Details for: ADPRH

Gene ID: 141

Symbol: ADPRH

Ensembl ID: ENSG00000144843

Description: ADP-ribosylarginine hydrolase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 28.7376
    Cell Significance Index: -4.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.1250
    Cell Significance Index: -4.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.5950
    Cell Significance Index: -4.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6254
    Cell Significance Index: -4.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.1252
    Cell Significance Index: -4.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3321
    Cell Significance Index: 32.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3253
    Cell Significance Index: 61.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2505
    Cell Significance Index: 4.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2099
    Cell Significance Index: 4.4700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2016
    Cell Significance Index: 2.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1936
    Cell Significance Index: 174.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1617
    Cell Significance Index: 26.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1488
    Cell Significance Index: 17.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1404
    Cell Significance Index: 8.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1250
    Cell Significance Index: 1.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1210
    Cell Significance Index: 13.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0927
    Cell Significance Index: 2.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0897
    Cell Significance Index: 1.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0778
    Cell Significance Index: 5.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0456
    Cell Significance Index: 1.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0436
    Cell Significance Index: 2.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0417
    Cell Significance Index: 2.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0283
    Cell Significance Index: 1.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0261
    Cell Significance Index: 0.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0174
    Cell Significance Index: 0.3600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0156
    Cell Significance Index: 0.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0104
    Cell Significance Index: 0.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0060
    Cell Significance Index: 0.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0044
    Cell Significance Index: 0.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0023
    Cell Significance Index: 0.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0015
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0007
    Cell Significance Index: 0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0006
    Cell Significance Index: 0.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0012
    Cell Significance Index: -0.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0041
    Cell Significance Index: -2.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0042
    Cell Significance Index: -5.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0045
    Cell Significance Index: -0.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0054
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0063
    Cell Significance Index: -4.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0066
    Cell Significance Index: -0.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0067
    Cell Significance Index: -0.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0076
    Cell Significance Index: -0.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0090
    Cell Significance Index: -3.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0098
    Cell Significance Index: -6.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0100
    Cell Significance Index: -1.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0103
    Cell Significance Index: -2.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0116
    Cell Significance Index: -3.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0131
    Cell Significance Index: -2.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0131
    Cell Significance Index: -0.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0137
    Cell Significance Index: -0.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0140
    Cell Significance Index: -0.4100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0143
    Cell Significance Index: -0.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0154
    Cell Significance Index: -0.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0168
    Cell Significance Index: -2.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0176
    Cell Significance Index: -0.4800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0182
    Cell Significance Index: -0.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0200
    Cell Significance Index: -0.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0232
    Cell Significance Index: -3.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0264
    Cell Significance Index: -5.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0276
    Cell Significance Index: -3.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0301
    Cell Significance Index: -0.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0302
    Cell Significance Index: -0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0345
    Cell Significance Index: -1.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0354
    Cell Significance Index: -1.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0378
    Cell Significance Index: -2.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0410
    Cell Significance Index: -2.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0429
    Cell Significance Index: -4.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0524
    Cell Significance Index: -4.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0529
    Cell Significance Index: -1.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0530
    Cell Significance Index: -1.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0607
    Cell Significance Index: -2.4900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0637
    Cell Significance Index: -1.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0709
    Cell Significance Index: -4.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0786
    Cell Significance Index: -4.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0798
    Cell Significance Index: -2.2300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0807
    Cell Significance Index: -3.5100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0809
    Cell Significance Index: -1.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0813
    Cell Significance Index: -4.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0870
    Cell Significance Index: -4.5700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0871
    Cell Significance Index: -1.1000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0887
    Cell Significance Index: -1.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0895
    Cell Significance Index: -3.1100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0905
    Cell Significance Index: -1.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0913
    Cell Significance Index: -2.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0927
    Cell Significance Index: -0.5600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1041
    Cell Significance Index: -1.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1092
    Cell Significance Index: -4.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1145
    Cell Significance Index: -4.0100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1189
    Cell Significance Index: -1.7100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1192
    Cell Significance Index: -1.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1214
    Cell Significance Index: -1.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1222
    Cell Significance Index: -4.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1268
    Cell Significance Index: -4.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Activity:** ADPRH is a hydrolase enzyme that cleaves ADP-ribosylarginine, a high-energy phosphate compound, into ADP-ribose and L-arginine. This activity is essential for the regulation of protein function and cellular signaling. 2. **Tissue Expression:** ADPRH is widely expressed in various tissues, including the small intestine, colon, brain, and immune cells, highlighting its involvement in multiple cellular processes. 3. **Cellular Localization:** The enzyme is found in the cytosol of cells, where it can interact with various proteins and regulate their activity. 4. **Regulatory Mechanisms:** ADPRH is regulated by post-translational modifications, including phosphorylation and ubiquitination, which can modulate its activity and substrate specificity. **Pathways and Functions:** 1. **Protein De-ADP-ribosylation:** ADPRH is involved in the de-ADP-ribosylation of proteins, which can modify their activity, localization, and stability. This process is crucial for regulating various cellular functions, including signaling, transcription, and cell growth. 2. **Cellular Signaling:** ADPRH regulates cellular signaling pathways, including those involved in immune responses, inflammation, and tissue homeostasis. 3. **Neurotransmission:** ADPRH is expressed in GABAergic interneurons and radial glial cells, suggesting its involvement in neuronal function and synaptic plasticity. 4. **Immune Regulation:** ADPRH is expressed in immature innate lymphoid cells and intestinal epithelial cells, highlighting its role in modulating immune responses and maintaining gut homeostasis. **Clinical Significance:** 1. **Gastrointestinal Disorders:** Alterations in ADPRH expression or activity have been linked to various gastrointestinal disorders, including inflammatory bowel disease, cancer, and neurodegenerative diseases. 2. **Neurological Disorders:** Dysregulation of ADPRH has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cancer:** ADPRH has been shown to regulate cancer cell growth, angiogenesis, and metastasis, making it a potential target for cancer therapy. 4. **Immunological Disorders:** ADPRH plays a crucial role in regulating immune responses, and its dysregulation has been linked to autoimmune diseases and immunodeficiency disorders. In conclusion, ADPRH is a multifunctional enzyme that plays a critical role in regulating various cellular processes, including protein de-ADP-ribosylation, cellular signaling, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of ADPRH and its potential therapeutic applications.

Genular Protein ID: 4133425743

Symbol: ADPRH_HUMAN

Name: ADP-ribose-L-arginine cleaving enzyme

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8349667

Title: Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase.

PubMed ID: 8349667

DOI: 10.1016/s0021-9258(17)46780-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 31599159

Title: The ARH and Macrodomain Families of alpha-ADP-ribose-acceptor Hydrolases Catalyze alpha-NAD+ Hydrolysis.

PubMed ID: 31599159

DOI: 10.1021/acschembio.9b00429

PubMed ID: 19407395

Title: Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1.

PubMed ID: 19407395

DOI: 10.1107/s1744309109014067

PubMed ID: 30472116

Title: (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.

PubMed ID: 30472116

DOI: 10.1016/j.chembiol.2018.11.001

Sequence Information:

  • Length: 357
  • Mass: 39507
  • Checksum: 4E23B12FAE84F12B
  • Sequence:
  • MEKYVAAMVL SAAGDALGYY NGKWEFLQDG EKIHRQLAQL GGLDALDVGR WRVSDDTVMH 
    LATAEALVEA GKAPKLTQLY YLLAKHYQDC MEDMDGRAPG GASVHNAMQL KPGKPNGWRI 
    PFNSHEGGCG AAMRAMCIGL RFPHHSQLDT LIQVSIESGR MTHHHPTGYL GALASALFTA 
    YAVNSRPPLQ WGKGLMELLP EAKKYIVQSG YFVEENLQHW SYFQTKWENY LKLRGILDGE 
    SAPTFPESFG VKERDQFYTS LSYSGWGGSS GHDAPMIAYD AVLAAGDSWK ELAHRAFFHG 
    GDSDSTAAIA GCWWGVMYGF KGVSPSNYEK LEYRNRLEET ARALYSLGSK EDTVISL

Genular Protein ID: 916951831

Symbol: B4E341_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 339
  • Mass: 36706
  • Checksum: 0686E3C3293A5D4A
  • Sequence:
  • MGAAVPGSRL GGSKISSLSA AKRRCGGPRR HPAYLGTVPE PGDPAPPQPA PSSTRSSQGL 
    FPGPGSPRHA RRSRVPVQAT AGGASVHNAM QLKPGKPNGW RIPFNSHEGG CGAAMRAMCI 
    GLRFPHHSQL DTLIQVSIES GRMTHHHPTG YLGALASALF TAYAVNSRPP LQWGKGLMEL 
    LPEAKKYIVQ SGYFVEENLQ HWSYFQTKWE NYLKLRGILD GESAPTFPES FGVKERDQFY 
    TSLSYSGWGG SSGHDAPMIA YDAVLAAGDS WKELAHRAFF HGGDSDSTAA IAGCWWGVMY 
    GFKGVSPSNY EKLEYRNRLE ETARALYSLG SKEDTVISL

Genular Protein ID: 3517165492

Symbol: A8K6X2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 357
  • Mass: 39477
  • Checksum: A0D84584A0705A21
  • Sequence:
  • MEKYVAAMVL SAAGDALGYY NGKWEFLQDG EKIHRQLAQL GGLDALDVGR WRVSDDTVMH 
    LATAEALVEA GKAPKLTQLY YLLAKHYQDC MEDMDGRAPG GASVHNAMQL KPGKPNGWRI 
    PFNSHEGGCG AAMRAMCIGL RFPHHSQLDA LIQVSIESGR MTHHHPTGYL GALASALFTA 
    YAVNSRPPLQ WGKGLMELLP EAKKYIVQSG YFVEENLQHW SYFQTKWENY LKLRGILDGE 
    SAPTFPESFG VKERDQFYTS LSYSGWGGSS GHDAPMIAYD AVLAAGDSWK ELAHRAFFHG 
    GDSDSTAAIA GCWWGVMYGF KGVSPSNYEK LEYRNRLEET ARALYSLGSK EDTVISL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.