Genular: Defining Cellular Identity and Function

Details for: Ccn2

Gene ID: 14219

Symbol: Ccn2

Ensembl ID: ENSMUSG00000019997

Description: cellular communication network factor 2

Associated with

Angiogenesis
(GO:0001525)
Calcium ion transmembrane import into cytosol
(GO:0097553)
Cartilage condensation
(GO:0001502)
Cell-matrix adhesion
(GO:0007160)
Cell adhesion
(GO:0007155)
Cell cortex
(GO:0005938)
Cell migration
(GO:0016477)
Chondrocyte differentiation
(GO:0002062)
Chondrocyte proliferation
(GO:0035988)
Connective tissue development
(GO:0061448)
Dna biosynthetic process
(GO:0071897)
Extracellular matrix
(GO:0031012)
Extracellular matrix constituent secretion
(GO:0070278)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Fibronectin binding
(GO:0001968)
Golgi apparatus
(GO:0005794)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular signal transduction
(GO:0035556)
Lung development
(GO:0030324)
Microtubule depolymerization
(GO:0007019)
Negative regulation of gene expression
(GO:0010629)
Ossification
(GO:0001503)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cardiac muscle contraction
(GO:0060452)
Positive regulation of cell activation
(GO:0050867)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of g0 to g1 transition
(GO:0070318)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of stress fiber assembly
(GO:0051496)
Reactive oxygen species metabolic process
(GO:0072593)
Regulation of chondrocyte differentiation
(GO:0032330)
Signal transduction
(GO:0007165)
Tissue homeostasis
(GO:0001894)

Other Information

Proteins

CCN family member 2

Genular Protein ID: 4210996430

Symbol: CCN2_MOUSE

Name: CCN family member 2

UniProtKB Accession Codes:

P29268 G5E830 Q922U0

Database IDs:

Citations:

PubMed ID: 1888698

Title: Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein.

PubMed ID: 1888698

PubMed ID: 2029337

Title: Identification of a gene family regulated by transforming growth factor-beta.

PubMed ID: 2029337

DOI: 10.1089/dna.1991.10.293

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9184077

Title: Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development.

PubMed ID: 9184077

DOI: 10.1006/excr.1997.3548

PubMed ID: 10082563

Title: Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo.

PubMed ID: 10082563

DOI: 10.1128/mcb.19.4.2958

PubMed ID: 30232710

Title: CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.

PubMed ID: 30232710

DOI: 10.1007/s12079-018-0487-x

Sequence Information:

Length: 348
Mass: 37824
Checksum: 9BD99E6D0BEFC7BC
Sequence:

MLASVAGPIS LALVLLALCT RPAMGQDCSA QCQCAAEAAP HCPAGVSLVL DGCGCCRVCA 
KQLGELCTER DPCDPHKGLF CDFGSPANRK IGVCTAKDGA PCVFGGSVYR SGESFQSSCK 
YQCTCLDGAV GCVPLCSMDV RLPSPDCPFP RRVKLPGKCC EEWVCDEPKD RTAVGPALAA 
YRLEDTFGPD PTMMRANCLV QTTEWSACSK TCGMGISTRV TNDNTFCRLE KQSRLCMVRP 
CEADLEENIK KGKKCIRTPK IAKPVKFELS GCTSVKTYRA KFCGVCTDGR CCTPHRTTTL 
PVEFKCPDGE IMKKNMMFIK TCACHYNCPG DNDIFESLYY RKMYGDMA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccn2

Associated with

Other Information

Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. PubMed ID: 1888698

Identification of a gene family regulated by transforming growth factor-beta. PubMed ID: 2029337

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development. PubMed ID: 9184077

Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. PubMed ID: 10082563

CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi. PubMed ID: 30232710