Genular: Defining Cellular Identity and Function

Details for: Fh1

Gene ID: 14194

Symbol: Fh1

Ensembl ID: ENSMUSG00000026526

Description: fumarate hydratase 1

Associated with

Citric acid cycle (tca cycle)
(R-MMU-71403)
Metabolism
(R-MMU-1430728)
Metabolism of proteins
(R-MMU-392499)
Mitochondrial protein degradation
(R-MMU-9837999)
Pyruvate metabolism and citric acid (tca) cycle
(R-MMU-71406)
The citric acid (tca) cycle and respiratory electron transport
(R-MMU-1428517)
Catalytic activity
(GO:0003824)
Chromosome
(GO:0005694)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Fumarate hydratase activity
(GO:0004333)
Fumarate metabolic process
(GO:0006106)
Histone binding
(GO:0042393)
Homeostasis of number of cells within a tissue
(GO:0048873)
Lyase activity
(GO:0016829)
Malate metabolic process
(GO:0006108)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Nucleus
(GO:0005634)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of double-strand break repair via nonhomologous end joining
(GO:2001034)
Regulation of arginine metabolic process
(GO:0000821)
Site of double-strand break
(GO:0035861)
Tricarboxylic acid cycle
(GO:0006099)
Tricarboxylic acid cycle enzyme complex
(GO:0045239)
Urea cycle
(GO:0000050)

Other Information

Proteins

EF-3

Genular Protein ID: 1914829321

Symbol: FUMH_MOUSE

Name: EF-3

UniProtKB Accession Codes:

P97807 Q3UIA9 Q99JL0 Q9DCX0

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9032278

Title: E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts.

PubMed ID: 9032278

DOI: 10.1128/mcb.17.3.1503

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

PubMed ID: 17418408

Title: Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.

PubMed ID: 17418408

DOI: 10.1016/j.ccr.2007.02.005

PubMed ID: 22014577

Title: Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.

PubMed ID: 22014577

DOI: 10.1016/j.ccr.2011.09.006

PubMed ID: 23643539

Title: A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.

PubMed ID: 23643539

DOI: 10.1016/j.celrep.2013.04.006

Sequence Information:

Length: 507
Mass: 54357
Checksum: 2F24F7B089608ABE
Sequence:

MYRALRLLAR SRRLLRVPSA GAAVSGEATT LPRCAPNVAR MASQNSFRVE FDTFGELKVP 
TDKYYGAQTV RSTMNFKIGG ATERMPIPVI QAFGILKRAA AEVNQEYGLD PKIASAIMKA 
ADEVAEGKLN DHFPLVVWQT GSGTQTNMNV NEVISNRAIE MLGGELGSKK PVHPNDHVNK 
SQSSNDTFPT AMHIAAAVEV HKVLLPGLQK LHDALSAKSK EFAQVIKIGR THTQDAVPLT 
LGQEFSGYVQ QVQYAMVRIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL 
PFVTAPNKFE ALAAHDALVE LSGAMNTAAC SLMKIANDIR FLGSGPRSGL GELILPENEP 
GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF ELNVFKPMMI KNVLHSARLL 
GDASVSFTDN CVVGIQANTE RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK 
ETAIELGYLT AEQFDEWVKP KDMLGPK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fh1

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. PubMed ID: 9032278

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. PubMed ID: 17418408

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. PubMed ID: 22014577

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia. PubMed ID: 23643539