Genular: Defining Cellular Identity and Function

Details for: Fgf18

Gene ID: 14172

Symbol: Fgf18

Ensembl ID: ENSMUSG00000057967

Description: fibroblast growth factor 18

Associated with

Downstream signaling of activated fgfr2
(R-MMU-5654696)
Downstream signaling of activated fgfr3
(R-MMU-5654708)
Downstream signaling of activated fgfr4
(R-MMU-5654716)
Fgfr2 ligand binding and activation
(R-MMU-190241)
Fgfr2c ligand binding and activation
(R-MMU-190375)
Fgfr3 ligand binding and activation
(R-MMU-190239)
Fgfr3b ligand binding and activation
(R-MMU-190371)
Fgfr3c ligand binding and activation
(R-MMU-190372)
Fgfr4 ligand binding and activation
(R-MMU-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-MMU-5658623)
Frs-mediated fgfr2 signaling
(R-MMU-5654700)
Frs-mediated fgfr3 signaling
(R-MMU-5654706)
Frs-mediated fgfr4 signaling
(R-MMU-5654712)
Igf1r signaling cascade
(R-MMU-2428924)
Insulin receptor signalling cascade
(R-MMU-74751)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of fgfr2 signaling
(R-MMU-5654727)
Negative regulation of fgfr3 signaling
(R-MMU-5654732)
Negative regulation of fgfr4 signaling
(R-MMU-5654733)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Phospholipase c-mediated cascade; fgfr2
(R-MMU-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-MMU-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-MMU-5654228)
Pi-3k cascade:fgfr2
(R-MMU-5654695)
Pi-3k cascade:fgfr3
(R-MMU-5654710)
Pi-3k cascade:fgfr4
(R-MMU-5654720)
Pi3k cascade
(R-MMU-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Shc-mediated cascade:fgfr2
(R-MMU-5654699)
Shc-mediated cascade:fgfr3
(R-MMU-5654704)
Shc-mediated cascade:fgfr4
(R-MMU-5654719)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Chondrocyte development
(GO:0002063)
Chondrocyte differentiation
(GO:0002062)
Cytoplasm
(GO:0005737)
Endochondral ossification
(GO:0001958)
Erk1 and erk2 cascade
(GO:0070371)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Intramembranous ossification
(GO:0001957)
Lung development
(GO:0030324)
Nervous system development
(GO:0007399)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Ossification
(GO:0001503)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chondrocyte differentiation
(GO:0032332)
Positive regulation of endothelial cell chemotaxis to fibroblast growth factor
(GO:2000546)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of hepatocyte proliferation
(GO:2000347)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030949)
Regulation of cell migration
(GO:0030334)
Signal transduction
(GO:0007165)
Type 1 fibroblast growth factor receptor binding
(GO:0005105)
Type 2 fibroblast growth factor receptor binding
(GO:0005111)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)

Other Information

Proteins

Fibroblast growth factor 18

Genular Protein ID: 2770242541

Symbol: FGF18_MOUSE

Name: Fibroblast growth factor 18

UniProtKB Accession Codes:

O89101

Database IDs:

Citations:

PubMed ID: 9742123

Title: FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation.

PubMed ID: 9742123

DOI: 10.1128/mcb.18.10.6063

PubMed ID: 9660775

Title: Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18.

PubMed ID: 9660775

DOI: 10.1074/jbc.273.29.18161

Sequence Information:

Length: 207
Mass: 23921
Checksum: CD5F987B271628B8
Sequence:

MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR 
TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP 
DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK 
GQAELQKPFK YTTVTKRSRR IRPTHPG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.