Details for: ADPRH

Gene ID: 141

Symbol: ADPRH

Ensembl ID: ENSG00000144843

Description: ADP-ribosylarginine hydrolase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2166
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.04
    Marker Score: 757.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5305
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.86
    Marker Score: 1639
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.84
    Marker Score: 2367
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1251
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11423
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 544
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.69
    Marker Score: 451
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.66
    Marker Score: 213
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.64
    Marker Score: 667.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.53
    Marker Score: 372
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 325
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.5
    Marker Score: 156
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.49
    Marker Score: 448
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.49
    Marker Score: 12479
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.44
    Marker Score: 442
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4
    Marker Score: 22174
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.39
    Marker Score: 2388
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.38
    Marker Score: 190
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.37
    Marker Score: 535
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.37
    Marker Score: 152
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.37
    Marker Score: 948
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.36
    Marker Score: 702
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.36
    Marker Score: 410
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.34
    Marker Score: 157
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.32
    Marker Score: 115
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.32
    Marker Score: 169
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.32
    Marker Score: 151
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.31
    Marker Score: 499
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.31
    Marker Score: 205
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.29
    Marker Score: 263
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.29
    Marker Score: 247
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.28
    Marker Score: 714
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.28
    Marker Score: 651
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.26
    Marker Score: 783
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.26
    Marker Score: 175
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.25
    Marker Score: 239
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.25
    Marker Score: 60
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.24
    Marker Score: 405
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.24
    Marker Score: 142
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.24
    Marker Score: 341
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.24
    Marker Score: 98
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.23
    Marker Score: 129
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.23
    Marker Score: 187
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.23
    Marker Score: 490
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.23
    Marker Score: 258
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.22
    Marker Score: 93
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.22
    Marker Score: 2542
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.22
    Marker Score: 95
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.22
    Marker Score: 196
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.22
    Marker Score: 214
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.21
    Marker Score: 51
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.21
    Marker Score: 258
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.21
    Marker Score: 49
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.21
    Marker Score: 55
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.21
    Marker Score: 210
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.2
    Marker Score: 494
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.2
    Marker Score: 1326
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.2
    Marker Score: 107
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.2
    Marker Score: 99
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2
    Marker Score: 208
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.2
    Marker Score: 137
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.2
    Marker Score: 215
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.2
    Marker Score: 361
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.2
    Marker Score: 391
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2
    Marker Score: 244
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.19
    Marker Score: 190
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.19
    Marker Score: 38
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.19
    Marker Score: 207
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.19
    Marker Score: 46
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.19
    Marker Score: 74
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.19
    Marker Score: 331
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.19
    Marker Score: 227
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.19
    Marker Score: 141
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.18
    Marker Score: 77
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 99
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.18
    Marker Score: 125

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * ADPRH is a transmembrane protein with a single transmembrane domain. * It is a member of the ADP-ribosylarginine hydrolase family. * It is expressed in high levels in the enterocyte of the small intestine, where it is involved in the de-adp-ribosylation of various proteins. * It is also expressed in immune cells, where it may regulate the activity of immune complexes. * It is expressed in neurons, where it may be involved in the regulation of synaptic plasticity. **Pathways and functions:** * ADPRH is involved in the regulation of protein de-adp-ribosylation. * It does this by catalyzing the hydrolysis of ADP-ribosylarginine residues from proteins. * This modification is important for the proper functioning of many cellular processes, including cell migration, differentiation, and signaling. * ADPRH is also involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in the ADPRH gene have been linked to several human diseases, including Crohn's disease, ulcerative colitis, and cancer. * These mutations can lead to the loss of ADPRH function, which can result in the accumulation of ADP-ribosylarginine-modified proteins. * This can lead to a variety of cellular problems, including inflammation, cell death, and cancer. **Additional notes:** * ADPRH is a highly conserved protein, with a similar sequence in mice and humans. * It is a member of the ADP-ribosylarginine hydrolase family, which is a large family of enzymes that are involved in the de-adp-ribosylation of various proteins. * ADPRH is a relatively new protein, with the first sequence of the human gene being published in 2002.

Genular Protein ID: 4133425743

Symbol: ADPRH_HUMAN

Name: ADP-ribose-L-arginine cleaving enzyme

UniProtKB Accession Codes:

P54922 B2R8H1 D3DN83

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 17 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 Rhea 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8349667

Title: Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase.

PubMed ID: 8349667

DOI: 10.1016/s0021-9258(17)46780-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 31599159

Title: The ARH and Macrodomain Families of alpha-ADP-ribose-acceptor Hydrolases Catalyze alpha-NAD+ Hydrolysis.

PubMed ID: 31599159

DOI: 10.1021/acschembio.9b00429

PubMed ID: 19407395

Title: Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1.

PubMed ID: 19407395

DOI: 10.1107/s1744309109014067

PubMed ID: 30472116

Title: (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.

PubMed ID: 30472116

DOI: 10.1016/j.chembiol.2018.11.001

Sequence Information:

  • Length: 357
  • Mass: 39507
  • Checksum: 4E23B12FAE84F12B
  • Sequence:
    • MEKYVAAMVL SAAGDALGYY NGKWEFLQDG EKIHRQLAQL GGLDALDVGR WRVSDDTVMH 
LATAEALVEA GKAPKLTQLY YLLAKHYQDC MEDMDGRAPG GASVHNAMQL KPGKPNGWRI 
PFNSHEGGCG AAMRAMCIGL RFPHHSQLDT LIQVSIESGR MTHHHPTGYL GALASALFTA 
YAVNSRPPLQ WGKGLMELLP EAKKYIVQSG YFVEENLQHW SYFQTKWENY LKLRGILDGE 
SAPTFPESFG VKERDQFYTS LSYSGWGGSS GHDAPMIAYD AVLAAGDSWK ELAHRAFFHG 
GDSDSTAAIA GCWWGVMYGF KGVSPSNYEK LEYRNRLEET ARALYSLGSK EDTVISL

Genular Protein ID: 3517165492

Symbol: A8K6X2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6X2

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 357
  • Mass: 39477
  • Checksum: A0D84584A0705A21
  • Sequence:
    • MEKYVAAMVL SAAGDALGYY NGKWEFLQDG EKIHRQLAQL GGLDALDVGR WRVSDDTVMH 
LATAEALVEA GKAPKLTQLY YLLAKHYQDC MEDMDGRAPG GASVHNAMQL KPGKPNGWRI 
PFNSHEGGCG AAMRAMCIGL RFPHHSQLDA LIQVSIESGR MTHHHPTGYL GALASALFTA 
YAVNSRPPLQ WGKGLMELLP EAKKYIVQSG YFVEENLQHW SYFQTKWENY LKLRGILDGE 
SAPTFPESFG VKERDQFYTS LSYSGWGGSS GHDAPMIAYD AVLAAGDSWK ELAHRAFFHG 
GDSDSTAAIA GCWWGVMYGF KGVSPSNYEK LEYRNRLEET ARALYSLGSK EDTVISL

Genular Protein ID: 916951831

Symbol: B4E341_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E341

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 339
  • Mass: 36706
  • Checksum: 0686E3C3293A5D4A
  • Sequence:
    • MGAAVPGSRL GGSKISSLSA AKRRCGGPRR HPAYLGTVPE PGDPAPPQPA PSSTRSSQGL 
FPGPGSPRHA RRSRVPVQAT AGGASVHNAM QLKPGKPNGW RIPFNSHEGG CGAAMRAMCI 
GLRFPHHSQL DTLIQVSIES GRMTHHHPTG YLGALASALF TAYAVNSRPP LQWGKGLMEL 
LPEAKKYIVQ SGYFVEENLQ HWSYFQTKWE NYLKLRGILD GESAPTFPES FGVKERDQFY 
TSLSYSGWGG SSGHDAPMIA YDAVLAAGDS WKELAHRAFF HGGDSDSTAA IAGCWWGVMY 
GFKGVSPSNY EKLEYRNRLE ETARALYSLG SKEDTVISL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.