Details for: CRYAB
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 9.75
Marker Score: 129641 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 6.92
Marker Score: 5418 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 4.39
Marker Score: 5902 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 4.29
Marker Score: 5187 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 4.13
Marker Score: 14669 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 4.11
Marker Score: 2746.5 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 4.06
Marker Score: 5293 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.03
Marker Score: 3432 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.9
Marker Score: 4164 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.8
Marker Score: 1251 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.64
Marker Score: 12925 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 3.61
Marker Score: 80652 - Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 3.49
Marker Score: 1450 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.09
Marker Score: 7035 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.97
Marker Score: 3697 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.97
Marker Score: 7098.5 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.85
Marker Score: 1877 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.79
Marker Score: 1629.5 - Cell Name: Mueller cell (CL0000636)
Fold Change: 2.75
Marker Score: 3819 - Cell Name: keratinocyte (CL0000312)
Fold Change: 2.7
Marker Score: 2255 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.69
Marker Score: 1121 - Cell Name: supporting cell (CL0000630)
Fold Change: 2.69
Marker Score: 5053 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 2.67
Marker Score: 16069.5 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.62
Marker Score: 992.5 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.57
Marker Score: 6322.5 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.57
Marker Score: 87362 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.54
Marker Score: 10965 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.54
Marker Score: 814 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.48
Marker Score: 2512 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 2.4
Marker Score: 758 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.31
Marker Score: 820 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.31
Marker Score: 9647.5 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.28
Marker Score: 2404.5 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 2.28
Marker Score: 1107 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.25
Marker Score: 2145 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.19
Marker Score: 4452 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.17
Marker Score: 1543 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.1
Marker Score: 10306.5 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.07
Marker Score: 5408 - Cell Name: keratocyte (CL0002363)
Fold Change: 2.05
Marker Score: 471 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.98
Marker Score: 924 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.96
Marker Score: 4793 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.95
Marker Score: 2358 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.93
Marker Score: 480 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.92
Marker Score: 560 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.91
Marker Score: 480 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.89
Marker Score: 481.5 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 1.84
Marker Score: 1028 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.84
Marker Score: 1733.5 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.83
Marker Score: 535.5 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.79
Marker Score: 20199.5 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.77
Marker Score: 15243.5 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.76
Marker Score: 1155 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.73
Marker Score: 3660 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.72
Marker Score: 1141 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.71
Marker Score: 4324 - Cell Name: macroglial cell (CL0000126)
Fold Change: 1.71
Marker Score: 3938 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.63
Marker Score: 6049 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.62
Marker Score: 836 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.5
Marker Score: 11674 - Cell Name: fat cell (CL0000136)
Fold Change: 1.47
Marker Score: 820 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.46
Marker Score: 495 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167475 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.45
Marker Score: 3182 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.4
Marker Score: 283 - Cell Name: glial cell (CL0000125)
Fold Change: 1.4
Marker Score: 1538 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.4
Marker Score: 1977 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 1.38
Marker Score: 591.5 - Cell Name: Schwann cell (CL0002573)
Fold Change: 1.35
Marker Score: 468 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.35
Marker Score: 425.5 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.33
Marker Score: 2564 - Cell Name: melanocyte (CL0000148)
Fold Change: 1.33
Marker Score: 537 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.31
Marker Score: 2147.5 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.29
Marker Score: 470 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.29
Marker Score: 410 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.29
Marker Score: 1554 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.24
Marker Score: 307 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.24
Marker Score: 2198 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.24
Marker Score: 1365 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.22
Marker Score: 19028 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.21
Marker Score: 2840 - Cell Name: reticular cell (CL0000432)
Fold Change: 1.2
Marker Score: 439 - Cell Name: granulocyte (CL0000094)
Fold Change: 1.19
Marker Score: 534 - Cell Name: endocardial cell (CL0002350)
Fold Change: 1.18
Marker Score: 667 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.18
Marker Score: 785 - Cell Name: fibroblast (CL0000057)
Fold Change: 1.18
Marker Score: 1135 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.16
Marker Score: 24770 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.13
Marker Score: 1175 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.12
Marker Score: 1212 - Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.11
Marker Score: 268 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.11
Marker Score: 1522 - Cell Name: pericyte (CL0000669)
Fold Change: 1.11
Marker Score: 646 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.1
Marker Score: 641 - Cell Name: lymphocyte (CL0000542)
Fold Change: 1.1
Marker Score: 555.5 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.09
Marker Score: 324 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.08
Marker Score: 537 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.08
Marker Score: 1790 - Cell Name: muscle cell (CL0000187)
Fold Change: 1
Marker Score: 284 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71755 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47978
Hover over a box to see details here...
Hover over a box to see details here...
Hover over a box to see details here...
Other Information
Genular Protein ID: 978141804
Symbol: CRYAB_HUMAN
Name: Alpha-crystallin B chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 838078
Title: The primary structure of the B2 chain of human alpha-crystallin.
PubMed ID: 838078
PubMed ID: 2387586
Title: Human alpha B-crystallin gene and preferential promoter function in lens.
PubMed ID: 2387586
PubMed ID: 1407707
Title: Accumulation of alpha B-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5'-flanking and coding sequence of the genomic DNA.
PubMed ID: 1407707
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1560006
Title: Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle.
PubMed ID: 1560006
PubMed ID: 8999933
Title: Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.
PubMed ID: 8999933
PubMed ID: 7498159
Title: The major protein expression profile and two-dimensional protein database of human heart.
PubMed ID: 7498159
PubMed ID: 2539261
Title: Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain.
PubMed ID: 2539261
PubMed ID: 8142454
Title: Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens.
PubMed ID: 8142454
PubMed ID: 8175657
Title: Post-translational modifications of water-soluble human lens crystallins from young adults.
PubMed ID: 8175657
PubMed ID: 10508479
Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
PubMed ID: 10508479
DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5
PubMed ID: 10930324
Title: The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage.
PubMed ID: 10930324
PubMed ID: 10751411
Title: Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27.
PubMed ID: 10751411
PubMed ID: 11577372
Title: Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans.
PubMed ID: 11577372
DOI: 10.1086/324158
PubMed ID: 11158243
Title: Ser-59 is the major phosphorylation site in alphaB-crystallin accumulated in the brains of patients with Alexander's disease.
PubMed ID: 11158243
PubMed ID: 11369851
Title: In vivo carbamylation and acetylation of water-soluble human lens alphaB-crystallin lysine 92.
PubMed ID: 11369851
DOI: 10.1110/ps.40901
PubMed ID: 14681890
Title: Myofibrillar myopathy caused by novel dominant negative alpha B-crystallin mutations.
PubMed ID: 14681890
DOI: 10.1002/ana.10767
PubMed ID: 14676215
Title: Association of the chaperone alphaB-crystallin with titin in heart muscle.
PubMed ID: 14676215
PubMed ID: 19464326
Title: HSPB7 is a SC35 speckle resident small heat shock protein.
PubMed ID: 19464326
PubMed ID: 20836128
Title: Importance of eye lens alpha-crystallin heteropolymer with 3:1 alphaA to alphaB ratio: stability, aggregation, and modifications.
PubMed ID: 20836128
DOI: 10.1002/iub.373
PubMed ID: 21337604
Title: Infantile muscular dystrophy in Canadian aboriginals is an alphaB-crystallinopathy.
PubMed ID: 21337604
DOI: 10.1002/ana.22331
PubMed ID: 22120592
Title: Acetylation of alphaA-crystallin in the human lens: effects on structure and chaperone function.
PubMed ID: 22120592
PubMed ID: 22890888
Title: Identification of histidine residues involved in Zn(2+) binding to alphaA- and alphaB-Crystallin by chemical modification and MALDI TOF mass spectrometry.
PubMed ID: 22890888
PubMed ID: 23542032
Title: Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.
PubMed ID: 23542032
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28470624
Title: alphaB-crystallin is a sensor for assembly intermediates and for the subunit topology of desmin intermediate filaments.
PubMed ID: 28470624
PubMed ID: 28493373
Title: The novel alphaB-crystallin (CRYAB) mutation p.D109G causes restrictive cardiomyopathy.
PubMed ID: 28493373
DOI: 10.1002/humu.23248
PubMed ID: 31786107
Title: Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens.
PubMed ID: 31786107
PubMed ID: 32272059
Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.
PubMed ID: 32272059
PubMed ID: 19646995
Title: Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20.
PubMed ID: 19646995
PubMed ID: 9731540
Title: A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy.
PubMed ID: 9731540
DOI: 10.1038/1765
PubMed ID: 12601044
Title: Alteration of protein-protein interactions of congenital cataract crystallin mutants.
PubMed ID: 12601044
DOI: 10.1167/iovs.02-0950
PubMed ID: 16483541
Title: Alpha B-crystallin mutation in dilated cardiomyopathy.
PubMed ID: 16483541
PubMed ID: 16793013
Title: alphaB-crystallin mutation in dilated cardiomyopathies: low prevalence in a consecutive series of 200 unrelated probands.
PubMed ID: 16793013
PubMed ID: 18587492
Title: Crystallin gene mutations in Indian families with inherited pediatric cataract.
PubMed ID: 18587492
PubMed ID: 21866213
Title: Mutation analysis of 12 genes in Chinese families with congenital cataracts.
PubMed ID: 21866213
PubMed ID: 21920752
Title: A novel CRYAB mutation resulting in multisystemic disease.
PubMed ID: 21920752
Sequence Information:
- Length: 175
- Mass: 20159
- Checksum: AE08BED46B7849CB
- Sequence:
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVT AAPKK
Genular Protein ID: 4145253263
Symbol: A0A024R3B9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
Sequence Information:
- Length: 108
- Mass: 12253
- Checksum: 69516E9976DC1238
- Sequence:
MRLEKDRFSV NLDVKHFSPE ELKVKVLGDV IEVHGKHEER QDEHGFISRE FHRKYRIPAD VDPLTITSSL SSDGVLTVNG PRKQVSGPER TIPITREEKP AVTAAPKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.