Details for: Fosb

Gene ID: 14282

Symbol: Fosb

Ensembl ID: ENSMUSG00000003545

Description: FBJ osteosarcoma oncogene B

Associated with

  • Cellular response to calcium ion
    (GO:0071277)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Double-stranded dna binding
    (GO:0003690)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription by rna polymerase ii
    (GO:0006366)

Other Information

Genular Protein ID: 774934385

Symbol: FOSB_MOUSE

Name: N/A

UniProtKB Accession Codes:

P13346 A0A140LIE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 22 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2498083

Title: The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity.

PubMed ID: 2498083

DOI: 10.1002/j.1460-2075.1989.tb03441.x

PubMed ID: 1741260

Title: Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter.

PubMed ID: 1741260

DOI: 10.1093/nar/20.2.343

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 1900040

Title: A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity.

PubMed ID: 1900040

DOI: 10.1016/0092-8674(91)90504-r

PubMed ID: 8706134

Title: A defect in nurturing in mice lacking the immediate early gene fosB.

PubMed ID: 8706134

DOI: 10.1016/s0092-8674(00)80101-4

PubMed ID: 9294222

Title: FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects.

PubMed ID: 9294222

DOI: 10.1073/pnas.94.19.10397

PubMed ID: 16687504

Title: Regulation of DeltaFosB stability by phosphorylation.

PubMed ID: 16687504

DOI: 10.1523/jneurosci.4970-05.2006

PubMed ID: 17241283

Title: Regulation of DeltaFosB transcriptional activity by Ser27 phosphorylation.

PubMed ID: 17241283

DOI: 10.1111/j.1460-9568.2006.05262.x

PubMed ID: 18407360

Title: Role of fosB in behaviours related to morphine reward and spatial memory.

PubMed ID: 18407360

DOI: 10.1016/j.bbr.2008.02.040

PubMed ID: 20473292

Title: DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses.

PubMed ID: 20473292

DOI: 10.1038/nn.2551

PubMed ID: 23303048

Title: fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior.

PubMed ID: 23303048

DOI: 10.1038/npp.2012.260

PubMed ID: 23319622

Title: DeltaFosB differentially modulates nucleus accumbens direct and indirect pathway function.

PubMed ID: 23319622

DOI: 10.1073/pnas.1221742110

PubMed ID: 26446228

Title: Experience-Dependent Induction of Hippocampal DeltaFosB Controls Learning.

PubMed ID: 26446228

DOI: 10.1523/jneurosci.2083-15.2015

PubMed ID: 29272704

Title: AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection.

PubMed ID: 29272704

DOI: 10.1016/j.molcel.2017.11.026

PubMed ID: 30902680

Title: Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning.

PubMed ID: 30902680

DOI: 10.1016/j.neuroscience.2019.03.022

Sequence Information:

  • Length: 338
  • Mass: 35977
  • Checksum: E9D031A4BEAE48EC
  • Sequence:
    • MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA 
ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP GTSYSTPGLS AYSTGGASGS 
GGPSTSTTTS GPVSARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT 
DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD 
LPGSTSAKED GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY 
TSSFVLTCPE VSAFAGAQRT SGSEQPSDPL NSPSLLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.