Genular: Defining Cellular Identity and Function

Details for: Fas

Gene ID: 14102

Symbol: Fas

Ensembl ID: ENSMUSG00000024778

Description: Fas cell surface death receptor

Associated with

Apoptosis
(R-MMU-109581)
Casp8 activity is inhibited
(R-MMU-5218900)
Caspase activation via death receptors in the presence of ligand
(R-MMU-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-MMU-5357769)
Death receptor signaling
(R-MMU-73887)
Dimerization of procaspase-8
(R-MMU-69416)
Fasl/ cd95l signaling
(R-MMU-75157)
Programmed cell death
(R-MMU-5357801)
Regulated necrosis
(R-MMU-5218859)
Regulation by c-flip
(R-MMU-3371378)
Regulation of necroptotic cell death
(R-MMU-5675482)
Ripk1-mediated regulated necrosis
(R-MMU-5213460)
Activation-induced cell death of t cells
(GO:0006924)
Apical plasma membrane
(GO:0016324)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
B cell mediated immunity
(GO:0019724)
Calmodulin binding
(GO:0005516)
Cd95 death-inducing signaling complex
(GO:0031265)
Cell surface
(GO:0009986)
Cellular response to amino acid starvation
(GO:0034198)
Cellular response to hyperoxia
(GO:0071455)
Cellular response to lithium ion
(GO:0071285)
Circadian rhythm
(GO:0007623)
Cytosol
(GO:0005829)
Death-inducing signaling complex
(GO:0031264)
Dendrite regeneration
(GO:0031104)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Fas signaling pathway
(GO:0036337)
Gene expression
(GO:0010467)
Hepatocyte apoptotic process
(GO:0097284)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Immunoglobulin production
(GO:0002377)
Inflammatory cell apoptotic process
(GO:0006925)
Kinase binding
(GO:0019900)
Lymphocyte apoptotic process
(GO:0070227)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Motor neuron apoptotic process
(GO:0097049)
Necroptotic signaling pathway
(GO:0097527)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of b cell activation
(GO:0050869)
Negative regulation of schwann cell migration
(GO:1900148)
Negative regulation of schwann cell proliferation
(GO:0010626)
Negative thymic t cell selection
(GO:0045060)
Neuronal cell body
(GO:0043025)
Neuron apoptotic process
(GO:0051402)
Nuclear body
(GO:0016604)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
(GO:2001269)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of release of cytochrome c from mitochondria
(GO:0090200)
Protease binding
(GO:0002020)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of apoptotic process
(GO:0042981)
Regulation of b cell differentiation
(GO:0045577)
Regulation of cell population proliferation
(GO:0042127)
Regulation of hematopoietic progenitor cell differentiation
(GO:1901532)
Regulation of myeloid cell differentiation
(GO:0045637)
Regulation of stress-activated mapk cascade
(GO:0032872)
Regulation of t cell differentiation
(GO:0045580)
Response to glucocorticoid
(GO:0051384)
Response to toxic substance
(GO:0009636)
Sarcolemma
(GO:0042383)
Secretory granule
(GO:0030141)
Signal transduction
(GO:0007165)
Spleen development
(GO:0048536)
T cell homeostasis
(GO:0043029)
Transmembrane signaling receptor activity
(GO:0004888)
Tumor necrosis factor receptor activity
(GO:0005031)

Other Information

Proteins

Tumor necrosis factor receptor superfamily member 6
Q8C350_MOUSE

Genular Protein ID: 1049835192

Symbol: TNR6_MOUSE

Name: Tumor necrosis factor receptor superfamily member 6

UniProtKB Accession Codes:

P25446 Q6GT31 Q9DCQ1

Database IDs:

Citations:

PubMed ID: 1371136

Title: The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

PubMed ID: 1371136

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 17545588

Title: A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas.

PubMed ID: 17545588

DOI: 10.1158/0008-5472.can-06-4006

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7680478

Title: Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

PubMed ID: 7680478

DOI: 10.1073/pnas.90.5.1756

PubMed ID: 9215629

Title: Daxx, a novel Fas-binding protein that activates JNK and apoptosis.

PubMed ID: 9215629

DOI: 10.1016/s0092-8674(00)80294-9

PubMed ID: 11034606

Title: FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun NH2-terminal kinase activation.

PubMed ID: 11034606

DOI: 10.1084/jem.192.8.1165

PubMed ID: 15383280

Title: Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions.

PubMed ID: 15383280

DOI: 10.1016/j.molcel.2004.08.020

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23785138

Title: p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.

PubMed ID: 23785138

DOI: 10.1523/jneurosci.2757-12.2013

PubMed ID: 1372394

Title: Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis.

PubMed ID: 1372394

DOI: 10.1038/356314a0

Sequence Information:

Length: 327
Mass: 37437
Checksum: D8DA95CA525CED56
Sequence:

MLWIWAVLPL VLAGSQLRVH TQGTNSISES LKLRRRVRET DKNCSEGLYQ GGPFCCQPCQ 
PGKKKVEDCK MNGGTPTCAP CTEGKEYMDK NHYADKCRRC TLCDEEHGLE VETNCTLTQN 
TKCKCKPDFY CDSPGCEHCV RCASCEHGTL EPCTATSNTN CRKQSPRNRL WLLTILVLLI 
PLVFIYRKYR KRKCWKRRQD DPESRTSSRE TIPMNASNLS LSKYIPRIAE DMTIQEAKKF 
ARENNIKEGK IDEIMHDSIQ DTAEQKVQLL LCWYQSHGKS DAYQDLIKGL KKAECRRTLD 
KFQDMVQKDL GKSTPDTGNE NEGQCLE

Genular Protein ID: 2342310511

Symbol: Q8C350_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C350 D3Z6E5

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 63
Mass: 7116
Checksum: 37283F7401ECAD82
Sequence:

MLWIWAVLPL VLAGSQLRVH TQGTNSISES LKLRRRVRET DKNCSEGLYQ GGPFCCQPCQ 
PEN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fas

Associated with

Other Information

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. PubMed ID: 1371136

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas. PubMed ID: 17545588

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. PubMed ID: 7680478

Daxx, a novel Fas-binding protein that activates JNK and apoptosis. PubMed ID: 9215629

FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun NH2-terminal kinase activation. PubMed ID: 11034606

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. PubMed ID: 15383280

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. PubMed ID: 23785138

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. PubMed ID: 1372394

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303