Genular: Defining Cellular Identity and Function

Details for: Fasn

Gene ID: 14104

Symbol: Fasn

Ensembl ID: ENSMUSG00000025153

Description: fatty acid synthase

Associated with

Chrebp activates metabolic gene expression
(R-MMU-163765)
Fatty acid metabolism
(R-MMU-8978868)
Fatty acyl-coa biosynthesis
(R-MMU-75105)
Integration of energy metabolism
(R-MMU-163685)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Metabolism of water-soluble vitamins and cofactors
(R-MMU-196849)
Vitamin b5 (pantothenate) metabolism
(R-MMU-199220)
(3r)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
(GO:0008659)
(3r)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
(GO:0019171)
3-oxoacyl-[acyl-carrier-protein] reductase (nadph) activity
(GO:0004316)
3-oxoacyl-[acyl-carrier-protein] synthase activity
(GO:0004315)
Acetyl-coa metabolic process
(GO:0006084)
Acyltransferase activity
(GO:0016746)
Biosynthetic process
(GO:0009058)
Catalytic activity
(GO:0003824)
Cellular response to interleukin-4
(GO:0071353)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Enoyl-[acyl-carrier-protein] reductase (nadph, a-specific) activity
(GO:0047117)
Establishment of endothelial intestinal barrier
(GO:0090557)
Ether lipid biosynthetic process
(GO:0008611)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid metabolic process
(GO:0006631)
Fatty acid synthase activity
(GO:0004312)
Fatty acyl-[acp] hydrolase activity
(GO:0016297)
Glandular epithelial cell development
(GO:0002068)
Glycogen granule
(GO:0042587)
Golgi apparatus
(GO:0005794)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Lipid biosynthetic process
(GO:0008610)
Lipid metabolic process
(GO:0006629)
Lyase activity
(GO:0016829)
Mammary gland development
(GO:0030879)
Metabolic process
(GO:0008152)
Mitochondrion
(GO:0005739)
Modulation by host of viral process
(GO:0044788)
Monocyte differentiation
(GO:0030224)
Neutrophil differentiation
(GO:0030223)
Oxidoreductase activity
(GO:0016491)
Phosphopantetheine binding
(GO:0031177)
Plasma membrane
(GO:0005886)
S-adenosylmethionine-dependent methyltransferase activity
(GO:0008757)
S-malonyltransferase activity
(GO:0016419)
Tissue development
(GO:0009888)
Transferase activity
(GO:0016740)
[acyl-carrier-protein] s-acetyltransferase activity
(GO:0004313)
[acyl-carrier-protein] s-malonyltransferase activity
(GO:0004314)

Other Information

Proteins

Fatty acid synthase

Genular Protein ID: 2901583518

Symbol: FAS_MOUSE

Name: Fatty acid synthase

UniProtKB Accession Codes:

P19096 B1ATU8 Q6PB72 Q8C4Z0 Q9EQR0

Database IDs:

Citations:

PubMed ID: 11029661

Title: Involvement of fatty acid synthase in axonal development in mouse embryos.

PubMed ID: 11029661

DOI: 10.1046/j.1365-2443.2000.00369.x

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 2920037

Title: Structure of mouse fatty acid synthase mRNA. Identification of the two NADPH binding sites.

PubMed ID: 2920037

DOI: 10.1016/0006-291x(89)92776-9

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21987372

Title: Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: evidence from cultured explants.

PubMed ID: 21987372

DOI: 10.1002/hep.24733

PubMed ID: 29328619

Title: Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering.

PubMed ID: 29328619

DOI: 10.1021/acschembio.7b00718

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 31811668

Title: Type I fatty acid synthase trapped in the octanoyl-bound state.

PubMed ID: 31811668

DOI: 10.1002/pro.3797

Sequence Information:

Length: 2504
Mass: 272428
Checksum: 2B48068B9D370C6F
Sequence:

MEEVVIAGMS GKLPESENLQ EFWANLIGGV DMVTDDDRRW KAGLYGLPKR SGKLKDLSKF 
DASFFGVHPK QAHTMDPQLR LLLEVSYEAI VDGGINPASL RGTNTGVWVG VSGSEASEAL 
SRDPETLLGY SMVGCQRAMM ANRLSFFFDF KGPSIALDTA CSSSLLALQN AYQAIRSGEC 
PAALVGGINL LLKPNTSVQF MKLGMLSPDG TCRSFDDSGS GYCRSEAVVA VLLTKKSLAR 
RVYATILNAG TNTDGSKEQG VTFPSGEVQE QLICSLYQPA GLAPESLEYI EAHGTGTKVG 
DPQELNGITR SLCAFRQAPL LIGSTKSNMG HPEPASGLAA LTKVLLSLEH GVWAPNLHFH 
NPNPEIPALL DGRLQVVDRP LPVRGGNVGI NSFGFGGSNV HVILQPNTRQ APAPTAHAAL 
PHLLHASGRT LEAVQDLLEQ GRQHSQDLAF VSMLNDIAAT PTAAMPFRGY TVLGVEGRVQ 
EVQQVSTNKR PLWFICSGMG TQWRGMGLSL MRLDSFRESI LRSDEAVKPL GVKVSDLLLS 
TDERTFDDIV HAFVSLTAIQ IALIDLLTSV GLKPDGIIGH SLGEVACGYA DGCLSQREAV 
LAAYWRGQCI KDAHLPPGSM AAVGLSWEEC KQRCPAGVVP ACHNSEDTVT ISGPQAAVNE 
FVEQLKQEGV FAKEVRTGGL AFHSYFMEGI APTLLQALKK VIREPRPRSA RWLSTSIPEA 
QWQSSLARTS SAEYNVNNLV SPVLFQEALW HIPEHAVVLE IAPHALLQAV LKRGVKSSCT 
IIPLMKRDHK DNLEFFLTNL GKVHLTGINV NPNALFPPVE FPAPRGTPLI SPHIKWDHSQ 
TWDVPVAEDF PNGSSSSSAT VYSIDASPES PDHYLVDHCI DGRVIFPGTG YLCLVWKTLA 
RSLGLSLEET PVVFENVSFH QATILPKTGT VALEVRLLEA SHAFEVSDTG NLIVSGKVYL 
WEDPNSKLFD HPEVPTPPES ASVSRLTQGE VYKELRLRGY DYGPQFQGIC EATLEGEQGK 
LLWKDNWVTF MDTMLQVSIL GSSQQSLQLP TRVTAIYIDP ATHRQKVYRL KEDTQVADVT 
TSRCLGITVS GGIHISRLQT TATSRRQQEQ LVPTLEKFVF TPHMEAECLS ESTALQKELQ 
LCKGLARALQ TKATQQGLKA AMLGQEDPPQ HGLPRLLAAA CQLQLNGNLQ LELGEALAQE 
RLLLPEDPLI SGLLNSQALK ACVDTALENL STLKMKVAEV LAGEGHLYSR IPALLNTQPM 
LQLEYTATDR HPQALKDVQT KLQQHDVAQG QWNPSDPAPS SLGALDLLVC NCALATLGDP 
ALALDNMVAA LKEGGFLLVH TVLKGHALGE TLACLPSEVQ PAPSLLSQEE WESLFSRKAL 
HLVGLKRSFY GTALFLCRRA IPQEKPIFLS VEDTSFQWVD SLKSTLATSS SQPVWLTAMD 
CPTSGVVGLV NCLRKEPGGH RIRCILLSNL SNTSHAPKLD PGSPELQQVL KHDLVMNVYR 
DGAWGAFRHF QLEQDKPKEQ TAHAFVNVLT RGDLASIRWV SSPLKHTQPS SSGAQLCTVY 
YASLNFRDIM LATGKLSPDA IPGKWASRDC MLGMEFSGRD RCGRRVMGLV PAEGLATSVL 
LSSDFLWDVP SSWTLEEAAS VPVVYTTAYY SLVVRGRIQR GETVLIHSGS GGVGQAAISI 
ALSLGCRVFT TVGSAEKRAY LQARFPQLDD TSFANSRDTS FEQHVLLHTG GKGVDLVLNS 
LAEEKLQASV RCLAQHGRFL EIGKFDLSNN HPLGMAIFLK NVTFHGILLD ALFEEANDSW 
REVAALLKAG IRDGVVKPLK CTVFPKAQVE DAFRYMAQGK HIGKVLVQVR EEEPEAVLPG 
AQPTLISAIS KTFCPAHKSY IITGGLGGFG LELARWLVLR GAQRLVLTSR SGIRTGYQAK 
HIREWRRQGI QVLVSTSNVS SLEGARALIA EATKLGPVGG VFNLAMVLRD AMLENQTPEL 
FQDVNKPKYN GTLNLDRATR EACPELDYFV AFSSVSCGRG NAGQTNYGFA NSTMERICEQ 
RRHDGLPGLA VQWGAIGDVG IVLEAMGTND TVIGGTLPQR ISSCMEVLDL FLNQPHAVLS 
SFVLAEKKAV AHGDGDTQRD LVKAVAHILG IRDLAGINLD STLADLGLDS LMGVEVRQIL 
EREHDLVLPM REVRQLTLRK LQEMSSKTDS ATDTTAPKSR SDTSLKQNQL NLSTLLVNPE 
GPTLTQLNSV QSSERPLFLV HPIEGSTTVF HSLAAKLSVP TYGLQCTQAA PLDSIPNLAA 
YYIDCIKQVQ PEGPYRIAGY SFGACVAFEM CSQLQAQQGP APTHNNLFLF DGSHTYVLAY 
TQSYRAKMTP GCEAEAEAEA LCFFIKQFLD VEHSKVLEAL LPLKSLEDRV AASVDLITKS 
HHSLDRRELS FAAVSFYHKL RAADQYKPKA KYHGNVTLLR AKTGGTYGED LGADYNLSQV 
CDGKVSVHII EGDHRTLLEG SGLESIINII HSSLAEPRVS VREG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fasn

Associated with

Other Information

Involvement of fatty acid synthase in axonal development in mouse embryos. PubMed ID: 11029661

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Structure of mouse fatty acid synthase mRNA. Identification of the two NADPH binding sites. PubMed ID: 2920037

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: evidence from cultured explants. PubMed ID: 21987372

Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering. PubMed ID: 29328619

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Type I fatty acid synthase trapped in the octanoyl-bound state. PubMed ID: 31811668