Genular: Defining Cellular Identity and Function

Details for: Srgap2

Gene ID: 14270

Symbol: Srgap2

Ensembl ID: ENSMUSG00000026425

Description: SLIT-ROBO Rho GTPase activating protein 2

Associated with

Cdc42 gtpase cycle
(R-MMU-9013148)
Rac1 gtpase cycle
(R-MMU-9013149)
Rac3 gtpase cycle
(R-MMU-9013423)
Rhof gtpase cycle
(R-MMU-9035034)
Rho gtpase cycle
(R-MMU-9012999)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Rhoq gtpase cycle
(R-MMU-9013406)
Rhou gtpase cycle
(R-MMU-9013420)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Cell projection
(GO:0042995)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Dendritic spine development
(GO:0060996)
Dendritic spine head
(GO:0044327)
Excitatory synapse assembly
(GO:1904861)
Extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
(GO:0021816)
Filopodium assembly
(GO:0046847)
Gtpase activator activity
(GO:0005096)
Identical protein binding
(GO:0042802)
Inhibitory synapse assembly
(GO:1904862)
Lamellipodium
(GO:0030027)
Membrane
(GO:0016020)
Mitochondrial inner membrane
(GO:0005743)
Negative regulation of cell migration
(GO:0030336)
Nervous system development
(GO:0007399)
Neuron projection morphogenesis
(GO:0048812)
Nucleus
(GO:0005634)
Phagocytic vesicle
(GO:0045335)
Plasma membrane
(GO:0005886)
Positive regulation of gtpase activity
(GO:0043547)
Postsynaptic density
(GO:0014069)
Postsynaptic membrane
(GO:0045211)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of cell migration
(GO:0030334)
Signal transduction
(GO:0007165)
Small gtpase binding
(GO:0031267)
Synapse
(GO:0045202)

Other Information

Proteins

Formin-binding protein 2

Genular Protein ID: 3545153808

Symbol: SRGP2_MOUSE

Name: Formin-binding protein 2

UniProtKB Accession Codes:

Q91Z67 B2RY13 Q3V1V8 Q61054

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11672528

Title: Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

PubMed ID: 11672528

DOI: 10.1016/s0092-8674(01)00530-x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 8605874

Title: Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.

PubMed ID: 8605874

DOI: 10.1002/j.1460-2075.1996.tb00442.x

PubMed ID: 19737524

Title: The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis.

PubMed ID: 19737524

DOI: 10.1016/j.cell.2009.06.047

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21148482

Title: Bi-modal regulation of a formin by srGAP2.

PubMed ID: 21148482

DOI: 10.1074/jbc.m110.190397

PubMed ID: 22126966

Title: SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes.

PubMed ID: 22126966

DOI: 10.1126/scisignal.2002189

PubMed ID: 22559944

Title: Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.

PubMed ID: 22559944

DOI: 10.1016/j.cell.2012.03.034

PubMed ID: 27373832

Title: SRGAP2 and its human-specific paralog co-regulate the development of excitatory and inhibitory synapses.

PubMed ID: 27373832

DOI: 10.1016/j.neuron.2016.06.013

PubMed ID: 26439400

Title: SrGAP2-dependent integration of membrane geometry and Slit-Robo-repulsive cues regulates fibroblast contact inhibition of locomotion.

PubMed ID: 26439400

DOI: 10.1016/j.devcel.2015.09.002

Sequence Information:

Length: 1071
Mass: 120798
Checksum: 9093C63476BA605D
Sequence:

MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE 
MDYSRNLEKL AERFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY 
LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK 
LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT 
ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDIIDQCC DLGYHASLNR ALRTFLSAEL 
NLEQSKHEGL DAIENAVENL DATSDKQRLM EMYNNVFCPP MKFEFQPHMG DMASQLCAQQ 
PVQSELVQRC QQLQSRLSTL KIENEEVKKT MEATLQTIQD IVTVEDFDVS DCFQYSNSME 
SVKSTVSETF MSKPSIAKRR ANQQETEQFY FTKMKEYLEG RNLITKLQAK HDLLQKTLGE 
SQRTDCSLAR RSSTVRKQDS SQAIPLVVES CIRFISRHGL QHEGIFRVSG SQVEVNDIKN 
AFERGEDPLA GDQNDHDMDS IAGVLKLYFR GLEHPLFPKD IFHDLIACVT MDNLQERAVH 
IRKVLLVLPK PTLIIMRYLF AFLNHLSQFS EENMMDPYNL AICFGPSLMS VPEGHDQVSC 
QAHVNELIKT IIIQHENIFP NPRELEGPIY SRGGSMEDYC DSTHGETTSA EDSTQDVTAE 
HHTSDDECEP IEAIAKFDYV GRTARELSFK KGASLLLYQR ASDDWWEGRH NGIDGLIPHQ 
YIVVQDTEDG VVERSSPKSE IEVMSEPPEE KVTARTGASC PSGGHVADIY LANINKQRKR 
PESGSIRKAF RSDSHGLGSS LTDSSSLGVG ASCRPSSQPI MSQNLPKEGP DKCSISGHGS 
LNSISRHSSL KNRMDSPQIR KTATAGRSKS FNNHRPMDPE VIAQDIEATM NSALNELQEL 
ERQSSAKHTP DVVLDTLEPL KTSPVVAPTS EPSSPLHTQL LKDPEPAFQR SASTAGDIAC 
AFRPVKSVKM AAPVKPPATR PKPTVFPKTN ATSPGVNSSA SPQATDKSCT V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Srgap2

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. PubMed ID: 11672528

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. PubMed ID: 8605874

The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. PubMed ID: 19737524

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Bi-modal regulation of a formin by srGAP2. PubMed ID: 21148482

SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes. PubMed ID: 22126966

Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. PubMed ID: 22559944

SRGAP2 and its human-specific paralog co-regulate the development of excitatory and inhibitory synapses. PubMed ID: 27373832

SrGAP2-dependent integration of membrane geometry and Slit-Robo-repulsive cues regulates fibroblast contact inhibition of locomotion. PubMed ID: 26439400