Details for: CRYGD

Gene ID: 1421

Symbol: CRYGD

Ensembl ID: ENSG00000118231

Description: crystallin gamma D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.08
    Marker Score: 2797
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.01
    Marker Score: 2438
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.85
    Marker Score: 2065
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.78
    Marker Score: 1043
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.47
    Marker Score: 1543
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.03
    Marker Score: 981
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.83
    Marker Score: 601
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 630
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.75
    Marker Score: 262
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.7
    Marker Score: 1116
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.69
    Marker Score: 1065
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.63
    Marker Score: 201
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.56
    Marker Score: 339
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.56
    Marker Score: 417
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.55
    Marker Score: 191
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.55
    Marker Score: 291
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.55
    Marker Score: 159
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.53
    Marker Score: 401
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.46
    Marker Score: 808
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.45
    Marker Score: 288
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.44
    Marker Score: 164
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.41
    Marker Score: 129
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.36
    Marker Score: 1462
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.35
    Marker Score: 1358
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.33
    Marker Score: 408
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.3
    Marker Score: 207
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.29
    Marker Score: 869
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.29
    Marker Score: 220
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.27
    Marker Score: 568.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.27
    Marker Score: 153.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.27
    Marker Score: 182
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 107
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.25
    Marker Score: 110
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.24
    Marker Score: 3241
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.24
    Marker Score: 328
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 155
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.22
    Marker Score: 303
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.22
    Marker Score: 219
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.22
    Marker Score: 185
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.21
    Marker Score: 557
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.2
    Marker Score: 99.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.2
    Marker Score: 459
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2
    Marker Score: 175
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.19
    Marker Score: 1930
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.18
    Marker Score: 54
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.17
    Marker Score: 294
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.17
    Marker Score: 62
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.14
    Marker Score: 141.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.14
    Marker Score: 197
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.13
    Marker Score: 85
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.12
    Marker Score: 124
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.12
    Marker Score: 246
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.12
    Marker Score: 112.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.11
    Marker Score: 174
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.11
    Marker Score: 116
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 124
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 129
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1
    Marker Score: 66
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.1
    Marker Score: 49.5
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.1
    Marker Score: 78.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.1
    Marker Score: 281
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1
    Marker Score: 631
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 92
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.09
    Marker Score: 44
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.09
    Marker Score: 63
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 22

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

## Summary The CRGD gene encodes for crystallin gamma D, a protein that is a key component of the lens fiber cells in the eye. These cells are responsible for the clear and sharp vision that we experience. ## Key characteristics * The CRGD gene is located on chromosome 19p13.1. * It is a large gene, with a length of approximately 30,000 base pairs. * It contains 27 exons and 27 introns. * The protein encoded by CRGD is a glycoprotein that is expressed in a variety of cell types in the eye, including lens epithelial cells, anterior and posterior chamber cells, and trabecular cells. ## Pathways and functions * The CRGD protein is a key component of the lens fiber cells, which are responsible for the clear and sharp vision that we experience. * It is involved in the assembly and maintenance of the lens fiber cell network. * It is also involved in the regulation of the growth and differentiation of lens fiber cells. ## Clinical significance * Mutations in the CRGD gene have been linked to a number of eye disorders, including cataracts, glaucoma, and age-related macular degeneration (AMD). * These disorders are characterized by the loss of vision, and they are often caused by mutations in genes that are involved in the development and maintenance of the eye lens. * Understanding the role of CRGD in eye development and disease could lead to the development of new treatments for these disorders. **Additional notes:** * The CRGD protein is a glycoprotein that is composed of three extracellular domains: a type I transmembrane domain, a cysteine-rich domain, and a carboxyl-terminal domain. * The type I transmembrane domain is responsible for binding to other proteins in the lens fiber cell network. * The cysteine-rich domain is responsible for the protein's stability and its interactions with other proteins. * The carboxyl-terminal domain is responsible for the protein's function.

Genular Protein ID: 848408585

Symbol: CRGD_HUMAN

Name: Gamma-crystallin D

UniProtKB Accession Codes:

P07320 Q17RF7 Q53R51 Q99681

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 14 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 4033658

Title: Structural and evolutionary relationships among five members of the human gamma-crystallin gene family.

PubMed ID: 4033658

DOI: 10.1128/mcb.5.6.1408-1414.1985

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8999933

Title: Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.

PubMed ID: 8999933

DOI: 10.1074/jbc.272.4.2268

PubMed ID: 15709761

Title: Decrease in protein solubility and cataract formation caused by the Pro23 to Thr mutation in human gamma D-crystallin.

PubMed ID: 15709761

DOI: 10.1021/bi0479611

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 12729747

Title: High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract.

PubMed ID: 12729747

DOI: 10.1016/s0022-2836(03)00375-9

PubMed ID: 12507494

Title: Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins.

PubMed ID: 12507494

DOI: 10.1016/s0006-291x(02)02895-4

PubMed ID: 10521291

Title: The gamma-crystallins and human cataracts: a puzzle made clearer.

PubMed ID: 10521291

DOI: 10.1086/302619

PubMed ID: 9927684

Title: Progressive juvenile-onset punctate cataracts caused by mutation of the gamma-D-crystallin gene.

PubMed ID: 9927684

DOI: 10.1073/pnas.96.3.1008

PubMed ID: 10915766

Title: Link between a novel human gamma-D-crystallin allele and a unique cataract phenotype explained by protein crystallography.

PubMed ID: 10915766

DOI: 10.1093/hmg/9.12.1779

PubMed ID: 10688888

Title: Molecular basis of a progressive juvenile-onset hereditary cataract.

PubMed ID: 10688888

DOI: 10.1073/pnas.040554397

PubMed ID: 11371638

Title: Crystal cataracts: human genetic cataract caused by protein crystallization.

PubMed ID: 11371638

DOI: 10.1073/pnas.101124798

PubMed ID: 12011157

Title: Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts.

PubMed ID: 12011157

DOI: 10.1136/jmg.39.5.352

PubMed ID: 12676897

Title: Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts.

PubMed ID: 12676897

DOI: 10.1136/jmg.40.4.262

PubMed ID: 16943771

Title: Two affected siblings with nuclear cataract associated with a novel missense mutation in the CRYGD gene.

PubMed ID: 16943771

PubMed ID: 17564961

Title: Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral state.

PubMed ID: 17564961

DOI: 10.1086/518616

PubMed ID: 18587492

Title: Crystallin gene mutations in Indian families with inherited pediatric cataract.

PubMed ID: 18587492

PubMed ID: 19390652

Title: Mutation analysis of CRYAA, CRYGC, and CRYGD associated with autosomal dominant congenital cataract in Brazilian families.

PubMed ID: 19390652

PubMed ID: 21031598

Title: A novel CRYGD mutation (p.Trp43Arg) causing autosomal dominant congenital cataract in a Chinese family.

PubMed ID: 21031598

DOI: 10.1002/humu.21386

PubMed ID: 21866213

Title: Mutation analysis of 12 genes in Chinese families with congenital cataracts.

PubMed ID: 21866213

PubMed ID: 29914532

Title: Clinical and genetic characteristics of Chinese patients with familial or sporadic pediatric cataract.

PubMed ID: 29914532

DOI: 10.1186/s13023-018-0828-0

PubMed ID: 31523120

Title: Mutation screening of crystallin genes in Chinese families with congenital cataracts.

PubMed ID: 31523120

PubMed ID: 33243271

Title: The genetic landscape of crystallins in congenital cataract.

PubMed ID: 33243271

DOI: 10.1186/s13023-020-01613-3

Sequence Information:

  • Length: 174
  • Mass: 20738
  • Checksum: 437EC83FD79F12E4
  • Sequence:
    • MGKITLYEDR GFQGRHYECS SDHPNLQPYL SRCNSARVDS GCWMLYEQPN YSGLQYFLRR 
GDYADHQQWM GLSDSVRSCR LIPHSGSHRI RLYEREDYRG QMIEFTEDCS CLQDRFRFNE 
IHSLNVLEGS WVLYELSNYR GRQYLLMPGD YRRYQDWGAT NARVGSLRRV IDFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.