Genular: Defining Cellular Identity and Function

Details for: Fbn1

Gene ID: 14118

Symbol: Fbn1

Ensembl ID: ENSMUSG00000027204

Description: fibrillin 1

Associated with

Degradation of the extracellular matrix
(R-MMU-1474228)
Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Integrin cell surface interactions
(R-MMU-216083)
Metabolism of proteins
(R-MMU-392499)
Molecules associated with elastic fibres
(R-MMU-2129379)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Activation of protein kinase a activity
(GO:0034199)
Anatomical structure morphogenesis
(GO:0009653)
Basement membrane
(GO:0005604)
Calcium ion binding
(GO:0005509)
Cell adhesion mediated by integrin
(GO:0033627)
Collagen-containing extracellular matrix
(GO:0062023)
Cytokine production
(GO:0001816)
Extracellular matrix
(GO:0031012)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Gene expression
(GO:0010467)
Glucose homeostasis
(GO:0042593)
Glucose metabolic process
(GO:0006006)
Heart development
(GO:0007507)
Heparin binding
(GO:0008201)
Hormone activity
(GO:0005179)
Identical protein binding
(GO:0042802)
Immunoglobulin production
(GO:0002377)
Integrin binding
(GO:0005178)
Kidney development
(GO:0001822)
Lung alveolus development
(GO:0048286)
Lung development
(GO:0030324)
Metanephros development
(GO:0001656)
Microfibril
(GO:0001527)
Negative regulation of brown fat cell differentiation
(GO:1903444)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of osteoclast development
(GO:2001205)
Negative regulation of osteoclast differentiation
(GO:0045671)
Positive regulation of appetite
(GO:0032100)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase a signaling
(GO:0010737)
Sequestering of bmp in extracellular matrix
(GO:0035582)
Sequestering of tgfbeta in extracellular matrix
(GO:0035583)
Skeletal system development
(GO:0001501)

Other Information

Proteins

FBN1_MOUSE

Genular Protein ID: 3900358928

Symbol: FBN1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q61554 A2AQ53 Q60826

Database IDs:

Citations:

PubMed ID: 7829516

Title: Primary structure and developmental expression of Fbn-1, the mouse fibrillin gene.

PubMed ID: 7829516

DOI: 10.1074/jbc.270.4.1798

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 16407178

Title: Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

PubMed ID: 16407178

DOI: 10.1074/jbc.m511599200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19940141

Title: ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation.

PubMed ID: 19940141

DOI: 10.1074/jbc.m109.076919

PubMed ID: 20855508

Title: Fibrillin-1 and -2 differentially modulate endogenous TGF-{beta} and BMP bioavailability during bone formation.

PubMed ID: 20855508

DOI: 10.1083/jcb.201003089

PubMed ID: 24039232

Title: Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism.

PubMed ID: 24039232

DOI: 10.1242/jcs.127571

PubMed ID: 27087445

Title: Asprosin, a fasting-induced glucogenic protein hormone.

PubMed ID: 27087445

DOI: 10.1016/j.cell.2016.02.063

PubMed ID: 29106398

Title: Asprosin is a centrally acting orexigenic hormone.

PubMed ID: 29106398

DOI: 10.1038/nm.4432

PubMed ID: 31798959

Title: The Asprosin-OLFR734 hormonal signaling axis modulates male fertility.

PubMed ID: 31798959

DOI: 10.1038/s41421-019-0122-x

PubMed ID: 31230984

Title: OLFR734 mediates glucose metabolism as a receptor of asprosin.

PubMed ID: 31230984

DOI: 10.1016/j.cmet.2019.05.022

PubMed ID: 30997682

Title: Asprosin attenuates insulin signaling pathway through PKCdelta-activated ER stress and inflammation in skeletal muscle.

PubMed ID: 30997682

DOI: 10.1002/jcp.28694

PubMed ID: 32337066

Title: The Asprosin-OLFR734 module regulates appetitive behaviors.

PubMed ID: 32337066

DOI: 10.1038/s41421-020-0152-4

PubMed ID: 33904407

Title: Asprosin-neutralizing antibodies as a treatment for metabolic syndrome.

PubMed ID: 33904407

DOI: 10.7554/elife.63784

PubMed ID: 33705351

Title: Novel adipokine asprosin modulates browning and adipogenesis in white adipose tissue.

PubMed ID: 33705351

DOI: 10.1530/joe-20-0503

Sequence Information:

Length: 2873
Mass: 312298
Checksum: 11C09D2C1ADE7292
Sequence:

MRRGGLLEVA LAFALLLESY TSHGADANLE AGSLKETRAN RAKRRGGGGH DALKGPNVCG 
SRYNAYCCPG WKTLPGGNQC IVPICRHSCG DGFCSRPNMC TCPSGQISPS CGSRSIQHCS 
IRCMNGGSCS DDHCLCQKGY IGTHCGQPVC ESGCLNGGRC VAPNRCACTY GFTGPQCERD 
YRTGPCFTVV SNQMCQGQLS GIVCTKTLCC ATVGRAWGHP CEMCPAQPHP CRRGFIPNIR 
TGACQDVDEC QAIPGMCQGG NCINTVGSFE CKCPAGHKFN EVSQKCEDID ECSTIPGVCD 
GGECTNTVSS YFCKCPPGFY TSPDGTRCVD VRPGYCYTAL ANGRCSNQLP QSITKMQCCC 
DLGRCWSPGV TVAPEMCPIR STEDFNKLCS VPLVIPGRPE YPPPPIGPLP PVQPVPPGYP 
PGPVIPAPRP PPEYPYPSPS REPPRVLPFN VTDYCQLVRY LCQNGRCIPT PGSYRCECNK 
GFQLDIRGEC IDVDECEKNP CTGGECINNQ GSYTCHCRAG YQSTLTRTEC RDIDECLQNG 
RICNNGRCIN TDGSFHCVCN AGFHVTRDGK NCEDMDECSI RNMCLNGMCI NEDGSFKCIC 
KPGFQLASDG RYCKDINECE TPGICMNGRC VNTDGSYRCE CFPGLAVGLD GRVCVDTHMR 
STCYGGYRRG QCVKPLFGAV TKSECCCAST EYAFGEPCQP CPAQNSAEYQ ALCSSGPGMT 
SAGTDINECA LDPDICPNGI CENLRGTYKC ICNSGYEVDI TGKNCVDINE CVLNSLLCDN 
GQCRNTPGSF VCTCPKGFVY KPDLKTCEDI DECESSPCIN GVCKNSPGSF ICECSPESTL 
DPTKTICIET IKGTCWQTVI DGRCEINING ATLKSECCSS LGAAWGSPCT ICQLDPICGK 
GFSRIKGTQC EDINECEVFP GVCKNGLCVN SRGSFKCECP NGMTLDATGR ICLDIRLETC 
FLKYDDEECT LPIAGRHRMD ACCCSVGAAW GTEECEECPL RNSREYEELC PRGPGFATKD 
ITNGKPFFKD INECKMIPSL CTHGKCRNTI GSFKCRCDSG FALDSEERNC TDIDECRISP 
DLCGRGQCVN TPGDFECKCD EGYESGFMMM KNCMDIDECQ RDPLLCRGGI CHNTEGSYRC 
ECPPGHQLSP NISACIDINE CELSANLCPH GRCVNLIGKY QCACNPGYHP THDRLFCVDI 
DECSIMNGGC ETFCTNSDGS YECSCQPGFA LMPDQRSCTD IDECEDNPNI CDGGQCTNIP 
GEYRCLCYDG FMASEDMKTC VDVNECDLNP NICLSGTCEN TKGSFICHCD MGYSGKKGKT 
GCTDINECEI GAHNCGRHAV CTNTAGSFKC SCSPGWIGDG IKCTDLDECS NGTHMCSQHA 
DCKNTMGSYR CLCKDGYTGD GFTCTDLDEC SENLNLCGNG QCLNAPGGYR CECDMGFVPS 
ADGKACEDID ECSLPNICVF GTCHNLPGLF RCECEIGYEL DRSGGNCTDV NECLDPTTCI 
SGNCVNTPGS YTCDCPPDFE LNPTRVGCVD TRSGNCYLDI RPRGDNGDTA CSNEIGVGVS 
KASCCCSLGK AWGTPCELCP SVNTSEYKIL CPGGEGFRPN PITVILEDID ECQELPGLCQ 
GGKCINTFGS FQCRCPTGYY LNEDTRVCDD VNECETPGIC GPGTCYNTVG NYTCICPPDY 
MQVNGGNNCM DMRRSLCYRN YYADNQTCDG ELLFNMTKKM CCCSYNIGRA WNKPCEQCPI 
PSTDEFATLC GSQRPGFVID IYTGLPVDID ECREIPGVCE NGVCINMVGS FRCECPVGFF 
YNDKLLVCED IDECQNGPVC QRNAECINTA GSYRCDCKPG YRLTSTGQCN DRNECQEIPN 
ICSHGQCIDT VGSFYCLCHT GFKTNVDQTM CLDINECERD ACGNGTCRNT IGSFNCRCNH 
GFILSHNNDC IDVDECATGN GNLCRNGQCV NTVGSFQCRC NEGYEVAPDG RTCVDINECV 
LDPGKCAPGT CQNLDGSYRC ICPPGYSLQN DKCEDIDECV EEPEICALGT CSNTEGSFKC 
LCPEGFSLSS TGRRCQDLRM SYCYAKFEGG KCSSPKSRNH SKQECCCALK GEGWGDPCEL 
CPTEPDEAFR QICPFGSGII VGPDDSAVDM DECKEPDVCR HGQCINTDGS YRCECPFGYI 
LEGNECVDTD ECSVGNPCGN GTCKNVIGGF ECTCEEGFEP GPMMTCEDIN ECAQNPLLCA 
FRCVNTYGSY ECKCPVGYVL REDRRMCKDE DECAEGKHDC TEKQMECKNL IGTYMCICGP 
GYQRRPDGEG CIDENECQTK PGICENGRCL NTLGSYTCEC NDGFTASPTQ DECLDNREGY 
CFSEVLQNMC QIGSSNRNPV TKSECCCDGG RGWGPHCEIC PFEGTVAYKK LCPHGRGFMT 
NGADIDECKV IHDVCRNGEC VNDRGSYHCI CKTGYTPDIT GTACVDLNEC NQAPKPCNFI 
CKNTEGSYQC SCPKGYILQE DGRSCKDLDE CATKQHNCQF LCVNTIGGFT CKCPPGFTQH 
HTACIDNNEC TSDINLCGSK GVCQNTPGSF TCECQRGFSL DQSGASCEDV DECEGNHRCQ 
HGCQNIIGGY RCSCPQGYLQ HYQWNQCVDE NECLSAHVCG GASCHNTLGS YKCMCPTGFQ 
YEQFSGGCQD INECGSSQAP CSYGCSNTEG GYLCGCPPGY FRIGQGHCVS GMGMGRGGPE 
PPASSEMDDN SLSPEACYEC KINGYPKRGR KRRSTNETDA SDIQDGSEME ANVSLASWDV 
EKPASFAFNI SHVNNKVRIL ELLPALTTLM NHNRYLIESG NEDGFFKINQ KEGVSYLHFT 
KKKPVAGTYS LQISSTPLYK KKELNQLEDR YDKDYLSGEL GDNLKMKIQI LLH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fbn1

Associated with

Other Information

Primary structure and developmental expression of Fbn-1, the mouse fibrillin gene. PubMed ID: 7829516

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Fibrillins 1 and 2 perform partially overlapping functions during aortic development. PubMed ID: 16407178

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation. PubMed ID: 19940141

Fibrillin-1 and -2 differentially modulate endogenous TGF-{beta} and BMP bioavailability during bone formation. PubMed ID: 20855508

Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism. PubMed ID: 24039232

Asprosin, a fasting-induced glucogenic protein hormone. PubMed ID: 27087445

Asprosin is a centrally acting orexigenic hormone. PubMed ID: 29106398

The Asprosin-OLFR734 hormonal signaling axis modulates male fertility. PubMed ID: 31798959

OLFR734 mediates glucose metabolism as a receptor of asprosin. PubMed ID: 31230984

Asprosin attenuates insulin signaling pathway through PKCdelta-activated ER stress and inflammation in skeletal muscle. PubMed ID: 30997682

The Asprosin-OLFR734 module regulates appetitive behaviors. PubMed ID: 32337066

Asprosin-neutralizing antibodies as a treatment for metabolic syndrome. PubMed ID: 33904407

Novel adipokine asprosin modulates browning and adipogenesis in white adipose tissue. PubMed ID: 33705351