Details for: CRY2

Gene ID: 1408

Symbol: CRY2

Ensembl ID: ENSG00000121671

Description: cryptochrome circadian regulator 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.67
    Marker Score: 11156
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.93
    Marker Score: 611
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.86
    Marker Score: 1090
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.79
    Marker Score: 2167
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.73
    Marker Score: 3514
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.7
    Marker Score: 538
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.56
    Marker Score: 583
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.52
    Marker Score: 1433.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.48
    Marker Score: 3242.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168351
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.46
    Marker Score: 2447
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.45
    Marker Score: 31012
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.43
    Marker Score: 88201
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.42
    Marker Score: 53849
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.4
    Marker Score: 13303
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.4
    Marker Score: 1546
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.35
    Marker Score: 11596
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.35
    Marker Score: 13924
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2031
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.31
    Marker Score: 10063
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.29
    Marker Score: 751
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.28
    Marker Score: 12033
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.27
    Marker Score: 25342
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.24
    Marker Score: 45779
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.24
    Marker Score: 2922
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19403
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.23
    Marker Score: 5113
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.23
    Marker Score: 18422
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.21
    Marker Score: 4681
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.21
    Marker Score: 27047
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.14
    Marker Score: 1537
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.14
    Marker Score: 9868
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.12
    Marker Score: 2361
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.11
    Marker Score: 325
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.08
    Marker Score: 6968
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.07
    Marker Score: 598
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.04
    Marker Score: 420
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.04
    Marker Score: 544
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.03
    Marker Score: 322
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.01
    Marker Score: 2059
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71734
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47959
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1
    Marker Score: 4295
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.98
    Marker Score: 3977
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.97
    Marker Score: 962
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.93
    Marker Score: 390
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.92
    Marker Score: 4970
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.91
    Marker Score: 791
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2710
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.9
    Marker Score: 1094
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.89
    Marker Score: 287
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.88
    Marker Score: 425
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.87
    Marker Score: 3108.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.87
    Marker Score: 458
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4913
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.86
    Marker Score: 2955
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.83
    Marker Score: 226
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.8
    Marker Score: 526
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8
    Marker Score: 4794
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 601.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.78
    Marker Score: 246
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.77
    Marker Score: 288
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.76
    Marker Score: 278
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.76
    Marker Score: 360
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.75
    Marker Score: 810
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.75
    Marker Score: 640
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.74
    Marker Score: 252
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.74
    Marker Score: 892
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.74
    Marker Score: 11819
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.72
    Marker Score: 1374
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3020.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.71
    Marker Score: 2012
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7
    Marker Score: 23947
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.7
    Marker Score: 808
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.69
    Marker Score: 412
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.68
    Marker Score: 467
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 323
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.67
    Marker Score: 1649
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.64
    Marker Score: 168
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.63
    Marker Score: 283
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.62
    Marker Score: 180
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.62
    Marker Score: 1192
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.6
    Marker Score: 550
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.59
    Marker Score: 3529
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.58
    Marker Score: 612
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.58
    Marker Score: 213
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.57
    Marker Score: 391
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 146
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.56
    Marker Score: 821

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Other Information

**Key characteristics:** * The CRY2 gene is involved in the regulation of circadian rhythms. * It is a member of the cryptochrome family of circadian clock proteins. * It is responsible for the circadian oscillation of D-loop DNA binding protein (DDB1) and the transcriptional repressor protein (NRF1). * It also regulates the expression of other clock genes. **Pathways and functions:** * **Blue light photoreceptor activity:** Cryptochrome 2 is a blue light photoreceptor that is responsible for the regulation of the circadian clock. * **Circadian clock:** Cryptochrome 2 is one of the key components of the circadian clock, along with cryptochrome 1. * **Damaged DNA binding:** Cryptochrome 2 binds to damaged DNA and recruits the DNA repair protein BRCA1 to repair the damage. * **Deoxyribodipyrimidine photo-lyase activity:** Cryptochrome 2 also has deoxyribodipyrimidine photo-lyase activity, which is involved in the repair of DNA damage caused by ultraviolet radiation. * **Dna (6-4) photolyase activity:** Cryptochrome 2 also has a role in the repair of DNA damage caused by ultraviolet radiation. * **Dna binding:** Cryptochrome 2 binds to DNA and recruits the DNA binding protein BRCA2 to repair the damage. * **Fad binding:** Cryptochrome 2 also binds to the transcription factor FAD and recruits it to regulate the expression of clock genes. * **Negative regulation of transcription by rna polymerase ii:** Cryptochrome 2 negatively regulates the transcription of other clock genes, including those encoding period proteins. * **Nuclear receptor binding:** Cryptochrome 2 also binds to nuclear receptors, including the RORE and PER2 receptors. * **Phosphatase binding:** Cryptochrome 2 also binds to phosphatases, which are enzymes that remove phosphate groups from molecules. This binding is important for the regulation of the circadian clock. * **Photoreactive repair:** Cryptochrome 2 is involved in the photoreactive repair of DNA damage caused by ultraviolet radiation. * **Protein binding:** Cryptochrome 2 binds to various proteins, including DDB1, NRF1, BRCA1, BRCA2, FAD, and other clock proteins. **Clinical significance:** * Mutations in the CRY2 gene have been linked to circadian disorders, such as jet lag and shift work disorder. * Cryptochrome 2 is a potential therapeutic target for these disorders.

Genular Protein ID: 889958176

Symbol: CRY2_HUMAN

Name: Cryptochrome-2

UniProtKB Accession Codes:

Q49AN0 B4DH32 B4DZD6 O75148 Q8IV71

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 33 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SABIO-RK 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8909283

Title: Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins.

PubMed ID: 8909283

DOI: 10.1021/bi962209o

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 9801304

Title: Characterization of photolyase/blue-light receptor homologs in mouse and human cells.

PubMed ID: 9801304

DOI: 10.1093/nar/26.22.5086

PubMed ID: 10531061

Title: Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.

PubMed ID: 10531061

DOI: 10.1126/science.286.5440.768

PubMed ID: 11889036

Title: Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein.

PubMed ID: 11889036

DOI: 10.1093/emboj/21.6.1301

PubMed ID: 14672706

Title: A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.

PubMed ID: 14672706

DOI: 10.1016/j.bbrc.2003.11.099

PubMed ID: 16790549

Title: Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

PubMed ID: 16790549

DOI: 10.1073/pnas.0604138103

PubMed ID: 17463251

Title: SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.

PubMed ID: 17463251

DOI: 10.1126/science.1141194

PubMed ID: 22798407

Title: Identification of small molecule activators of cryptochrome.

PubMed ID: 22798407

DOI: 10.1126/science.1223710

PubMed ID: 23303907

Title: Metabolism and the circadian clock converge.

PubMed ID: 23303907

DOI: 10.1152/physrev.00016.2012

PubMed ID: 23916625

Title: Molecular architecture of the mammalian circadian clock.

PubMed ID: 23916625

DOI: 10.1016/j.tcb.2013.07.002

PubMed ID: 26569474

Title: A magnetic protein biocompass.

PubMed ID: 26569474

DOI: 10.1038/nmat4484

PubMed ID: 30530698

Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.

PubMed ID: 30530698

DOI: 10.1073/pnas.1816411115

PubMed ID: 31138685

Title: TIMELESS mutation alters phase responsiveness and causes advanced sleep phase.

PubMed ID: 31138685

DOI: 10.1073/pnas.1819110116

Sequence Information:

  • Length: 593
  • Mass: 66947
  • Checksum: BF380424092BEBFB
  • Sequence:
    • MAATVATAAA VAPAPAPGTD SASSVHWFRK GLRLHDNPAL LAAVRGARCV RCVYILDPWF 
AASSSVGINR WRFLLQSLED LDTSLRKLNS RLFVVRGQPA DVFPRLFKEW GVTRLTFEYD 
SEPFGKERDA AIMKMAKEAG VEVVTENSHT LYDLDRIIEL NGQKPPLTYK RFQAIISRME 
LPKKPVGLVT SQQMESCRAE IQENHDETYG VPSLEELGFP TEGLGPAVWQ GGETEALARL 
DKHLERKAWV ANYERPRMNA NSLLASPTGL SPYLRFGCLS CRLFYYRLWD LYKKVKRNST 
PPLSLFGQLL WREFFYTAAT NNPRFDRMEG NPICIQIPWD RNPEALAKWA EGKTGFPWID 
AIMTQLRQEG WIHHLARHAV ACFLTRGDLW VSWESGVRVF DELLLDADFS VNAGSWMWLS 
CSAFFQQFFH CYCPVGFGRR TDPSGDYIRR YLPKLKAFPS RYIYEPWNAP ESIQKAAKCI 
IGVDYPRPIV NHAETSRLNI ERMKQIYQQL SRYRGLCLLA SVPSCVEDLS HPVAEPSSSQ 
AGSMSSAGPR PLPSGPASPK RKLEAAEEPP GEELSKRARV AELPTPELPS KDA

Genular Protein ID: 1560361551

Symbol: A0A0D2X7Z3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0D2X7Z3

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 3 GO 6 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 6 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PROSITE 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 614
  • Mass: 68944
  • Checksum: 49E113E9E9D398EA
  • Sequence:
    • MGGVHVAYRG GAGVAGAVWT VMAATVATAA AVAPAPAPGT DSASSVHWFR KGLRLHDNPA 
LLAAVRGARC VRCVYILDPW FAASSSVGIN RWRFLLQSLE DLDTSLRKLN SRLFVVRGQP 
ADVFPRLFKE WGVTRLTFEY DSEPFGKERD AAIMKMAKEA GVEVVTENSH TLYDLDRIIE 
LNGQKPPLTY KRFQAIISRM ELPKKPVGLV TSQQMESCRA EIQENHDETY GVPSLEELGF 
PTEGLGPAVW QGGETEALAR LDKHLERKAW VANYERPRMN ANSLLASPTG LSPYLRFGCL 
SCRLFYYRLW DLYKKVKRNS TPPLSLFGQL LWREFFYTAA TNNPRFDRME GNPICIQIPW 
DRNPEALAKW AEGKTGFPWI DAIMTQLRQE GWIHHLARHA VACFLTRGDL WVSWESGVRV 
FDELLLDADF SVNAGSWMWL SCSAFFQQFF HCYCPVGFGR RTDPSGDYIR RYLPKLKAFP 
SRYIYEPWNA PESIQKAAKC IIGVDYPRPI VNHAETSRLN IERMKQIYQQ LSRYRGLCLL 
ASVPSCVEDL SHPVAEPSSS QAGSMSSAGP RPLPSGPASP KRKLEAAEEP PGEELSKRAR 
VAELPTPELP SKDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.