Details for: CRYGB

Gene ID: 1419

Symbol: CRYGB

Ensembl ID: ENSG00000182187

Description: crystallin gamma B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.7
    Marker Score: 30281
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3177
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2001
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2223
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1177
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 507
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1389
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 495
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1178
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 527
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.57
    Marker Score: 544
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 734
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.38
    Marker Score: 220
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.27
    Marker Score: 542
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.24
    Marker Score: 453
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.23
    Marker Score: 77
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.21
    Marker Score: 206
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 162
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 199
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.16
    Marker Score: 2480
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 317.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.13
    Marker Score: 169
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 133
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1
    Marker Score: 127
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.07
    Marker Score: 123
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.06
    Marker Score: 367
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.04
    Marker Score: 61
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 88
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.04
    Marker Score: 143
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.03
    Marker Score: 54
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 68
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 59
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.02
    Marker Score: 181
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.01
    Marker Score: 157

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Other Information

**Key characteristics:** * The CRYGB gene is located on chromosome 13q14.1. * It is a large gene, encoding for a protein of 1,251 amino acids. * The protein is a transmembrane protein that is expressed in the lens fiber cells. * It is a key regulator of lens development and function. **Pathways and functions:** * The CRYGB protein is essential for the assembly and maintenance of the lens fiber cells. * It is involved in the regulation of the cell cycle, cell migration, and differentiation. * Mutations in the CRYGB gene can lead to the formation of abnormal lens fibers, which can result in vision problems such as cataracts and glaucoma. * CRYGB is also involved in the development of the visual pathway, from the retina to the brain. **Clinical significance:** * Mutations in the CRYGB gene have been linked to several eye diseases, including cataracts, glaucoma, and AMD. * CryGB is a promising target for the treatment of these diseases. * The development of drugs that target the CRYGB gene is currently underway. **Additional information:** * The CRYGB protein is also expressed in other tissues, including the skin, heart, and brain. * Mutations in the CRYGB gene have also been linked to other eye disorders, such as retinal dystrophy and macular degeneration. * The CRYGB protein is a highly conserved protein, with a similar gene found in other mammals.

Genular Protein ID: 2927005285

Symbol: CRGB_HUMAN

Name: Gamma-crystallin B

UniProtKB Accession Codes:

P07316 Q17RB5 Q53ST2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 4065573

Title: Two human gamma-crystallin genes are linked and riddled with Alu-repeats.

PubMed ID: 4065573

DOI: 10.1016/0378-1119(85)90218-5

PubMed ID: 2777080

Title: Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region.

PubMed ID: 2777080

DOI: 10.1016/0378-1119(89)90223-0

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23288985

Title: Novel crystallin gamma B mutations in a Kuwaiti family with autosomal dominant congenital cataracts reveal genetic and clinical heterogeneity.

PubMed ID: 23288985

PubMed ID: 12507494

Title: Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins.

PubMed ID: 12507494

DOI: 10.1016/s0006-291x(02)02895-4

PubMed ID: 14517968

Title: Prediction of possible sites for posttranslational modifications in human gamma crystallins: effect of glycation on the structure of human gamma-B-crystallin as analyzed by molecular modeling.

PubMed ID: 14517968

DOI: 10.1002/prot.10493

PubMed ID: 17628592

Title: Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein.

PubMed ID: 17628592

DOI: 10.1016/j.jmb.2007.06.045

PubMed ID: 12011157

Title: Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts.

PubMed ID: 12011157

DOI: 10.1136/jmg.39.5.352

PubMed ID: 12676897

Title: Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts.

PubMed ID: 12676897

DOI: 10.1136/jmg.40.4.262

Sequence Information:

  • Length: 175
  • Mass: 20908
  • Checksum: E0B605353FC62AFC
  • Sequence:
    • MGKITFYEDR AFQGRSYECT TDCPNLQPYF SRCNSIRVES GCWMIYERPN YQGHQYFLRR 
GEYPDYQQWM GLSDSIRSCC LIPPHSGAYR MKIYDRDELR GQMSELTDDC ISVQDRFHLT 
EIHSLNVLEG SWILYEMPNY RGRQYLLRPG EYRRFLDWGA PNAKVGSLRR VMDLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.