Details for: CRYAB

Gene ID: 1410

Symbol: CRYAB

Ensembl ID: ENSG00000109846

Description: crystallin alpha B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 146.6691
    Cell Significance Index: -60.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.6747
    Cell Significance Index: -57.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 122.1148
    Cell Significance Index: -49.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.1711
    Cell Significance Index: -49.8100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 19.1019
    Cell Significance Index: 604.1600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 12.1474
    Cell Significance Index: 296.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 8.8353
    Cell Significance Index: 240.4900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 7.8211
    Cell Significance Index: 126.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 6.3874
    Cell Significance Index: 94.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.7522
    Cell Significance Index: 164.8900
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 4.9288
    Cell Significance Index: 14.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.6708
    Cell Significance Index: 474.2400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.3351
    Cell Significance Index: 12.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.9110
    Cell Significance Index: 223.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.8464
    Cell Significance Index: 4381.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6541
    Cell Significance Index: 124.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.1072
    Cell Significance Index: 2865.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9451
    Cell Significance Index: 90.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.7080
    Cell Significance Index: 3150.0500
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.5938
    Cell Significance Index: 7.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5679
    Cell Significance Index: 200.9900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.3094
    Cell Significance Index: 13.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2702
    Cell Significance Index: 561.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0889
    Cell Significance Index: 57.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8940
    Cell Significance Index: 122.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4729
    Cell Significance Index: 890.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4056
    Cell Significance Index: 257.6200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.3646
    Cell Significance Index: 3.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2377
    Cell Significance Index: 6.1100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0711
    Cell Significance Index: 1.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0532
    Cell Significance Index: 10.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0428
    Cell Significance Index: 19.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0284
    Cell Significance Index: 10.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0233
    Cell Significance Index: 1.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0135
    Cell Significance Index: 9.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0059
    Cell Significance Index: -0.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0743
    Cell Significance Index: -56.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0829
    Cell Significance Index: -45.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0853
    Cell Significance Index: -63.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0980
    Cell Significance Index: -14.2400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1036
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1049
    Cell Significance Index: -65.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1168
    Cell Significance Index: -65.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1209
    Cell Significance Index: -13.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1918
    Cell Significance Index: -34.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2192
    Cell Significance Index: -37.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2244
    Cell Significance Index: -64.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2560
    Cell Significance Index: -19.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2592
    Cell Significance Index: -31.8700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2715
    Cell Significance Index: -5.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2784
    Cell Significance Index: -22.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2993
    Cell Significance Index: -59.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3243
    Cell Significance Index: -68.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3399
    Cell Significance Index: -21.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3628
    Cell Significance Index: -4.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3928
    Cell Significance Index: -26.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4086
    Cell Significance Index: -47.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4522
    Cell Significance Index: -47.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4939
    Cell Significance Index: -58.2500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.5641
    Cell Significance Index: -4.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5748
    Cell Significance Index: -9.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5803
    Cell Significance Index: -35.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6864
    Cell Significance Index: -12.1300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.7243
    Cell Significance Index: -8.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.7302
    Cell Significance Index: -11.3000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.7723
    Cell Significance Index: -10.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7906
    Cell Significance Index: -39.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8327
    Cell Significance Index: -34.1200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.8444
    Cell Significance Index: -6.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8587
    Cell Significance Index: -44.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8903
    Cell Significance Index: -24.8800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.8961
    Cell Significance Index: -7.1600
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.9275
    Cell Significance Index: -7.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9641
    Cell Significance Index: -62.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0334
    Cell Significance Index: -63.3600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.0399
    Cell Significance Index: -13.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0439
    Cell Significance Index: -17.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0713
    Cell Significance Index: -55.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1004
    Cell Significance Index: -61.7500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.1267
    Cell Significance Index: -12.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1452
    Cell Significance Index: -42.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.2164
    Cell Significance Index: -55.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.2780
    Cell Significance Index: -26.7500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.3052
    Cell Significance Index: -18.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3538
    Cell Significance Index: -47.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.3924
    Cell Significance Index: -35.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4242
    Cell Significance Index: -63.0000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.4590
    Cell Significance Index: -36.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.5130
    Cell Significance Index: -29.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6048
    Cell Significance Index: -56.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.6252
    Cell Significance Index: -47.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.6661
    Cell Significance Index: -63.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.6954
    Cell Significance Index: -39.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.7443
    Cell Significance Index: -57.1100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -1.7725
    Cell Significance Index: -22.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.7866
    Cell Significance Index: -56.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.7889
    Cell Significance Index: -51.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.8001
    Cell Significance Index: -57.6600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -1.8289
    Cell Significance Index: -12.1400
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: -1.8703
    Cell Significance Index: -10.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural role in the eye lens**: CRYAB is a crucial component of the eye lens, where it forms a homodimeric complex with the alpha-A crystallin subunit. This complex is essential for maintaining the structural integrity of the lens and preventing amyloid fibril formation. 2. **Protein refolding and stabilization**: CRYAB has the ability to bind to unfolded proteins, facilitating their refolding and stabilization. This function is critical in maintaining protein homeostasis and preventing protein aggregation. 3. **Negative regulation of amyloid fibril formation**: CRYAB has been shown to inhibit amyloid fibril formation, which is a hallmark of various neurodegenerative diseases. 4. **Cellular stress response**: CRYAB plays a role in responding to cellular stressors, including heat shock, hydrogen peroxide, and hypoxia. 5. **Regulation of programmed cell death**: CRYAB has been implicated in the regulation of programmed cell death, also known as apoptosis. **Pathways and Functions:** 1. **Actin filament bundle**: CRYAB interacts with actin filaments, forming a bundle that regulates cellular processes, including cell migration and division. 2. **Amyloid-beta binding**: CRYAB binds to amyloid-beta peptides, preventing their aggregation and formation of amyloid fibrils. 3. **Apoptotic process involved in morphogenesis**: CRYAB regulates apoptosis during morphogenesis, a critical process in development and tissue formation. 4. **Cardiac myofibril**: CRYAB is a component of the cardiac myofibril, where it regulates muscle contraction and relaxation. 5. **Cellular responses to stimuli**: CRYAB responds to various cellular stimuli, including estradiol, heat, and hydrogen peroxide, by modulating protein refolding and cellular homeostasis. **Clinical Significance:** 1. **Neurodegenerative diseases**: CRYAB's role in preventing amyloid fibril formation and regulating apoptosis makes it a potential therapeutic target for neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Muscular dystrophy**: CRYAB's involvement in regulating muscle contraction and relaxation makes it a potential therapeutic target for muscular dystrophy. 3. **Cardiac disease**: CRYAB's role in regulating cardiac myofibril function makes it a potential therapeutic target for cardiac disease. 4. **Cancer**: CRYAB's regulation of apoptosis and cellular stress response makes it a potential therapeutic target for cancer. In conclusion, CRYAB is a multifunctional protein that plays a critical role in maintaining cellular homeostasis and responding to cellular stressors. Its widespread expression and involvement in various cellular processes make it a promising therapeutic target for various diseases. Further research is needed to fully elucidate the functions of CRYAB and its potential as a therapeutic target.

Genular Protein ID: 978141804

Symbol: CRYAB_HUMAN

Name: Alpha-crystallin B chain

UniProtKB Accession Codes:

P02511 B0YIX0 O43416 Q9UC37 Q9UC38 Q9UC39 Q9UC40 Q9UC41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTC 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 9 EMDB 1 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 838078

Title: The primary structure of the B2 chain of human alpha-crystallin.

PubMed ID: 838078

DOI: 10.1016/0014-5793(77)80757-6

PubMed ID: 2387586

Title: Human alpha B-crystallin gene and preferential promoter function in lens.

PubMed ID: 2387586

DOI: 10.1016/0888-7543(90)90204-8

PubMed ID: 1407707

Title: Accumulation of alpha B-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5'-flanking and coding sequence of the genomic DNA.

PubMed ID: 1407707

DOI: 10.1016/0304-3940(92)90689-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1560006

Title: Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle.

PubMed ID: 1560006

DOI: 10.1016/s0021-9258(18)42574-4

PubMed ID: 8999933

Title: Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.

PubMed ID: 8999933

DOI: 10.1074/jbc.272.4.2268

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 2539261

Title: Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain.

PubMed ID: 2539261

DOI: 10.1016/0092-8674(89)90173-6

PubMed ID: 8142454

Title: Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens.

PubMed ID: 8142454

DOI: 10.1016/0167-4838(94)90003-5

PubMed ID: 8175657

Title: Post-translational modifications of water-soluble human lens crystallins from young adults.

PubMed ID: 8175657

DOI: 10.1016/s0021-9258(18)99902-3

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 10930324

Title: The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage.

PubMed ID: 10930324

DOI: 10.1006/exer.2000.0868

PubMed ID: 10751411

Title: Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27.

PubMed ID: 10751411

DOI: 10.1074/jbc.m001981200

PubMed ID: 11577372

Title: Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans.

PubMed ID: 11577372

DOI: 10.1086/324158

PubMed ID: 11158243

Title: Ser-59 is the major phosphorylation site in alphaB-crystallin accumulated in the brains of patients with Alexander's disease.

PubMed ID: 11158243

DOI: 10.1046/j.1471-4159.2001.00038.x

PubMed ID: 11369851

Title: In vivo carbamylation and acetylation of water-soluble human lens alphaB-crystallin lysine 92.

PubMed ID: 11369851

DOI: 10.1110/ps.40901

PubMed ID: 14681890

Title: Myofibrillar myopathy caused by novel dominant negative alpha B-crystallin mutations.

PubMed ID: 14681890

DOI: 10.1002/ana.10767

PubMed ID: 14676215

Title: Association of the chaperone alphaB-crystallin with titin in heart muscle.

PubMed ID: 14676215

DOI: 10.1074/jbc.m307473200

PubMed ID: 19464326

Title: HSPB7 is a SC35 speckle resident small heat shock protein.

PubMed ID: 19464326

DOI: 10.1016/j.bbamcr.2009.05.005

PubMed ID: 20836128

Title: Importance of eye lens alpha-crystallin heteropolymer with 3:1 alphaA to alphaB ratio: stability, aggregation, and modifications.

PubMed ID: 20836128

DOI: 10.1002/iub.373

PubMed ID: 21337604

Title: Infantile muscular dystrophy in Canadian aboriginals is an alphaB-crystallinopathy.

PubMed ID: 21337604

DOI: 10.1002/ana.22331

PubMed ID: 22120592

Title: Acetylation of alphaA-crystallin in the human lens: effects on structure and chaperone function.

PubMed ID: 22120592

DOI: 10.1016/j.bbadis.2011.11.011

PubMed ID: 22890888

Title: Identification of histidine residues involved in Zn(2+) binding to alphaA- and alphaB-Crystallin by chemical modification and MALDI TOF mass spectrometry.

PubMed ID: 22890888

DOI: 10.1007/s10930-012-9439-0

PubMed ID: 23542032

Title: Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.

PubMed ID: 23542032

DOI: 10.1016/j.febslet.2013.03.024

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28470624

Title: alphaB-crystallin is a sensor for assembly intermediates and for the subunit topology of desmin intermediate filaments.

PubMed ID: 28470624

DOI: 10.1007/s12192-017-0788-7

PubMed ID: 28493373

Title: The novel alphaB-crystallin (CRYAB) mutation p.D109G causes restrictive cardiomyopathy.

PubMed ID: 28493373

DOI: 10.1002/humu.23248

PubMed ID: 31786107

Title: Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens.

PubMed ID: 31786107

DOI: 10.1016/j.bbagen.2019.129496

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 19646995

Title: Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20.

PubMed ID: 19646995

DOI: 10.1016/j.jmb.2009.07.069

PubMed ID: 28939839

Title: Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase.

PubMed ID: 28939839

DOI: 10.1038/s41467-017-00865-1

PubMed ID: 9731540

Title: A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy.

PubMed ID: 9731540

DOI: 10.1038/1765

PubMed ID: 12601044

Title: Alteration of protein-protein interactions of congenital cataract crystallin mutants.

PubMed ID: 12601044

DOI: 10.1167/iovs.02-0950

PubMed ID: 16483541

Title: Alpha B-crystallin mutation in dilated cardiomyopathy.

PubMed ID: 16483541

DOI: 10.1016/j.bbrc.2006.01.154

PubMed ID: 16793013

Title: alphaB-crystallin mutation in dilated cardiomyopathies: low prevalence in a consecutive series of 200 unrelated probands.

PubMed ID: 16793013

DOI: 10.1016/j.bbrc.2006.05.203

PubMed ID: 18587492

Title: Crystallin gene mutations in Indian families with inherited pediatric cataract.

PubMed ID: 18587492

PubMed ID: 21866213

Title: Mutation analysis of 12 genes in Chinese families with congenital cataracts.

PubMed ID: 21866213

PubMed ID: 21920752

Title: A novel CRYAB mutation resulting in multisystemic disease.

PubMed ID: 21920752

DOI: 10.1016/j.nmd.2011.07.004

Sequence Information:

  • Length: 175
  • Mass: 20159
  • Checksum: AE08BED46B7849CB
  • Sequence:
    • MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW 
FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR 
KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVT AAPKK

Genular Protein ID: 4145253263

Symbol: A0A024R3B9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024R3B9

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 5 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 108
  • Mass: 12253
  • Checksum: 69516E9976DC1238
  • Sequence:
    • MRLEKDRFSV NLDVKHFSPE ELKVKVLGDV IEVHGKHEER QDEHGFISRE FHRKYRIPAD 
VDPLTITSSL SSDGVLTVNG PRKQVSGPER TIPITREEKP AVTAAPKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.