Details for: CRYGC

Gene ID: 1420

Symbol: CRYGC

Ensembl ID: ENSG00000163254

Description: crystallin gamma C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 5.0737
    Cell Significance Index: 105.2500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 4.9423
    Cell Significance Index: 69.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.1065
    Cell Significance Index: 89.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.0738
    Cell Significance Index: 51.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6717
    Cell Significance Index: 102.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4893
    Cell Significance Index: 32.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.9270
    Cell Significance Index: 13.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9156
    Cell Significance Index: 29.3300
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.7537
    Cell Significance Index: 6.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6908
    Cell Significance Index: 31.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5429
    Cell Significance Index: 103.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3969
    Cell Significance Index: 39.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2949
    Cell Significance Index: 6.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2820
    Cell Significance Index: 254.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1974
    Cell Significance Index: 32.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1627
    Cell Significance Index: 2.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1093
    Cell Significance Index: 11.8900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0964
    Cell Significance Index: 3.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0952
    Cell Significance Index: 6.5900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.0809
    Cell Significance Index: 0.8700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0294
    Cell Significance Index: 0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0060
    Cell Significance Index: 0.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0035
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0002
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0004
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0083
    Cell Significance Index: -0.1000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0095
    Cell Significance Index: -0.1000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0112
    Cell Significance Index: -0.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0118
    Cell Significance Index: -0.2300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0166
    Cell Significance Index: -0.1800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0186
    Cell Significance Index: -0.2500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0200
    Cell Significance Index: -0.2400
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0233
    Cell Significance Index: -0.2500
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0260
    Cell Significance Index: -0.2600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0271
    Cell Significance Index: -0.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0278
    Cell Significance Index: -1.6700
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0306
    Cell Significance Index: -0.3000
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0338
    Cell Significance Index: -0.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0351
    Cell Significance Index: -7.0500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0382
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0392
    Cell Significance Index: -0.3600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0463
    Cell Significance Index: -0.4400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0481
    Cell Significance Index: -0.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0499
    Cell Significance Index: -0.7100
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0512
    Cell Significance Index: -0.5300
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0523
    Cell Significance Index: -0.4900
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0691
    Cell Significance Index: -0.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0758
    Cell Significance Index: -2.0300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0778
    Cell Significance Index: -1.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0910
    Cell Significance Index: -26.1900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0914
    Cell Significance Index: -1.4500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0964
    Cell Significance Index: -1.3000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0990
    Cell Significance Index: -1.2700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1031
    Cell Significance Index: -1.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1043
    Cell Significance Index: -1.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1054
    Cell Significance Index: -3.4500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1060
    Cell Significance Index: -1.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1070
    Cell Significance Index: -3.7500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1090
    Cell Significance Index: -1.1500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1190
    Cell Significance Index: -1.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1236
    Cell Significance Index: -1.2800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1291
    Cell Significance Index: -1.1700
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1351
    Cell Significance Index: -1.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1380
    Cell Significance Index: -4.4000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1417
    Cell Significance Index: -1.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1431
    Cell Significance Index: -3.8200
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.1437
    Cell Significance Index: -1.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1516
    Cell Significance Index: -3.3200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1527
    Cell Significance Index: -1.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1561
    Cell Significance Index: -2.6300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1609
    Cell Significance Index: -2.7500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1629
    Cell Significance Index: -1.4000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1715
    Cell Significance Index: -3.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1717
    Cell Significance Index: -3.7100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1719
    Cell Significance Index: -1.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1780
    Cell Significance Index: -3.5200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1849
    Cell Significance Index: -0.9900
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: -0.1899
    Cell Significance Index: -1.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1926
    Cell Significance Index: -3.7900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1983
    Cell Significance Index: -2.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2008
    Cell Significance Index: -3.3600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2033
    Cell Significance Index: -1.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2099
    Cell Significance Index: -3.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2128
    Cell Significance Index: -2.8000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2396
    Cell Significance Index: -3.2900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2414
    Cell Significance Index: -3.3100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2423
    Cell Significance Index: -3.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2436
    Cell Significance Index: -5.1700
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.2511
    Cell Significance Index: -2.6500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2574
    Cell Significance Index: -2.8200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2603
    Cell Significance Index: -2.6600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2626
    Cell Significance Index: -3.1400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2636
    Cell Significance Index: -2.8000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2751
    Cell Significance Index: -3.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The CRYGC gene is a member of the crystallin gene family, which is responsible for encoding the major structural proteins of the lens. The gamma-C subunit is one of the four subunits that make up the gamma-crystallin protein, which is composed of two alpha-A, two alpha-B, two gamma-A, and two gamma-C subunits. The gamma-C subunit is known to be involved in the formation of the lens's crystalline structure and plays a crucial role in maintaining its transparency and refractive index. The CRYGC gene has been identified as a significant player in lens development and maintenance, particularly in the context of camera-type eye development. Its expression in various cell types also suggests a role in cellular stress response, cell adhesion, and maintenance of tissue homeostasis. **Pathways and Functions** The CRYGC gene is involved in several key pathways and functions, including: 1. **Lens Development**: The gamma-C subunit is essential for the formation of the lens's crystalline structure, which is critical for maintaining its transparency and refractive index. 2. **Cellular Stress Response**: The CRYGC gene is expressed in microglial cells, which are involved in the immune response and cellular stress response. The gamma-C subunit may play a role in modulating cellular stress responses and maintaining tissue homeostasis. 3. **Cell Adhesion**: The gamma-C subunit is involved in cell adhesion, which is critical for maintaining tissue structure and function. 4. **Protein Binding**: The gamma-C subunit interacts with other proteins, such as actin and tubulin, to regulate cellular processes and maintain tissue homeostasis. 5. **Structural Constituent of Eye Lens**: The CRYGC gene is a structural constituent of the eye lens, providing essential support and structure to the lens. **Clinical Significance** Dysregulation of the CRYGC gene has been implicated in various ocular and systemic diseases, including: 1. **Cataracts**: Mutations in the CRYGC gene have been associated with cataract formation, highlighting its critical role in lens development and maintenance. 2. **Glaucoma**: The gamma-C subunit may play a role in regulating intraocular pressure and maintaining optic nerve function. 3. **Systemic Diseases**: The CRYGC gene's expression in various cell types suggests a broader role in systemic disease, potentially involving cellular stress response, cell adhesion, and maintenance of tissue homeostasis. In conclusion, the CRYGC gene plays a critical role in maintaining the structural integrity and transparency of the eye lens, as well as regulating cellular stress responses, cell adhesion, and tissue homeostasis. Further research is needed to fully elucidate the functions and clinical significance of the CRYGC gene.

Genular Protein ID: 2849810845

Symbol: CRGC_HUMAN

Name: Gamma-crystallin C

UniProtKB Accession Codes:

P07315 Q53R50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 4065573

Title: Two human gamma-crystallin genes are linked and riddled with Alu-repeats.

PubMed ID: 4065573

DOI: 10.1016/0378-1119(85)90218-5

PubMed ID: 4033658

Title: Structural and evolutionary relationships among five members of the human gamma-crystallin gene family.

PubMed ID: 4033658

DOI: 10.1128/mcb.5.6.1408-1414.1985

PubMed ID: 2777080

Title: Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region.

PubMed ID: 2777080

DOI: 10.1016/0378-1119(89)90223-0

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8999933

Title: Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.

PubMed ID: 8999933

DOI: 10.1074/jbc.272.4.2268

PubMed ID: 12876325

Title: Methylation and carbamylation of human gamma-crystallins.

PubMed ID: 12876325

DOI: 10.1110/ps.0305403

PubMed ID: 22876111

Title: A nonsense mutation of CRYGC associated with autosomal dominant congenital nuclear cataracts and microcornea in a Chinese pedigree.

PubMed ID: 22876111

PubMed ID: 12507494

Title: Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins.

PubMed ID: 12507494

DOI: 10.1016/s0006-291x(02)02895-4

PubMed ID: 10521291

Title: The gamma-crystallins and human cataracts: a puzzle made clearer.

PubMed ID: 10521291

DOI: 10.1086/302619

PubMed ID: 10914683

Title: A 5-base insertion in the gammaC-crystallin gene is associated with autosomal dominant variable zonular pulverulent cataract.

PubMed ID: 10914683

DOI: 10.1007/s004390000289

PubMed ID: 12011157

Title: Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts.

PubMed ID: 12011157

DOI: 10.1136/jmg.39.5.352

PubMed ID: 12601044

Title: Alteration of protein-protein interactions of congenital cataract crystallin mutants.

PubMed ID: 12601044

DOI: 10.1167/iovs.02-0950

PubMed ID: 18587492

Title: Crystallin gene mutations in Indian families with inherited pediatric cataract.

PubMed ID: 18587492

PubMed ID: 21423869

Title: Mutation screening and genotype phenotype correlation of alpha-crystallin, gamma-crystallin and GJA8 gene in congenital cataract.

PubMed ID: 21423869

PubMed ID: 22052681

Title: A novel mutation impairing the tertiary structure and stability of gammaC-crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens.

PubMed ID: 22052681

DOI: 10.1002/humu.21648

PubMed ID: 29386872

Title: Mutations in crystallin genes result in congenital cataract associated with other ocular abnormalities.

PubMed ID: 29386872

PubMed ID: 29914532

Title: Clinical and genetic characteristics of Chinese patients with familial or sporadic pediatric cataract.

PubMed ID: 29914532

DOI: 10.1186/s13023-018-0828-0

PubMed ID: 33243271

Title: The genetic landscape of crystallins in congenital cataract.

PubMed ID: 33243271

DOI: 10.1186/s13023-020-01613-3

Sequence Information:

  • Length: 174
  • Mass: 20879
  • Checksum: B01DC167171A7668
  • Sequence:
    • MGKITFYEDR AFQGRSYETT TDCPNLQPYF SRCNSIRVES GCWMLYERPN YQGQQYLLRR 
GEYPDYQQWM GLSDSIRSCC LIPQTVSHRL RLYEREDHKG LMMELSEDCP SIQDRFHLSE 
IRSLHVLEGC WVLYELPNYR GRQYLLRPQE YRRCQDWGAM DAKAGSLRRV VDLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.