Genular: Defining Cellular Identity and Function

Details for: Fgfr4

Gene ID: 14186

Symbol: Fgfr4

Ensembl ID: ENSMUSG00000005320

Description: fibroblast growth factor receptor 4

Associated with

Betaklotho-mediated ligand binding
(R-MMU-1307965)
Downstream signaling of activated fgfr4
(R-MMU-5654716)
Fgfr4 ligand binding and activation
(R-MMU-190322)
Frs-mediated fgfr4 signaling
(R-MMU-5654712)
Igf1r signaling cascade
(R-MMU-2428924)
Insulin receptor signalling cascade
(R-MMU-74751)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of fgfr4 signaling
(R-MMU-5654733)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Phospholipase c-mediated cascade; fgfr4
(R-MMU-5654228)
Pi-3k cascade:fgfr4
(R-MMU-5654720)
Pi3k cascade
(R-MMU-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Shc-mediated cascade:fgfr4
(R-MMU-5654719)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Signal transduction
(R-MMU-162582)
Alveolar secondary septum development
(GO:0061144)
Atp binding
(GO:0005524)
Cell-cell junction
(GO:0005911)
Cell migration
(GO:0016477)
Cholesterol homeostasis
(GO:0042632)
Endoplasmic reticulum
(GO:0005783)
Endosome
(GO:0005768)
Fibroblast growth factor binding
(GO:0017134)
Fibroblast growth factor receptor activity
(GO:0005007)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Glucose homeostasis
(GO:0042593)
Golgi apparatus
(GO:0005794)
Heparin binding
(GO:0008201)
Kinase activity
(GO:0016301)
Lung development
(GO:0030324)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of fibroblast growth factor production
(GO:0090272)
Negative regulation of gene expression
(GO:0010629)
Nucleotide binding
(GO:0000166)
Organ induction
(GO:0001759)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphate ion homeostasis
(GO:0055062)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of catalytic activity
(GO:0043085)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of parathyroid hormone secretion
(GO:2000830)
Positive regulation of proteolysis
(GO:0045862)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Receptor complex
(GO:0043235)
Regulation of bile acid biosynthetic process
(GO:0070857)
Regulation of extracellular matrix disassembly
(GO:0010715)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of phosphate transport
(GO:0010966)
Regulation of phosphorus metabolic process
(GO:0051174)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Transport vesicle
(GO:0030133)
Vitamin d3 metabolic process
(GO:0070640)

Other Information

Proteins

Fibroblast growth factor receptor 4
A0A0R4IZY3_MOUSE

Genular Protein ID: 3922124133

Symbol: FGFR4_MOUSE

Name: Fibroblast growth factor receptor 4

UniProtKB Accession Codes:

Q03142 Q27Q87 Q5J7D9 Q8C3V5 Q8CIB8

Database IDs:

Citations:

PubMed ID: 1723680

Title: FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse.

PubMed ID: 1723680

DOI: 10.1242/dev.113.2.641

PubMed ID: 18186042

Title: FGFR4 and its novel splice form in myogenic cells: interplay of glycosylation and tyrosine phosphorylation.

PubMed ID: 18186042

DOI: 10.1002/jcp.21365

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1281307

Title: An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.

PubMed ID: 1281307

PubMed ID: 9716527

Title: FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung.

PubMed ID: 9716527

DOI: 10.1242/dev.125.18.3615

PubMed ID: 10809780

Title: Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4.

PubMed ID: 10809780

DOI: 10.1074/jbc.275.20.15482

PubMed ID: 17664243

Title: FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver.

PubMed ID: 17664243

DOI: 10.2337/db07-0648

PubMed ID: 17452648

Title: BetaKlotho is required for metabolic activity of fibroblast growth factor 21.

PubMed ID: 17452648

DOI: 10.1073/pnas.0701600104

PubMed ID: 19237543

Title: FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action.

PubMed ID: 19237543

DOI: 10.1074/jbc.m808747200

PubMed ID: 19656770

Title: The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.

PubMed ID: 19656770

DOI: 10.1074/mcp.m900195-mcp200

PubMed ID: 21561999

Title: Regulation of serum 1,25(OH)2Vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4.

PubMed ID: 21561999

DOI: 10.1152/ajprenal.00740.2010

PubMed ID: 26675719

Title: Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site.

PubMed ID: 26675719

DOI: 10.1038/nature16449

Sequence Information:

Length: 799
Mass: 88661
Checksum: 799E17845CD4021E
Sequence:

MWLLLALLSI FQGTPALSLE ASEEMEQEPC LAPILEQQEQ VLTVALGQPV RLCCGRTERG 
RHWYKEGSRL ASAGRVRGWR GRLEIASFLP EDAGRYLCLA RGSMTVVHNL TLLMDDSLTS 
ISNDEDPKTL SSSSSGHVYP QQAPYWTHPQ RMEKKLHAVP AGNTVKFRCP AAGNPMPTIH 
WLKDGQAFHG ENRIGGIRLR HQHWSLVMES VVPSDRGTYT CLVENSLGSI RYSYLLDVLE 
RSPHRPILQA GLPANTTAVV GSDVELLCKV YSDAQPHIQW LKHVVINGSS FGADGFPYVQ 
VLKTTDINSS EVEVLYLRNV SAEDAGEYTC LAGNSIGLSY QSAWLTVLPE EDLTWTTATP 
EARYTDIILY VSGSLVLLVL LLLAGVYHRQ VIRGHYSRQP VTIQKLSRFP LARQFSLESR 
SSGKSSLSLV RGVRLSSSGP PLLTGLVNLD LPLDPLWEFP RDRLVLGKPL GEGCFGQVVR 
AEAFGMDPSR PDQTSTVAVK MLKDNASDKD LADLVSEMEV MKLIGRHKNI INLLGVCTQE 
GPLYVIVECA AKGNLREFLR ARRPPGPDLS PDGPRSSEGP LSFPALVSCA YQVARGMQYL 
ESRKCIHRDL AARNVLVTED DVMKIADFGL ARGVHHIDYY KKTSNGRLPV KWMAPEALFD 
RVYTHQSDVW SFEILLWEIF TLGGSPYPGI PVEELFSLLR EGHRMERPPN CPSELYGLMR 
ECWHAAPSQR PTFKQLVEAL DKVLLAVSEE YLDLRLTFGP FSPSNGDASS TCSSSDSVFS 
HDPLPLEPSP FPFSDSQTT

Genular Protein ID: 3412555442

Symbol: A0A0R4IZY3_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4IZY3

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 799
Mass: 88589
Checksum: 7AFE17845FB4037E
Sequence:

MWLLLALLSI FQGTPALSLE ASEEMEQEPC LAPILEQQEQ VLTVALGQPV RLCCGRTERG 
RHWYKEGSRL ASAGRVRGWR GRLEIASFLP EDAGRYLCLA RGSMTVVHNL TLLMDDSLTS 
ISNDEDPKTL SSSSSGHVYP QQAPYWTHPQ RMEKKLHAVP AGNTVKFRCP AAGNPMPTIH 
WLKDGQAFHG ENRIGGIRLR HQHWSLVMES VVPSDRGTYT CLVENSLGSI RYSYLLDVLE 
RSPHRPILQA GLPANTTAVV GSDVELLCKV YSDAQPHIQW LKHVVINGSS FGADGFPYVQ 
VLKTTDINSS EVEVLYLRNV SAEDAGEYTC LAGNSIGLSY QSAWLTVLPE EDLTWTTATP 
EARYTDIILY VSGSLVLLVL LLLAGVYHRQ VIRGHYSRQP VTIQKLSRFP LARQFSLESR 
SSGKSSLSLV RGVRLSSSGP PLLTGLVNLD LPLDPLWEFP RDRLVLGKPL GEGCFGQVVR 
AEAFGMDPSR PDQTSTVAVK MLKDNASDKD LADLVSEMEV MKLIGRHKNI INLLGVCTQE 
GPLYVIVECA AKGNLREFLR ARRPPGPDLS PDGPRSSEGP LSFPALVSCA YQVARGMQYL 
ESRKCIHRDL AARNVLVTED DVMKIADFGL ARGVHHIDYY KKTSNGRLPV KWMAPEALFD 
RVYTHQSDVW SFGILLWEIF TLGGSPYPGI PVEELFSLLR EGHRMERPPN CPSELYGLMR 
ECWHAAPSQR PTFKQLVEAL DKVLLAVSEE YLDLRLTFGP FSPSNGDASS TCSSSDSVFS 
HDPLPLEPSP FPFSDSQTT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fgfr4

Associated with

Other Information

FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse. PubMed ID: 1723680

FGFR4 and its novel splice form in myogenic cells: interplay of glycosylation and tyrosine phosphorylation. PubMed ID: 18186042

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. PubMed ID: 1281307

FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. PubMed ID: 9716527

Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. PubMed ID: 10809780

FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. PubMed ID: 17664243

BetaKlotho is required for metabolic activity of fibroblast growth factor 21. PubMed ID: 17452648

FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action. PubMed ID: 19237543

The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation. PubMed ID: 19656770

Regulation of serum 1,25(OH)2Vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4. PubMed ID: 21561999

Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site. PubMed ID: 26675719

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303