Genular: Defining Cellular Identity and Function

Details for: Fap

Gene ID: 14089

Symbol: Fap

Ensembl ID: ENSMUSG00000000392

Description: fibroblast activation protein

Associated with

Anchoring junction
(GO:0070161)
Angiogenesis
(GO:0001525)
Apical part of cell
(GO:0045177)
Apoptotic process
(GO:0006915)
Basal part of cell
(GO:0045178)
Cell adhesion
(GO:0007155)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Dipeptidyl-peptidase activity
(GO:0008239)
Endopeptidase activity
(GO:0004175)
Endothelial cell migration
(GO:0043542)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Integrin binding
(GO:0005178)
Lamellipodium
(GO:0030027)
Melanocyte apoptotic process
(GO:1902362)
Melanocyte proliferation
(GO:0097325)
Membrane
(GO:0016020)
Negative regulation of cell proliferation involved in contact inhibition
(GO:0060244)
Negative regulation of extracellular matrix disassembly
(GO:0010716)
Negative regulation of extracellular matrix organization
(GO:1903054)
Peptidase activity
(GO:0008233)
Peptidase complex
(GO:1905368)
Plasma membrane
(GO:0005886)
Positive regulation of execution phase of apoptosis
(GO:1900119)
Protease binding
(GO:0002020)
Protein homodimerization activity
(GO:0042803)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Regulation of cell cycle
(GO:0051726)
Regulation of collagen catabolic process
(GO:0010710)
Serine-type endopeptidase activity
(GO:0004252)
Serine-type peptidase activity
(GO:0008236)

Other Information

Proteins

SEPR_MOUSE

Genular Protein ID: 2478346068

Symbol: SEPR_MOUSE

Name: N/A

UniProtKB Accession Codes:

P97321

Database IDs:

Citations:

PubMed ID: 9139873

Title: Mouse fibroblast activation protein: molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers.

PubMed ID: 9139873

DOI: 10.1002/(sici)1097-0215(19970502)71:3<383::aid-ijc14>3.0.co;2-h

PubMed ID: 9688278

Title: Mouse fibroblast-activation protein--conserved Fap gene organization and biochemical function as a serine protease.

PubMed ID: 9688278

DOI: 10.1046/j.1432-1327.1998.2540650.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10629066

Title: Targeted disruption of mouse fibroblast activation protein.

PubMed ID: 10629066

DOI: 10.1128/mcb.20.3.1089-1094.2000

PubMed ID: 11330865

Title: Expression of the fibroblast activation protein during mouse embryo development.

PubMed ID: 11330865

PubMed ID: 15133496

Title: FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor.

PubMed ID: 15133496

DOI: 10.1038/sj.onc.1207730

PubMed ID: 21051638

Title: Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.

PubMed ID: 21051638

DOI: 10.1126/science.1195300

PubMed ID: 23710635

Title: Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model.

PubMed ID: 23710635

DOI: 10.5483/bmbrep.2013.46.5.172

PubMed ID: 24371721

Title: Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs.

PubMed ID: 24371721

DOI: 10.1016/j.fob.2013.12.001

Sequence Information:

Length: 761
Mass: 87945
Checksum: 9174C3AEDA213B25
Sequence:

MKTWLKTVFG VTTLAALALV VICIVLRPSR VYKPEGNTKR ALTLKDILNG TFSYKTYFPN 
WISEQEYLHQ SEDDNIVFYN IETRESYIIL SNSTMKSVNA TDYGLSPDRQ FVYLESDYSK 
LWRYSYTATY YIYDLQNGEF VRGYELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP 
FQITYTGREN RIFNGIPDWV YEEEMLATKY ALWWSPDGKF LAYVEFNDSD IPIIAYSYYG 
DGQYPRTINI PYPKAGAKNP VVRVFIVDTT YPHHVGPMEV PVPEMIASSD YYFSWLTWVS 
SERVCLQWLK RVQNVSVLSI CDFREDWHAW ECPKNQEHVE ESRTGWAGGF FVSTPAFSQD 
ATSYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAIYI FRVTQDSLFY SSNEFEGYPG 
RRNIYRISIG NSPPSKKCVT CHLRKERCQY YTASFSYKAK YYALVCYGPG LPISTLHDGR 
TDQEIQVLEE NKELENSLRN IQLPKVEIKK LKDGGLTFWY KMILPPQFDR SKKYPLLIQV 
YGGPCSQSVK SVFAVNWITY LASKEGIVIA LVDGRGTAFQ GDKFLHAVYR KLGVYEVEDQ 
LTAVRKFIEM GFIDEERIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASIY 
SERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA 
QVDFQAMWYS DQNHGISSGR SQNHLYTHMT HFLKQCFSLS D

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fap

Associated with

Other Information

Mouse fibroblast activation protein: molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers. PubMed ID: 9139873

Mouse fibroblast-activation protein--conserved Fap gene organization and biochemical function as a serine protease. PubMed ID: 9688278

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Targeted disruption of mouse fibroblast activation protein. PubMed ID: 10629066

Expression of the fibroblast activation protein during mouse embryo development. PubMed ID: 11330865

FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor. PubMed ID: 15133496

Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. PubMed ID: 21051638

Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model. PubMed ID: 23710635

Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. PubMed ID: 24371721