Genular: Defining Cellular Identity and Function

Details for: Fasl

Gene ID: 14103

Symbol: Fasl

Ensembl ID: ENSMUSG00000000817

Description: Fas ligand

Associated with

Apoptosis
(R-MMU-109581)
Casp8 activity is inhibited
(R-MMU-5218900)
Caspase activation via death receptors in the presence of ligand
(R-MMU-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-MMU-5357769)
Death receptor signaling
(R-MMU-73887)
Dimerization of procaspase-8
(R-MMU-69416)
Fasl/ cd95l signaling
(R-MMU-75157)
Programmed cell death
(R-MMU-5357801)
Regulated necrosis
(R-MMU-5218859)
Regulation by c-flip
(R-MMU-3371378)
Regulation of necroptotic cell death
(R-MMU-5675482)
Ripk1-mediated regulated necrosis
(R-MMU-5213460)
Signal transduction
(R-MMU-162582)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Caveola
(GO:0005901)
Cell surface
(GO:0009986)
Cytokine activity
(GO:0005125)
Cytoplasmic vesicle
(GO:0031410)
Death receptor binding
(GO:0005123)
Endosomal lumen acidification
(GO:0048388)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Immune response
(GO:0006955)
Inflammatory cell apoptotic process
(GO:0006925)
Intracellular chloride ion homeostasis
(GO:0030644)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Necroptotic process
(GO:0070266)
Necroptotic signaling pathway
(GO:0097527)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of phosphatidylserine exposure on apoptotic cell surface
(GO:1905782)
Release of sequestered calcium ion into cytosol by endoplasmic reticulum
(GO:1903514)
Retinal cell programmed cell death
(GO:0046666)
T cell apoptotic process
(GO:0070231)
Tumor necrosis factor receptor binding
(GO:0005164)

Other Information

Proteins

Tumor necrosis factor ligand superfamily member 6
Q99PH8_MOUSE

Genular Protein ID: 1344824756

Symbol: TNFL6_MOUSE

Name: Tumor necrosis factor ligand superfamily member 6

UniProtKB Accession Codes:

P41047 Q61217 Q9R1F2

Database IDs:

Citations:

PubMed ID: 7511063

Title: Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand.

PubMed ID: 7511063

DOI: 10.1016/0092-8674(94)90375-1

PubMed ID: 7544870

Title: Comparative molecular modelling of the Fas-ligand and other members of the TNF family.

PubMed ID: 7544870

DOI: 10.1016/0161-5890(95)00016-8

PubMed ID: 7889405

Title: The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster.

PubMed ID: 7889405

DOI: 10.1016/1074-7613(94)90106-6

PubMed ID: 10552956

Title: Cloning and expression of a short Fas ligand: a new alternatively spliced product of the mouse Fas ligand gene.

PubMed ID: 10552956

PubMed ID: 7532682

Title: Fas-mediated cytotoxicity by freshly isolated natural killer cells.

PubMed ID: 7532682

DOI: 10.1084/jem.181.3.1235

PubMed ID: 10779162

Title: Antigen-specific induction of peripheral T cell tolerance in vivo by codelivery of DNA vectors encoding antigen and Fas ligand.

PubMed ID: 10779162

DOI: 10.1089/10430340050015464

PubMed ID: 19794494

Title: Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.

PubMed ID: 19794494

DOI: 10.1038/nature08402

PubMed ID: 7495745

Title: Characterization of the non-functional Fas ligand of gld mice.

PubMed ID: 7495745

DOI: 10.1093/intimm/7.9.1381

PubMed ID: 9108079

Title: Polymorphism of murine Fas ligand that affects the biological activity.

PubMed ID: 9108079

DOI: 10.1073/pnas.94.8.3914

Sequence Information:

Length: 279
Mass: 31442
Checksum: 37972E2728E0A1CA
Sequence:

MQQPMNYPCP QIFWVDSSAT SSWAPPGSVF PCPSCGPRGP DQRRPPPPPP PVSPLPPPSQ 
PLPLPPLTPL KKKDHNTNLW LPVVFFMVLV ALVGMGLGMY QLFHLQKELA ELREFTNQSL 
KVSSFEKQIA NPSTPSEKKE PRSVAHLTGN PHSRSIPLEW EDTYGTALIS GVKYKKGGLV 
INETGLYFVY SKVYFRGQSC NNQPLNHKVY MRNSKYPEDL VLMEEKRLNY CTTGQIWAHS 
SYLGAVFNLT SADHLYVNIS QLSLINFEES KTFFGLYKL

Genular Protein ID: 498365216

Symbol: Q99PH8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q99PH8

Database IDs:

Sequence Information:

Length: 131
Mass: 14538
Checksum: 7FB9C3E7242EB424
Sequence:

MQQPMNYPCP QIFWVDSSAT SSWAPPGSVF PCPSCGPRGP DQRRPPPPPP PVSPLPPPSQ 
PLPLPPLTPL KKKDHNTNLW LPVVFFMVLV ALVGMGLGMY QLFHLQKELA ELRDPTPVHP 
LKKKSRGVWP I

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fasl

Associated with

Other Information

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. PubMed ID: 7511063

Comparative molecular modelling of the Fas-ligand and other members of the TNF family. PubMed ID: 7544870

The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. PubMed ID: 7889405

Cloning and expression of a short Fas ligand: a new alternatively spliced product of the mouse Fas ligand gene. PubMed ID: 10552956

Fas-mediated cytotoxicity by freshly isolated natural killer cells. PubMed ID: 7532682

Antigen-specific induction of peripheral T cell tolerance in vivo by codelivery of DNA vectors encoding antigen and Fas ligand. PubMed ID: 10779162

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. PubMed ID: 19794494

Characterization of the non-functional Fas ligand of gld mice. PubMed ID: 7495745

Polymorphism of murine Fas ligand that affects the biological activity. PubMed ID: 9108079