Details for: CRYGS

Gene ID: 1427

Symbol: CRYGS

Ensembl ID: ENSG00000213139

Description: crystallin gamma S

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 30.4092
    Cell Significance Index: -4.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.3185
    Cell Significance Index: -4.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.7075
    Cell Significance Index: -4.3500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 10.6810
    Cell Significance Index: -4.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.9742
    Cell Significance Index: -4.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.5900
    Cell Significance Index: 2161.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2816
    Cell Significance Index: -2.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.2544
    Cell Significance Index: -4.9500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.1449
    Cell Significance Index: 16.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.8365
    Cell Significance Index: 1287.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.7061
    Cell Significance Index: 1302.2400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.6287
    Cell Significance Index: 19.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5843
    Cell Significance Index: 111.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4857
    Cell Significance Index: 48.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4550
    Cell Significance Index: 9.6900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.3924
    Cell Significance Index: 2.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3185
    Cell Significance Index: 287.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2950
    Cell Significance Index: 18.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2430
    Cell Significance Index: 39.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2422
    Cell Significance Index: 3.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2229
    Cell Significance Index: 44.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1897
    Cell Significance Index: 11.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1646
    Cell Significance Index: 4.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1284
    Cell Significance Index: 3.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1248
    Cell Significance Index: 24.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1228
    Cell Significance Index: 44.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1105
    Cell Significance Index: 7.6500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1103
    Cell Significance Index: 1.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0946
    Cell Significance Index: 4.2900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0710
    Cell Significance Index: 1.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0707
    Cell Significance Index: 1.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0565
    Cell Significance Index: 8.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0551
    Cell Significance Index: 4.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0507
    Cell Significance Index: 1.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0469
    Cell Significance Index: 1.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0396
    Cell Significance Index: 0.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0364
    Cell Significance Index: 2.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0351
    Cell Significance Index: 0.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0290
    Cell Significance Index: 1.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0193
    Cell Significance Index: 0.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0166
    Cell Significance Index: 0.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0138
    Cell Significance Index: 0.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0117
    Cell Significance Index: 0.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0117
    Cell Significance Index: 8.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0084
    Cell Significance Index: 1.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0024
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0019
    Cell Significance Index: 3.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0015
    Cell Significance Index: 0.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0009
    Cell Significance Index: 0.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0035
    Cell Significance Index: -0.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0038
    Cell Significance Index: -0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0058
    Cell Significance Index: -2.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -5.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0072
    Cell Significance Index: -3.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0082
    Cell Significance Index: -2.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0084
    Cell Significance Index: -0.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0099
    Cell Significance Index: -6.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0159
    Cell Significance Index: -2.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0199
    Cell Significance Index: -2.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0216
    Cell Significance Index: -2.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0216
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0243
    Cell Significance Index: -5.1200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0299
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0300
    Cell Significance Index: -3.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0349
    Cell Significance Index: -4.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0355
    Cell Significance Index: -0.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0367
    Cell Significance Index: -4.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0378
    Cell Significance Index: -1.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0399
    Cell Significance Index: -4.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0407
    Cell Significance Index: -2.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0447
    Cell Significance Index: -4.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0461
    Cell Significance Index: -1.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0461
    Cell Significance Index: -2.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0489
    Cell Significance Index: -2.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0490
    Cell Significance Index: -0.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0506
    Cell Significance Index: -2.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0513
    Cell Significance Index: -0.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0529
    Cell Significance Index: -3.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0533
    Cell Significance Index: -1.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0588
    Cell Significance Index: -2.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0623
    Cell Significance Index: -4.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0627
    Cell Significance Index: -1.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0634
    Cell Significance Index: -3.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0663
    Cell Significance Index: -4.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0702
    Cell Significance Index: -1.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0733
    Cell Significance Index: -1.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0741
    Cell Significance Index: -2.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0859
    Cell Significance Index: -1.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0908
    Cell Significance Index: -1.5300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0936
    Cell Significance Index: -2.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0990
    Cell Significance Index: -3.2400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0994
    Cell Significance Index: -1.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1005
    Cell Significance Index: -3.5200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1016
    Cell Significance Index: -2.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1029
    Cell Significance Index: -1.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1088
    Cell Significance Index: -2.9100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1129
    Cell Significance Index: -1.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CRYGS gene encodes a protein, gamma-crystallin S, which is a structural component of the eye lens. This protein is characterized by its ability to form crystalline structures that provide optical clarity to the lens. The gene is specifically expressed in cells that are involved in lens development and maintenance, such as anterior lens cells, lens epithelial cells, and secondary lens fibers. CRYGS is also expressed in other cell types, including goblet cells, choroid plexus epithelial cells, and GABAergic interneurons, suggesting a broader role in cellular differentiation and development. **Pathways and Functions:** The CRYGS gene is involved in several key pathways, including: 1. **Lens development in camera-type eye**: CRYGS plays a crucial role in the development of the eye lens, particularly in the formation of the lens fiber cells. 2. **Morphogenesis of an epithelium**: The gene is involved in the development and differentiation of epithelial cells, including lens epithelial cells and goblet cells. 3. **Protein binding**: CRYGS interacts with other proteins, such as gamma-crystallin A, to form crystalline structures that provide optical clarity to the lens. 4. **Structural constituent of eye lens**: The gene is essential for the formation and maintenance of the eye lens structure. **Functions:** The functions of the CRYGS gene can be summarized as follows: 1. **Lens lens formation**: CRYGS is involved in the formation of lens fiber cells, which are essential for the development of the eye lens. 2. **Cell differentiation**: The gene promotes the differentiation of lens epithelial cells and goblet cells into their respective cell types. 3. **Crystalline structure formation**: CRYGS interacts with other proteins to form crystalline structures that provide optical clarity to the lens. **Clinical Significance:** The CRYGS gene has significant clinical implications, particularly in the context of eye development and lens disorders. Mutations in the CRYGS gene have been associated with: 1. **Cataracts**: CRYGS mutations can lead to cataract formation, which is a common cause of vision loss in older adults. 2. **Lens opacities**: The gene is also involved in the development of lens opacities, which can cause vision problems. 3. **Eye development disorders**: Mutations in CRYGS can also lead to eye development disorders, such as microphthalmia and anophthalmia. In conclusion, CRYGS is a critical gene involved in eye development and cell differentiation. Its dysregulation can lead to various eye disorders, highlighting the importance of understanding the functions and clinical significance of this gene in the field of immunology and ophthalmology.

Genular Protein ID: 3262301463

Symbol: CRYGS_HUMAN

Name: Gamma-crystallin S

UniProtKB Accession Codes:

P22914 B2RAF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 12 PDBsum 12 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 1445197

Title: Primary structure of beta s-crystallin from human lens.

PubMed ID: 1445197

DOI: 10.1042/bj2870375

PubMed ID: 10837510

Title: The human gene for gammaS-crystallin: alternative transcripts and expressed sequences from the first intron.

PubMed ID: 10837510

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7733876

Title: The complete sequence of human lens gamma s-crystallin.

PubMed ID: 7733876

DOI: 10.1042/bj3070407

PubMed ID: 8999933

Title: Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.

PubMed ID: 8999933

DOI: 10.1074/jbc.272.4.2268

PubMed ID: 11706012

Title: The X-ray crystal structure of human gamma S-crystallin C-terminal domain.

PubMed ID: 11706012

DOI: 10.1074/jbc.m110083200

PubMed ID: 16141006

Title: Gamma-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans.

PubMed ID: 16141006

DOI: 10.1136/jmg.2004.028274

PubMed ID: 18587492

Title: Crystallin gene mutations in Indian families with inherited pediatric cataract.

PubMed ID: 18587492

PubMed ID: 21866213

Title: Mutation analysis of 12 genes in Chinese families with congenital cataracts.

PubMed ID: 21866213

PubMed ID: 28839118

Title: High-Throughput Genetic Screening of 51 Pediatric Cataract Genes Identifies Causative Mutations in Inherited Pediatric Cataract in South Eastern Australia.

PubMed ID: 28839118

DOI: 10.1534/g3.117.300109

Sequence Information:

  • Length: 178
  • Mass: 21007
  • Checksum: 29C46720A80EF6C2
  • Sequence:
    • MSKTGTKITF YEDKNFQGRR YDCDCDCADF HTYLSRCNSI KVEGGTWAVY ERPNFAGYMY 
ILPQGEYPEY QRWMGLNDRL SSCRAVHLPS GGQYKIQIFE KGDFSGQMYE TTEDCPSIME 
QFHMREIHSC KVLEGVWIFY ELPNYRGRQY LLDKKEYRKP IDWGAASPAV QSFRRIVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.