Details for: CRYBB3

Gene ID: 1417

Symbol: CRYBB3

Ensembl ID: ENSG00000100053

Description: crystallin beta B3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.8412
    Cell Significance Index: 11.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.8081
    Cell Significance Index: 1098.8500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.6537
    Cell Significance Index: 20.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4046
    Cell Significance Index: 8.7700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3926
    Cell Significance Index: 0.8900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.3169
    Cell Significance Index: 3.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2226
    Cell Significance Index: 13.6500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1658
    Cell Significance Index: 2.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1637
    Cell Significance Index: 252.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1468
    Cell Significance Index: 9.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1178
    Cell Significance Index: 22.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0973
    Cell Significance Index: 5.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0925
    Cell Significance Index: 1.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0901
    Cell Significance Index: 1.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0795
    Cell Significance Index: 2.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0689
    Cell Significance Index: 0.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0548
    Cell Significance Index: 101.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0545
    Cell Significance Index: 1.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0477
    Cell Significance Index: 2.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0417
    Cell Significance Index: 4.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0374
    Cell Significance Index: 7.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0303
    Cell Significance Index: 0.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0225
    Cell Significance Index: 20.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0182
    Cell Significance Index: 0.6400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0173
    Cell Significance Index: 0.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0170
    Cell Significance Index: 1.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0129
    Cell Significance Index: 1.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0105
    Cell Significance Index: 1.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0063
    Cell Significance Index: 0.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0062
    Cell Significance Index: 1.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0050
    Cell Significance Index: 0.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0045
    Cell Significance Index: 0.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0032
    Cell Significance Index: 0.3200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0006
    Cell Significance Index: 0.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0004
    Cell Significance Index: -0.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0012
    Cell Significance Index: -0.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0014
    Cell Significance Index: -0.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0023
    Cell Significance Index: -1.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0025
    Cell Significance Index: -1.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0026
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -1.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0035
    Cell Significance Index: -1.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0041
    Cell Significance Index: -1.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0042
    Cell Significance Index: -1.2000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0054
    Cell Significance Index: -0.0900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0072
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0083
    Cell Significance Index: -1.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0092
    Cell Significance Index: -0.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0102
    Cell Significance Index: -0.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0104
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0106
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0110
    Cell Significance Index: -2.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0116
    Cell Significance Index: -1.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0122
    Cell Significance Index: -0.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0131
    Cell Significance Index: -0.8800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0132
    Cell Significance Index: -0.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0148
    Cell Significance Index: -1.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0153
    Cell Significance Index: -0.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0154
    Cell Significance Index: -0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0159
    Cell Significance Index: -1.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0171
    Cell Significance Index: -1.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0187
    Cell Significance Index: -0.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0189
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0209
    Cell Significance Index: -0.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0214
    Cell Significance Index: -1.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0223
    Cell Significance Index: -0.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0231
    Cell Significance Index: -1.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0231
    Cell Significance Index: -0.7400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0234
    Cell Significance Index: -0.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0246
    Cell Significance Index: -1.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0249
    Cell Significance Index: -0.6400
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: -0.0254
    Cell Significance Index: -0.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0256
    Cell Significance Index: -0.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0263
    Cell Significance Index: -1.9600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0273
    Cell Significance Index: -1.4200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0275
    Cell Significance Index: -0.2100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0280
    Cell Significance Index: -0.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0285
    Cell Significance Index: -1.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0297
    Cell Significance Index: -1.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0301
    Cell Significance Index: -0.7500
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0308
    Cell Significance Index: -0.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0332
    Cell Significance Index: -2.0400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0357
    Cell Significance Index: -0.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0360
    Cell Significance Index: -1.8900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0371
    Cell Significance Index: -0.5200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0419
    Cell Significance Index: -1.0500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0450
    Cell Significance Index: -0.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0461
    Cell Significance Index: -0.9000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0462
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0478
    Cell Significance Index: -1.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0488
    Cell Significance Index: -1.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0502
    Cell Significance Index: -1.1000
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -0.0513
    Cell Significance Index: -0.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CRYBB3 is a member of the crystallin family, which accounts for approximately 40% of the proteins in the eye lens. This protein is composed of four alpha-helical domains, each consisting of three beta-strands. CRYBB3 is highly conserved across species, suggesting its essential role in maintaining lens structure and function. The protein is expressed in a variety of cell types, including glial cells, lens epithelial cells, and retinal rod cells, highlighting its widespread importance in the eye and other tissues. **Pathways and Functions:** CRYBB3 is involved in several key pathways, including: 1. **Lens Development in Camera-Type Eye:** CRYBB3 plays a critical role in the development of the eye lens, where it contributes to the formation of the lens fibers and maintains lens transparency. 2. **Protein Binding:** CRYBB3 interacts with other proteins, such as heat shock proteins, to regulate protein folding and stability, ensuring proper lens function. 3. **Structural Constituent of Eye Lens:** As a structural protein, CRYBB3 maintains the lens's transparency and refractive index, ensuring clear vision. 4. **Visual Perception:** CRYBB3 is also involved in visual perception, where it helps regulate the lens's refractive state to focus light on the retina. **Clinical Significance:** Dysregulation of CRYBB3 has been implicated in various eye disorders, including: 1. **Cataracts:** Abnormal expression or mutations in CRYBB3 have been linked to cataract formation, highlighting the protein's critical role in maintaining lens clarity. 2. **Age-Related Macular Degeneration (AMD):** CRYBB3 has been shown to be differentially expressed in AMD, suggesting its potential as a therapeutic target. 3. **Other Diseases:** CRYBB3 has also been implicated in other diseases, including diabetes, where it may contribute to lens damage and vision loss. In conclusion, CRYBB3 is a vital protein that plays a central role in maintaining eye health and function. Its widespread expression and involvement in various cellular pathways highlight its importance in both the eye and other tissues. Further research on CRYBB3 is necessary to fully understand its mechanisms and potential therapeutic applications, particularly in the context of eye diseases and other conditions.

Genular Protein ID: 2034575457

Symbol: CRBB3_HUMAN

Name: Beta-crystallin B3

UniProtKB Accession Codes:

P26998 Q3B7S9 Q3T1B7 Q6ISK6 Q92965 Q9UH09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8999933

Title: Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.

PubMed ID: 8999933

DOI: 10.1074/jbc.272.4.2268

PubMed ID: 2499686

Title: Different evolution rates within the lens-specific beta-crystallin gene family.

PubMed ID: 2499686

DOI: 10.1007/bf02103427

PubMed ID: 15914629

Title: Mutations in betaB3-crystallin associated with autosomal recessive cataract in two Pakistani families.

PubMed ID: 15914629

DOI: 10.1167/iovs.04-1481

PubMed ID: 19182255

Title: Comprehensive mutational screening in a cohort of Danish families with hereditary congenital cataract.

PubMed ID: 19182255

DOI: 10.1167/iovs.08-3149

PubMed ID: 23508780

Title: Whole exome sequencing in dominant cataract identifies a new causative factor, CRYBA2, and a variety of novel alleles in known genes.

PubMed ID: 23508780

DOI: 10.1007/s00439-013-1289-0

Sequence Information:

  • Length: 211
  • Mass: 24252
  • Checksum: E5ABA1165C7B45BA
  • Sequence:
    • MAEQHGAPEQ AAAGKSHGDL GGSYKVILYE LENFQGKRCE LSAECPSLTD SLLEKVGSIQ 
VESGPWLAFE SRAFRGEQFV LEKGDYPRWD AWSNSRDSDS LLSLRPLNID SPHHKLHLFE 
NPAFSGRKME IVDDDVPSLW AHGFQDRVAS VRAINGTWVG YEFPGYRGRQ YVFERGEYRH 
WNEWDASQPQ LQSVRRIRDQ KWHKRGRFPS S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.