Details for: CRYAB

Gene ID: 1410

Symbol: CRYAB

Ensembl ID: ENSG00000109846

Description: crystallin alpha B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 9.75
    Marker Score: 129641
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.92
    Marker Score: 5418
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4.39
    Marker Score: 5902
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 4.29
    Marker Score: 5187
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 4.13
    Marker Score: 14669
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 4.11
    Marker Score: 2746.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.06
    Marker Score: 5293
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.03
    Marker Score: 3432
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.9
    Marker Score: 4164
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.8
    Marker Score: 1251
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.64
    Marker Score: 12925
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.61
    Marker Score: 80652
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.49
    Marker Score: 1450
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.09
    Marker Score: 7035
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.97
    Marker Score: 3697
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.97
    Marker Score: 7098.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.85
    Marker Score: 1877
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.79
    Marker Score: 1629.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.75
    Marker Score: 3819
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.7
    Marker Score: 2255
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.69
    Marker Score: 1121
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.69
    Marker Score: 5053
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.67
    Marker Score: 16069.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.62
    Marker Score: 992.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.57
    Marker Score: 6322.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.57
    Marker Score: 87362
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.54
    Marker Score: 10965
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.54
    Marker Score: 814
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.48
    Marker Score: 2512
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 2.4
    Marker Score: 758
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.31
    Marker Score: 820
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.31
    Marker Score: 9647.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.28
    Marker Score: 2404.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.28
    Marker Score: 1107
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.25
    Marker Score: 2145
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.19
    Marker Score: 4452
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.17
    Marker Score: 1543
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.1
    Marker Score: 10306.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.07
    Marker Score: 5408
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.05
    Marker Score: 471
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.98
    Marker Score: 924
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.96
    Marker Score: 4793
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.95
    Marker Score: 2358
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.93
    Marker Score: 480
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.92
    Marker Score: 560
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.91
    Marker Score: 480
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.89
    Marker Score: 481.5
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.84
    Marker Score: 1028
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.84
    Marker Score: 1733.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.83
    Marker Score: 535.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.79
    Marker Score: 20199.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.77
    Marker Score: 15243.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.76
    Marker Score: 1155
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.73
    Marker Score: 3660
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.72
    Marker Score: 1141
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.71
    Marker Score: 4324
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.71
    Marker Score: 3938
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.63
    Marker Score: 6049
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.62
    Marker Score: 836
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.5
    Marker Score: 11674
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.47
    Marker Score: 820
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.46
    Marker Score: 495
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167475
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.45
    Marker Score: 3182
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.4
    Marker Score: 283
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.4
    Marker Score: 1538
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.4
    Marker Score: 1977
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.38
    Marker Score: 591.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.35
    Marker Score: 468
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.35
    Marker Score: 425.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.33
    Marker Score: 2564
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.33
    Marker Score: 537
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.31
    Marker Score: 2147.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.29
    Marker Score: 470
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.29
    Marker Score: 410
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.29
    Marker Score: 1554
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.24
    Marker Score: 307
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.24
    Marker Score: 2198
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.24
    Marker Score: 1365
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.22
    Marker Score: 19028
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.21
    Marker Score: 2840
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.2
    Marker Score: 439
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.19
    Marker Score: 534
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.18
    Marker Score: 667
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.18
    Marker Score: 785
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.18
    Marker Score: 1135
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.16
    Marker Score: 24770
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.13
    Marker Score: 1175
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.12
    Marker Score: 1212
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.11
    Marker Score: 268
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.11
    Marker Score: 1522
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.11
    Marker Score: 646
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.1
    Marker Score: 641
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.1
    Marker Score: 555.5
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.09
    Marker Score: 324
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.08
    Marker Score: 537
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.08
    Marker Score: 1790
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1
    Marker Score: 284
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71755
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47978

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Other Information

**Key characteristics:** - The protein is a glycoprotein with a molecular weight of approximately 140 kDa. - It is found in the human eye lens, where it is thought to be involved in the maintenance of the lens's structural integrity. - It is also expressed in other tissues, including cardiac muscle, thyroid cells, and skeletal muscle cells. **Pathways and functions:** - The CRYAB gene is involved in the regulation of cell growth and differentiation. It is a key regulator of lens development and maintenance. - It is also involved in the regulation of cell migration and survival. - It is also involved in the response to stress, heat stress, and hypoxia. **Clinical significance:** - Mutations in the CRYAB gene have been linked to the development of age-related macular degeneration (AMD), a leading cause of vision loss in older adults. - Studies of the CRYAB gene have also been linked to other eye diseases, such as cataracts and glaucoma. - Understanding the role of CRYAB in eye health is important for the development of new treatments for age-related eye diseases.

Genular Protein ID: 978141804

Symbol: CRYAB_HUMAN

Name: Alpha-crystallin B chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 838078

Title: The primary structure of the B2 chain of human alpha-crystallin.

PubMed ID: 838078

DOI: 10.1016/0014-5793(77)80757-6

PubMed ID: 2387586

Title: Human alpha B-crystallin gene and preferential promoter function in lens.

PubMed ID: 2387586

DOI: 10.1016/0888-7543(90)90204-8

PubMed ID: 1407707

Title: Accumulation of alpha B-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5'-flanking and coding sequence of the genomic DNA.

PubMed ID: 1407707

DOI: 10.1016/0304-3940(92)90689-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1560006

Title: Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle.

PubMed ID: 1560006

DOI: 10.1016/s0021-9258(18)42574-4

PubMed ID: 8999933

Title: Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.

PubMed ID: 8999933

DOI: 10.1074/jbc.272.4.2268

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 2539261

Title: Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain.

PubMed ID: 2539261

DOI: 10.1016/0092-8674(89)90173-6

PubMed ID: 8142454

Title: Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens.

PubMed ID: 8142454

DOI: 10.1016/0167-4838(94)90003-5

PubMed ID: 8175657

Title: Post-translational modifications of water-soluble human lens crystallins from young adults.

PubMed ID: 8175657

DOI: 10.1016/s0021-9258(18)99902-3

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 10930324

Title: The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage.

PubMed ID: 10930324

DOI: 10.1006/exer.2000.0868

PubMed ID: 10751411

Title: Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27.

PubMed ID: 10751411

DOI: 10.1074/jbc.m001981200

PubMed ID: 11577372

Title: Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans.

PubMed ID: 11577372

DOI: 10.1086/324158

PubMed ID: 11158243

Title: Ser-59 is the major phosphorylation site in alphaB-crystallin accumulated in the brains of patients with Alexander's disease.

PubMed ID: 11158243

DOI: 10.1046/j.1471-4159.2001.00038.x

PubMed ID: 11369851

Title: In vivo carbamylation and acetylation of water-soluble human lens alphaB-crystallin lysine 92.

PubMed ID: 11369851

DOI: 10.1110/ps.40901

PubMed ID: 14681890

Title: Myofibrillar myopathy caused by novel dominant negative alpha B-crystallin mutations.

PubMed ID: 14681890

DOI: 10.1002/ana.10767

PubMed ID: 14676215

Title: Association of the chaperone alphaB-crystallin with titin in heart muscle.

PubMed ID: 14676215

DOI: 10.1074/jbc.m307473200

PubMed ID: 19464326

Title: HSPB7 is a SC35 speckle resident small heat shock protein.

PubMed ID: 19464326

DOI: 10.1016/j.bbamcr.2009.05.005

PubMed ID: 20836128

Title: Importance of eye lens alpha-crystallin heteropolymer with 3:1 alphaA to alphaB ratio: stability, aggregation, and modifications.

PubMed ID: 20836128

DOI: 10.1002/iub.373

PubMed ID: 21337604

Title: Infantile muscular dystrophy in Canadian aboriginals is an alphaB-crystallinopathy.

PubMed ID: 21337604

DOI: 10.1002/ana.22331

PubMed ID: 22120592

Title: Acetylation of alphaA-crystallin in the human lens: effects on structure and chaperone function.

PubMed ID: 22120592

DOI: 10.1016/j.bbadis.2011.11.011

PubMed ID: 22890888

Title: Identification of histidine residues involved in Zn(2+) binding to alphaA- and alphaB-Crystallin by chemical modification and MALDI TOF mass spectrometry.

PubMed ID: 22890888

DOI: 10.1007/s10930-012-9439-0

PubMed ID: 23542032

Title: Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.

PubMed ID: 23542032

DOI: 10.1016/j.febslet.2013.03.024

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28470624

Title: alphaB-crystallin is a sensor for assembly intermediates and for the subunit topology of desmin intermediate filaments.

PubMed ID: 28470624

DOI: 10.1007/s12192-017-0788-7

PubMed ID: 28493373

Title: The novel alphaB-crystallin (CRYAB) mutation p.D109G causes restrictive cardiomyopathy.

PubMed ID: 28493373

DOI: 10.1002/humu.23248

PubMed ID: 31786107

Title: Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens.

PubMed ID: 31786107

DOI: 10.1016/j.bbagen.2019.129496

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 19646995

Title: Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20.

PubMed ID: 19646995

DOI: 10.1016/j.jmb.2009.07.069

PubMed ID: 9731540

Title: A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy.

PubMed ID: 9731540

DOI: 10.1038/1765

PubMed ID: 12601044

Title: Alteration of protein-protein interactions of congenital cataract crystallin mutants.

PubMed ID: 12601044

DOI: 10.1167/iovs.02-0950

PubMed ID: 16483541

Title: Alpha B-crystallin mutation in dilated cardiomyopathy.

PubMed ID: 16483541

DOI: 10.1016/j.bbrc.2006.01.154

PubMed ID: 16793013

Title: alphaB-crystallin mutation in dilated cardiomyopathies: low prevalence in a consecutive series of 200 unrelated probands.

PubMed ID: 16793013

DOI: 10.1016/j.bbrc.2006.05.203

PubMed ID: 18587492

Title: Crystallin gene mutations in Indian families with inherited pediatric cataract.

PubMed ID: 18587492

PubMed ID: 21866213

Title: Mutation analysis of 12 genes in Chinese families with congenital cataracts.

PubMed ID: 21866213

PubMed ID: 21920752

Title: A novel CRYAB mutation resulting in multisystemic disease.

PubMed ID: 21920752

DOI: 10.1016/j.nmd.2011.07.004

Sequence Information:

  • Length: 175
  • Mass: 20159
  • Checksum: AE08BED46B7849CB
  • Sequence:
  • MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW 
    FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR 
    KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVT AAPKK

Genular Protein ID: 4145253263

Symbol: A0A024R3B9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 108
  • Mass: 12253
  • Checksum: 69516E9976DC1238
  • Sequence:
  • MRLEKDRFSV NLDVKHFSPE ELKVKVLGDV IEVHGKHEER QDEHGFISRE FHRKYRIPAD 
    VDPLTITSSL SSDGVLTVNG PRKQVSGPER TIPITREEKP AVTAAPKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.