Genular: Defining Cellular Identity and Function

Details for: Fhl2

Gene ID: 14200

Symbol: Fhl2

Ensembl ID: ENSMUSG00000008136

Description: four and a half LIM domains 2

Associated with

Atrial cardiac muscle cell development
(GO:0055014)
Bhlh transcription factor binding
(GO:0043425)
Cytoplasm
(GO:0005737)
Heart trabecula formation
(GO:0060347)
Identical protein binding
(GO:0042802)
M band
(GO:0031430)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of calcineurin-nfat signaling cascade
(GO:0070885)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to hormone
(GO:0009725)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Transcription factor binding
(GO:0008134)
Ventricular cardiac muscle cell development
(GO:0055015)
Z disc
(GO:0030018)

Other Information

Proteins

Four and a half LIM domains protein 2

Genular Protein ID: 1901313033

Symbol: FHL2_MOUSE

Name: Four and a half LIM domains protein 2

UniProtKB Accession Codes:

O70433 P97448

Database IDs:

Citations:

PubMed ID: 10049693

Title: The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle.

PubMed ID: 10049693

DOI: 10.1006/bbrc.1999.0179

PubMed ID: 10906474

Title: Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system.

PubMed ID: 10906474

DOI: 10.1016/s0925-4773(00)00341-5

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20013826

Title: Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitors.

PubMed ID: 20013826

DOI: 10.1002/stem.274

PubMed ID: 22851699

Title: FHL2 binds calcineurin and represses pathological cardiac growth.

PubMed ID: 22851699

DOI: 10.1128/mcb.05948-11

Sequence Information:

Length: 279
Mass: 32073
Checksum: 6D8CBC4B4424BFF2
Sequence:

MTERFDCHHC NESLYGKKYI LKEENPHCVA CFEELYANTC EECGTPIGCD CKDLSYKDRH 
WHEGCFHCSR CGSSLVDKPF AAKEEQLLCT DCYSNEYSSK CQECKKTIMP GTRKMEYKGS 
SWHETCFTCQ RCQQPIGTKS FIPKENQNFC VPCYEKQYAL QCVQCKKPIT TGGVTYREQP 
WHKECFVCTA CKKQLSGQRF TARDEFPYCL TCFCDLYAKK CAGCTNPISG LGGTKYISFE 
ERQWHNDCFN CKKCSLSLVG RGFLTERDDI LCPDCGKDI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fhl2

Associated with

Other Information

The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. PubMed ID: 10049693

Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system. PubMed ID: 10906474

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079