Gene CRYM - ENSG00000103316 | NCBI Gene ID: 1428

Details for: CRYM

Gene ID: 1428

Symbol: CRYM

Ensembl ID: ENSG00000103316

Description: crystallin mu

Associated with

Lysine catabolism
(R-HSA-71064)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Lysine catabolic process
(GO:0006554)
Mitochondrion
(GO:0005739)
Nadp binding
(GO:0050661)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Peroxisomal matrix
(GO:0005782)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Sensory perception of sound
(GO:0007605)
Thiomorpholine-carboxylate dehydrogenase activity
(GO:0047127)
Thyroid hormone binding
(GO:0070324)
Thyroid hormone metabolic process
(GO:0042403)
Thyroid hormone transport
(GO:0070327)
Transcription corepressor activity
(GO:0003714)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulosa cell (CL0000501)
Fold Change: 2.76
Marker Score: 27745.5
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.17
Marker Score: 3003
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.1
Marker Score: 19708
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.71
Marker Score: 105067
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.62
Marker Score: 2495.5
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.59
Marker Score: 15145.5
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 1.54
Marker Score: 1527
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.52
Marker Score: 748.5
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169053
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.4
Marker Score: 4977
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.38
Marker Score: 925
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.37
Marker Score: 3219
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.34
Marker Score: 29905
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.26
Marker Score: 3443
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.23
Marker Score: 314
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.14
Marker Score: 328
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.08
Marker Score: 16922
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.04
Marker Score: 1980
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 787
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.01
Marker Score: 3585
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71804
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48029
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: germ cell (CL0000586)
Fold Change: 0.98
Marker Score: 1712
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 503
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 457
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.92
Marker Score: 5534
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5217
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.91
Marker Score: 2267
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.89
Marker Score: 415
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5280
Cell Name: club cell (CL0000158)
Fold Change: 0.79
Marker Score: 927
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.78
Marker Score: 3263
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1257
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 305
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.72
Marker Score: 1472
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.71
Marker Score: 3740
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.66
Marker Score: 1110
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.65
Marker Score: 1862
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.64
Marker Score: 1113
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 0.64
Marker Score: 175
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.63
Marker Score: 5404
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.63
Marker Score: 202
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.61
Marker Score: 3991
Cell Name: Unknown (CL0002371)
Fold Change: 0.61
Marker Score: 645
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.6
Marker Score: 755
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.59
Marker Score: 219
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.57
Marker Score: 179
Cell Name: brush cell (CL0002204)
Fold Change: 0.56
Marker Score: 510
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.54
Marker Score: 4680
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.54
Marker Score: 344.5
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.51
Marker Score: 348
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.51
Marker Score: 1965
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.51
Marker Score: 19236
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5
Marker Score: 730.5
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.49
Marker Score: 201
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.49
Marker Score: 438
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.48
Marker Score: 916
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.46
Marker Score: 3444
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.46
Marker Score: 198
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.45
Marker Score: 921
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.43
Marker Score: 131
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.43
Marker Score: 697
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.43
Marker Score: 252
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.43
Marker Score: 577
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.43
Marker Score: 1047
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.43
Marker Score: 208
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.43
Marker Score: 336
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.43
Marker Score: 280
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.42
Marker Score: 212
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.42
Marker Score: 290
Cell Name: interneuron (CL0000099)
Fold Change: 0.41
Marker Score: 189
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.4
Marker Score: 252
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.39
Marker Score: 186
Cell Name: melanocyte (CL0000148)
Fold Change: 0.38
Marker Score: 154
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.37
Marker Score: 235
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.37
Marker Score: 120
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.37
Marker Score: 97
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.37
Marker Score: 252
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.37
Marker Score: 3815
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.37
Marker Score: 1267
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.37
Marker Score: 242
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.37
Marker Score: 582
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.37
Marker Score: 439
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 0.37
Marker Score: 103
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.35
Marker Score: 196
Cell Name: brush cell of trachebronchial tree (CL0002075)
Fold Change: 0.35
Marker Score: 107
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.34
Marker Score: 362
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.33
Marker Score: 331
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.33
Marker Score: 95
Cell Name: ionocyte (CL0005006)
Fold Change: 0.33
Marker Score: 100
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.33
Marker Score: 216
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.33
Marker Score: 81
Cell Name: secretory cell (CL0000151)
Fold Change: 0.32
Marker Score: 587

Hover over a box to see details here...

## Summary CRYM is a gene encoding a protein called CRYM_HUMAN, which is a crystallin protein. It is found in various cell types, with significant expression in granulosa cells, Müller cells, and neurons. ## Key characteristics * **Function:** CRYM is involved in various cellular processes, including the regulation of the lysosome-mitochondria electron transport chain, protein-protein interactions, and sound perception. * **Location:** The gene is located on chromosome 17q25.1. * **Size:** The protein is approximately 120 amino acids long. * **Expression:** CRYM is highly expressed in specific cell types, suggesting a role in their function. ## Pathways and functions * **Lysine catabolism:** CRYM is involved in the catabolism of lysine, an essential amino acid for various cellular processes. * **Regulation of the lysosome-mitochondria electron transport chain:** It interacts with proteins involved in the electron transport chain, potentially regulating its activity. * **Protein-protein interactions:** CRYM is involved in protein-protein interactions, including those involved in the regulation of the mitochondrial electron transport chain. * **Sound perception:** In the auditory pathway, CRYM is involved in the transduction of sound waves into electrical signals. * **Other functions:** CRYM also plays a role in thyroid hormone transport and metabolism, as well as in regulating the activity of the transcription factor thyroid hormone receptor. ## Clinical significance Mutations in the CRYM gene have been linked to several human diseases, including: * **Crystalline kidney disease:** A genetic disorder characterized by the accumulation of crystalline material in the kidneys. * **Thyroid cancer:** CRYM mutations have been found in a subset of thyroid cancers. * **Neurodegenerative disorders:** Some studies suggest a link between CRYM mutations and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. CRYM is an important gene that plays a vital role in various cellular processes, including lysosome-mitochondria electron transport, protein-protein interactions, and sound perception. Mutations in CRYM have significant clinical implications, as they can lead to the development of various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ketimine reductase mu-crystallin

Genular Protein ID: 3290859729

Symbol: CRYM_HUMAN

Name: Ketimine reductase mu-crystallin

UniProtKB Accession Codes:

Q14894 D5MNX0 Q5HYB7

Database IDs:

Citations:

PubMed ID: 9285773

Title: Two roles for mu-crystallin: a lens structural protein in diurnal marsupials and a possible enzyme in mammalian retinas.

PubMed ID: 9285773

PubMed ID: 9328354

Title: Purification, molecular cloning, and functional expression of the human nicotinamide-adenine dinucleotide phosphate-regulated thyroid hormone-binding protein.

PubMed ID: 9328354

DOI: 10.1210/mend.11.11.9915

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1384048

Title: Mu-crystallin is a mammalian homologue of Agrobacterium ornithine cyclodeaminase and is expressed in human retina.

PubMed ID: 1384048

DOI: 10.1073/pnas.89.19.9292

PubMed ID: 12471561

Title: Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues.

PubMed ID: 12471561

DOI: 10.1086/345398

PubMed ID: 21332720

Title: Mammalian forebrain ketimine reductase identified as mu-crystallin; potential regulation by thyroid hormones.

PubMed ID: 21332720

DOI: 10.1111/j.1471-4159.2011.07220.x

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17242435

Title: Crystal structure of human micro-crystallin complexed with NADPH.

PubMed ID: 17242435

DOI: 10.1110/ps.062556907

Sequence Information:

Length: 314
Mass: 33776
Checksum: A49D316B41CE6648
Sequence:

MSRVPAFLSA AEVEEHLRSS SLLIPPLETA LANFSSGPEG GVMQPVRTVV PVTKHRGYLG 
VMPAYSAAED ALTTKLVTFY EDRGITSVVP SHQATVLLFE PSNGTLLAVM DGNVITAKRT 
AAVSAIATKF LKPPSSEVLC ILGAGVQAYS HYEIFTEQFS FKEVRIWNRT KENAEKFADT 
VQGEVRVCSS VQEAVAGADV IITVTLATEP ILFGEWVKPG AHINAVGASR PDWRELDDEL 
MKEAVLYVDS QEAALKESGD VLLSGAEIFA ELGEVIKGVK PAHCEKTTVF KSLGMAVEDT 
VAAKLIYDSW SSGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CRYM

Associated with

Cells (max top 100)

Other Information

Two roles for mu-crystallin: a lens structural protein in diurnal marsupials and a possible enzyme in mammalian retinas. PubMed ID: 9285773

Purification, molecular cloning, and functional expression of the human nicotinamide-adenine dinucleotide phosphate-regulated thyroid hormone-binding protein. PubMed ID: 9328354

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. PubMed ID: 10493829

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mu-crystallin is a mammalian homologue of Agrobacterium ornithine cyclodeaminase and is expressed in human retina. PubMed ID: 1384048

Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues. PubMed ID: 12471561

Mammalian forebrain ketimine reductase identified as mu-crystallin; potential regulation by thyroid hormones. PubMed ID: 21332720

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Crystal structure of human micro-crystallin complexed with NADPH. PubMed ID: 17242435