Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 95.6635
Cell Significance Index: -14.8800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 59.3353
Cell Significance Index: -15.0500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.0442
Cell Significance Index: -14.8500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.8122
Cell Significance Index: -15.5700 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 3.1113
Cell Significance Index: 75.3700 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.2404
Cell Significance Index: 23.1100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.4812
Cell Significance Index: 56.0900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3468
Cell Significance Index: 270.1700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.2459
Cell Significance Index: 55.1100 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.1103
Cell Significance Index: 5.4000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9989
Cell Significance Index: 51.8900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9422
Cell Significance Index: 102.4900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9409
Cell Significance Index: 72.2100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.9132
Cell Significance Index: 15.6500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8577
Cell Significance Index: 139.5000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.8365
Cell Significance Index: 23.8700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8334
Cell Significance Index: 50.0300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5328
Cell Significance Index: 24.1500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5280
Cell Significance Index: 36.5200 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.3600
Cell Significance Index: 3.0600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3429
Cell Significance Index: 23.0600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3390
Cell Significance Index: 64.5100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.3203
Cell Significance Index: 2.9500 - Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
Fold Change: 0.2830
Cell Significance Index: 2.8600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1947
Cell Significance Index: 38.6400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1914
Cell Significance Index: 12.0700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1657
Cell Significance Index: 4.7800 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.1373
Cell Significance Index: 0.9300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1255
Cell Significance Index: 2.7200 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.0914
Cell Significance Index: 2.2800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0764
Cell Significance Index: 1.9100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0749
Cell Significance Index: 26.8800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0743
Cell Significance Index: 51.4100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0721
Cell Significance Index: 4.4300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0705
Cell Significance Index: 6.9700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0471
Cell Significance Index: 5.4900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0441
Cell Significance Index: 24.0800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0418
Cell Significance Index: 1.4700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0268
Cell Significance Index: 0.5700 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.0260
Cell Significance Index: 0.2000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0213
Cell Significance Index: 39.2200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0102
Cell Significance Index: 19.2500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0026
Cell Significance Index: 4.0500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0006
Cell Significance Index: 0.4300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0010
Cell Significance Index: -0.1400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0013
Cell Significance Index: -0.1600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0024
Cell Significance Index: -3.2900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0061
Cell Significance Index: -1.1000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0144
Cell Significance Index: -9.1400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0157
Cell Significance Index: -11.5200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0172
Cell Significance Index: -1.7600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0176
Cell Significance Index: -0.5600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0184
Cell Significance Index: -13.6500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0250
Cell Significance Index: -15.6000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0251
Cell Significance Index: -14.1300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0257
Cell Significance Index: -11.6800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0378
Cell Significance Index: -10.8800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0456
Cell Significance Index: -1.4600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0520
Cell Significance Index: -7.1400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0693
Cell Significance Index: -3.8900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0753
Cell Significance Index: -15.8600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0830
Cell Significance Index: -10.6400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0854
Cell Significance Index: -14.5800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0867
Cell Significance Index: -1.2800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0906
Cell Significance Index: -10.6800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0983
Cell Significance Index: -2.0400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1008
Cell Significance Index: -2.6500 - Cell Name: salivary gland glandular cell (CL1001596)
Fold Change: -0.1078
Cell Significance Index: -0.6000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1160
Cell Significance Index: -14.9800 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.1217
Cell Significance Index: -0.9300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1221
Cell Significance Index: -9.6700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1288
Cell Significance Index: -6.7600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1390
Cell Significance Index: -15.9200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1395
Cell Significance Index: -6.5100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1411
Cell Significance Index: -14.6900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1621
Cell Significance Index: -4.5300 - Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: -0.1668
Cell Significance Index: -1.8400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1738
Cell Significance Index: -5.6900 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.1787
Cell Significance Index: -1.7000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1796
Cell Significance Index: -6.2900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1829
Cell Significance Index: -3.5700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1830
Cell Significance Index: -5.3900 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.1870
Cell Significance Index: -2.3200 - Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
Fold Change: -0.1917
Cell Significance Index: -1.2800 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.2019
Cell Significance Index: -2.2000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2086
Cell Significance Index: -15.5500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2129
Cell Significance Index: -4.5500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2162
Cell Significance Index: -13.9500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2246
Cell Significance Index: -11.7000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2307
Cell Significance Index: -2.7500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2427
Cell Significance Index: -14.8800 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.2613
Cell Significance Index: -3.3500 - Cell Name: lung secretory cell (CL1000272)
Fold Change: -0.2653
Cell Significance Index: -2.0200 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.2822
Cell Significance Index: -2.9200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2895
Cell Significance Index: -7.8800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2951
Cell Significance Index: -13.8700 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.3064
Cell Significance Index: -9.6900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3073
Cell Significance Index: -6.1700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3093
Cell Significance Index: -4.2200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3172
Cell Significance Index: -7.7400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3290859729
Symbol: CRYM_HUMAN
Name: Ketimine reductase mu-crystallin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9285773
Title: Two roles for mu-crystallin: a lens structural protein in diurnal marsupials and a possible enzyme in mammalian retinas.
PubMed ID: 9285773
PubMed ID: 9328354
Title: Purification, molecular cloning, and functional expression of the human nicotinamide-adenine dinucleotide phosphate-regulated thyroid hormone-binding protein.
PubMed ID: 9328354
PubMed ID: 10493829
Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
PubMed ID: 10493829
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1384048
Title: Mu-crystallin is a mammalian homologue of Agrobacterium ornithine cyclodeaminase and is expressed in human retina.
PubMed ID: 1384048
PubMed ID: 12471561
Title: Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues.
PubMed ID: 12471561
DOI: 10.1086/345398
PubMed ID: 21332720
Title: Mammalian forebrain ketimine reductase identified as mu-crystallin; potential regulation by thyroid hormones.
PubMed ID: 21332720
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 17242435
Title: Crystal structure of human micro-crystallin complexed with NADPH.
PubMed ID: 17242435
DOI: 10.1110/ps.062556907
Sequence Information:
- Length: 314
- Mass: 33776
- Checksum: A49D316B41CE6648
- Sequence:
MSRVPAFLSA AEVEEHLRSS SLLIPPLETA LANFSSGPEG GVMQPVRTVV PVTKHRGYLG VMPAYSAAED ALTTKLVTFY EDRGITSVVP SHQATVLLFE PSNGTLLAVM DGNVITAKRT AAVSAIATKF LKPPSSEVLC ILGAGVQAYS HYEIFTEQFS FKEVRIWNRT KENAEKFADT VQGEVRVCSS VQEAVAGADV IITVTLATEP ILFGEWVKPG AHINAVGASR PDWRELDDEL MKEAVLYVDS QEAALKESGD VLLSGAEIFA ELGEVIKGVK PAHCEKTTVF KSLGMAVEDT VAAKLIYDSW SSGK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.