Details for: CRY1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 181.2978
Cell Significance Index: -28.2000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 115.5559
Cell Significance Index: -29.3100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 65.3961
Cell Significance Index: -30.8800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 64.4666
Cell Significance Index: -26.1900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 27.4734
Cell Significance Index: -26.2300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 23.9992
Cell Significance Index: -29.5900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.0009
Cell Significance Index: -29.4700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.5975
Cell Significance Index: -29.9800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.6789
Cell Significance Index: 94.2100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.0862
Cell Significance Index: 107.4500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.9609
Cell Significance Index: 24.7000 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.9501
Cell Significance Index: 122.7500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9308
Cell Significance Index: 840.4300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.8473
Cell Significance Index: 21.1800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7151
Cell Significance Index: 141.9100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.7008
Cell Significance Index: 20.0900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6942
Cell Significance Index: 15.0400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6834
Cell Significance Index: 137.0900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6478
Cell Significance Index: 18.6700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6033
Cell Significance Index: 16.4200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5994
Cell Significance Index: 44.6700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5857
Cell Significance Index: 95.2600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5090
Cell Significance Index: 55.3700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5057
Cell Significance Index: 6.9000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4904
Cell Significance Index: 22.2300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.4754
Cell Significance Index: 10.4100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4640
Cell Significance Index: 12.3900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4271
Cell Significance Index: 295.3800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.4139
Cell Significance Index: 48.2400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3818
Cell Significance Index: 29.3000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3661
Cell Significance Index: 689.3900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3415
Cell Significance Index: 17.7400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3355
Cell Significance Index: 120.3400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3254
Cell Significance Index: 15.3000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2978
Cell Significance Index: 17.8800 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.2656
Cell Significance Index: 3.8200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2215
Cell Significance Index: 4.7400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2157
Cell Significance Index: 137.0000 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.2152
Cell Significance Index: 4.2000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1951
Cell Significance Index: 23.9900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1946
Cell Significance Index: 13.4600 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.1627
Cell Significance Index: 3.9700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1577
Cell Significance Index: 30.0100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1562
Cell Significance Index: 8.2000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1442
Cell Significance Index: 19.8000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1428
Cell Significance Index: 219.9100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1401
Cell Significance Index: 8.8300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1326
Cell Significance Index: 72.4100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1258
Cell Significance Index: 0.7600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1213
Cell Significance Index: 21.8700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.1164
Cell Significance Index: 1.9600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1075
Cell Significance Index: 47.5200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.1032
Cell Significance Index: 1.2800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0954
Cell Significance Index: 129.7000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0823
Cell Significance Index: 151.7300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0729
Cell Significance Index: 1.2500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0557
Cell Significance Index: 25.2900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0507
Cell Significance Index: 3.4100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0445
Cell Significance Index: 0.5300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0245
Cell Significance Index: 1.1400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0048
Cell Significance Index: 0.8200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0068
Cell Significance Index: -0.9900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0100
Cell Significance Index: -7.4000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0199
Cell Significance Index: -12.4200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0200
Cell Significance Index: -2.5700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0221
Cell Significance Index: -12.4600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0307
Cell Significance Index: -22.4900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0310
Cell Significance Index: -23.4300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0480
Cell Significance Index: -2.9500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0668
Cell Significance Index: -14.0800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0809
Cell Significance Index: -2.2600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0852
Cell Significance Index: -8.7000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0883
Cell Significance Index: -25.4000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0969
Cell Significance Index: -4.2900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1114
Cell Significance Index: -11.6000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1567
Cell Significance Index: -4.1200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1595
Cell Significance Index: -2.6700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1676
Cell Significance Index: -11.8500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1686
Cell Significance Index: -19.2500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1687
Cell Significance Index: -19.3300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1840
Cell Significance Index: -11.8700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1928
Cell Significance Index: -7.3000 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1939
Cell Significance Index: -2.7900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2383
Cell Significance Index: -28.1100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2384
Cell Significance Index: -7.6400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2531
Cell Significance Index: -5.3900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2623
Cell Significance Index: -5.4900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3410
Cell Significance Index: -17.7600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3527
Cell Significance Index: -27.9300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3662
Cell Significance Index: -22.4500 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.3911
Cell Significance Index: -2.6500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4172
Cell Significance Index: -14.5000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.4444
Cell Significance Index: -6.5600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4682
Cell Significance Index: -9.4000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4762
Cell Significance Index: -7.0300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.4812
Cell Significance Index: -11.5400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.5093
Cell Significance Index: -4.6900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5094
Cell Significance Index: -13.6500 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.5384
Cell Significance Index: -4.3900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.5532
Cell Significance Index: -19.4400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3988928960
Symbol: CRY1_HUMAN
Name: Cryptochrome-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8909283
Title: Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins.
PubMed ID: 8909283
DOI: 10.1021/bi962209o
PubMed ID: 8921389
Title: Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors.
PubMed ID: 8921389
PubMed ID: 8600518
Title: Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family.
PubMed ID: 8600518
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10531061
Title: Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.
PubMed ID: 10531061
PubMed ID: 14672706
Title: A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.
PubMed ID: 14672706
PubMed ID: 16790549
Title: Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.
PubMed ID: 16790549
PubMed ID: 17463251
Title: SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.
PubMed ID: 17463251
PubMed ID: 20852621
Title: Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis.
PubMed ID: 20852621
DOI: 10.1038/nm.2214
PubMed ID: 21613214
Title: Biochemical analysis of the canonical model for the mammalian circadian clock.
PubMed ID: 21613214
PubMed ID: 22170608
Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.
PubMed ID: 22170608
DOI: 10.1038/nature10700
PubMed ID: 23133559
Title: Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene.
PubMed ID: 23133559
PubMed ID: 22798407
Title: Identification of small molecule activators of cryptochrome.
PubMed ID: 22798407
PubMed ID: 23303907
Title: Metabolism and the circadian clock converge.
PubMed ID: 23303907
PubMed ID: 23916625
Title: Molecular architecture of the mammalian circadian clock.
PubMed ID: 23916625
PubMed ID: 26431207
Title: CUL4-DDB1-CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1.
PubMed ID: 26431207
PubMed ID: 27565346
Title: Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.
PubMed ID: 27565346
PubMed ID: 28388406
Title: Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder.
PubMed ID: 28388406
PubMed ID: 30530698
Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.
PubMed ID: 30530698
Sequence Information:
- Length: 586
- Mass: 66395
- Checksum: 96A5B09A6364D3B9
- Sequence:
MGVNAVHWFR KGLRLHDNPA LKECIQGADT IRCVYILDPW FAGSSNVGIN RWRFLLQCLE DLDANLRKLN SRLFVIRGQP ADVFPRLFKE WNITKLSIEY DSEPFGKERD AAIKKLATEA GVEVIVRISH TLYDLDKIIE LNGGQPPLTY KRFQTLISKM EPLEIPVETI TSEVIEKCTT PLSDDHDEKY GVPSLEELGF DTDGLSSAVW PGGETEALTR LERHLERKAW VANFERPRMN ANSLLASPTG LSPYLRFGCL SCRLFYFKLT DLYKKVKKNS SPPLSLYGQL LWREFFYTAA TNNPRFDKME GNPICVQIPW DKNPEALAKW AEGRTGFPWI DAIMTQLRQE GWIHHLARHA VACFLTRGDL WISWEEGMKV FEELLLDADW SINAGSWMWL SCSSFFQQFF HCYCPVGFGR RTDPNGDYIR RYLPVLRGFP AKYIYDPWNA PEGIQKVAKC LIGVNYPKPM VNHAEASRLN IERMKQIYQQ LSRYRGLGLL ASVPSNPNGN GGFMGYSAEN IPGCSSSGSC SQGSGILHYA HGDSQQTHLL KQGRSSMGTG LSGGKRPSQE EDTQSIGPKV QRQSTN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.