Details for: Foxc2

Gene ID: 14234

Symbol: Foxc2

Ensembl ID: ENSMUSG00000046714

Description: forkhead box C2

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Apoptotic process involved in outflow tract morphogenesis
    (GO:0003275)
  • Artery morphogenesis
    (GO:0048844)
  • Blood vessel development
    (GO:0001568)
  • Blood vessel diameter maintenance
    (GO:0097746)
  • Blood vessel remodeling
    (GO:0001974)
  • Branching involved in blood vessel morphogenesis
    (GO:0001569)
  • Camera-type eye development
    (GO:0043010)
  • Cardiac muscle cell proliferation
    (GO:0060038)
  • Cell differentiation
    (GO:0030154)
  • Cell population proliferation
    (GO:0008283)
  • Chromatin dna binding
    (GO:0031490)
  • Collagen fibril organization
    (GO:0030199)
  • Dna-binding transcription activator activity
    (GO:0001216)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Embryonic heart tube development
    (GO:0035050)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Embryonic viscerocranium morphogenesis
    (GO:0048703)
  • Glomerular endothelium development
    (GO:0072011)
  • Glomerular mesangial cell development
    (GO:0072144)
  • Heart development
    (GO:0007507)
  • Heart morphogenesis
    (GO:0003007)
  • Identical protein binding
    (GO:0042802)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Kidney development
    (GO:0001822)
  • Lymphangiogenesis
    (GO:0001946)
  • Lymph vessel development
    (GO:0001945)
  • Metanephros development
    (GO:0001656)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of apoptotic process involved in outflow tract morphogenesis
    (GO:1902257)
  • Negative regulation of cold-induced thermogenesis
    (GO:0120163)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neural crest cell development
    (GO:0014032)
  • Notch signaling pathway
    (GO:0007219)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Ossification
    (GO:0001503)
  • Paraxial mesodermal cell fate commitment
    (GO:0048343)
  • Paraxial mesoderm formation
    (GO:0048341)
  • Podocyte differentiation
    (GO:0072112)
  • Positive regulation of cell adhesion mediated by integrin
    (GO:0033630)
  • Positive regulation of cell migration involved in sprouting angiogenesis
    (GO:0090050)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of integrin activation
    (GO:0033625)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular wound healing
    (GO:0035470)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of organ growth
    (GO:0046620)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to hormone
    (GO:0009725)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal system development
    (GO:0001501)
  • Somitogenesis
    (GO:0001756)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Ureteric bud development
    (GO:0001657)
  • Vascular endothelial growth factor receptor signaling pathway
    (GO:0048010)
  • Ventricular cardiac muscle tissue morphogenesis
    (GO:0055010)

Other Information

Genular Protein ID: 2112330466

Symbol: FOXC2_MOUSE

Name: Forkhead box protein C2

UniProtKB Accession Codes:

Q61850 P97948 Q63869 Q8C694

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 65 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 6 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8674414

Title: Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development.

PubMed ID: 8674414

DOI: 10.1242/dev.122.6.1751

PubMed ID: 9169153

Title: Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures.

PubMed ID: 9169153

DOI: 10.1006/geno.1997.4695

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 8325367

Title: MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme.

PubMed ID: 8325367

DOI: 10.1016/0014-5793(93)81785-x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 28179430

Title: Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

PubMed ID: 28179430

DOI: 10.1161/circresaha.116.308825

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 494
  • Mass: 52874
  • Checksum: 232C0D6FA64320A6
  • Sequence:
    • MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYGA GMGRSYAPYH 
HQPAAPKDLV KPPYSYIALI TMAIQNAPEK KITLNGIYQF IMDRFPFYRE NKQGWQNSIR 
HNLSLNECFV KVPRDDKKPG KGSYWTLDPD SYNMFENGSF LRRRRRFKKK DVPKDKEERA 
HLKEPPSTTA KGAPTGTPVA DGPKEAEKKV VVKSEAASPA LPVITKVETL SPEGALQASP 
RSASSTPAGS PDGSLPEHHA AAPNGLPGFS VETIMTLRTS PPGGDLSPAA ARAGLVVPPL 
ALPYAAAPPA AYTQPCAQGL EAAGSAGYQC SMRAMSLYTG AERPAHVCVP PALDEALSDH 
PSGPGSPLGA LNLAAGQEGA LGASGHHHQH HGHLHPQAPP PAPQPPPAPQ PATQATSWYL 
NHGGDLSHLP GHTFATQQQT FPNVREMFNS HRLGLDNSSL GESQVSNASC QLPYRATPSL 
YRHAAPYSYD CTKY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.