Details for: CRYBA4

Gene ID: 1413

Symbol: CRYBA4

Ensembl ID: ENSG00000196431

Description: crystallin beta A4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.44
    Marker Score: 4631
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.31
    Marker Score: 4002
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.73
    Marker Score: 1596
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1509
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4824
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251819.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.01
    Marker Score: 417
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.94
    Marker Score: 430
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 666
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.78
    Marker Score: 1481
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 428
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.62
    Marker Score: 196
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 395
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 487
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.56
    Marker Score: 1137
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.45
    Marker Score: 2974
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 408
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.35
    Marker Score: 260
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.24
    Marker Score: 142
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 136
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 108.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.18
    Marker Score: 53
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.18
    Marker Score: 48
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 95
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.16
    Marker Score: 2528
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.14
    Marker Score: 55
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.14
    Marker Score: 186
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.13
    Marker Score: 183
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.13
    Marker Score: 252
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.12
    Marker Score: 92
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.12
    Marker Score: 145
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.11
    Marker Score: 220
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.11
    Marker Score: 64
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.1
    Marker Score: 132
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.09
    Marker Score: 136
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.09
    Marker Score: 68
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 90
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.07
    Marker Score: 56
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 85
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.04
    Marker Score: 67
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 53
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.04
    Marker Score: 64
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.04
    Marker Score: 14

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Other Information

**Key characteristics** - CRIBA4 is a transmembrane protein that is expressed in the lens epithelial cells of the eye. - It is a crystallin protein that is involved in the development and maintenance of the eye lens. - Mutations in the CRIBA4 gene have been linked to the development of cataracts. **Pathways and functions** - CRIBA4 is involved in the regulation of the heat shock response in the lens. - It is a key regulator of the expression of heat shock proteins (HSPs). - HSPs are proteins that are produced when the body is exposed to stress. - CRIBA4 binds to HSPs and activates them, which helps to protect the lens from damage. - Mutations in the CRIBA4 gene can lead to a decrease in the production of HSPs, which can increase the risk of lens damage and cataracts. **Clinical significance** - Mutations in the CRIBA4 gene have been linked to the development of cataracts. - Early detection and treatment of cataracts can help to prevent vision loss. - CRIBA4 is a potential therapeutic target for the treatment of cataracts. **Additional information** - The CRIBA4 gene is located on chromosome 15q26.1. - It is a protein of approximately 130 kDa. - It is expressed in the lens epithelial cells of the eye. - It is a highly conserved protein, with a similar protein found in other vertebrates.

Genular Protein ID: 3124810487

Symbol: CRBA4_HUMAN

Name: Beta-crystallin A4

UniProtKB Accession Codes:

P53673 Q4VB22 Q6ICE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8999933

Title: Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.

PubMed ID: 8999933

DOI: 10.1074/jbc.272.4.2268

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7504514

Title: Regional fine mapping of the beta crystallin genes on chromosome 22 excludes these genes as physically linked markers for neurofibromatosis type 2.

PubMed ID: 7504514

DOI: 10.1002/gcc.2870080208

PubMed ID: 16960806

Title: CRYBA4, a novel human cataract gene, is also involved in microphthalmia.

PubMed ID: 16960806

DOI: 10.1086/507712

PubMed ID: 20577656

Title: A missense mutation in CRYBA4 associated with congenital cataract and microcornea.

PubMed ID: 20577656

Sequence Information:

  • Length: 196
  • Mass: 22374
  • Checksum: 104EC68E3CDE5740
  • Sequence:
    • MTLQCTKSAG PWKMVVWDED GFQGRRHEFT AECPSVLELG FETVRSLKVL SGAWVGFEHA 
GFQGQQYILE RGEYPSWDAW GGNTAYPAER LTSFRPAACA NHRDSRLTIF EQENFLGKKG 
ELSDDYPSLQ AMGWEGNEVG SFHVHSGAWV CSQFPGYRGF QYVLECDHHS GDYKHFREWG 
SHAPTFQVQS IRRIQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.