Genular: Defining Cellular Identity and Function

Details for: Fgf4

Gene ID: 14175

Symbol: Fgf4

Ensembl ID: ENSMUSG00000050917

Description: fibroblast growth factor 4

Associated with

Downstream signaling of activated fgfr1
(R-MMU-5654687)
Downstream signaling of activated fgfr2
(R-MMU-5654696)
Downstream signaling of activated fgfr3
(R-MMU-5654708)
Downstream signaling of activated fgfr4
(R-MMU-5654716)
Fgfr1 ligand binding and activation
(R-MMU-190242)
Fgfr1c ligand binding and activation
(R-MMU-190373)
Fgfr2 ligand binding and activation
(R-MMU-190241)
Fgfr2c ligand binding and activation
(R-MMU-190375)
Fgfr3 ligand binding and activation
(R-MMU-190239)
Fgfr3c ligand binding and activation
(R-MMU-190372)
Fgfr4 ligand binding and activation
(R-MMU-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-MMU-5658623)
Frs-mediated fgfr1 signaling
(R-MMU-5654693)
Frs-mediated fgfr2 signaling
(R-MMU-5654700)
Frs-mediated fgfr3 signaling
(R-MMU-5654706)
Frs-mediated fgfr4 signaling
(R-MMU-5654712)
Igf1r signaling cascade
(R-MMU-2428924)
Insulin receptor signalling cascade
(R-MMU-74751)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of fgfr1 signaling
(R-MMU-5654726)
Negative regulation of fgfr2 signaling
(R-MMU-5654727)
Negative regulation of fgfr3 signaling
(R-MMU-5654732)
Negative regulation of fgfr4 signaling
(R-MMU-5654733)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Phospholipase c-mediated cascade: fgfr1
(R-MMU-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-MMU-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-MMU-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-MMU-5654228)
Pi-3k cascade:fgfr1
(R-MMU-5654689)
Pi-3k cascade:fgfr2
(R-MMU-5654695)
Pi-3k cascade:fgfr3
(R-MMU-5654710)
Pi-3k cascade:fgfr4
(R-MMU-5654720)
Pi3k cascade
(R-MMU-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Shc-mediated cascade:fgfr1
(R-MMU-5654688)
Shc-mediated cascade:fgfr2
(R-MMU-5654699)
Shc-mediated cascade:fgfr3
(R-MMU-5654704)
Shc-mediated cascade:fgfr4
(R-MMU-5654719)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Signal transduction
(R-MMU-162582)
Animal organ morphogenesis
(GO:0009887)
Apoptotic process
(GO:0006915)
Apoptotic process involved in morphogenesis
(GO:0060561)
Cartilage condensation
(GO:0001502)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Chondroblast differentiation
(GO:0060591)
Cranial suture morphogenesis
(GO:0060363)
Cytoplasm
(GO:0005737)
Embryonic hindlimb morphogenesis
(GO:0035116)
Embryonic limb morphogenesis
(GO:0030326)
Epithelial cell apoptotic process
(GO:1904019)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Mesenchymal cell proliferation
(GO:0010463)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of stem cell proliferation
(GO:2000648)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
Regulation of endothelial cell chemotaxis to fibroblast growth factor
(GO:2000544)
Regulation of gene expression
(GO:0010468)
Somatic stem cell population maintenance
(GO:0035019)
Stem cell population maintenance
(GO:0019827)
Stem cell proliferation
(GO:0072089)

Other Information

Proteins

Heparin-binding growth factor 4

Genular Protein ID: 1406421725

Symbol: FGF4_MOUSE

Name: Heparin-binding growth factor 4

UniProtKB Accession Codes:

P11403 P15657 Q542N0

Database IDs:

Citations:

PubMed ID: 2740210

Title: The mouse homologue of hst/k-FGF: sequence, genome organization and location relative to int-2.

PubMed ID: 2740210

DOI: 10.1093/nar/17.11.4037

PubMed ID: 2318343

Title: Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis.

PubMed ID: 2318343

DOI: 10.1016/0012-1606(90)90211-z

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8898217

Title: Msx1 controls inductive signaling in mammalian tooth morphogenesis.

PubMed ID: 8898217

DOI: 10.1242/dev.122.10.3035

Sequence Information:

Length: 202
Mass: 21919
Checksum: 62D4563AF7D9AA31
Sequence:

MAKRGPTTGT LLPRVLLALV VALADRGTAA PNGTRHAELG HGWDGLVARS LARLPVAAQP 
PQAAVRSGAG DYLLGLKRLR RLYCNVGIGF HLQVLPDGRI GGVHADTRDS LLELSPVQRG 
VVSIFGVASR FFVAMSSRGK LFGVPFFTDE CKFKEILLPN NYNAYESYAY PGMFMALSKN 
GRTKKGNRVS PTMKVTHFLP RL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fgf4

Associated with

Other Information

The mouse homologue of hst/k-FGF: sequence, genome organization and location relative to int-2. PubMed ID: 2740210

Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis. PubMed ID: 2318343

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334