Genular: Defining Cellular Identity and Function

Details for: Fos

Gene ID: 14281

Symbol: Fos

Ensembl ID: ENSMUSG00000021250

Description: FBJ osteosarcoma oncogene

Associated with

Activation of the ap-1 family of transcription factors
(R-MMU-450341)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Cytokine signaling in immune system
(R-MMU-1280215)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated mapk activation
(R-MMU-2871796)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-17 signaling
(R-MMU-448424)
Map kinase activation
(R-MMU-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-MMU-450282)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Oxidative stress induced senescence
(R-MMU-2559580)
Signaling by interleukins
(R-MMU-449147)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Cellular response to cadmium ion
(GO:0071276)
Cellular response to calcium ion
(GO:0071277)
Cellular response to extracellular stimulus
(GO:0031668)
Cellular response to reactive oxygen species
(GO:0034614)
Chromatin binding
(GO:0003682)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Endoplasmic reticulum
(GO:0005783)
Identical protein binding
(GO:0042802)
Nervous system development
(GO:0007399)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoclast differentiation
(GO:0030316)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein-dna complex
(GO:0032993)
Protein binding
(GO:0005515)
R-smad binding
(GO:0070412)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to muscle stretch
(GO:0035994)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal muscle cell differentiation
(GO:0035914)
Smad protein signal transduction
(GO:0060395)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Transcription factor ap-1 complex
(GO:0035976)
Transcription regulator complex
(GO:0005667)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)

Other Information

Proteins

Cellular oncogene fos

Genular Protein ID: 3842194569

Symbol: FOS_MOUSE

Name: Cellular oncogene fos

UniProtKB Accession Codes:

P01101

Database IDs:

Citations:

PubMed ID: 6301687

Title: Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.

PubMed ID: 6301687

DOI: 10.1016/0092-8674(83)90306-9

PubMed ID: 2991903

Title: Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.

PubMed ID: 2991903

DOI: 10.1073/pnas.82.15.4987

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11397794

Title: Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ.

PubMed ID: 11397794

DOI: 10.1074/jbc.m101522200

PubMed ID: 12134156

Title: Molecular interpretation of ERK signal duration by immediate early gene products.

PubMed ID: 12134156

DOI: 10.1038/ncb822

PubMed ID: 12972619

Title: Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor.

PubMed ID: 12972619

DOI: 10.1128/mcb.23.19.7030-7043.2003

PubMed ID: 15719069

Title: Essential role of RSK2 in c-Fos-dependent osteosarcoma development.

PubMed ID: 15719069

DOI: 10.1172/jci22877

PubMed ID: 21998197

Title: c-Fos activates and physically interacts with specific enzymes of the pathway of synthesis of polyphosphoinositides.

PubMed ID: 21998197

DOI: 10.1091/mbc.e11-03-0259

PubMed ID: 22105363

Title: The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity.

PubMed ID: 22105363

DOI: 10.1038/onc.2011.510

PubMed ID: 29272704

Title: AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection.

PubMed ID: 29272704

DOI: 10.1016/j.molcel.2017.11.026

Sequence Information:

Length: 380
Mass: 40838
Checksum: 475966265952B624
Sequence:

MMFSGFNADY EASSSRCSSA SPAGDSLSYY HSPADSFSSM GSPVNTQDFC ADLSVSSANF 
IPTVTAISTS PDLQWLVQPT LVSSVAPSQT RAPHPYGLPT QSAGAYARAG MVKTVSGGRA 
QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDEKSALQ 
TEIANLLKEK EKLEFILAAH RPACKIPDDL GFPEEMSVAS LDLTGGLPEA STPESEEAFT 
LPLLNDPEPK PSLEPVKSIS NVELKAEPFD DFLFPASSRP SGSETSRSVP DVDLSGSFYA 
ADWEPLHSNS LGMGPMVTEL EPLCTPVVTC TPGCTTYTSS FVFTYPEADS FPSCAAAHRK 
GSSSNEPSSD SLSSPTLLAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fos

Associated with

Other Information

Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini. PubMed ID: 6301687

Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene. PubMed ID: 2991903

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ. PubMed ID: 11397794

Molecular interpretation of ERK signal duration by immediate early gene products. PubMed ID: 12134156

Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor. PubMed ID: 12972619

Essential role of RSK2 in c-Fos-dependent osteosarcoma development. PubMed ID: 15719069

c-Fos activates and physically interacts with specific enzymes of the pathway of synthesis of polyphosphoinositides. PubMed ID: 21998197

The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity. PubMed ID: 22105363

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection. PubMed ID: 29272704