Genular: Defining Cellular Identity and Function

Details for: Fkbp8

Gene ID: 14232

Symbol: Fkbp8

Ensembl ID: ENSMUSG00000019428

Description: FK506 binding protein 8

Associated with

Deubiquitination
(R-MMU-5688426)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Ub-specific processing proteases
(R-MMU-5689880)
Apoptotic process
(GO:0006915)
Bmp signaling pathway
(GO:0030509)
Calmodulin binding
(GO:0005516)
Camera-type eye development
(GO:0043010)
Cell fate specification
(GO:0001708)
Cytosol
(GO:0005829)
Disordered domain specific binding
(GO:0097718)
Dorsal/ventral neural tube patterning
(GO:0021904)
Dorsal/ventral pattern formation
(GO:0009953)
Endomembrane system
(GO:0012505)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Identical protein binding
(GO:0042802)
Isomerase activity
(GO:0016853)
Membrane
(GO:0016020)
Mitochondrial envelope
(GO:0005740)
Mitochondrion
(GO:0005739)
Multicellular organism growth
(GO:0035264)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of protein phosphorylation
(GO:0001933)
Neural tube development
(GO:0021915)
Neuron fate specification
(GO:0048665)
Peptidyl-prolyl cis-trans isomerase activity
(GO:0003755)
Positive regulation of bmp signaling pathway
(GO:0030513)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Protein folding chaperone
(GO:0044183)
Protein localization to mitochondrion
(GO:0070585)
Regulation of autophagy of mitochondrion
(GO:1903146)
Regulation of bmp signaling pathway
(GO:0030510)
Regulation of gene expression
(GO:0010468)
Smoothened signaling pathway
(GO:0007224)

Other Information

Proteins

Peptidyl-prolyl cis-trans isomerase FKBP8

Genular Protein ID: 939100395

Symbol: FKBP8_MOUSE

Name: Peptidyl-prolyl cis-trans isomerase FKBP8

UniProtKB Accession Codes:

O35465 Q3UK86 Q6GTX9 Q811M7 Q811R4 Q8C2F0 Q99L93

Database IDs:

Citations:

PubMed ID: 12510191

Title: Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.

PubMed ID: 12510191

DOI: 10.1038/ncb894

PubMed ID: 15105374

Title: FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues.

PubMed ID: 15105374

DOI: 10.1242/dev.01122

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10197430

Title: muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo.

PubMed ID: 10197430

DOI: 10.1002/(sici)1522-2683(19990201)20:2<249::aid-elps249>3.0.co;2-f

PubMed ID: 14667822

Title: Fkbp8: novel isoforms, genomic organization, and characterization of a forebrain promoter in transgenic mice.

PubMed ID: 14667822

DOI: 10.1016/j.ygeno.2003.07.001

PubMed ID: 18459960

Title: Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse.

PubMed ID: 18459960

DOI: 10.1111/j.1365-2443.2008.01194.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 402
Mass: 43529
Checksum: 609A954FAD3A76F8
Sequence:

MASWAEPSEP AALRLPGAPL LEGFEVLDGV DDAEEEDDLS GLPPLEDMGQ PTVEEAEQPG 
ALAREFLAAT EPEPAPAPAP EEWLDILGNG LLRMKTLVPG PKGSSRPLKG QVVTVHLQMS 
LENGTRVQEE PELAFTLGDC DVIQALDLSV PLMDVGETAM VTADSKYCYG PQGRSPYIPP 
HAALCLEVTL KTAEDGPDLE MLSGQERVAL ANRKRECGNA HYQRADFVLA ANSYDLAIKA 
ITSNTKVDMT CEEEEELLQL KVKCLNNLAA SQLKLDHYRA ALRSCSQVLE HQPDNIKALF 
RKGKVLAQQG EYSEAIPILR AALKLEPSNK TIHAELSKLV KKRAAQRSTE TALYRKMLGN 
PSRLPAKCPG KGAWSIPWKW LFGATAVALG GVALSVVIAA RN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fkbp8

Associated with

Other Information

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. PubMed ID: 12510191

FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. PubMed ID: 15105374

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo. PubMed ID: 10197430

Fkbp8: novel isoforms, genomic organization, and characterization of a forebrain promoter in transgenic mice. PubMed ID: 14667822

Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse. PubMed ID: 18459960

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079