Genular: Defining Cellular Identity and Function

Details for: Ptk2

Gene ID: 14083

Symbol: Ptk2

Ensembl ID: ENSMUSG00000022607

Description: PTK2 protein tyrosine kinase 2

Associated with

Apoptosis
(R-MMU-109581)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
Axon guidance
(R-MMU-422475)
Dcc mediated attractive signaling
(R-MMU-418885)
Developmental biology
(R-MMU-1266738)
Eph-ephrin signaling
(R-MMU-2682334)
Ephb-mediated forward signaling
(R-MMU-3928662)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
Grb2:sos provides linkage to mapk signaling for integrins
(R-MMU-354194)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Integrin signaling
(R-MMU-354192)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Met activates ptk2 signaling
(R-MMU-8874081)
Met promotes cell motility
(R-MMU-8875878)
Ncam signaling for neurite out-growth
(R-MMU-375165)
Nervous system development
(R-MMU-9675108)
Netrin-1 signaling
(R-MMU-373752)
P130cas linkage to mapk signaling for integrins
(R-MMU-372708)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet aggregation (plug formation)
(R-MMU-76009)
Programmed cell death
(R-MMU-5357801)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of actin dynamics for phagocytic cup formation
(R-MMU-2029482)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate wasps and waves
(R-MMU-5663213)
Signaling by met
(R-MMU-6806834)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Actin binding
(GO:0003779)
Angiogenesis
(GO:0001525)
Atp binding
(GO:0005524)
Axonogenesis
(GO:0007409)
Blood vessel development
(GO:0001568)
Cell migration
(GO:0016477)
Central nervous system neuron axonogenesis
(GO:0021955)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Identical protein binding
(GO:0042802)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Jnk cascade
(GO:0007254)
Jun kinase binding
(GO:0008432)
Kinase activity
(GO:0016301)
Mapk cascade
(GO:0000165)
Microtubule cytoskeleton organization
(GO:0000226)
Molecular function activator activity
(GO:0140677)
Multicellular organism development
(GO:0007275)
Negative regulation of autophagy
(GO:0010507)
Neuron migration
(GO:0001764)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nuclear migration
(GO:0007097)
Nucleotide binding
(GO:0000166)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphatase binding
(GO:0019902)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Phosphorylation
(GO:0016310)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of fibroblast migration
(GO:0010763)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Protein tyrosine phosphatase activity
(GO:0004725)
Regulation of cell shape
(GO:0008360)
Regulation of epithelial cell migration
(GO:0010632)
Regulation of protein phosphorylation
(GO:0001932)
Sh2 domain binding
(GO:0042169)
Signal complex assembly
(GO:0007172)
Transferase activity
(GO:0016740)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

Focal adhesion kinase-related nonkinase

Genular Protein ID: 3384930616

Symbol: FAK1_MOUSE

Name: Focal adhesion kinase-related nonkinase

UniProtKB Accession Codes:

P34152 O08578 Q5DTH7 Q8C513 Q8CFH7 Q8CHM2 Q8K2S0 Q9DAW3

Database IDs:

Citations:

PubMed ID: 1528852

Title: Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

PubMed ID: 1528852

DOI: 10.1073/pnas.89.18.8487

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9353341

Title: Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity.

PubMed ID: 9353341

DOI: 10.1074/jbc.272.45.28720

PubMed ID: 7997267

Title: Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.

PubMed ID: 7997267

DOI: 10.1038/372786a0

PubMed ID: 7622520

Title: Interaction of focal adhesion kinase with cytoskeletal protein talin.

PubMed ID: 7622520

DOI: 10.1074/jbc.270.28.16995

PubMed ID: 7529876

Title: Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases.

PubMed ID: 7529876

DOI: 10.1128/mcb.15.2.954

PubMed ID: 7478517

Title: Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK.

PubMed ID: 7478517

PubMed ID: 8824286

Title: Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase.

PubMed ID: 8824286

DOI: 10.1074/jbc.271.42.26329

PubMed ID: 8816475

Title: Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.

PubMed ID: 8816475

DOI: 10.1128/mcb.16.10.5623

PubMed ID: 9148935

Title: Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.

PubMed ID: 9148935

DOI: 10.1074/jbc.272.20.13189

PubMed ID: 9422762

Title: Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.

PubMed ID: 9422762

DOI: 10.1074/jbc.273.2.1003

PubMed ID: 9461600

Title: A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions.

PubMed ID: 9461600

DOI: 10.1074/jbc.273.7.4073

PubMed ID: 9756887

Title: Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase.

PubMed ID: 9756887

DOI: 10.1074/jbc.273.41.26516

PubMed ID: 10373530

Title: Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

PubMed ID: 10373530

DOI: 10.1128/mcb.19.7.4806

PubMed ID: 10896938

Title: p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.

PubMed ID: 10896938

DOI: 10.1074/jbc.m003074200

PubMed ID: 10806474

Title: FAK integrates growth-factor and integrin signals to promote cell migration.

PubMed ID: 10806474

DOI: 10.1038/35010517

PubMed ID: 11278462

Title: Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion.

PubMed ID: 11278462

DOI: 10.1074/jbc.m009063200

PubMed ID: 11369769

Title: The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase.

PubMed ID: 11369769

DOI: 10.1074/jbc.m101678200

PubMed ID: 11420674

Title: Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies.

PubMed ID: 11420674

DOI: 10.1038/sj.onc.1204359

PubMed ID: 12221124

Title: Regulation of focal adhesion kinase by a novel protein inhibitor FIP200.

PubMed ID: 12221124

DOI: 10.1091/mbc.e02-05-0295

PubMed ID: 12941275

Title: Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration.

PubMed ID: 12941275

DOI: 10.1016/s0092-8674(03)00605-6

PubMed ID: 12464388

Title: The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells.

PubMed ID: 12464388

DOI: 10.1016/s0898-6568(02)00076-1

PubMed ID: 12702722

Title: Direct interaction of focal adhesion kinase with p190RhoGEF.

PubMed ID: 12702722

DOI: 10.1074/jbc.m302381200

PubMed ID: 14500712

Title: PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation.

PubMed ID: 14500712

DOI: 10.1074/jbc.m308562200

PubMed ID: 12674328

Title: Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast.

PubMed ID: 12674328

DOI: 10.1359/jbmr.2003.18.4.669

PubMed ID: 14676198

Title: Focal adhesion kinase regulation of N-WASP subcellular localization and function.

PubMed ID: 14676198

DOI: 10.1074/jbc.m310739200

PubMed ID: 15494733

Title: Focal adhesion kinase in netrin-1 signaling.

PubMed ID: 15494733

DOI: 10.1038/nn1330

PubMed ID: 15494734

Title: Activation of FAK and Src are receptor-proximal events required for netrin signaling.

PubMed ID: 15494734

DOI: 10.1038/nn1329

PubMed ID: 15967814

Title: Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis.

PubMed ID: 15967814

DOI: 10.1083/jcb.200411155

PubMed ID: 16000375

Title: Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.

PubMed ID: 16000375

DOI: 10.1091/mbc.e05-02-0131

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16391003

Title: Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.

PubMed ID: 16391003

DOI: 10.1083/jcb.200506184

PubMed ID: 17093062

Title: FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX.

PubMed ID: 17093062

DOI: 10.1091/mbc.e06-03-0207

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 18206965

Title: Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.

PubMed ID: 18206965

DOI: 10.1016/j.molcel.2007.11.031

PubMed ID: 19372463

Title: Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth.

PubMed ID: 19372463

DOI: 10.1161/circresaha.109.195941

PubMed ID: 19473962

Title: Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis.

PubMed ID: 19473962

DOI: 10.1074/jbc.m109.018259

PubMed ID: 19147981

Title: Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.

PubMed ID: 19147981

DOI: 10.1172/jci37160

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22056317

Title: Focal adhesion kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways.

PubMed ID: 22056317

DOI: 10.1016/j.yjmcc.2011.10.015

PubMed ID: 22685302

Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.

PubMed ID: 22685302

DOI: 10.1074/jbc.m112.340174

PubMed ID: 20552554

Title: The role of focal adhesion kinase in early development.

PubMed ID: 20552554

DOI: 10.14670/hh-25.1039

PubMed ID: 21482413

Title: Focal adhesion kinase: exploring Fak structure to gain insight into function.

PubMed ID: 21482413

DOI: 10.1016/b978-0-12-386041-5.00005-4

PubMed ID: 25059660

Title: Src kinase determines the dynamic exchange of the docking protein NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesions.

PubMed ID: 25059660

DOI: 10.1074/jbc.m113.544106

PubMed ID: 28362576

Title: Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

PubMed ID: 28362576

DOI: 10.7554/elife.23172

PubMed ID: 11799401

Title: The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin.

PubMed ID: 11799401

DOI: 10.1038/nsb755

Sequence Information:

Length: 1052
Mass: 119243
Checksum: 4B7453C5D81F0F63
Sequence:

MAAAYLDPNL NHTPSSSTKT HLGTGMERSP GAMERVLKVF HYFESSSEPT TWASIIRHGD 
ATDVRGIIQK IVDSHKVKHV ACYGFRLSHL RSEEVHWLHV DMGVSSVREK YELAHPPEEW 
KYELRIRYLP KGFLNQFTED KPTLNFFYQQ VKSDYMQEIA DQVDQEIALK LGCLEIRRSY 
WEMRGNALEK KSNYEVLEKD VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI 
LKFFEILSPV YRFDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGCNP THLADFNQVQ 
TIQYSNSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL VNGATQSFII 
RPQKEGERAL PSIPKLANSE KQGMRTHAVS VSETDDYAEI IDEEDTYTMP STRDYEIQRE 
RIELGRCIGE GQFGDVHQGV YLSPENPALA VAIKTCKNCT SDSVREKFLQ EALTMRQFDH 
PHIVKLIGVI TENPVWIIME LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK 
RFVHRDIAAR NVLVSSNDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT 
SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT LYSLMTKCWA 
YDPSRRPRFT ELKAQLSTIL EEEKVQQEER MRMESRRQAT VSWDSGGSDE APPKPSRPGY 
PSPRSSEGFY PSPQHMVQTN HYQVSGYPGS HGIPAMAGSI YQGQASLLDQ TELWNHRPQE 
MSMWQPSVED SAALDLRGMG QVLPPHLMEE RLIRQQQEME EDQRWLEKEE RFLKPDVRLS 
RGSIDREDGS FQGPTGNQHI YQPVGKPDPA APPKKPPRPG APGHLSNLSS ISSPADSYNE 
GVKLQPQEIS PPPTANLDRS NDKVYENVTG LVKAVIEMSS KIQPAPPEEY VPMVKEVGLA 
LRTLLATVDE TIPALPASTH REIEMAQKLL NSDLGELISK MKLAQQYVMT SLQQEYKKQM 
LTAAHALAVD AKNLLDVIDQ ARLKMLGQTR PH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptk2

Associated with

Other Information

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. PubMed ID: 1528852

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity. PubMed ID: 9353341

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. PubMed ID: 7997267

Interaction of focal adhesion kinase with cytoskeletal protein talin. PubMed ID: 7622520

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. PubMed ID: 7529876

Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. PubMed ID: 7478517

Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. PubMed ID: 8824286

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. PubMed ID: 8816475

Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. PubMed ID: 9148935

Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. PubMed ID: 9422762

A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions. PubMed ID: 9461600

Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase. PubMed ID: 9756887

Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. PubMed ID: 10373530

p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor. PubMed ID: 10896938

FAK integrates growth-factor and integrin signals to promote cell migration. PubMed ID: 10806474

Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. PubMed ID: 11278462

The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase. PubMed ID: 11369769

Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies. PubMed ID: 11420674

Regulation of focal adhesion kinase by a novel protein inhibitor FIP200. PubMed ID: 12221124

Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. PubMed ID: 12941275

The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells. PubMed ID: 12464388

Direct interaction of focal adhesion kinase with p190RhoGEF. PubMed ID: 12702722

PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. PubMed ID: 14500712

Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. PubMed ID: 12674328

Focal adhesion kinase regulation of N-WASP subcellular localization and function. PubMed ID: 14676198

Focal adhesion kinase in netrin-1 signaling. PubMed ID: 15494733

Activation of FAK and Src are receptor-proximal events required for netrin signaling. PubMed ID: 15494734

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. PubMed ID: 15967814

Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. PubMed ID: 16000375

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. PubMed ID: 16391003

FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX. PubMed ID: 17093062

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. PubMed ID: 18206965

Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth. PubMed ID: 19372463

Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis. PubMed ID: 19473962

Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. PubMed ID: 19147981

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Focal adhesion kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways. PubMed ID: 22056317

Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. PubMed ID: 22685302

The role of focal adhesion kinase in early development. PubMed ID: 20552554

Focal adhesion kinase: exploring Fak structure to gain insight into function. PubMed ID: 21482413

Src kinase determines the dynamic exchange of the docking protein NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesions. PubMed ID: 25059660

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks. PubMed ID: 28362576

The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. PubMed ID: 11799401