Genular: Defining Cellular Identity and Function

Details for: Fcer1g

Gene ID: 14127

Symbol: Fcer1g

Ensembl ID: ENSMUSG00000058715

Description: Fc receptor, IgE, high affinity I, gamma polypeptide

Associated with

C-type lectin receptors (clrs)
(R-MMU-5621481)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Dectin-2 family
(R-MMU-5621480)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated ca+2 mobilization
(R-MMU-2871809)
Fceri mediated mapk activation
(R-MMU-2871796)
Fceri mediated nf-kb activation
(R-MMU-2871837)
Gpvi-mediated activation cascade
(R-MMU-114604)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet adhesion to exposed collagen
(R-MMU-75892)
Role of lat2/ntal/lab on calcium mobilization
(R-MMU-2730905)
Antigen processing and presentation of exogenous peptide antigen via mhc class i
(GO:0042590)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to low-density lipoprotein particle stimulus
(GO:0071404)
Defense response to bacterium
(GO:0042742)
External side of plasma membrane
(GO:0009897)
Fc-epsilon receptor i complex
(GO:0032998)
Fc-epsilon receptor signaling pathway
(GO:0038095)
Fc-gamma receptor iii complex
(GO:0033001)
Fc-gamma receptor signaling pathway
(GO:0038094)
Fc receptor mediated stimulatory signaling pathway
(GO:0002431)
Identical protein binding
(GO:0042802)
Ige binding
(GO:0019863)
Ige receptor activity
(GO:0019767)
Igg binding
(GO:0019864)
Immune system process
(GO:0002376)
Immunoglobulin mediated immune response
(GO:0016064)
Innate immune response
(GO:0045087)
Integrin-mediated signaling pathway
(GO:0007229)
Interleukin-2 production
(GO:0032623)
Interleukin-3-mediated signaling pathway
(GO:0038156)
Interleukin-6 production
(GO:0032635)
Mast cell activation
(GO:0045576)
Mast cell apoptotic process
(GO:0033024)
Mast cell cytokine production
(GO:0032762)
Mast cell degranulation
(GO:0043303)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Negative regulation of mast cell apoptotic process
(GO:0033026)
Neutrophil activation involved in immune response
(GO:0002283)
Neutrophil chemotaxis
(GO:0030593)
Osteoclast differentiation
(GO:0030316)
Phagocytosis, engulfment
(GO:0006911)
Plasma membrane
(GO:0005886)
Positive regulation of immune response
(GO:0050778)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of mast cell cytokine production
(GO:0032765)
Positive regulation of mast cell degranulation
(GO:0043306)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of protein localization to cell surface
(GO:2000010)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type i hypersensitivity
(GO:0001812)
Positive regulation of type iia hypersensitivity
(GO:0001798)
Positive regulation of type iii hypersensitivity
(GO:0001805)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein localization to plasma membrane
(GO:0072659)
Receptor internalization
(GO:0031623)
Regulation of immune response
(GO:0050776)
Regulation of platelet activation
(GO:0010543)
Serotonin secretion by platelet
(GO:0002554)
Signal transduction
(GO:0007165)
T cell differentiation involved in immune response
(GO:0002292)
Transmembrane signaling receptor activity
(GO:0004888)
Tumor necrosis factor production
(GO:0032640)

Other Information

Proteins

High affinity immunoglobulin epsilon receptor subunit gamma

Genular Protein ID: 1274031352

Symbol: FCERG_MOUSE

Name: High affinity immunoglobulin epsilon receptor subunit gamma

UniProtKB Accession Codes:

P20491

Database IDs:

Citations:

PubMed ID: 2527850

Title: Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells.

PubMed ID: 2527850

DOI: 10.1016/s0021-9258(19)84829-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9171347

Title: The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen.

PubMed ID: 9171347

DOI: 10.1093/emboj/16.9.2333

PubMed ID: 14764707

Title: Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo.

PubMed ID: 14764707

DOI: 10.4049/jimmunol.172.4.2374

PubMed ID: 17050534

Title: Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses.

PubMed ID: 17050534

DOI: 10.1074/jbc.m606542200

PubMed ID: 17086186

Title: Integrin signaling in neutrophils and macrophages uses adapters containing immunoreceptor tyrosine-based activation motifs.

PubMed ID: 17086186

DOI: 10.1038/ni1407

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 18776906

Title: Mincle is an ITAM-coupled activating receptor that senses damaged cells.

PubMed ID: 18776906

DOI: 10.1038/ni.1651

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19098920

Title: Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils.

PubMed ID: 19098920

DOI: 10.1038/ni.1686

PubMed ID: 20817736

Title: Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5.

PubMed ID: 20817736

DOI: 10.1074/jbc.m110.137166

PubMed ID: 23602766

Title: C-type lectin MCL is an FcRgamma-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.

PubMed ID: 23602766

DOI: 10.1016/j.immuni.2013.03.010

Sequence Information:

Length: 86
Mass: 9652
Checksum: 83184DE22FCC9ECB
Sequence:

MISAVILFLL LLVEQAAALG EPQLCYILDA VLFLYGIVLT LLYCRLKIQV RKAAIASREK 
ADAVYTGLNT RSQETYETLK HEKPPQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fcer1g

Associated with

Other Information

Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells. PubMed ID: 2527850

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. PubMed ID: 9171347

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. PubMed ID: 14764707

Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. PubMed ID: 17050534

Integrin signaling in neutrophils and macrophages uses adapters containing immunoreceptor tyrosine-based activation motifs. PubMed ID: 17086186

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Mincle is an ITAM-coupled activating receptor that senses damaged cells. PubMed ID: 18776906

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. PubMed ID: 19098920

Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5. PubMed ID: 20817736

C-type lectin MCL is an FcRgamma-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. PubMed ID: 23602766