Details for: CRYGB

Gene ID: 1419

Symbol: CRYGB

Ensembl ID: ENSG00000182187

Description: crystallin gamma B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.3656
    Cell Significance Index: 46.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8626
    Cell Significance Index: 20.8900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.7266
    Cell Significance Index: 10.2100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.6286
    Cell Significance Index: 19.8800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3122
    Cell Significance Index: 4.5500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2454
    Cell Significance Index: 3.1700
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.1855
    Cell Significance Index: 1.0400
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.1674
    Cell Significance Index: 1.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0551
    Cell Significance Index: 3.4700
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.0519
    Cell Significance Index: 0.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0262
    Cell Significance Index: 0.3800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0221
    Cell Significance Index: 0.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0105
    Cell Significance Index: 0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0071
    Cell Significance Index: 13.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0064
    Cell Significance Index: 9.8600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0049
    Cell Significance Index: 0.0700
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0039
    Cell Significance Index: 0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0039
    Cell Significance Index: 5.2600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0029
    Cell Significance Index: 0.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0029
    Cell Significance Index: 0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0022
    Cell Significance Index: 0.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0020
    Cell Significance Index: 0.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0008
    Cell Significance Index: -0.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0009
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0016
    Cell Significance Index: -0.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0019
    Cell Significance Index: -0.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0024
    Cell Significance Index: -0.1100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0032
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0037
    Cell Significance Index: -0.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0046
    Cell Significance Index: -0.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0051
    Cell Significance Index: -0.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0061
    Cell Significance Index: -0.4100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0063
    Cell Significance Index: -0.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0078
    Cell Significance Index: -0.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0080
    Cell Significance Index: -0.2800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0089
    Cell Significance Index: -0.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0090
    Cell Significance Index: -0.4000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0093
    Cell Significance Index: -0.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0097
    Cell Significance Index: -0.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0100
    Cell Significance Index: -0.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0113
    Cell Significance Index: -0.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0116
    Cell Significance Index: -0.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0117
    Cell Significance Index: -0.3300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0133
    Cell Significance Index: -0.1500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0137
    Cell Significance Index: -0.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0137
    Cell Significance Index: -0.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0144
    Cell Significance Index: -0.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0169
    Cell Significance Index: -0.3400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0176
    Cell Significance Index: -0.4300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0187
    Cell Significance Index: -0.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0188
    Cell Significance Index: -0.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0194
    Cell Significance Index: -0.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0207
    Cell Significance Index: -0.4100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0210
    Cell Significance Index: -0.2800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0216
    Cell Significance Index: -0.4300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0216
    Cell Significance Index: -0.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0217
    Cell Significance Index: -0.5200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0225
    Cell Significance Index: -0.2200
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0227
    Cell Significance Index: -0.2500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0233
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0243
    Cell Significance Index: -0.4000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0254
    Cell Significance Index: -0.4400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0255
    Cell Significance Index: -0.1700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0255
    Cell Significance Index: -0.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0257
    Cell Significance Index: -0.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0281
    Cell Significance Index: -0.4700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0284
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0291
    Cell Significance Index: -0.4000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0291
    Cell Significance Index: -0.4700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0292
    Cell Significance Index: -0.4100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0296
    Cell Significance Index: -0.4500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0309
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0315
    Cell Significance Index: -0.3500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0316
    Cell Significance Index: -0.3700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0319
    Cell Significance Index: -0.3700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0320
    Cell Significance Index: -0.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0323
    Cell Significance Index: -0.6300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0326
    Cell Significance Index: -0.3500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0329
    Cell Significance Index: -0.4600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0330
    Cell Significance Index: -0.3500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0337
    Cell Significance Index: -0.4500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0338
    Cell Significance Index: -0.3000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0339
    Cell Significance Index: -0.4400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0341
    Cell Significance Index: -0.4600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0341
    Cell Significance Index: -0.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Crystallin family member**: CRYGB is a member of the crystallin family, which is composed of alpha, beta, gamma, and delta crystallins. These proteins are responsible for maintaining the transparency and refractive index of the lens in the eye. 2. **Expression in multiple cell types**: CRYGB is expressed in various cell types, including progenitor cells, endothelial cells, and cells of the epithelium in different organs such as the intestine and the lens. 3. **Lens development and maintenance**: CRYGB plays a crucial role in lens development and maintenance, particularly in the formation of lens fiber cells. 4. **Cellular morphology and homeostasis**: The protein is involved in maintaining cellular morphology and homeostasis, particularly in the lens and epithelial cells. **Pathways and Functions** 1. **Lens development**: CRYGB is involved in the development of the lens, particularly in the formation of lens fiber cells. The protein helps to regulate the expression of other genes involved in lens development. 2. **Cellular morphogenesis**: CRYGB plays a role in regulating cellular morphogenesis, particularly in the lens and epithelial cells. The protein helps to maintain the shape and structure of these cells. 3. **Visual perception**: As a member of the crystallin family, CRYGB is involved in maintaining the transparency and refractive index of the lens, which is essential for visual perception. 4. **Cellular stress response**: The protein may also play a role in the cellular stress response, particularly in the lens and epithelial cells. CRYGB may help to protect these cells against oxidative stress and other forms of cellular damage. **Clinical Significance** 1. **Cataract formation**: Mutations in the CRYGB gene have been associated with cataract formation, particularly in the lens. CRYGB plays a crucial role in maintaining the transparency and refractive index of the lens, and mutations in the gene can lead to lens opacification and cataract formation. 2. **Eye diseases**: CRYGB has been implicated in various eye diseases, including age-related macular degeneration and glaucoma. The protein's role in maintaining the transparency and refractive index of the lens makes it a potential target for therapeutic intervention in these diseases. 3. **Intestinal disorders**: CRYGB has also been implicated in intestinal disorders, including inflammatory bowel disease (IBD) and colorectal cancer. The protein's expression in intestinal cells makes it a potential biomarker for these disorders. 4. **Cancer research**: CRYGB has been identified as a potential oncogene, and its expression has been found to be elevated in various types of cancer, including breast, lung, and colon cancer. The protein's role in regulating cellular morphology and homeostasis makes it a potential target for therapeutic intervention in cancer. In conclusion, CRYGB is a protein that plays a crucial role in maintaining the transparency and refractive index of the lens in the eye, as well as regulating cellular morphology and homeostasis in various cell types. Mutations in the CRYGB gene have been associated with cataract formation and other eye diseases, and the protein's expression has been implicated in various intestinal disorders and cancers. Further research is needed to fully understand the role of CRYGB in human disease and to develop therapeutic interventions targeting this protein.

Genular Protein ID: 2927005285

Symbol: CRGB_HUMAN

Name: Gamma-crystallin B

UniProtKB Accession Codes:

P07316 Q17RB5 Q53ST2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 4065573

Title: Two human gamma-crystallin genes are linked and riddled with Alu-repeats.

PubMed ID: 4065573

DOI: 10.1016/0378-1119(85)90218-5

PubMed ID: 2777080

Title: Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region.

PubMed ID: 2777080

DOI: 10.1016/0378-1119(89)90223-0

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23288985

Title: Novel crystallin gamma B mutations in a Kuwaiti family with autosomal dominant congenital cataracts reveal genetic and clinical heterogeneity.

PubMed ID: 23288985

PubMed ID: 12507494

Title: Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins.

PubMed ID: 12507494

DOI: 10.1016/s0006-291x(02)02895-4

PubMed ID: 14517968

Title: Prediction of possible sites for posttranslational modifications in human gamma crystallins: effect of glycation on the structure of human gamma-B-crystallin as analyzed by molecular modeling.

PubMed ID: 14517968

DOI: 10.1002/prot.10493

PubMed ID: 17628592

Title: Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein.

PubMed ID: 17628592

DOI: 10.1016/j.jmb.2007.06.045

PubMed ID: 12011157

Title: Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts.

PubMed ID: 12011157

DOI: 10.1136/jmg.39.5.352

PubMed ID: 12676897

Title: Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts.

PubMed ID: 12676897

DOI: 10.1136/jmg.40.4.262

Sequence Information:

  • Length: 175
  • Mass: 20908
  • Checksum: E0B605353FC62AFC
  • Sequence:
    • MGKITFYEDR AFQGRSYECT TDCPNLQPYF SRCNSIRVES GCWMIYERPN YQGHQYFLRR 
GEYPDYQQWM GLSDSIRSCC LIPPHSGAYR MKIYDRDELR GQMSELTDDC ISVQDRFHLT 
EIHSLNVLEG SWILYEMPNY RGRQYLLRPG EYRRFLDWGA PNAKVGSLRR VMDLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.