Genular: Defining Cellular Identity and Function

Details for: Fadd

Gene ID: 14082

Symbol: Fadd

Ensembl ID: ENSMUSG00000031077

Description: Fas associated via death domain

Associated with

Apoptosis
(R-MMU-109581)
Casp8 activity is inhibited
(R-MMU-5218900)
Caspase activation via death receptors in the presence of ligand
(R-MMU-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-MMU-5357769)
Death receptor signaling
(R-MMU-73887)
Dimerization of procaspase-8
(R-MMU-69416)
Fasl/ cd95l signaling
(R-MMU-75157)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Programmed cell death
(R-MMU-5357801)
Regulated necrosis
(R-MMU-5218859)
Regulation by c-flip
(R-MMU-3371378)
Regulation of necroptotic cell death
(R-MMU-5675482)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Ripk1-mediated regulated necrosis
(R-MMU-5213460)
Tnfr1-induced proapoptotic signaling
(R-MMU-5357786)
Tnf signaling
(R-MMU-75893)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Trail signaling
(R-MMU-75158)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Trif-mediated programmed cell death
(R-MMU-2562578)
Activation of cysteine-type endopeptidase activity
(GO:0097202)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Cardiac muscle tissue development
(GO:0048738)
Caspase binding
(GO:0089720)
Cd95 death-inducing signaling complex
(GO:0031265)
Cell body
(GO:0044297)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Death-inducing signaling complex
(GO:0031264)
Death-inducing signaling complex assembly
(GO:0071550)
Death effector domain binding
(GO:0035877)
Death receptor binding
(GO:0005123)
Defense response to virus
(GO:0051607)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Lymph node development
(GO:0048535)
Molecular adaptor activity
(GO:0060090)
Motor neuron apoptotic process
(GO:0097049)
Necroptotic signaling pathway
(GO:0097527)
Negative regulation of activation-induced cell death of t cells
(GO:0070236)
Negative regulation of necroptotic process
(GO:0060546)
Plasma membrane
(GO:0005886)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of adaptive immune response
(GO:0002821)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cd8-positive, alpha-beta cytotoxic t cell extravasation
(GO:2000454)
Positive regulation of execution phase of apoptosis
(GO:1900119)
Positive regulation of extrinsic apoptotic signaling pathway
(GO:2001238)
Positive regulation of innate immune response
(GO:0045089)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of macrophage differentiation
(GO:0045651)
Positive regulation of proteolysis
(GO:0045862)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type ii interferon production
(GO:0032729)
Positive regulation of type i interferon-mediated signaling pathway
(GO:0060340)
Protease binding
(GO:0002020)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Receptor serine/threonine kinase binding
(GO:0033612)
Regulation of apoptotic process
(GO:0042981)
Regulation of necroptotic process
(GO:0060544)
Ripoptosome
(GO:0097342)
Signaling adaptor activity
(GO:0035591)
Signal transduction
(GO:0007165)
Spleen development
(GO:0048536)
T cell differentiation
(GO:0030217)
T cell differentiation in thymus
(GO:0033077)
T cell homeostasis
(GO:0043029)
Thymus development
(GO:0048538)
Trail-activated apoptotic signaling pathway
(GO:0036462)
Tumor necrosis factor receptor binding
(GO:0005164)
Tumor necrosis factor receptor superfamily binding
(GO:0032813)

Other Information

Proteins

FADD_MOUSE

Genular Protein ID: 1803897935

Symbol: FADD_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q61160 Q3TC37 Q61082

Database IDs:

Citations:

PubMed ID: 8649383

Title: A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis.

PubMed ID: 8649383

DOI: 10.1128/mcb.16.6.2756

PubMed ID: 8565075

Title: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.

PubMed ID: 8565075

DOI: 10.1016/s0092-8674(00)80984-8

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15383280

Title: Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions.

PubMed ID: 15383280

DOI: 10.1016/j.molcel.2004.08.020

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 28842570

Title: Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.

PubMed ID: 28842570

DOI: 10.1038/s41467-017-00406-w

PubMed ID: 29440439

Title: Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis.

PubMed ID: 29440439

DOI: 10.1073/pnas.1722013115

PubMed ID: 30185824

Title: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.

PubMed ID: 30185824

DOI: 10.1038/s41418-018-0166-8

PubMed ID: 31519887

Title: K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation.

PubMed ID: 31519887

DOI: 10.1038/s41467-019-12033-8

PubMed ID: 34471287

Title: AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.

PubMed ID: 34471287

DOI: 10.1038/s41586-021-03875-8

PubMed ID: 10347191

Title: The solution structure of FADD death domain. Structural basis of death domain interactions of Fas and FADD.

PubMed ID: 10347191

DOI: 10.1074/jbc.274.23.16337

Sequence Information:

Length: 205
Mass: 22960
Checksum: 4BC8D86B33A58783
Sequence:

MDPFLVLLHS LSGSLSGNDL MELKFLCRER VSKRKLERVQ SGLDLFTVLL EQNDLERGHT 
GLLRELLASL RRHDLLQRLD DFEAGTATAA PPGEADLQVA FDIVCDNVGR DWKRLARELK 
VSEAKMDGIE EKYPRSLSER VRESLKVWKN AEKKNASVAG LVKALRTCRL NLVADLVEEA 
QESVSKSENM SPVLRDSTVS SSETP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fadd

Associated with

Other Information

A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis. PubMed ID: 8649383

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. PubMed ID: 8565075

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. PubMed ID: 15383280

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. PubMed ID: 28842570

Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. PubMed ID: 29440439

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development. PubMed ID: 30185824

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. PubMed ID: 31519887

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. PubMed ID: 34471287

The solution structure of FADD death domain. Structural basis of death domain interactions of Fas and FADD. PubMed ID: 10347191