Details for: PARP1

Gene ID: 142

Symbol: PARP1

Ensembl ID: ENSG00000143799

Description: poly(ADP-ribose) polymerase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.86
    Marker Score: 8483
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.64
    Marker Score: 1299
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.61
    Marker Score: 35115
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.52
    Marker Score: 4394
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.35
    Marker Score: 23788
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.27
    Marker Score: 1380
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.25
    Marker Score: 3241
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.25
    Marker Score: 8848
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.2
    Marker Score: 8990
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.17
    Marker Score: 2315
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.16
    Marker Score: 2174
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.12
    Marker Score: 505
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.11
    Marker Score: 1594
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.1
    Marker Score: 1972
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.08
    Marker Score: 5667
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.08
    Marker Score: 1956
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.07
    Marker Score: 571
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.05
    Marker Score: 2419
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.01
    Marker Score: 1453
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.99
    Marker Score: 1248
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.96
    Marker Score: 4088
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.93
    Marker Score: 12353
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.9
    Marker Score: 18855
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.89
    Marker Score: 3204.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.88
    Marker Score: 2109
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.87
    Marker Score: 6915
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.86
    Marker Score: 535
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.85
    Marker Score: 593
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.85
    Marker Score: 2614
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.82
    Marker Score: 1207
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.81
    Marker Score: 476
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.8
    Marker Score: 20959
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.8
    Marker Score: 415
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.77
    Marker Score: 2354
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.77
    Marker Score: 1036
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.76
    Marker Score: 1569
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.74
    Marker Score: 1849
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.74
    Marker Score: 1364
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.7
    Marker Score: 2136
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.7
    Marker Score: 420
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.7
    Marker Score: 594
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.69
    Marker Score: 16993.5
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.68
    Marker Score: 585
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.66
    Marker Score: 1209
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.66
    Marker Score: 872
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.65
    Marker Score: 1741
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.63
    Marker Score: 812
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.62
    Marker Score: 4419
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.61
    Marker Score: 1551.5
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.6
    Marker Score: 785
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.59
    Marker Score: 11837
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.58
    Marker Score: 644
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.57
    Marker Score: 1695
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.57
    Marker Score: 554
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.55
    Marker Score: 17479
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.52
    Marker Score: 876
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.52
    Marker Score: 1016
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.52
    Marker Score: 837
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.51
    Marker Score: 3443
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.51
    Marker Score: 449
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.5
    Marker Score: 464
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.49
    Marker Score: 355
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.48
    Marker Score: 19559
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.48
    Marker Score: 789
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.48
    Marker Score: 699
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.48
    Marker Score: 889
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.46
    Marker Score: 4177
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.46
    Marker Score: 805
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.46
    Marker Score: 992
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.45
    Marker Score: 3419
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.45
    Marker Score: 436
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.45
    Marker Score: 1088
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.43
    Marker Score: 700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.43
    Marker Score: 499
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.42
    Marker Score: 1398
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.42
    Marker Score: 2969
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.41
    Marker Score: 965
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.41
    Marker Score: 473
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.41
    Marker Score: 835
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.4
    Marker Score: 1166
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.4
    Marker Score: 484
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.4
    Marker Score: 1319
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.4
    Marker Score: 282
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.39
    Marker Score: 2719
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.38
    Marker Score: 47769
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.36
    Marker Score: 1318
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.36
    Marker Score: 361
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.36
    Marker Score: 8077
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.36
    Marker Score: 2428
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.35
    Marker Score: 296.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.35
    Marker Score: 1982
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.34
    Marker Score: 501
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.34
    Marker Score: 784
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.33
    Marker Score: 1136
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.33
    Marker Score: 1328
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.33
    Marker Score: 943
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.33
    Marker Score: 3238
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.32
    Marker Score: 5098
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.32
    Marker Score: 3126
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.31
    Marker Score: 2774

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Other Information

**Key characteristics:** * PARP1 is a highly conserved protein with a conserved catalytic domain responsible for DNA repair. * It is a heterodimeric protein, with two subunits of different sizes. * It is a key regulator of the cell cycle, and its activity is tightly controlled by various factors, including DNA damage, cell cycle stage, and post-translational modifications. **Pathways and functions:** * PARP1 is involved in multiple cellular pathways, including DNA repair, cell cycle regulation, and apoptosis. * In DNA repair, PARP1 is responsible for repairing double-strand breaks caused by various agents, including ionizing radiation, chemicals, and viruses. * In cell cycle regulation, PARP1 helps to ensure that DNA damage is repaired before cells divide. * In apoptosis, PARP1 is involved in the regulation of cell death. **Clinical significance:** * Mutations in PARP1 have been linked to various human diseases, including cancer and neurodegenerative disorders. * PARP inhibitors are being investigated as potential treatments for cancer and other diseases that are characterized by DNA damage. **Additional notes:** * PARP1 is a highly conserved protein, with a similar protein found in other organisms. * It is a key regulator of the cell cycle and is essential for maintaining genomic integrity. * Mutations in PARP1 have been linked to various human diseases, including cancer and neurodegenerative disorders.

Genular Protein ID: 1577874424

Symbol: PARP1_HUMAN

Name: Poly[ADP-ribose] synthase 1

UniProtKB Accession Codes:

P09874 B1ANJ4 Q8IUZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 5 CPTC 1 CTD 1 ChEBI 39 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 22 DrugCentral 1 EC 1 ELM 1 EMBL 36 EMDB 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 87 PIR 1 PIRSF 1 PRO 1 PROSITE 7 PROSITE-ProRule 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 1 Rhea 20 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 5 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3120710

Title: Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase.

PubMed ID: 3120710

DOI: 10.1016/0006-291x(87)90921-1

PubMed ID: 2824474

Title: Primary structure of human poly(ADP-ribose) synthetase as deduced from cDNA sequence.

PubMed ID: 2824474

DOI: 10.1016/s0021-9258(18)47687-9

PubMed ID: 2891139

Title: cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase.

PubMed ID: 2891139

DOI: 10.1073/pnas.84.23.8370

PubMed ID: 2513174

Title: Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene.

PubMed ID: 2513174

DOI: 10.1089/dna.1989.8.575

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2125269

Title: Human poly(ADP-ribose) polymerase gene. Cloning of the promoter region.

PubMed ID: 2125269

DOI: 10.1111/j.1432-1033.1990.tb15647.x

PubMed ID: 2108670

Title: Characterization of a putative promoter region of the human poly(ADP-ribose) polymerase gene: structural similarity to that of the DNA polymerase beta gene.

PubMed ID: 2108670

DOI: 10.1016/0006-291x(90)92082-b

PubMed ID: 17177976

Title: Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.

PubMed ID: 17177976

DOI: 10.1111/j.1365-2249.2006.03249.x

PubMed ID: 3121332

Title: Isolation of a cDNA clone for human NAD+: protein ADP-ribosyltransferase.

PubMed ID: 3121332

PubMed ID: 3113420

Title: Molecular cloning of cDNA for human poly(ADP-ribose) polymerase and expression of its gene during HL-60 cell differentiation.

PubMed ID: 3113420

DOI: 10.1016/0006-291x(87)90543-2

PubMed ID: 2109322

Title: The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.

PubMed ID: 2109322

DOI: 10.1073/pnas.87.8.2990

PubMed ID: 2123876

Title: The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA.

PubMed ID: 2123876

DOI: 10.1016/s0021-9258(18)45824-3

PubMed ID: 2121735

Title: Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity.

PubMed ID: 2121735

DOI: 10.1016/s0021-9258(17)30651-8

PubMed ID: 1505517

Title: The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity.

PubMed ID: 1505517

DOI: 10.1002/j.1460-2075.1992.tb05404.x

PubMed ID: 7852410

Title: Role of glutamic acid 988 of human poly-ADP-ribose polymerase in polymer formation. Evidence for active site similarities to the ADP-ribosylating toxins.

PubMed ID: 7852410

DOI: 10.1074/jbc.270.7.3247

PubMed ID: 7596430

Title: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.

PubMed ID: 7596430

DOI: 10.1038/376037a0

PubMed ID: 9315851

Title: Random mutagenesis of the poly(ADP-ribose) polymerase catalytic domain reveals amino acids involved in polymer branching.

PubMed ID: 9315851

DOI: 10.1021/bi971055p

PubMed ID: 9721847

Title: Irreversible binding of poly(ADP)ribose polymerase cleavage product to DNA ends revealed by atomic force microscopy: possible role in apoptosis.

PubMed ID: 9721847

PubMed ID: 9518481

Title: Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication.

PubMed ID: 9518481

DOI: 10.1093/nar/26.8.1891

PubMed ID: 10497198

Title: Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.

PubMed ID: 10497198

DOI: 10.1074/jbc.274.40.28379

PubMed ID: 10467406

Title: Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro.

PubMed ID: 10467406

DOI: 10.1038/sj.onc.1202823

PubMed ID: 15607977

Title: NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1.

PubMed ID: 15607977

DOI: 10.1016/j.cell.2004.11.002

PubMed ID: 15044383

Title: Aprataxin, a novel protein that protects against genotoxic stress.

PubMed ID: 15044383

DOI: 10.1093/hmg/ddh122

PubMed ID: 16374543

Title: Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis.

PubMed ID: 16374543

DOI: 10.1007/s10495-005-3276-y

PubMed ID: 16904257

Title: The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions.

PubMed ID: 16904257

DOI: 10.1016/j.mce.2006.06.008

PubMed ID: 17396150

Title: A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.

PubMed ID: 17396150

DOI: 10.1038/sj.emboj.7601663

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18172500

Title: Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins.

PubMed ID: 18172500

DOI: 10.1038/nature06420

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19344625

Title: Poly(ADP-ribose) polymerase-1 (PARP-1) transcriptionally regulates angiotensin AT2 receptor (AT2R) and AT2R binding protein (ATBP) genes.

PubMed ID: 19344625

DOI: 10.1016/j.bcp.2009.02.025

PubMed ID: 19779455

Title: PARP-1 transcriptional activity is regulated by sumoylation upon heat shock.

PubMed ID: 19779455

DOI: 10.1038/emboj.2009.279

PubMed ID: 19764761

Title: Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications.

PubMed ID: 19764761

DOI: 10.1021/ja906135d

PubMed ID: 19710015

Title: The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.

PubMed ID: 19710015

DOI: 10.1074/jbc.m109.023457

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19661379

Title: Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.

PubMed ID: 19661379

DOI: 10.1126/science.1177321

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20064938

Title: PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.

PubMed ID: 20064938

DOI: 10.1074/jbc.m109.077834

PubMed ID: 20388712

Title: The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.

PubMed ID: 20388712

DOI: 10.1074/jbc.m110.105668

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20106667

Title: Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

PubMed ID: 20106667

DOI: 10.1016/j.tibs.2009.12.003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21266351

Title: hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genotoxic stress.

PubMed ID: 21266351

DOI: 10.1158/0008-5472.can-10-1831

PubMed ID: 21577210

Title: Poly(ADP-ribose)-dependent regulation of Snail1 protein stability.

PubMed ID: 21577210

DOI: 10.1038/onc.2011.153

PubMed ID: 21799911

Title: Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.

PubMed ID: 21799911

DOI: 10.1371/journal.pone.0022595

PubMed ID: 21680843

Title: SIRT6 promotes DNA repair under stress by activating PARP1.

PubMed ID: 21680843

DOI: 10.1126/science.1202723

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22863007

Title: Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.

PubMed ID: 22863007

DOI: 10.1016/j.cell.2012.06.028

PubMed ID: 22464733

Title: Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes.

PubMed ID: 22464733

DOI: 10.1016/j.molcel.2012.02.016

PubMed ID: 22002106

Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.

PubMed ID: 22002106

DOI: 10.1074/mcp.m111.013680

PubMed ID: 22451931

Title: Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.

PubMed ID: 22451931

DOI: 10.1073/pnas.1200934109

PubMed ID: 22753495

Title: Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.

PubMed ID: 22753495

DOI: 10.1073/pnas.1200583109

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23966166

Title: ZNF365 promotes stalled replication forks recovery to maintain genome stability.

PubMed ID: 23966166

DOI: 10.4161/cc.25882

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23230272

Title: BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8.

PubMed ID: 23230272

DOI: 10.1128/mcb.00990-12

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25043379

Title: Family-wide analysis of poly(ADP-ribose) polymerase activity.

PubMed ID: 25043379

DOI: 10.1038/ncomms5426

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24906880

Title: PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.

PubMed ID: 24906880

DOI: 10.1093/nar/gku505

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25533949

Title: A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.

PubMed ID: 25533949

DOI: 10.1038/nature14028

PubMed ID: 27067600

Title: HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity.

PubMed ID: 27067600

DOI: 10.1016/j.molcel.2016.03.008

PubMed ID: 27471034

Title: Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.

PubMed ID: 27471034

DOI: 10.1093/nar/gkw675

PubMed ID: 27257257

Title: ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.

PubMed ID: 27257257

DOI: 10.1126/science.aad9335

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 29220653

Title: A Poly-ADP-Ribose trigger releases the auto-inhibition of a chromatin remodeling oncogene.

PubMed ID: 29220653

DOI: 10.1016/j.molcel.2017.11.019

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30257210

Title: Interplay of histone marks with serine ADP-ribosylation.

PubMed ID: 30257210

DOI: 10.1016/j.celrep.2018.08.092

PubMed ID: 29954836

Title: Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site.

PubMed ID: 29954836

DOI: 10.15252/embr.201745310

PubMed ID: 30356214

Title: Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.

PubMed ID: 30356214

DOI: 10.1038/s41586-018-0629-6

PubMed ID: 30104678

Title: PARP2 mediates branched poly ADP-ribosylation in response to DNA damage.

PubMed ID: 30104678

DOI: 10.1038/s41467-018-05588-5

PubMed ID: 31609975

Title: KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells.

PubMed ID: 31609975

DOI: 10.1371/journal.pbio.3000468

PubMed ID: 33186521

Title: An HPF1/PARP1-based chemical biology strategy for exploring ADP-ribosylation.

PubMed ID: 33186521

DOI: 10.1016/j.cell.2020.09.055

PubMed ID: 27568560

Title: JNK phosphorylates SIRT6 to stimulate DNA double-strand break repair in response to oxidative stress by recruiting PARP1 to DNA Breaks.

PubMed ID: 27568560

DOI: 10.1016/j.celrep.2016.08.006

PubMed ID: 27256882

Title: Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.

PubMed ID: 27256882

DOI: 10.1126/science.aaf7865

PubMed ID: 30675909

Title: Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity.

PubMed ID: 30675909

DOI: 10.1002/ijc.32131

PubMed ID: 31848352

Title: PARP1 exhibits enhanced association and catalytic efficiency with gammaH2A.X-nucleosome.

PubMed ID: 31848352

DOI: 10.1038/s41467-019-13641-0

PubMed ID: 31796734

Title: Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage.

PubMed ID: 31796734

DOI: 10.1038/s41467-019-13167-5

PubMed ID: 32844745

Title: PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response.

PubMed ID: 32844745

DOI: 10.7554/elife.60637

PubMed ID: 32028527

Title: HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.

PubMed ID: 32028527

DOI: 10.1038/s41586-020-2013-6

PubMed ID: 32358582

Title: Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy.

PubMed ID: 32358582

DOI: 10.1038/s41467-020-15858-w

PubMed ID: 32315358

Title: PARP1-cGAS-NF-kappaB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease.

PubMed ID: 32315358

DOI: 10.1371/journal.ppat.1008474

PubMed ID: 34732825

Title: Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.

PubMed ID: 34732825

DOI: 10.1038/s42003-021-02780-0

PubMed ID: 34049076

Title: PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damage.

PubMed ID: 34049076

DOI: 10.1016/j.dnarep.2021.103132

PubMed ID: 33683197

Title: HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase.

PubMed ID: 33683197

DOI: 10.7554/elife.65773

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

PubMed ID: 33168626

Title: The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis.

PubMed ID: 33168626

DOI: 10.1074/jbc.ra120.014479

PubMed ID: 33412112

Title: CARM1 regulates replication fork speed and stress response by stimulating PARP1.

PubMed ID: 33412112

DOI: 10.1016/j.molcel.2020.12.010

PubMed ID: 34102106

Title: XRCC1 prevents toxic PARP1 trapping during DNA base excision repair.

PubMed ID: 34102106

DOI: 10.1016/j.molcel.2021.05.009

PubMed ID: 34811483

Title: XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair.

PubMed ID: 34811483

DOI: 10.1038/s41556-021-00792-w

PubMed ID: 34210965

Title: Serine-linked PARP1 auto-modification controls PARP inhibitor response.

PubMed ID: 34210965

DOI: 10.1038/s41467-021-24361-9

PubMed ID: 34625544

Title: The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.

PubMed ID: 34625544

DOI: 10.1038/s41467-021-26172-4

PubMed ID: 34737271

Title: SPINDOC binds PARP1 to facilitate PARylation.

PubMed ID: 34737271

DOI: 10.1038/s41467-021-26588-y

PubMed ID: 34795260

Title: HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.

PubMed ID: 34795260

DOI: 10.1038/s41467-021-27043-8

PubMed ID: 34465625

Title: Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling.

PubMed ID: 34465625

DOI: 10.1073/pnas.2107277118

PubMed ID: 35124853

Title: PARP1 is activated by membrane damage and is involved in membrane repair through poly(ADP-ribosyl)ation.

PubMed ID: 35124853

DOI: 10.1111/gtc.12926

PubMed ID: 35025765

Title: RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1.

PubMed ID: 35025765

DOI: 10.1172/jci147301

Sequence Information:

  • Length: 1014
  • Mass: 113084
  • Checksum: 6A5FC01EB91C046B
  • Sequence:
    • MAESSDKLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH WYHFSCFWKV 
GHSIRHPDVE VDGFSELRWD DQQKVKKTAE AGGVTGKGQD GIGSKAEKTL GDFAAEYAKS 
NRSTCKGCME KIEKGQVRLS KKMVDPEKPQ LGMIDRWYHP GCFVKNREEL GFRPEYSASQ 
LKGFSLLATE DKEALKKQLP GVKSEGKRKG DEVDGVDEVA KKKSKKEKDK DSKLEKALKA 
QNDLIWNIKD ELKKVCSTND LKELLIFNKQ QVPSGESAIL DRVADGMVFG ALLPCEECSG 
QLVFKSDAYY CTGDVTAWTK CMVKTQTPNR KEWVTPKEFR EISYLKKLKV KKQDRIFPPE 
TSASVAATPP PSTASAPAAV NSSASADKPL SNMKILTLGK LSRNKDEVKA MIEKLGGKLT 
GTANKASLCI STKKEVEKMN KKMEEVKEAN IRVVSEDFLQ DVSASTKSLQ ELFLAHILSP 
WGAEVKAEPV EVVAPRGKSG AALSKKSKGQ VKEEGINKSE KRMKLTLKGG AAVDPDSGLE 
HSAHVLEKGG KVFSATLGLV DIVKGTNSYY KLQLLEDDKE NRYWIFRSWG RVGTVIGSNK 
LEQMPSKEDA IEHFMKLYEE KTGNAWHSKN FTKYPKKFYP LEIDYGQDEE AVKKLTVNPG 
TKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK LSKRQIQAAY SILSEVQQAV 
SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP LLNNADSVQA KVEMLDNLLD IEVAYSLLRG 
GSDDSSKDPI DVNYEKLKTD IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE 
REGECQRYKP FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM 
VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG LGKTTPDPSA 
NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK YLLKLKFNFK TSLW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.