Genular: Defining Cellular Identity and Function

Details for: Flt3l

Gene ID: 14256

Symbol: Flt3l

Ensembl ID: ENSMUSG00000110206

Description: FMS-like tyrosine kinase 3 ligand

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Flt3 signaling
(R-MMU-9607240)
Flt3 signaling through src family kinases
(R-MMU-9706374)
Igf1r signaling cascade
(R-MMU-2428924)
Immune system
(R-MMU-168256)
Insulin receptor signalling cascade
(R-MMU-74751)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of flt3
(R-MMU-9706369)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi3k cascade
(R-MMU-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Signal transduction
(R-MMU-162582)
Cell surface
(GO:0009986)
Cytokine activity
(GO:0005125)
Embryonic hemopoiesis
(GO:0035162)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Homeostasis of number of cells within a tissue
(GO:0048873)
Lymphocyte differentiation
(GO:0030098)
Membrane
(GO:0016020)
Natural killer cell differentiation
(GO:0001779)
Negative regulation of apoptotic process in bone marrow cell
(GO:0071866)
Plasma membrane
(GO:0005886)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cell proliferation in bone marrow
(GO:0071864)
Positive regulation of myoblast differentiation
(GO:0045663)
Positive regulation of myoblast fusion
(GO:1901741)
Positive regulation of natural killer cell differentiation
(GO:0032825)
Positive regulation of natural killer cell proliferation
(GO:0032819)
Positive regulation of osteoclast proliferation
(GO:0090290)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein phosphorylation
(GO:0006468)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of myeloid dendritic cell activation
(GO:0030885)

Other Information

Proteins

Fms-related tyrosine kinase 3 ligand

Genular Protein ID: 2311991951

Symbol: FLT3L_MOUSE

Name: Fms-related tyrosine kinase 3 ligand

UniProtKB Accession Codes:

P49772 Q64085

Database IDs:

Citations:

PubMed ID: 8145851

Title: Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs.

PubMed ID: 8145851

DOI: 10.1038/368643a0

PubMed ID: 7505204

Title: Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells.

PubMed ID: 7505204

DOI: 10.1016/0092-8674(93)90325-k

PubMed ID: 7566977

Title: Structural analysis of human and murine flt3 ligand genomic loci.

PubMed ID: 7566977

PubMed ID: 7824267

Title: Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs.

PubMed ID: 7824267

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

Sequence Information:

Length: 232
Mass: 26141
Checksum: 3A3680D3CB69FBA6
Sequence:

MTVLAPAWSP NSSLLLLLLL LSPCLRGTPD CYFSHSPISS NFKVKFRELT DHLLKDYPVT 
VAVNLQDEKH CKALWSLFLA QRWIEQLKTV AGSKMQTLLE DVNTEIHFVT SCTFQPLPEC 
LRFVQTNISH LLKDTCTQLL ALKPCIGKAC QNFSRCLEVQ CQPDSSTLLP PRSPIALEAT 
ELPEPRPRQL LLLLLLLLPL TLVLLAAAWG LRWQRARRRG ELHPGVPLPS HP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Flt3l

Associated with

Other Information

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. PubMed ID: 8145851

Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. PubMed ID: 7505204

Structural analysis of human and murine flt3 ligand genomic loci. PubMed ID: 7566977