Details for: CRY1

Gene ID: 1407

Symbol: CRY1

Ensembl ID: ENSG00000008405

Description: cryptochrome circadian regulator 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 181.2978
    Cell Significance Index: -28.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.5559
    Cell Significance Index: -29.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.3961
    Cell Significance Index: -30.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.4666
    Cell Significance Index: -26.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.4734
    Cell Significance Index: -26.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.9992
    Cell Significance Index: -29.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.0009
    Cell Significance Index: -29.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5975
    Cell Significance Index: -29.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6789
    Cell Significance Index: 94.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0862
    Cell Significance Index: 107.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9609
    Cell Significance Index: 24.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9501
    Cell Significance Index: 122.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9308
    Cell Significance Index: 840.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8473
    Cell Significance Index: 21.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7151
    Cell Significance Index: 141.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7008
    Cell Significance Index: 20.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6942
    Cell Significance Index: 15.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6834
    Cell Significance Index: 137.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6478
    Cell Significance Index: 18.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6033
    Cell Significance Index: 16.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5994
    Cell Significance Index: 44.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5857
    Cell Significance Index: 95.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5090
    Cell Significance Index: 55.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5057
    Cell Significance Index: 6.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4904
    Cell Significance Index: 22.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4754
    Cell Significance Index: 10.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4640
    Cell Significance Index: 12.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4271
    Cell Significance Index: 295.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4139
    Cell Significance Index: 48.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3818
    Cell Significance Index: 29.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3661
    Cell Significance Index: 689.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3415
    Cell Significance Index: 17.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3355
    Cell Significance Index: 120.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3254
    Cell Significance Index: 15.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2978
    Cell Significance Index: 17.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2656
    Cell Significance Index: 3.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2215
    Cell Significance Index: 4.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2157
    Cell Significance Index: 137.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2152
    Cell Significance Index: 4.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1951
    Cell Significance Index: 23.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1946
    Cell Significance Index: 13.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1627
    Cell Significance Index: 3.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1577
    Cell Significance Index: 30.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1562
    Cell Significance Index: 8.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1442
    Cell Significance Index: 19.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1428
    Cell Significance Index: 219.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1401
    Cell Significance Index: 8.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1326
    Cell Significance Index: 72.4100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1258
    Cell Significance Index: 0.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1213
    Cell Significance Index: 21.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1164
    Cell Significance Index: 1.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1075
    Cell Significance Index: 47.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1032
    Cell Significance Index: 1.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0954
    Cell Significance Index: 129.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0823
    Cell Significance Index: 151.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0729
    Cell Significance Index: 1.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0557
    Cell Significance Index: 25.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0507
    Cell Significance Index: 3.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0445
    Cell Significance Index: 0.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0245
    Cell Significance Index: 1.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0048
    Cell Significance Index: 0.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0068
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0100
    Cell Significance Index: -7.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0199
    Cell Significance Index: -12.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0200
    Cell Significance Index: -2.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0221
    Cell Significance Index: -12.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0307
    Cell Significance Index: -22.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0310
    Cell Significance Index: -23.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0480
    Cell Significance Index: -2.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0668
    Cell Significance Index: -14.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0809
    Cell Significance Index: -2.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0852
    Cell Significance Index: -8.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0883
    Cell Significance Index: -25.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0969
    Cell Significance Index: -4.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1114
    Cell Significance Index: -11.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1567
    Cell Significance Index: -4.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1595
    Cell Significance Index: -2.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1676
    Cell Significance Index: -11.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1686
    Cell Significance Index: -19.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1687
    Cell Significance Index: -19.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1840
    Cell Significance Index: -11.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1928
    Cell Significance Index: -7.3000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1939
    Cell Significance Index: -2.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2383
    Cell Significance Index: -28.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2384
    Cell Significance Index: -7.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2531
    Cell Significance Index: -5.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2623
    Cell Significance Index: -5.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3410
    Cell Significance Index: -17.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3527
    Cell Significance Index: -27.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3662
    Cell Significance Index: -22.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3911
    Cell Significance Index: -2.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4172
    Cell Significance Index: -14.5000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4444
    Cell Significance Index: -6.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4682
    Cell Significance Index: -9.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4762
    Cell Significance Index: -7.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4812
    Cell Significance Index: -11.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5093
    Cell Significance Index: -4.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5094
    Cell Significance Index: -13.6500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5384
    Cell Significance Index: -4.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5532
    Cell Significance Index: -19.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Blue-light photoreceptor activity**: CRY1 is sensitive to blue light, which is the primary wavelength of light that regulates the circadian clock. Its expression and activity are modulated by the intensity and duration of blue light exposure. 2. **Circadian clock regulation**: CRY1 is involved in the regulation of the circadian clock by interacting with other key clock genes, such as PER2 and BMAL1. Its expression is oscillatory, meaning it oscillates in a rhythmic manner throughout the day, reflecting the circadian rhythm. 3. **DNA damage response**: CRY1 also plays a role in the response to DNA damage, particularly in the context of UV radiation. It is involved in the activation of DNA repair pathways and the regulation of cell cycle checkpoints. 4. **Gene expression regulation**: CRY1 regulates the expression of various genes involved in circadian rhythm, including those involved in glucocorticoid secretion, gluconeogenesis, and glucose homeostasis. **Pathways and Functions** 1. **Blue light signaling pathway**: CRY1 interacts with the blue light receptor, RGS9, to regulate the circadian clock. This interaction leads to the activation of downstream signaling pathways, including the activation of PER2 and BMAL1, which in turn regulate the expression of clock genes. 2. **Circadian clock regulation**: CRY1 regulates the circadian clock by interacting with other clock genes, such as PER2 and BMAL1. Its expression is oscillatory, reflecting the circadian rhythm. 3. **DNA damage response**: CRY1 regulates the response to DNA damage by interacting with DNA repair proteins, such as DDB1 and DDB2. It also regulates the expression of genes involved in DNA repair and cell cycle checkpoints. 4. **Gene expression regulation**: CRY1 regulates the expression of various genes involved in circadian rhythm, including those involved in glucocorticoid secretion, gluconeogenesis, and glucose homeostasis. **Clinical Significance** 1. **Circadian rhythm disorders**: Dysregulation of CRY1 has been implicated in various circadian rhythm disorders, including delayed sleep phase syndrome and non-24-hour sleep-wake disorder. 2. **Cancer**: CRY1 has been implicated in the development and progression of certain cancers, including melanoma and lung cancer. 3. **Neurological disorders**: CRY1 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Metabolic disorders**: CRY1 regulates the expression of genes involved in gluconeogenesis and glucose homeostasis, and its dysregulation has been implicated in various metabolic disorders, including type 2 diabetes and metabolic syndrome. In conclusion, CRY1 is a crucial gene involved in the regulation of the circadian clock and the response to DNA damage. Its dysregulation has been implicated in various diseases associated with disrupted circadian rhythms and metabolic disorders. Further research is needed to fully understand the mechanisms by which CRY1 regulates the circadian clock and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 3988928960

Symbol: CRY1_HUMAN

Name: Cryptochrome-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8909283

Title: Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins.

PubMed ID: 8909283

DOI: 10.1021/bi962209o

PubMed ID: 8921389

Title: Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors.

PubMed ID: 8921389

DOI: 10.1006/geno.1996.0539

PubMed ID: 8600518

Title: Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family.

PubMed ID: 8600518

DOI: 10.1126/science.272.5258.109

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10531061

Title: Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.

PubMed ID: 10531061

DOI: 10.1126/science.286.5440.768

PubMed ID: 14672706

Title: A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.

PubMed ID: 14672706

DOI: 10.1016/j.bbrc.2003.11.099

PubMed ID: 16790549

Title: Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

PubMed ID: 16790549

DOI: 10.1073/pnas.0604138103

PubMed ID: 17463251

Title: SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.

PubMed ID: 17463251

DOI: 10.1126/science.1141194

PubMed ID: 20852621

Title: Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis.

PubMed ID: 20852621

DOI: 10.1038/nm.2214

PubMed ID: 21613214

Title: Biochemical analysis of the canonical model for the mammalian circadian clock.

PubMed ID: 21613214

DOI: 10.1074/jbc.m111.254680

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 23133559

Title: Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene.

PubMed ID: 23133559

DOI: 10.1371/journal.pone.0048152

PubMed ID: 22798407

Title: Identification of small molecule activators of cryptochrome.

PubMed ID: 22798407

DOI: 10.1126/science.1223710

PubMed ID: 23303907

Title: Metabolism and the circadian clock converge.

PubMed ID: 23303907

DOI: 10.1152/physrev.00016.2012

PubMed ID: 23916625

Title: Molecular architecture of the mammalian circadian clock.

PubMed ID: 23916625

DOI: 10.1016/j.tcb.2013.07.002

PubMed ID: 26431207

Title: CUL4-DDB1-CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1.

PubMed ID: 26431207

DOI: 10.1371/journal.pone.0139725

PubMed ID: 27565346

Title: Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.

PubMed ID: 27565346

DOI: 10.1016/j.cell.2016.07.027

PubMed ID: 28388406

Title: Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder.

PubMed ID: 28388406

DOI: 10.1016/j.cell.2017.03.027

PubMed ID: 30530698

Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.

PubMed ID: 30530698

DOI: 10.1073/pnas.1816411115

Sequence Information:

  • Length: 586
  • Mass: 66395
  • Checksum: 96A5B09A6364D3B9
  • Sequence:
  • MGVNAVHWFR KGLRLHDNPA LKECIQGADT IRCVYILDPW FAGSSNVGIN RWRFLLQCLE 
    DLDANLRKLN SRLFVIRGQP ADVFPRLFKE WNITKLSIEY DSEPFGKERD AAIKKLATEA 
    GVEVIVRISH TLYDLDKIIE LNGGQPPLTY KRFQTLISKM EPLEIPVETI TSEVIEKCTT 
    PLSDDHDEKY GVPSLEELGF DTDGLSSAVW PGGETEALTR LERHLERKAW VANFERPRMN 
    ANSLLASPTG LSPYLRFGCL SCRLFYFKLT DLYKKVKKNS SPPLSLYGQL LWREFFYTAA 
    TNNPRFDKME GNPICVQIPW DKNPEALAKW AEGRTGFPWI DAIMTQLRQE GWIHHLARHA 
    VACFLTRGDL WISWEEGMKV FEELLLDADW SINAGSWMWL SCSSFFQQFF HCYCPVGFGR 
    RTDPNGDYIR RYLPVLRGFP AKYIYDPWNA PEGIQKVAKC LIGVNYPKPM VNHAEASRLN 
    IERMKQIYQQ LSRYRGLGLL ASVPSNPNGN GGFMGYSAEN IPGCSSSGSC SQGSGILHYA 
    HGDSQQTHLL KQGRSSMGTG LSGGKRPSQE EDTQSIGPKV QRQSTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.