Genular: Defining Cellular Identity and Function

Details for: Folr1

Gene ID: 14275

Symbol: Folr1

Ensembl ID: ENSMUSG00000001827

Description: folate receptor alpha

Associated with

Asparagine n-linked glycosylation
(R-MMU-446203)
Cargo concentration in the er
(R-MMU-5694530)
Copi-mediated anterograde transport
(R-MMU-6807878)
Copii-mediated vesicle transport
(R-MMU-204005)
Er to golgi anterograde transport
(R-MMU-199977)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Transport to the golgi and subsequent modification
(R-MMU-948021)
Vesicle-mediated transport
(R-MMU-5653656)
Anterior neural tube closure
(GO:0061713)
Apical plasma membrane
(GO:0016324)
Axon regeneration
(GO:0031103)
Basolateral plasma membrane
(GO:0016323)
Brush border membrane
(GO:0031526)
Cardiac neural crest cell migration involved in outflow tract morphogenesis
(GO:0003253)
Cell adhesion
(GO:0007155)
Cellular response to folic acid
(GO:0071231)
Cytoplasmic vesicle
(GO:0031410)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Folic acid binding
(GO:0005542)
Folic acid metabolic process
(GO:0046655)
Folic acid receptor activity
(GO:0061714)
Folic acid transport
(GO:0015884)
Fusion of sperm to egg plasma membrane involved in single fertilization
(GO:0007342)
Heart looping
(GO:0001947)
Membrane
(GO:0016020)
Neural crest cell migration involved in heart formation
(GO:0003147)
Nucleus
(GO:0005634)
Pharyngeal arch artery morphogenesis
(GO:0061626)
Plasma membrane
(GO:0005886)
Post-translational protein targeting to endoplasmic reticulum membrane
(GO:0006620)
Regulation of canonical wnt signaling pathway
(GO:0060828)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Response to axon injury
(GO:0048678)
Side of membrane
(GO:0098552)
Signaling receptor activity
(GO:0038023)
Sperm-egg recognition
(GO:0035036)

Other Information

Proteins

Folate receptor alpha

Genular Protein ID: 4096587548

Symbol: FOLR1_MOUSE

Name: Folate receptor alpha

UniProtKB Accession Codes:

P35846 Q9R222

Database IDs:

Citations:

PubMed ID: 1894617

Title: Characterization of two cDNAs encoding folate-binding proteins from L1210 murine leukemia cells. Increased expression associated with a genomic rearrangement.

PubMed ID: 1894617

DOI: 10.1016/s0021-9258(19)47365-1

PubMed ID: 10216260

Title: Retinoic acid-dependent upregulation of mouse folate receptor-alpha expression in embryonic stem cells, and conservation of alternative splicing patterns.

PubMed ID: 10216260

DOI: 10.1016/s0378-1119(99)00081-5

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1429588

Title: Insertion of an intracisternal A particle within the 5'-regulatory region of a gene encoding folate-binding protein in L1210 leukemia cells in response to low folate selection. Association with increased protein expression.

PubMed ID: 1429588

DOI: 10.1016/s0021-9258(18)41678-x

PubMed ID: 10508523

Title: Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development.

PubMed ID: 10508523

DOI: 10.1038/13861

PubMed ID: 12854656

Title: Neural and orofacial defects in Folp1 knockout mice.

PubMed ID: 12854656

DOI: 10.1002/bdra.10045

PubMed ID: 15259034

Title: Developmental consequences of abnormal folate transport during murine heart morphogenesis.

PubMed ID: 15259034

DOI: 10.1002/bdra.20043

PubMed ID: 15703271

Title: Renal tubular reabsorption of folate mediated by folate binding protein 1.

PubMed ID: 15703271

DOI: 10.1681/asn.2004080711

PubMed ID: 17286298

Title: Cardiovascular abnormalities in Folr1 knockout mice and folate rescue.

PubMed ID: 17286298

DOI: 10.1002/bdra.20347

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 255
Mass: 29449
Checksum: A12ACA978BC8E134
Sequence:

MAHLMTVQLL LLVMWMAECA QSRATRARTE LLNVCMDAKH HKEKPGPEDN LHDQCSPWKT 
NSCCSTNTSQ EAHKDISYLY RFNWNHCGTM TSECKRHFIQ DTCLYECSPN LGPWIQQVDQ 
SWRKERILDV PLCKEDCQQW WEDCQSSFTC KSNWHKGWNW SSGHNECPVG ASCHPFTFYF 
PTSAALCEEI WSHSYKLSNY SRGSGRCIQM WFDPAQGNPN EEVARFYAEA MSGAGFHGTW 
PLLCSLSLVL LWVIS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Folr1

Associated with

Other Information

Characterization of two cDNAs encoding folate-binding proteins from L1210 murine leukemia cells. Increased expression associated with a genomic rearrangement. PubMed ID: 1894617

Retinoic acid-dependent upregulation of mouse folate receptor-alpha expression in embryonic stem cells, and conservation of alternative splicing patterns. PubMed ID: 10216260

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Insertion of an intracisternal A particle within the 5'-regulatory region of a gene encoding folate-binding protein in L1210 leukemia cells in response to low folate selection. Association with increased protein expression. PubMed ID: 1429588

Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. PubMed ID: 10508523

Neural and orofacial defects in Folp1 knockout mice. PubMed ID: 12854656

Developmental consequences of abnormal folate transport during murine heart morphogenesis. PubMed ID: 15259034

Renal tubular reabsorption of folate mediated by folate binding protein 1. PubMed ID: 15703271

Cardiovascular abnormalities in Folr1 knockout mice and folate rescue. PubMed ID: 17286298

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079