Genular: Defining Cellular Identity and Function

Details for: Fpr2

Gene ID: 14289

Symbol: Fpr2

Ensembl ID: ENSMUSG00000052270

Description: formyl peptide receptor 2

Associated with

Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
Formyl peptide receptors bind formyl peptides and many other ligands
(R-MMU-444473)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Amyloid-beta binding
(GO:0001540)
Calcium-mediated signaling
(GO:0019722)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to amyloid-beta
(GO:1904646)
Chemotaxis
(GO:0006935)
Complement receptor activity
(GO:0004875)
Complement receptor mediated signaling pathway
(GO:0002430)
Cytoplasm
(GO:0005737)
Defense response to bacterium
(GO:0042742)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Immune response-regulating cell surface receptor signaling pathway
(GO:0002768)
Inflammatory response
(GO:0006954)
Membrane
(GO:0016020)
N-formyl peptide receptor activity
(GO:0004982)
Negative regulation of inflammatory response
(GO:0050728)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive chemotaxis
(GO:0050918)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of innate immune response
(GO:0045089)
Positive regulation of monocyte chemotaxis
(GO:0090026)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of superoxide anion generation
(GO:0032930)
Rage receptor binding
(GO:0050786)
Scavenger receptor binding
(GO:0005124)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)

Other Information

Proteins

Formyl peptide receptor 2

Genular Protein ID: 1266416764

Symbol: FPR2_MOUSE

Name: Formyl peptide receptor 2

UniProtKB Accession Codes:

O88536

Database IDs:

Citations:

PubMed ID: 9722950

Title: Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse.

PubMed ID: 9722950

DOI: 10.1006/geno.1998.5376

PubMed ID: 12218158

Title: Identification, cloning, and functional characterization of a murine lipoxin A4 receptor homologue gene.

PubMed ID: 12218158

DOI: 10.4049/jimmunol.169.6.3363

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10477558

Title: N-formylpeptides induce two distinct concentration optima for mouse neutrophil chemotaxis by differential interaction with two N-formylpeptide receptor (FPR) subtypes. Molecular characterization of FPR2, a second mouse neutrophil FPR.

PubMed ID: 10477558

DOI: 10.1084/jem.190.5.741

PubMed ID: 15879124

Title: Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant.

PubMed ID: 15879124

DOI: 10.4049/jimmunol.174.10.6257

PubMed ID: 17237393

Title: F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor.

PubMed ID: 17237393

DOI: 10.4049/jimmunol.178.3.1450

PubMed ID: 19387439

Title: Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors.

PubMed ID: 19387439

DOI: 10.1038/nature08029

PubMed ID: 19497865

Title: Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ.

PubMed ID: 19497865

DOI: 10.1073/pnas.0904464106

PubMed ID: 29138422

Title: FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2.

PubMed ID: 29138422

DOI: 10.1038/s41598-017-15586-0

Sequence Information:

Length: 351
Mass: 39422
Checksum: B16BCE7FA9AA8F43
Sequence:

MESNYSIHLN GSEVVVYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV AGFRMPHTVT 
TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL VHIVVDVNLF GSVFLIALIA 
LDRCICVLHP VWAQNHRTVS LARKVVVGPW IFALILTLPI FIFLTTVRIP GGDVYCTFNF 
GSWAQTDEEK LNTAITFVTT RGIIRFLIGF SMPMSIVAVC YGLIAVKINR RNLVNSSRPL 
RVLTAVVASF FICWFPFQLV ALLGTVWFKE TLLSGSYKIL DMFVNPTSSL AYFNSCLNPM 
LYVFMGQDFR ERFIHSLPYS LERALSEDSG QTSDSSTSST SPPADIELKA P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fpr2

Associated with

Other Information

Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse. PubMed ID: 9722950

Identification, cloning, and functional characterization of a murine lipoxin A4 receptor homologue gene. PubMed ID: 12218158

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

N-formylpeptides induce two distinct concentration optima for mouse neutrophil chemotaxis by differential interaction with two N-formylpeptide receptor (FPR) subtypes. Molecular characterization of FPR2, a second mouse neutrophil FPR. PubMed ID: 10477558

Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant. PubMed ID: 15879124

F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor. PubMed ID: 17237393

Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors. PubMed ID: 19387439

Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ. PubMed ID: 19497865

FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2. PubMed ID: 29138422