CRY1 | ENSG00000008405 | NCBI 1407

Details for: CRY1

Gene ID: 1407

Symbol: CRY1

Ensembl ID: ENSG00000008405

Description: cryptochrome circadian regulator 1

Associated with

Circadian clock
(R-HSA-400253)
Blue light photoreceptor activity
(GO:0009882)
Blue light signaling pathway
(GO:0009785)
Circadian regulation of gene expression
(GO:0032922)
Circadian rhythm
(GO:0007623)
Cytoplasm
(GO:0005737)
Deoxyribodipyrimidine photo-lyase activity
(GO:0003904)
Dna (6-4) photolyase activity
(GO:0003914)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
E-box binding
(GO:0070888)
Entrainment of circadian clock by photoperiod
(GO:0043153)
Fad binding
(GO:0071949)
Gluconeogenesis
(GO:0006094)
Glucose homeostasis
(GO:0042593)
Histone deacetylase binding
(GO:0042826)
Lipid storage
(GO:0019915)
Mitochondrion
(GO:0005739)
Negative regulation of circadian rhythm
(GO:0042754)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of glucocorticoid receptor signaling pathway
(GO:2000323)
Negative regulation of glucocorticoid secretion
(GO:2000850)
Negative regulation of gluconeogenesis
(GO:0045721)
Negative regulation of g protein-coupled receptor signaling pathway
(GO:0045744)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear receptor binding
(GO:0016922)
Nucleus
(GO:0005634)
Phosphatase binding
(GO:0019902)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of protein ubiquitination
(GO:0031398)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of circadian rhythm
(GO:0042752)
Regulation of dna damage checkpoint
(GO:2000001)
Response to activity
(GO:0014823)
Response to glucagon
(GO:0033762)
Response to insulin
(GO:0032868)
Response to light stimulus
(GO:0009416)
Signal transduction in response to dna damage
(GO:0042770)

Other Information

Proteins

Cryptochrome-1

Genular Protein ID: 3988928960

Symbol: CRY1_HUMAN

Name: Cryptochrome-1

UniProtKB Accession Codes:

Q16526

Database IDs:

Citations:

PubMed ID: 8909283

Title: Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins.

PubMed ID: 8909283

DOI: 10.1021/bi962209o

PubMed ID: 8921389

Title: Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors.

PubMed ID: 8921389

DOI: 10.1006/geno.1996.0539

PubMed ID: 8600518

Title: Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family.

PubMed ID: 8600518

DOI: 10.1126/science.272.5258.109

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10531061

Title: Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.

PubMed ID: 10531061

DOI: 10.1126/science.286.5440.768

PubMed ID: 14672706

Title: A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.

PubMed ID: 14672706

DOI: 10.1016/j.bbrc.2003.11.099

PubMed ID: 16790549

Title: Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

PubMed ID: 16790549

DOI: 10.1073/pnas.0604138103

PubMed ID: 17463251

Title: SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.

PubMed ID: 17463251

DOI: 10.1126/science.1141194

PubMed ID: 20852621

Title: Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis.

PubMed ID: 20852621

DOI: 10.1038/nm.2214

PubMed ID: 21613214

Title: Biochemical analysis of the canonical model for the mammalian circadian clock.

PubMed ID: 21613214

DOI: 10.1074/jbc.m111.254680

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 23133559

Title: Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene.

PubMed ID: 23133559

DOI: 10.1371/journal.pone.0048152

PubMed ID: 22798407

Title: Identification of small molecule activators of cryptochrome.

PubMed ID: 22798407

DOI: 10.1126/science.1223710

PubMed ID: 23303907

Title: Metabolism and the circadian clock converge.

PubMed ID: 23303907

DOI: 10.1152/physrev.00016.2012

PubMed ID: 23916625

Title: Molecular architecture of the mammalian circadian clock.

PubMed ID: 23916625

DOI: 10.1016/j.tcb.2013.07.002

PubMed ID: 26431207

Title: CUL4-DDB1-CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1.

PubMed ID: 26431207

DOI: 10.1371/journal.pone.0139725

PubMed ID: 27565346

Title: Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.

PubMed ID: 27565346

DOI: 10.1016/j.cell.2016.07.027

PubMed ID: 28388406

Title: Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder.

PubMed ID: 28388406

DOI: 10.1016/j.cell.2017.03.027

PubMed ID: 30530698

Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.

PubMed ID: 30530698

DOI: 10.1073/pnas.1816411115

Sequence Information:

Length: 586
Mass: 66395
Checksum: 96A5B09A6364D3B9
Sequence:

MGVNAVHWFR KGLRLHDNPA LKECIQGADT IRCVYILDPW FAGSSNVGIN RWRFLLQCLE 
DLDANLRKLN SRLFVIRGQP ADVFPRLFKE WNITKLSIEY DSEPFGKERD AAIKKLATEA 
GVEVIVRISH TLYDLDKIIE LNGGQPPLTY KRFQTLISKM EPLEIPVETI TSEVIEKCTT 
PLSDDHDEKY GVPSLEELGF DTDGLSSAVW PGGETEALTR LERHLERKAW VANFERPRMN 
ANSLLASPTG LSPYLRFGCL SCRLFYFKLT DLYKKVKKNS SPPLSLYGQL LWREFFYTAA 
TNNPRFDKME GNPICVQIPW DKNPEALAKW AEGRTGFPWI DAIMTQLRQE GWIHHLARHA 
VACFLTRGDL WISWEEGMKV FEELLLDADW SINAGSWMWL SCSSFFQQFF HCYCPVGFGR 
RTDPNGDYIR RYLPVLRGFP AKYIYDPWNA PEGIQKVAKC LIGVNYPKPM VNHAEASRLN 
IERMKQIYQQ LSRYRGLGLL ASVPSNPNGN GGFMGYSAEN IPGCSSSGSC SQGSGILHYA 
HGDSQQTHLL KQGRSSMGTG LSGGKRPSQE EDTQSIGPKV QRQSTN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CRY1

Associated with

Other Information

Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. PubMed ID: 8909283

Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors. PubMed ID: 8921389

Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family. PubMed ID: 8600518

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. PubMed ID: 10531061

A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. PubMed ID: 14672706

Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5. PubMed ID: 16790549

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. PubMed ID: 17463251

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. PubMed ID: 20852621

Biochemical analysis of the canonical model for the mammalian circadian clock. PubMed ID: 21613214

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. PubMed ID: 22170608

Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene. PubMed ID: 23133559

Identification of small molecule activators of cryptochrome. PubMed ID: 22798407

Metabolism and the circadian clock converge. PubMed ID: 23303907

Molecular architecture of the mammalian circadian clock. PubMed ID: 23916625

CUL4-DDB1-CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1. PubMed ID: 26431207

Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation. PubMed ID: 27565346

Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder. PubMed ID: 28388406

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks. PubMed ID: 30530698