Genular: Defining Cellular Identity and Function

Details for: Fgf8

Gene ID: 14179

Symbol: Fgf8

Ensembl ID: ENSMUSG00000025219

Description: fibroblast growth factor 8

Associated with

Downstream signaling of activated fgfr1
(R-MMU-5654687)
Downstream signaling of activated fgfr2
(R-MMU-5654696)
Downstream signaling of activated fgfr3
(R-MMU-5654708)
Downstream signaling of activated fgfr4
(R-MMU-5654716)
Fgfr1 ligand binding and activation
(R-MMU-190242)
Fgfr1c ligand binding and activation
(R-MMU-190373)
Fgfr2 ligand binding and activation
(R-MMU-190241)
Fgfr2c ligand binding and activation
(R-MMU-190375)
Fgfr3 ligand binding and activation
(R-MMU-190239)
Fgfr3b ligand binding and activation
(R-MMU-190371)
Fgfr3c ligand binding and activation
(R-MMU-190372)
Fgfr4 ligand binding and activation
(R-MMU-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-MMU-5658623)
Frs-mediated fgfr1 signaling
(R-MMU-5654693)
Frs-mediated fgfr2 signaling
(R-MMU-5654700)
Frs-mediated fgfr3 signaling
(R-MMU-5654706)
Frs-mediated fgfr4 signaling
(R-MMU-5654712)
Igf1r signaling cascade
(R-MMU-2428924)
Insulin receptor signalling cascade
(R-MMU-74751)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of fgfr1 signaling
(R-MMU-5654726)
Negative regulation of fgfr2 signaling
(R-MMU-5654727)
Negative regulation of fgfr3 signaling
(R-MMU-5654732)
Negative regulation of fgfr4 signaling
(R-MMU-5654733)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Phospholipase c-mediated cascade: fgfr1
(R-MMU-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-MMU-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-MMU-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-MMU-5654228)
Pi-3k cascade:fgfr1
(R-MMU-5654689)
Pi-3k cascade:fgfr2
(R-MMU-5654695)
Pi-3k cascade:fgfr3
(R-MMU-5654710)
Pi-3k cascade:fgfr4
(R-MMU-5654720)
Pi3k cascade
(R-MMU-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Shc-mediated cascade:fgfr1
(R-MMU-5654688)
Shc-mediated cascade:fgfr2
(R-MMU-5654699)
Shc-mediated cascade:fgfr3
(R-MMU-5654704)
Shc-mediated cascade:fgfr4
(R-MMU-5654719)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Signal transduction
(R-MMU-162582)
Apoptotic process
(GO:0006915)
Blood vessel remodeling
(GO:0001974)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cell population proliferation
(GO:0008283)
Chemoattractant activity
(GO:0042056)
Determination of left/right symmetry
(GO:0007368)
Dorsal/ventral pattern formation
(GO:0009953)
Embryo development ending in birth or egg hatching
(GO:0009792)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Forebrain dorsal/ventral pattern formation
(GO:0021798)
Gonad development
(GO:0008406)
Growth factor activity
(GO:0008083)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Heart morphogenesis
(GO:0003007)
Kidney development
(GO:0001822)
Mapk cascade
(GO:0000165)
Mesodermal cell migration
(GO:0008078)
Motor neuron axon guidance
(GO:0008045)
Multicellular organism development
(GO:0007275)
Neural plate morphogenesis
(GO:0001839)
Organ induction
(GO:0001759)
Outflow tract morphogenesis
(GO:0003151)
Outflow tract septum morphogenesis
(GO:0003148)
Pallium development
(GO:0021543)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein phosphorylation
(GO:0001934)
Response to oxidative stress
(GO:0006979)
Subpallium development
(GO:0021544)
Telencephalon development
(GO:0021537)
Type 1 fibroblast growth factor receptor binding
(GO:0005105)
Type 2 fibroblast growth factor receptor binding
(GO:0005111)

Other Information

Proteins

Genular Protein ID: 3462098245

Symbol: FGF8_MOUSE

Name: Fibroblast growth factor 8

UniProtKB Accession Codes:

P37237

Database IDs:

Citations:

PubMed ID: 1409588

Title: Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.

PubMed ID: 1409588

DOI: 10.1073/pnas.89.19.8928

PubMed ID: 7884899

Title: Fgf-8, activated by proviral insertion, cooperates with the Wnt-1 transgene in murine mammary tumorigenesis.

PubMed ID: 7884899

DOI: 10.1128/jvi.69.4.2501-2507.1995

PubMed ID: 7583127

Title: A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth.

PubMed ID: 7583127

DOI: 10.1016/s0960-9822(95)00157-6

Sequence Information:

Length: 268
Mass: 30420
Checksum: 3330A9F342AD7109
Sequence:

MGSPRSALSC LLLHLLVLCL QAQVRSAAQK RGPGAGNPAD TLGQGHEDRP FGQRSRAGKN 
FTNPAPNYPE EGSKEQRDSV LPKVTQRHVR EQSLVTDQLS RRLIRTYQLY SRTSGKHVQV 
LANKRINAMA EDGDPFAKLI VETDTFGSRV RVRGAETGLY ICMNKKGKLI AKSNGKGKDC 
VFTEIVLENN YTALQNAKYE GWYMAFTRKG RPRKGSKTRQ HQREVHFMKR LPRGHHTTEQ 
SLRFEFLNYP PFTRSLRGSQ RTWAPEPR

Genular Protein ID: 670820454

Symbol: Q80ZL6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q80ZL6

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 244
Mass: 27596
Checksum: E76B29E0D992C0D7
Sequence:

MGSPRSALSC LLLHLLVLCL QAQEGPGGGP ALGREPTSLL RAGREPQGVS QQVTVQSSPN 
FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD 
TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM 
AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA 
PEPR

Genular Protein ID: 1761666802

Symbol: Q3V279_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3V279

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 215
Mass: 24711
Checksum: A39424271EF7CBFF
Sequence:

MGSPRSALSC LLLHLLVLCL QAQVTVQSSP NFTQHVREQS LVTDQLSRRL IRTYQLYSRT 
SGKHVQVLAN KRINAMAEDG DPFAKLIVET DTFGSRVRVR GAETGLYICM NKKGKLIAKS 
NGKGKDCVFT EIVLENNYTA LQNAKYEGWY MAFTRKGRPR KGSKTRQHQR EVHFMKRLPR 
GHHTTEQSLR FEFLNYPPFT RSLRGSQRTW APEPR

Genular Protein ID: 1367442364

Symbol: D3Z207_MOUSE

Name: N/A

UniProtKB Accession Codes:

D3Z207

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 233
Mass: 26406
Checksum: 73FF6ABDDD9E8D6D
Sequence:

MGSPRSALSC LLLHLLVLCL QAQEGPGGGP ALGREPTSLL RAGREPQGVS QQHVREQSLV 
TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP FAKLIVETDT FGSRVRVRGA 
ETGLYICMNK KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA FTRKGRPRKG 
SKTRQHQREV HFMKRLPRGH HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fgf8

Associated with

Other Information

Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. PubMed ID: 1409588

Fgf-8, activated by proviral insertion, cooperates with the Wnt-1 transgene in murine mammary tumorigenesis. PubMed ID: 7884899

A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. PubMed ID: 7583127

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 1409588

PubMed ID: 7884899

PubMed ID: 7583127

PubMed ID: 15489334

PubMed ID: 19468303

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 19468303