Details for: CRYGS

Gene ID: 1427

Symbol: CRYGS

Ensembl ID: ENSG00000213139

Description: crystallin gamma S

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.77
    Marker Score: 5069
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.62
    Marker Score: 4384
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.82
    Marker Score: 1650
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.14
    Marker Score: 829
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.01
    Marker Score: 932
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5265
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 583.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3047.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.68
    Marker Score: 425
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 413
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.55
    Marker Score: 8582
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1105
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 347.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3043
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.48
    Marker Score: 153
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.46
    Marker Score: 4399
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.46
    Marker Score: 28136
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 217
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.45
    Marker Score: 702
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.39
    Marker Score: 14456
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.39
    Marker Score: 14707
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 159
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.36
    Marker Score: 3674
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.35
    Marker Score: 3045
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.35
    Marker Score: 1361
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.33
    Marker Score: 251
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.32
    Marker Score: 6272
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.29
    Marker Score: 132.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.28
    Marker Score: 2177
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.28
    Marker Score: 4232
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.28
    Marker Score: 1162
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.28
    Marker Score: 789
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.27
    Marker Score: 113
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.27
    Marker Score: 2558
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.26
    Marker Score: 101
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 155
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.25
    Marker Score: 292
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.25
    Marker Score: 101
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.23
    Marker Score: 950
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.23
    Marker Score: 92
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.21
    Marker Score: 4508
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.2
    Marker Score: 71
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.19
    Marker Score: 97
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 165
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.19
    Marker Score: 1221
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.19
    Marker Score: 128
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.19
    Marker Score: 812
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 68
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.18
    Marker Score: 139
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.18
    Marker Score: 186
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.17
    Marker Score: 186
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.17
    Marker Score: 236
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.17
    Marker Score: 139
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.17
    Marker Score: 62
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.16
    Marker Score: 313
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.16
    Marker Score: 171
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.16
    Marker Score: 55
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.16
    Marker Score: 120
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.15
    Marker Score: 531
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.14
    Marker Score: 766
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 438
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.14
    Marker Score: 655
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.14
    Marker Score: 149
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.14
    Marker Score: 171
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.14
    Marker Score: 132
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 121
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 75
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.13
    Marker Score: 90
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.13
    Marker Score: 121
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.12
    Marker Score: 436
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 149
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.12
    Marker Score: 175
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.12
    Marker Score: 227.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.12
    Marker Score: 68

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Other Information

**Key characteristics:** - It is a glycoprotein with a molecular weight of approximately 100 kDa. - It is a secreted protein that is present in the aqueous humor of the eye. - It is involved in the structural integrity and transparency of the lens. - It is also involved in the regulation of the blood-aqueous barrier. **Pathways and functions:** - CryGS is involved in the development and maintenance of the lens. - It is essential for the proper formation of the crystalline lens. - It also helps to regulate the transparency and refractive index of the lens. - It is involved in the regulation of the blood-aqueous barrier. **Clinical significance:** - Mutations in the CRYGS gene have been linked to a number of eye conditions, including cataracts, glaucoma, and refractive errors. - CryGS inhibitors are being investigated as a potential treatment for these disorders. **Additional information:** - The CRYGS gene is located on chromosome 19p13.2. - It is expressed in high levels in the lens of the eye. - It is also expressed in the choroid plexus, which is a network of blood vessels that supplies the eye with oxygen and nutrients. - Mutations in the CRYGS gene can lead to a condition called congenital bilateral cataracts, which is a condition in which the lens of the eye becomes cloudy and cannot be corrected with glasses.

Genular Protein ID: 3262301463

Symbol: CRYGS_HUMAN

Name: Gamma-crystallin S

UniProtKB Accession Codes:

P22914 B2RAF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 15 PDBsum 12 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 1445197

Title: Primary structure of beta s-crystallin from human lens.

PubMed ID: 1445197

DOI: 10.1042/bj2870375

PubMed ID: 10837510

Title: The human gene for gammaS-crystallin: alternative transcripts and expressed sequences from the first intron.

PubMed ID: 10837510

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7733876

Title: The complete sequence of human lens gamma s-crystallin.

PubMed ID: 7733876

DOI: 10.1042/bj3070407

PubMed ID: 8999933

Title: Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.

PubMed ID: 8999933

DOI: 10.1074/jbc.272.4.2268

PubMed ID: 11706012

Title: The X-ray crystal structure of human gamma S-crystallin C-terminal domain.

PubMed ID: 11706012

DOI: 10.1074/jbc.m110083200

PubMed ID: 16141006

Title: Gamma-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans.

PubMed ID: 16141006

DOI: 10.1136/jmg.2004.028274

PubMed ID: 18587492

Title: Crystallin gene mutations in Indian families with inherited pediatric cataract.

PubMed ID: 18587492

PubMed ID: 21866213

Title: Mutation analysis of 12 genes in Chinese families with congenital cataracts.

PubMed ID: 21866213

PubMed ID: 28839118

Title: High-Throughput Genetic Screening of 51 Pediatric Cataract Genes Identifies Causative Mutations in Inherited Pediatric Cataract in South Eastern Australia.

PubMed ID: 28839118

DOI: 10.1534/g3.117.300109

Sequence Information:

  • Length: 178
  • Mass: 21007
  • Checksum: 29C46720A80EF6C2
  • Sequence:
    • MSKTGTKITF YEDKNFQGRR YDCDCDCADF HTYLSRCNSI KVEGGTWAVY ERPNFAGYMY 
ILPQGEYPEY QRWMGLNDRL SSCRAVHLPS GGQYKIQIFE KGDFSGQMYE TTEDCPSIME 
QFHMREIHSC KVLEGVWIFY ELPNYRGRQY LLDKKEYRKP IDWGAASPAV QSFRRIVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.