Details for: Fah

Gene ID: 14085

Symbol: Fah

Ensembl ID: ENSMUSG00000030630

Description: fumarylacetoacetate hydrolase

Associated with

Other Information

Genular Protein ID: 1795835302

Symbol: FAAA_MOUSE

Name: Fumarylacetoacetase

UniProtKB Accession Codes:

P35505 Q3TY87 Q9QW65

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CPTAC 2 CTD 1 ChEBI 14 ChiTaRS 1 DNASU 1 EC 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PIR 2 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1741389

Title: Murine fumarylacetoacetate hydrolase (Fah) gene is disrupted by a neonatally lethal albino deletion that defines the hepatocyte-specific developmental regulation 1 (hsdr-1) locus.

PubMed ID: 1741389

DOI: 10.1073/pnas.89.4.1363

PubMed ID: 1524868

Title: Nucleotide sequence of a cDNA encoding murine fumarylacetoacetate hydrolase.

PubMed ID: 1524868

DOI: 10.1016/0885-4505(92)90044-y

PubMed ID: 1644288

Title: Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice.

PubMed ID: 1644288

DOI: 10.1101/gad.6.8.1430

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11209059

Title: Point mutations in the murine fumarylacetoacetate hydrolase gene: animal models for the human genetic disorder hereditary tyrosinemia type 1.

PubMed ID: 11209059

DOI: 10.1073/pnas.98.2.641

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 10508789

Title: Crystal structure and mechanism of a carbon-carbon bond hydrolase.

PubMed ID: 10508789

DOI: 10.1016/s0969-2126(99)80170-1

PubMed ID: 11154690

Title: Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitor.

PubMed ID: 11154690

DOI: 10.1074/jbc.m007621200

Sequence Information:

  • Length: 419
  • Mass: 46176
  • Checksum: 771C247377B59102
  • Sequence:
    • MSFIPVAEDS DFPIQNLPYG VFSTQSNPKP RIGVAIGDQI LDLSVIKHLF TGPALSKHQH 
VFDETTLNNF MGLGQAAWKE ARASLQNLLS ASQARLRDDK ELRQRAFTSQ ASATMHLPAT 
IGDYTDFYSS RQHATNVGIM FRGKENALLP NWLHLPVGYH GRASSIVVSG TPIRRPMGQM 
RPDNSKPPVY GACRLLDMEL EMAFFVGPGN RFGEPIPISK AHEHIFGMVL MNDWSARDIQ 
QWEYVPLGPF LGKSFGTTIS PWVVPMDALM PFVVPNPKQD PKPLPYLCHS QPYTFDINLS 
VSLKGEGMSQ AATICRSNFK HMYWTMLQQL THHSVNGCNL RPGDLLASGT ISGSDPESFG 
SMLELSWKGT KAIDVEQGQT RTFLLDGDEV IITGHCQGDG YRVGFGQCAG KVLPALSPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.