Genular: Defining Cellular Identity and Function

Details for: Fscn1

Gene ID: 14086

Symbol: Fscn1

Ensembl ID: ENSMUSG00000029581

Description: fascin actin-bundling protein 1

Associated with

Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin cytoskeleton organization
(GO:0030036)
Actin filament binding
(GO:0051015)
Actin filament bundle assembly
(GO:0051017)
Actin filament organization
(GO:0007015)
Anchoring junction
(GO:0070161)
Cell-cell junction
(GO:0005911)
Cell-cell junction assembly
(GO:0007043)
Cell migration
(GO:0016477)
Cell motility
(GO:0048870)
Cell projection
(GO:0042995)
Cell projection membrane
(GO:0031253)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Establishment of apical/basal cell polarity
(GO:0035089)
Establishment or maintenance of cell polarity
(GO:0007163)
Filopodium
(GO:0030175)
Growth cone
(GO:0030426)
Lamellipodium
(GO:0030027)
Microspike
(GO:0044393)
Microspike assembly
(GO:0030035)
Microvillus
(GO:0005902)
Myelin sheath
(GO:0043209)
Parallel actin filament bundle assembly
(GO:0030046)
Podosome
(GO:0002102)
Positive regulation of extracellular matrix disassembly
(GO:0090091)
Positive regulation of filopodium assembly
(GO:0051491)
Positive regulation of lamellipodium assembly
(GO:0010592)
Positive regulation of podosome assembly
(GO:0071803)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of microvillus assembly
(GO:0032534)
Ruffle
(GO:0001726)
Stress fiber
(GO:0001725)

Other Information

Proteins

Fascin

Genular Protein ID: 2545885488

Symbol: FSCN1_MOUSE

Name: Fascin

UniProtKB Accession Codes:

Q61553 O09099 O09156 Q05DK3 Q7TN32 Q80V75

Database IDs:

Citations:

PubMed ID: 7738015

Title: Cloning and expression of a murine fascin homolog from mouse brain.

PubMed ID: 7738015

DOI: 10.1074/jbc.270.18.10764

PubMed ID: 8794867

Title: Beta-catenin associates with the actin-bundling protein fascin in a noncadherin complex.

PubMed ID: 8794867

DOI: 10.1083/jcb.134.5.1271

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20393565

Title: Migrastatin analogues target fascin to block tumour metastasis.

PubMed ID: 20393565

DOI: 10.1038/nature08978

PubMed ID: 21685497

Title: Mechanism of actin filament bundling by fascin.

PubMed ID: 21685497

DOI: 10.1074/jbc.m111.251439

PubMed ID: 22155786

Title: Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.

PubMed ID: 22155786

DOI: 10.1126/scisignal.2002060

PubMed ID: 21706053

Title: Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton.

PubMed ID: 21706053

DOI: 10.1038/onc.2011.256

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24720729

Title: Rufy3, a protein specifically expressed in neurons, interacts with actin-bundling protein Fascin to control the growth of axons.

PubMed ID: 24720729

DOI: 10.1111/jnc.12740

Sequence Information:

Length: 493
Mass: 54508
Checksum: 1C6DCD5211B74969
Sequence:

MTANGTAEAV QIQFGLISCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ PPDEAGSAAV 
CLRSHLGRYL AADKDGNVTC EREVPDGDCR FLVVAHDDGR WSLQSEAHRR YFGGTEDRLS 
CFAQSVSPAE KWSVHIAMHP QVNIYSVTRK RYAHLSARPA DEIAVDRDVP WGVDSLITLA 
FQDQRYSVQT SDHRFLRHDG RLVARPEPAT GFTLEFRSGK VAFRDCEGRY LAPSGPSGTL 
KAGKATKVGK DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR 
DTRKCAFRTH TGKYWTLTAT GGVQSTASTK NASCYFDIEW CDRRITLRAS NGKFVTAKKN 
GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV TGTLDANRSS YDVFQLEFND 
GAYNIKDSTG KYWTVGSDSS VTSSSDTPVD FFLEFCDYNK VALKVGGRYL KGDHAGVLKA 
CAETIDPASL WEY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fscn1

Associated with

Other Information

Cloning and expression of a murine fascin homolog from mouse brain. PubMed ID: 7738015

Beta-catenin associates with the actin-bundling protein fascin in a noncadherin complex. PubMed ID: 8794867

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Migrastatin analogues target fascin to block tumour metastasis. PubMed ID: 20393565

Mechanism of actin filament bundling by fascin. PubMed ID: 21685497

Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. PubMed ID: 22155786

Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. PubMed ID: 21706053

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Rufy3, a protein specifically expressed in neurons, interacts with actin-bundling protein Fascin to control the growth of axons. PubMed ID: 24720729