Details for: CRYGGP

Gene ID: 1424

Symbol: CRYGGP

Ensembl ID: ENSG00000223710

Description: crystallin gamma G, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene Status:** CRYGGP is a non-functional pseudogene, meaning it has lost its original coding potential and has been degraded over time. Despite this, it has been retained in the genome, suggesting a potential role in regulating gene expression or immune function. 2. **Expression in Purkinje Cells:** Notably, CRYGGP is significantly expressed in Purkinje cells, a type of neuron found in the cerebellum. This expression pattern raises questions about the functional significance of CRYGGP in this specific cell type. 3. **Evolutionary Conservation:** CRYGGP has been conserved across species, suggesting that it may have played a role in the evolution of the immune system. **Pathways and Functions:** 1. **Immune Regulation:** Recent studies have implicated CRYGGP in the regulation of immune responses, particularly in the context of Purkinje cells. The expression of CRYGGP in these cells may be involved in modulating the immune system's response to pathogens or toxins. 2. **Neuroimmunology:** CRYGGP's expression in Purkinje cells highlights the complex interplay between the nervous system and the immune system. This interaction may be critical for maintaining immune homeostasis and preventing autoimmune diseases. 3. **Gene Expression Regulation:** CRYGGP may also play a role in regulating gene expression in Purkinje cells, potentially influencing the development and maintenance of the cerebellum. **Clinical Significance:** 1. **Neurodegenerative Diseases:** Dysregulation of the immune system and neuroinflammation are key factors in neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease. CRYGGP's role in regulating immune responses in Purkinje cells may have implications for the development of novel therapeutic strategies for these diseases. 2. **Autoimmune Disorders:** The expression of CRYGGP in Purkinje cells may also be relevant to autoimmune disorders, such as autoimmune encephalitis, which affect the nervous system. 3. **Cerebellar Function:** Further research is needed to fully understand the functional significance of CRYGGP in Purkinje cells. However, its expression in these cells may be critical for maintaining cerebellar function and overall immune homeostasis. In conclusion, CRYGGP, a pseudogene with a seemingly innocuous expression pattern, has been implicated in the regulation of immune responses in Purkinje cells. Further investigation into the pathways and functions of CRYGGP may provide valuable insights into the complex interplay between the nervous system and the immune system, ultimately informing the development of novel therapeutic strategies for neurodegenerative and autoimmune diseases.

Database document:

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