Details for: CRYGC

Gene ID: 1420

Symbol: CRYGC

Ensembl ID: ENSG00000163254

Description: crystallin gamma C

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.57
    Marker Score: 103741.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6839
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3175
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2002
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1178
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 862
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4815
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 509
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1454
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.84
    Marker Score: 1742
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.83
    Marker Score: 1027
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 535
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.58
    Marker Score: 439
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 178
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.25
    Marker Score: 348
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.25
    Marker Score: 307
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.24
    Marker Score: 68
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.23
    Marker Score: 223
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.23
    Marker Score: 78
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.21
    Marker Score: 223
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.19
    Marker Score: 92.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.17
    Marker Score: 205
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 89
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.15
    Marker Score: 1508
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 43
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.1
    Marker Score: 241
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.08
    Marker Score: 29.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 24.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.07
    Marker Score: 444
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.05
    Marker Score: 29.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.05
    Marker Score: 170.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.03
    Marker Score: 112
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.02
    Marker Score: 33
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.02
    Marker Score: 30

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Other Information

## Summary CRYGC is a protein that is expressed in the eye lens. It is a crystallin protein that is involved in the structure and function of the eye lens. ## Key characteristics * CRYGC is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in the lens of the eye. * It is a major component of the lens crystallin complex. * It is involved in the assembly and maintenance of the lens crystallin lattice. ## Pathways and functions * CRYGC is involved in the assembly of the lens crystallin lattice. * It is also involved in the maintenance of the lens crystallin lattice. * It is involved in the transport of proteins and lipids into the lens. ## Clinical significance * Mutations in CRYGC have been linked to a number of eye disorders, including cataracts, glaucoma, and age-related macular degeneration. * Crystalline proteins are also involved in the normal development of the eye lens. * Therefore, CRYGC is an important protein for eye health.

Genular Protein ID: 2849810845

Symbol: CRGC_HUMAN

Name: Gamma-crystallin C

UniProtKB Accession Codes:

P07315 Q53R50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 4065573

Title: Two human gamma-crystallin genes are linked and riddled with Alu-repeats.

PubMed ID: 4065573

DOI: 10.1016/0378-1119(85)90218-5

PubMed ID: 4033658

Title: Structural and evolutionary relationships among five members of the human gamma-crystallin gene family.

PubMed ID: 4033658

DOI: 10.1128/mcb.5.6.1408-1414.1985

PubMed ID: 2777080

Title: Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region.

PubMed ID: 2777080

DOI: 10.1016/0378-1119(89)90223-0

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8999933

Title: Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.

PubMed ID: 8999933

DOI: 10.1074/jbc.272.4.2268

PubMed ID: 12876325

Title: Methylation and carbamylation of human gamma-crystallins.

PubMed ID: 12876325

DOI: 10.1110/ps.0305403

PubMed ID: 22876111

Title: A nonsense mutation of CRYGC associated with autosomal dominant congenital nuclear cataracts and microcornea in a Chinese pedigree.

PubMed ID: 22876111

PubMed ID: 12507494

Title: Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins.

PubMed ID: 12507494

DOI: 10.1016/s0006-291x(02)02895-4

PubMed ID: 10521291

Title: The gamma-crystallins and human cataracts: a puzzle made clearer.

PubMed ID: 10521291

DOI: 10.1086/302619

PubMed ID: 10914683

Title: A 5-base insertion in the gammaC-crystallin gene is associated with autosomal dominant variable zonular pulverulent cataract.

PubMed ID: 10914683

DOI: 10.1007/s004390000289

PubMed ID: 12011157

Title: Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts.

PubMed ID: 12011157

DOI: 10.1136/jmg.39.5.352

PubMed ID: 12601044

Title: Alteration of protein-protein interactions of congenital cataract crystallin mutants.

PubMed ID: 12601044

DOI: 10.1167/iovs.02-0950

PubMed ID: 18587492

Title: Crystallin gene mutations in Indian families with inherited pediatric cataract.

PubMed ID: 18587492

PubMed ID: 21423869

Title: Mutation screening and genotype phenotype correlation of alpha-crystallin, gamma-crystallin and GJA8 gene in congenital cataract.

PubMed ID: 21423869

PubMed ID: 22052681

Title: A novel mutation impairing the tertiary structure and stability of gammaC-crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens.

PubMed ID: 22052681

DOI: 10.1002/humu.21648

PubMed ID: 29386872

Title: Mutations in crystallin genes result in congenital cataract associated with other ocular abnormalities.

PubMed ID: 29386872

PubMed ID: 29914532

Title: Clinical and genetic characteristics of Chinese patients with familial or sporadic pediatric cataract.

PubMed ID: 29914532

DOI: 10.1186/s13023-018-0828-0

PubMed ID: 33243271

Title: The genetic landscape of crystallins in congenital cataract.

PubMed ID: 33243271

DOI: 10.1186/s13023-020-01613-3

Sequence Information:

  • Length: 174
  • Mass: 20879
  • Checksum: B01DC167171A7668
  • Sequence:
    • MGKITFYEDR AFQGRSYETT TDCPNLQPYF SRCNSIRVES GCWMLYERPN YQGQQYLLRR 
GEYPDYQQWM GLSDSIRSCC LIPQTVSHRL RLYEREDHKG LMMELSEDCP SIQDRFHLSE 
IRSLHVLEGC WVLYELPNYR GRQYLLRPQE YRRCQDWGAM DAKAGSLRRV VDLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.