKLN SRLFVIRGQP ADVFPRLFKE WNITKLSIEY DSEPFGKERD AAIKKLATEA 
GVEVIVRISH TLYDLDKIIE LNGGQPPLTY KRFQTLISKM EPLEIPVETI TSEVIEKCTT 
PLSDDHDEKY GVPSLEELGF DTDGLSSAVW PGGETEALTR LERHLERKAW VANFERPRMN 
ANSLLASPTG LSPYLRFGCL SCRLFYFKLT DLYKKVKKNS SPPLSLYGQL LWREFFYTAA 
TNNPRFDKME GNPICVQIPW DKNPEALAKW AEGRTGFPWI DAIMTQLRQE GWIHHLARHA 
VACFLTRGDL WISWEEGMKV FEELLLDADW SINAGSWMWL SCSSFFQQFF HCYCPVGFGR 
RTDPNGDYIR RYLPVLRGFP AKYIYDPWNA PEGIQKVAKC LIGVNYPKPM VNHAEASRLN 
IERMKQIYQQ LSRYRGLGLL ASVPSNPNGN GGFMGYSAEN IPGCSSSGSC SQGSGILHYA 
HGDSQQTHLL KQGRSSMGTG LSGGKRPSQE EDTQSIGPKV QRQSTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.