Genular: Defining Cellular Identity and Function

Details for: Fga

Gene ID: 14161

Symbol: Fga

Ensembl ID: ENSMUSG00000028001

Description: fibrinogen alpha chain

Associated with

Common pathway of fibrin clot formation
(R-MMU-140875)
Extracellular matrix organization
(R-MMU-1474244)
Formation of fibrin clot (clotting cascade)
(R-MMU-140877)
Grb2:sos provides linkage to mapk signaling for integrins
(R-MMU-354194)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Integrin cell surface interactions
(R-MMU-216083)
Integrin signaling
(R-MMU-354192)
Map2k and mapk activation
(R-MMU-5674135)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism of proteins
(R-MMU-392499)
P130cas linkage to mapk signaling for integrins
(R-MMU-372708)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet aggregation (plug formation)
(R-MMU-76009)
Platelet degranulation
(R-MMU-114608)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Regulation of tlr by endogenous ligand
(R-MMU-5686938)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Signal transduction
(R-MMU-162582)
Toll-like receptor cascades
(R-MMU-168898)
Adaptive immune response
(GO:0002250)
Blood coagulation
(GO:0007596)
Blood coagulation, common pathway
(GO:0072377)
Blood coagulation, fibrin clot formation
(GO:0072378)
Blood microparticle
(GO:0072562)
Cell-matrix adhesion
(GO:0007160)
Cell adhesion molecule binding
(GO:0050839)
Cell cortex
(GO:0005938)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Endoplasmic reticulum
(GO:0005783)
External side of plasma membrane
(GO:0009897)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibrinogen complex
(GO:0005577)
Fibrinolysis
(GO:0042730)
Hemostasis
(GO:0007599)
Immune system process
(GO:0002376)
Induction of bacterial agglutination
(GO:0043152)
Innate immune response
(GO:0045087)
Metal ion binding
(GO:0046872)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Plasminogen activation
(GO:0031639)
Platelet activation
(GO:0030168)
Platelet aggregation
(GO:0070527)
Platelet alpha granule
(GO:0031091)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of exocytosis
(GO:0045921)
Positive regulation of heterotypic cell-cell adhesion
(GO:0034116)
Positive regulation of peptide hormone secretion
(GO:0090277)
Positive regulation of protein secretion
(GO:0050714)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of vasoconstriction
(GO:0045907)
Protein-containing complex assembly
(GO:0065003)
Protein polymerization
(GO:0051258)
Response to calcium ion
(GO:0051592)
Signaling receptor binding
(GO:0005102)
Structural molecule activity
(GO:0005198)
Synapse
(GO:0045202)

Other Information

Proteins

Fibrinogen alpha chain

Genular Protein ID: 3382803350

Symbol: FIBA_MOUSE

Name: Fibrinogen alpha chain

UniProtKB Accession Codes:

E9PV24 Q99K47

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7649481

Title: Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.

PubMed ID: 7649481

DOI: 10.1101/gad.9.16.2020

PubMed ID: 10930441

Title: Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen.

PubMed ID: 10930441

DOI: 10.1172/jci9896

PubMed ID: 11389004

Title: Wound-healing defects in mice lacking fibrinogen.

PubMed ID: 11389004

DOI: 10.1182/blood.v97.12.3691

PubMed ID: 12629066

Title: Fibrin-mediated protection against infection-stimulated immunopathology.

PubMed ID: 12629066

DOI: 10.1084/jem.20021493

PubMed ID: 15972474

Title: Infection-stimulated fibrin deposition controls hemorrhage and limits hepatic bacterial growth during listeriosis.

PubMed ID: 15972474

DOI: 10.1128/iai.73.7.3888-3895.2005

PubMed ID: 19332769

Title: Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.

PubMed ID: 19332769

DOI: 10.1182/blood-2008-03-145821

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23487423

Title: Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis.

PubMed ID: 23487423

DOI: 10.4049/jimmunol.1203253

Sequence Information:

Length: 789
Mass: 87429
Checksum: 16B968D6E4952CF7
Sequence:

MLSLRVTCLI LSVASTVWTT DTEDKGEFLS EGGGVRGPRV VERHQSQCKD SDWPFCSDDD 
WNHKCPSGCR MKGLIDEANQ DFTNRINKLK NSLFDFQRNN KDSNSLTRNI MEYLRGDFAN 
ANNFDNTYGQ VSEDLRRRIE ILRRKVIEKA QQIQALQSNV RAQLIDMKRL EVDIDIKIRS 
CKGSCSRAVN REINLQDYEG HQKQLQQVIA KELLPTKDRQ YLPALKMSPV PDLVPGSFKS 
QLQEAPPEWK ALTEMRQMRM ELERPGKDGG SRGDSPGDSR GDSRGDFATR GPGSKAENPT 
NPGPGGSGYW RPGNSGSGSD GNRNPGTTGS DGTGDWGTGS PRPGSDSGNF RPANPNWGVF 
SEFGDSSSPA TRKEYHTGKA VTSKGDKELL IGKEKVTSSG TSTTHRSCSK TITKTVTGPD 
GRREVVKEVI TSDDGSDCGD ATELDISHSF SGSLDELSER HPDLSGFFDN HFGLISPNFK 
EFGSKTHSDS DILTNIEDPS SHVPEFSSSS KTSTVKKQVT KTYKMADEAG SEAHREGETR 
NTKRGRARAR PTRDCDDVLQ TQTSGAQNGI FSIKPPGSSK VFSVYCDQET SLGGWLLIQQ 
RMDGSLNFNR TWQDYKRGFG SLNDKGEGEF WLGNDYLHLL TLRGSVLRVE LEDWAGKEAY 
AEYHFRVGSE AEGYALQVSS YRGTAGDALV QGSVEEGTEY TSHSNMQFST FDRDADQWEE 
NCAEVYGGGW WYNSCQAANL NGIYYPGGTY DPRNNSPYEI ENGVVWVPFR GADYSLRAVR 
MKIRPLVGQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fga

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. PubMed ID: 7649481

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. PubMed ID: 10930441

Wound-healing defects in mice lacking fibrinogen. PubMed ID: 11389004

Fibrin-mediated protection against infection-stimulated immunopathology. PubMed ID: 12629066

Infection-stimulated fibrin deposition controls hemorrhage and limits hepatic bacterial growth during listeriosis. PubMed ID: 15972474

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression. PubMed ID: 19332769

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis. PubMed ID: 23487423