Details for: CRYGA

Gene ID: 1418

Symbol: CRYGA

Ensembl ID: ENSG00000168582

Description: crystallin gamma A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.6571
    Cell Significance Index: 169.6100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.2287
    Cell Significance Index: 38.1000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.6069
    Cell Significance Index: 26.0300
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.5881
    Cell Significance Index: 20.9000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.5135
    Cell Significance Index: 20.7600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.4510
    Cell Significance Index: 20.3800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.2983
    Cell Significance Index: 16.8000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.2979
    Cell Significance Index: 41.0500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.0609
    Cell Significance Index: 11.2700
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.2651
    Cell Significance Index: 2.1700
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.1027
    Cell Significance Index: 1.3200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1026
    Cell Significance Index: 1.4900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0378
    Cell Significance Index: 0.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0370
    Cell Significance Index: 0.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0218
    Cell Significance Index: 4.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0047
    Cell Significance Index: 1.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0016
    Cell Significance Index: 2.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0013
    Cell Significance Index: 2.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0010
    Cell Significance Index: 0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0027
    Cell Significance Index: -0.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0061
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0071
    Cell Significance Index: -1.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0076
    Cell Significance Index: -1.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0090
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0100
    Cell Significance Index: -1.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0161
    Cell Significance Index: -0.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0162
    Cell Significance Index: -0.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0167
    Cell Significance Index: -0.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0185
    Cell Significance Index: -0.8200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0195
    Cell Significance Index: -0.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0204
    Cell Significance Index: -0.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0207
    Cell Significance Index: -0.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0209
    Cell Significance Index: -1.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0209
    Cell Significance Index: -0.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0214
    Cell Significance Index: -0.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0219
    Cell Significance Index: -0.6100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0245
    Cell Significance Index: -0.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0251
    Cell Significance Index: -0.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0265
    Cell Significance Index: -0.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0275
    Cell Significance Index: -0.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0276
    Cell Significance Index: -1.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0306
    Cell Significance Index: -0.8200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0308
    Cell Significance Index: -0.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0315
    Cell Significance Index: -1.2900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0328
    Cell Significance Index: -0.5000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0409
    Cell Significance Index: -0.8100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0427
    Cell Significance Index: -0.5700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0428
    Cell Significance Index: -0.5200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0468
    Cell Significance Index: -0.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0494
    Cell Significance Index: -1.0500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0498
    Cell Significance Index: -1.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0514
    Cell Significance Index: -1.1100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0531
    Cell Significance Index: -0.6200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0532
    Cell Significance Index: -1.0600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0536
    Cell Significance Index: -0.5800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0568
    Cell Significance Index: -0.7500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0569
    Cell Significance Index: -0.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0578
    Cell Significance Index: -1.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0584
    Cell Significance Index: -1.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0592
    Cell Significance Index: -1.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0596
    Cell Significance Index: -1.4300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0601
    Cell Significance Index: -0.8600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0602
    Cell Significance Index: -0.9000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0623
    Cell Significance Index: -0.7800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0624
    Cell Significance Index: -0.6800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0638
    Cell Significance Index: -0.8000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0645
    Cell Significance Index: -1.0900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0665
    Cell Significance Index: -1.3000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0671
    Cell Significance Index: -1.1600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0671
    Cell Significance Index: -0.7400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0735
    Cell Significance Index: -0.7500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0743
    Cell Significance Index: -1.0200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0756
    Cell Significance Index: -0.9000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0785
    Cell Significance Index: -0.8600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0798
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0810
    Cell Significance Index: -1.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0822
    Cell Significance Index: -1.3900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0833
    Cell Significance Index: -0.8500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0842
    Cell Significance Index: -0.8600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0852
    Cell Significance Index: -1.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0853
    Cell Significance Index: -1.2600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0858
    Cell Significance Index: -0.9400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0873
    Cell Significance Index: -1.1400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0877
    Cell Significance Index: -1.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0884
    Cell Significance Index: -1.4800
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0887
    Cell Significance Index: -1.0300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0892
    Cell Significance Index: -1.1300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0893
    Cell Significance Index: -0.8800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0897
    Cell Significance Index: -0.9400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0902
    Cell Significance Index: -1.4600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0910
    Cell Significance Index: -1.0800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0920
    Cell Significance Index: -0.9900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0924
    Cell Significance Index: -1.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Crystallin structure:** CRYGA is a component of the gamma-crystallin complex, which is responsible for maintaining the structural integrity of the eye lens. The gamma-crystallin complex is composed of six subunits, with CRYGA being one of the most abundant subunits. 2. **Expression patterns:** CRYGA is highly expressed in the lens of the eye, as well as in other cell types such as erythrocytes, hematopoietic stem cells, and cerebral cortex interneurons. 3. **Cellular localization:** CRYGA is primarily localized to the eye lens, but it is also found in other tissues, including the blood vessels, megakaryocytes, and goblet cells. **Pathways and Functions:** 1. **Lens development and maintenance:** CRYGA plays a critical role in the structure and transparency of the eye lens, which is essential for clear vision. Mutations in the CRYGA gene have been associated with cataracts, a leading cause of blindness worldwide. 2. **Cellular differentiation and survival:** CRYGA is also involved in the regulation of cellular differentiation and survival in various cell types, including hematopoietic stem cells and cerebral cortex interneurons. 3. **Antioxidant function:** CRYGA has been shown to have antioxidant properties, which help protect cells from oxidative stress and damage. 4. **Visual perception:** CRYGA is also involved in the regulation of visual perception, particularly in the context of lens development and maintenance. **Clinical Significance:** 1. **Cataract formation:** Mutations in the CRYGA gene have been associated with cataract formation, which is a leading cause of blindness worldwide. 2. **Eye diseases:** CRYGA has been implicated in various eye diseases, including age-related macular degeneration, glaucoma, and diabetic retinopathy. 3. **Neurological disorders:** CRYGA has also been linked to neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 4. **Cancer research:** CRYGA has been identified as a potential biomarker for cancer, particularly in the context of breast and lung cancer. In conclusion, CRYGA is a multifunctional protein that plays a critical role in maintaining eye health and beyond. Its widespread expression in various cell types highlights its importance in different tissues and organs. Further research is needed to fully elucidate the functions of CRYGA and its role in human disease.

Genular Protein ID: 2057010196

Symbol: CRGA_HUMAN

Name: Gamma-crystallin A

UniProtKB Accession Codes:

P11844 Q53ST5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3670288

Title: Gamma-crystallins of the human eye lens: expression analysis of five members of the gene family.

PubMed ID: 3670288

DOI: 10.1128/mcb.7.8.2671-2679.1987

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 12507494

Title: Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins.

PubMed ID: 12507494

DOI: 10.1016/s0006-291x(02)02895-4

PubMed ID: 12011157

Title: Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts.

PubMed ID: 12011157

DOI: 10.1136/jmg.39.5.352

PubMed ID: 28839118

Title: High-Throughput Genetic Screening of 51 Pediatric Cataract Genes Identifies Causative Mutations in Inherited Pediatric Cataract in South Eastern Australia.

PubMed ID: 28839118

DOI: 10.1534/g3.117.300109

PubMed ID: 33243271

Title: The genetic landscape of crystallins in congenital cataract.

PubMed ID: 33243271

DOI: 10.1186/s13023-020-01613-3

Sequence Information:

  • Length: 174
  • Mass: 20877
  • Checksum: 99889A7641728090
  • Sequence:
    • MGKITFYEDR DFQGRCYNCI SDCPNLRVYF SRCNSIRVDS GCWMLYERPN YQGHQYFLRR 
GKYPDYQHWM GLSDSVQSCR IIPHTSSHKL RLYERDDYRG LMSELTDDCA CVPELFRLPE 
IYSLHVLEGC WVLYEMPNYR GRQYLLRPGD YRRYHDWGGA DAKVGSLRRV TDLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.