Genular: Defining Cellular Identity and Function

Details for: Flt4

Gene ID: 14257

Symbol: Flt4

Ensembl ID: ENSMUSG00000020357

Description: FMS-like tyrosine kinase 4

Associated with

Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Vegf binds to vegfr leading to receptor dimerization
(R-MMU-195399)
Vegf ligand-receptor interactions
(R-MMU-194313)
Angiogenesis
(GO:0001525)
Atp binding
(GO:0005524)
Blood vessel morphogenesis
(GO:0048514)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Growth factor binding
(GO:0019838)
Kinase activity
(GO:0016301)
Lung alveolus development
(GO:0048286)
Lymphangiogenesis
(GO:0001946)
Lymph vessel development
(GO:0001945)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of protein kinase c signaling
(GO:0090037)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Receptor complex
(GO:0043235)
Regulation of blood vessel remodeling
(GO:0060312)
Regulation of mapk cascade
(GO:0043408)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Respiratory system process
(GO:0003016)
Sprouting angiogenesis
(GO:0002040)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Vascular endothelial growth factor receptor activity
(GO:0005021)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)
Vascular endothelial growth factor signaling pathway
(GO:0038084)
Vasculature development
(GO:0001944)

Other Information

Proteins

Vascular endothelial growth factor receptor 3

Genular Protein ID: 3425155588

Symbol: VGFR3_MOUSE

Name: Vascular endothelial growth factor receptor 3

UniProtKB Accession Codes:

P35917

Database IDs:

Citations:

PubMed ID: 8393164

Title: Molecular cloning of murine FLT and FLT4.

PubMed ID: 8393164

PubMed ID: 1319394

Title: Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene.

PubMed ID: 1319394

DOI: 10.1016/0888-7543(92)90277-y

PubMed ID: 9794766

Title: Cardiovascular failure in mouse embryos deficient in VEGF receptor-3.

PubMed ID: 9794766

DOI: 10.1126/science.282.5390.946

PubMed ID: 16944957

Title: Proteome-wide characterization of N-glycosylation events by diagonal chromatography.

PubMed ID: 16944957

DOI: 10.1021/pr060186m

PubMed ID: 18594512

Title: Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.

PubMed ID: 18594512

DOI: 10.1038/nature07083

PubMed ID: 20697430

Title: VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis.

PubMed ID: 20697430

DOI: 10.1038/cr.2010.116

PubMed ID: 20445537

Title: Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.

PubMed ID: 20445537

DOI: 10.1038/nature09002

PubMed ID: 21481239

Title: Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer.

PubMed ID: 21481239

DOI: 10.1186/1476-4598-10-36

PubMed ID: 21909098

Title: VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

PubMed ID: 21909098

DOI: 10.1038/ncb2331

PubMed ID: 28179430

Title: Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

PubMed ID: 28179430

DOI: 10.1161/circresaha.116.308825

Sequence Information:

Length: 1363
Mass: 153016
Checksum: F1BF8A2BDEF99BE9
Sequence:

MQPGAALNLR LWLCLGLLQG LANGYSMTPP TLNITEDSYV IDTGDSLSIS CRGQHPLEWT 
WPGAQEVLTT GGKDSEDTRV VHDCEGTEAR PYCKVLLLAQ THANNTGSYH CYYKYIKARI 
EGTTAASTYV FVRDFKHPFI NKPDTLLVNR KDSMWVPCLV SIPGLNITLR SQSSALHPDG 
QEVLWDDRRG MRVPTQLLRD ALYLQCETTW GDQNFLSNLF VVHITGNELY DIQLYPKKSM 
ELLVGEKLVL NCTVWAEFDS GVTFDWDYPG KQAERAKWVP ERRSQQTHTE LSSILTIHNV 
SQNDLGPYVC EANNGIQRFR ESTEVIVHEK PFISVEWLKG PVLEATAGDE LVKLPVKLAA 
YPPPEFQWYK DRKAVTGRHN PHALVLKEVT EASAGVYTLA LWNSAAGLRQ NISLELVVNV 
PPHIHEKEAS SPSIYSRHSR QTLTCTAYGV PQPLSVQWHW RPWTPCKTFA QRSLRRRQQR 
DGMPQCRDWK EVTTQDAVNP IESLDSWTEF VEGKNKTVSK LVIQDANVSA MYKCVVVNKV 
GQDERLIYFY VTTIPDGFSI ESEPSEDPLE GQSVRLSCRA DNYTYEHLRW YRLNLSTLHD 
AQGNPLLLDC KNVHLFATPL EANLEEAEPG ARHATLSLNI PRVAPEDEGD YVCEVQDRRS 
QDKHCHKKYL SVQALEAPRL TQNLTDLLVN VSDSLEMRCP VAGAHVPSIV WYKDERLLEK 
ESGIDLADSN QRLSIQRVRE EDAGRYLCSV CNAKGCVNSS ASVAVEGSED KGSMEIVILI 
GTGVIAVFFW VLLLLIFCNM KRPAHADIKT GYLSIIMDPG EVPLEEQCEY LSYDASQWEF 
PRERLHLGRV LGHGAFGKVV EASAFGINKG SSCDTVAVKM LKEGATASEH RALMSELKIL 
IHIGNHLNVV NLLGACTKPN GPLMVIVEFC KYGNLSNFLR VKRDTFNPYA EKSPEQRRRF 
RAMVEGAKAD RRRPGSSDRA LFTRFLMGKG SARRAPLVQE AEDLWLSPLT MEDLVCYSFQ 
VARGMEFLAS RKCIHRDLAA RNILLSESDI VKICDFGLAR DIYKDPDYVR KGSARLPLKW 
MAPESIFDKV YTTQSDVWSF GVLLWEIFSL GASPYPGVQI NEEFCQRLKD GTRMRAPELA 
TPAIRHIMQS CWSGDPKARP AFSDLVEILG DLLQGGGWQE EEEERMALHS SQSSEEDGFM 
QASTTALHIT EADADDSPPS MHCHSLAARY YNCVSFPGRL ARGTKTPGSS RMKTFEELPM 
TPTTYKASMD NQTDSGMVLA SEEFEELESR HRPEGSFSCK GPGQHMDIPR GHPDPQGRRR 
RPTQGAQGGK VFYNNEYGEV SQPCTEGDCC PSAGSTFFAD SSY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Flt4

Associated with

Other Information

Molecular cloning of murine FLT and FLT4. PubMed ID: 8393164

Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene. PubMed ID: 1319394

Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. PubMed ID: 9794766

Proteome-wide characterization of N-glycosylation events by diagonal chromatography. PubMed ID: 16944957

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. PubMed ID: 18594512

VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. PubMed ID: 20697430

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. PubMed ID: 20445537

Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. PubMed ID: 21481239

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. PubMed ID: 21909098

Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. PubMed ID: 28179430