Genular: Defining Cellular Identity and Function

Details for: Fem1b

Gene ID: 14155

Symbol: Fem1b

Ensembl ID: ENSMUSG00000032244

Description: fem 1 homolog b

Associated with

Metabolism of proteins
(R-MMU-392499)
Neddylation
(R-MMU-8951664)
Post-translational protein modification
(R-MMU-597592)
Apoptotic process
(GO:0006915)
Branching involved in prostate gland morphogenesis
(GO:0060442)
Cul2-ring ubiquitin ligase complex
(GO:0031462)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Death receptor binding
(GO:0005123)
Epithelial cell maturation
(GO:0002070)
Epithelial cell maturation involved in prostate gland development
(GO:0060743)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Regulation of dna damage checkpoint
(GO:2000001)
Regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902041)
Regulation of ubiquitin-protein transferase activity
(GO:0051438)
Ubiquitin-dependent protein catabolic process via the c-end degron rule pathway
(GO:0140627)
Ubiquitin ligase-substrate adaptor activity
(GO:1990756)

Other Information

Proteins

FEM1-beta

Genular Protein ID: 2295001399

Symbol: FEM1B_MOUSE

Name: FEM1-beta

UniProtKB Accession Codes:

Q9Z2G0 Q3TV57 Q3ULQ3 Q3V148 Q80U13 Q99NC9 Q9QZL3

Database IDs:

Citations:

PubMed ID: 9828124

Title: The murine fem1 gene family: homologs of the Caenorhabditis elegans sex-determination protein FEM-1.

PubMed ID: 9828124

DOI: 10.1006/geno.1998.5569

PubMed ID: 10542291

Title: F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis.

PubMed ID: 10542291

DOI: 10.1074/jbc.274.45.32461

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12693553

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 12693553

DOI: 10.1093/dnares/10.1.35

PubMed ID: 15601915

Title: Putative homeodomain transcription factor 1 interacts with the feminization factor homolog fem1b in male germ cells.

PubMed ID: 15601915

DOI: 10.1095/biolreprod.104.035964

PubMed ID: 16024793

Title: Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene.

PubMed ID: 16024793

DOI: 10.1128/mcb.25.15.6570-6577.2005

PubMed ID: 18816836

Title: Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development.

PubMed ID: 18816836

DOI: 10.1002/dvdy.21694

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21723927

Title: Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37.

PubMed ID: 21723927

DOI: 10.1016/j.gene.2011.06.025

PubMed ID: 32941802

Title: A cellular mechanism to detect and alleviate reductive stress.

PubMed ID: 32941802

DOI: 10.1016/j.cell.2020.08.034

PubMed ID: 34562363

Title: Structural basis and regulation of the reductive stress response.

PubMed ID: 34562363

DOI: 10.1016/j.cell.2021.09.002

Sequence Information:

Length: 627
Mass: 70223
Checksum: 72D4ABA2D4576F1B
Sequence:

MEGLAGYVYK AASEGKVLTL AALLLNRSES DIRYLLGYVS QQGGQRSTPL IIAARNGHAK 
VVRLLLEHYR VQTQQTGTVR FDGYVIDGAT ALWCAAGAGH FEVVKLLVSH GANVNHTTVT 
NSTPLRAACF DGRLDIVKYL VENNANISIA NKYDNTCLMI AAYKGHTDVV RYLLEQRADP 
NAKAHCGATA LHFAAEAGHI DIVKELIKWR AAIVVNGHGM TPLKVAAESC KADVVELLLS 
HADCDRRSRI EALELLGASF ANDRENYDIM KTYHYLYLAM LERFQDGDNI LEKEVLPPIH 
AYGNRTECRN PQELEAIRQD RDALHMEGLI VRERILGADN IDVSHPIIYR GAVYADNMEF 
EQCIKLWLHA LHLRQKGNRN THKDLLRFAQ VFSQMIHLNE AVKAPDIECV LRCSVLEIEQ 
SMNRVKNISD ADVHSAMDNY ECNLYTFLYL VCISTKTQCS EEDQCRINKQ IYNLIHLDPR 
TREGFSLLHL AVNSNTPVDD FHTNDVCSFP NALVTKLLLD CGAEVNAVDN EGNSALHIIV 
QYNRPISDFL TLHSIIISLV EAGAHTDMTN KQNKTPLDKS TTGVSEILLK TQMKMSLKCL 
AARAVRANDI NYQDQIPRTL EEFVGFH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fem1b

Associated with

Other Information

The murine fem1 gene family: homologs of the Caenorhabditis elegans sex-determination protein FEM-1. PubMed ID: 9828124

F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis. PubMed ID: 10542291

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 12693553

Putative homeodomain transcription factor 1 interacts with the feminization factor homolog fem1b in male germ cells. PubMed ID: 15601915

Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene. PubMed ID: 16024793

Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development. PubMed ID: 18816836

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37. PubMed ID: 21723927

A cellular mechanism to detect and alleviate reductive stress. PubMed ID: 32941802

Structural basis and regulation of the reductive stress response. PubMed ID: 34562363