CRYAA | ENSG00000160202 | NCBI 1409

Details for: CRYAA

Gene ID: 1409

Symbol: CRYAA

Ensembl ID: ENSG00000160202

Description: crystallin alpha A

Associated with

Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Identical protein binding
(GO:0042802)
Lens development in camera-type eye
(GO:0002088)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of intracellular transport
(GO:0032387)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein refolding
(GO:0042026)
Protein stabilization
(GO:0050821)
Response to heat
(GO:0009408)
Structural constituent of eye lens
(GO:0005212)
Structural molecule activity
(GO:0005198)
Unfolded protein binding
(GO:0051082)
Visual perception
(GO:0007601)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: photoreceptor cell (CL0000210)
Fold Change: 9.3353
Cell Significance Index: 131.1200
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 1.7248
Cell Significance Index: 14.1200
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.4536
Cell Significance Index: 6.2200
Cell Name: bipolar neuron (CL0000103)
Fold Change: 0.2675
Cell Significance Index: 1.5000
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.1233
Cell Significance Index: 3.9000
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.0962
Cell Significance Index: 1.2500
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.0661
Cell Significance Index: 1.1300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0105
Cell Significance Index: 14.3000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0096
Cell Significance Index: 14.7200
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.0088
Cell Significance Index: 0.0500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0024
Cell Significance Index: 4.5000
Cell Name: neutrophil (CL0000775)
Fold Change: 0.0002
Cell Significance Index: 0.0000
Cell Name: retinal astrocyte (CL4033015)
Fold Change: -0.0004
Cell Significance Index: 0.0000
Cell Name: neural cell (CL0002319)
Fold Change: -0.0019
Cell Significance Index: -0.0200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0026
Cell Significance Index: -0.7400
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.0040
Cell Significance Index: -0.0400
Cell Name: germ cell (CL0000586)
Fold Change: -0.0059
Cell Significance Index: -0.0400
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0072
Cell Significance Index: -3.9300
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0094
Cell Significance Index: -0.0700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0157
Cell Significance Index: -0.2200
Cell Name: basal cell (CL0000646)
Fold Change: -0.0159
Cell Significance Index: -0.1900
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0243
Cell Significance Index: -0.6200
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0295
Cell Significance Index: -0.3900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0301
Cell Significance Index: -4.1400
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0312
Cell Significance Index: -0.3100
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0335
Cell Significance Index: -0.4000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0344
Cell Significance Index: -6.9000
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.0386
Cell Significance Index: -0.3900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0410
Cell Significance Index: -0.4500
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.0432
Cell Significance Index: -0.3900
Cell Name: amacrine cell (CL0000561)
Fold Change: -0.0487
Cell Significance Index: -0.6100
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: -0.0495
Cell Significance Index: -0.3700
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.0544
Cell Significance Index: -0.6600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0613
Cell Significance Index: -6.2600
Cell Name: late promyelocyte (CL0002151)
Fold Change: -0.0647
Cell Significance Index: -0.4300
Cell Name: retinal cone cell (CL0000573)
Fold Change: -0.0753
Cell Significance Index: -0.9400
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0951
Cell Significance Index: -1.2000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1037
Cell Significance Index: -2.7800
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1070
Cell Significance Index: -1.2800
Cell Name: Mueller cell (CL0000636)
Fold Change: -0.1079
Cell Significance Index: -0.8300
Cell Name: retina horizontal cell (CL0000745)
Fold Change: -0.1164
Cell Significance Index: -1.4600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1171
Cell Significance Index: -3.4500
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.1177
Cell Significance Index: -1.5400
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.1260
Cell Significance Index: -1.0400
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: -0.1300
Cell Significance Index: -1.6700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1436
Cell Significance Index: -2.1200
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.1486
Cell Significance Index: -1.4700
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: -0.1502
Cell Significance Index: -1.5900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1554
Cell Significance Index: -8.7200
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.1560
Cell Significance Index: -1.6300
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1975
Cell Significance Index: -6.9200
Cell Name: enterocyte (CL0000584)
Fold Change: -0.2051
Cell Significance Index: -1.2700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2100
Cell Significance Index: -6.8800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2126
Cell Significance Index: -6.7700
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.2212
Cell Significance Index: -4.4100
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2217
Cell Significance Index: -3.5900
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.2364
Cell Significance Index: -3.3700
Cell Name: acinar cell (CL0000622)
Fold Change: -0.2452
Cell Significance Index: -3.0800
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2457
Cell Significance Index: -6.1300
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: -0.2629
Cell Significance Index: -2.3000
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: -0.2790
Cell Significance Index: -3.2600
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: -0.2895
Cell Significance Index: -3.0600
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: -0.2954
Cell Significance Index: -2.4900
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.3001
Cell Significance Index: -3.2600
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.3023
Cell Significance Index: -3.9500
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3166
Cell Significance Index: -6.8400
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3232
Cell Significance Index: -6.3200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3258
Cell Significance Index: -6.9200
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.3323
Cell Significance Index: -6.9400
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3344
Cell Significance Index: -6.6100
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3393
Cell Significance Index: -7.4300
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3400
Cell Significance Index: -6.8300
Cell Name: melanocyte (CL0000148)
Fold Change: -0.3490
Cell Significance Index: -3.2700
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.3506
Cell Significance Index: -6.9000
Cell Name: chromaffin cell (CL0000166)
Fold Change: -0.3513
Cell Significance Index: -3.8700
Cell Name: podocyte (CL0000653)
Fold Change: -0.3557
Cell Significance Index: -4.0800
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.3690
Cell Significance Index: -3.9200
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.3703
Cell Significance Index: -4.3000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3833
Cell Significance Index: -6.4200
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3864
Cell Significance Index: -4.0000
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.3924
Cell Significance Index: -6.7900
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.3950
Cell Significance Index: -4.1400
Cell Name: plasma cell (CL0000786)
Fold Change: -0.3992
Cell Significance Index: -4.4600
Cell Name: neuron (CL0000540)
Fold Change: -0.4009
Cell Significance Index: -3.8000
Cell Name: glial cell (CL0000125)
Fold Change: -0.4016
Cell Significance Index: -4.4000
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.4085
Cell Significance Index: -6.8700
Cell Name: precursor cell (CL0011115)
Fold Change: -0.4132
Cell Significance Index: -3.1300
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.4162
Cell Significance Index: -4.3900
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: -0.4169
Cell Significance Index: -4.3800
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.4315
Cell Significance Index: -5.9900
Cell Name: mast cell (CL0000097)
Fold Change: -0.4392
Cell Significance Index: -5.7800
Cell Name: sympathetic neuron (CL0011103)
Fold Change: -0.4440
Cell Significance Index: -3.9200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.4474
Cell Significance Index: -6.5000
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: -0.4492
Cell Significance Index: -4.8500
Cell Name: mesangial cell (CL0000650)
Fold Change: -0.4521
Cell Significance Index: -5.7200
Cell Name: microglial cell (CL0000129)
Fold Change: -0.4542
Cell Significance Index: -5.3400
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.4556
Cell Significance Index: -4.9000
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: -0.4565
Cell Significance Index: -4.3100
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.4617
Cell Significance Index: -6.1400
Cell Name: thymocyte (CL0000893)
Fold Change: -0.4646
Cell Significance Index: -5.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The CRYAA gene is characterized by its high expression levels in the lens, where it is essential for maintaining lens transparency and refractive structure. The protein encoded by CRYAA is a type of alpha-crystallin, which is a major component of the lens. Unlike beta-crystallins, which are primarily responsible for maintaining lens transparency, alpha-crystallins have a chaperone function, helping to prevent protein aggregation and maintain lens homeostasis. The CRYAA gene is also highly conserved across species, suggesting its importance in maintaining lens function across evolution. **Pathways and Functions** The CRYAA gene is involved in several key pathways that are essential for maintaining lens function and overall eye health. These include: * **Negative regulation of apoptotic process**: The CRYAA protein has been shown to inhibit apoptosis (programmed cell death) in lens epithelial cells, which is essential for maintaining lens homeostasis. * **Negative regulation of intracellular transport**: The CRYAA protein helps regulate the transport of proteins and other molecules within the lens, maintaining proper lens structure and function. * **Unfolded protein binding**: The CRYAA protein has been shown to bind to unfolded proteins, preventing their aggregation and helping to maintain lens homeostasis. * **Response to heat**: The CRYAA protein helps the lens respond to heat stress, maintaining lens transparency and refractive structure under conditions of thermal stress. **Clinical Significance** Dysregulation of the CRYAA gene has been implicated in various ocular and systemic disorders, including: * **Cataracts**: Mutations in the CRYAA gene have been associated with cataract formation, which is a major cause of blindness worldwide. * **Glaucoma**: The CRYAA protein has been shown to be involved in the regulation of intraocular pressure, and mutations in the CRYAA gene have been associated with glaucoma. * **Systemic diseases**: The CRYAA protein has also been implicated in the pathogenesis of systemic diseases, including diabetes and Alzheimer's disease, where it may play a role in maintaining protein homeostasis and preventing aggregation. In conclusion, the CRYAA gene plays a crucial role in maintaining lens function and overall eye health. Its dysregulation has significant clinical implications, and further research is needed to fully understand its role in ocular and systemic diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.