Details for: CRYZ

Gene ID: 1429

Symbol: CRYZ

Ensembl ID: ENSG00000116791

Description: crystallin zeta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.9920
    Cell Significance Index: -14.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.2136
    Cell Significance Index: -12.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9388
    Cell Significance Index: -14.7200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 4.7062
    Cell Significance Index: 18.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6587
    Cell Significance Index: -12.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7544
    Cell Significance Index: -14.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.5390
    Cell Significance Index: -10.8700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.6843
    Cell Significance Index: 28.5200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.4423
    Cell Significance Index: 19.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.1428
    Cell Significance Index: 36.1000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.6404
    Cell Significance Index: 27.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2266
    Cell Significance Index: 73.6400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.2187
    Cell Significance Index: 4.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0202
    Cell Significance Index: 9.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0070
    Cell Significance Index: 27.4100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.9601
    Cell Significance Index: 7.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9259
    Cell Significance Index: 183.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7466
    Cell Significance Index: 17.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7445
    Cell Significance Index: 16.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7303
    Cell Significance Index: 37.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7263
    Cell Significance Index: 9.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7246
    Cell Significance Index: 71.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6445
    Cell Significance Index: 581.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6384
    Cell Significance Index: 348.6600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5638
    Cell Significance Index: 7.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5154
    Cell Significance Index: 148.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4910
    Cell Significance Index: 88.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4301
    Cell Significance Index: 62.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4209
    Cell Significance Index: 29.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4102
    Cell Significance Index: 66.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3190
    Cell Significance Index: 9.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2922
    Cell Significance Index: 35.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2712
    Cell Significance Index: 31.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2551
    Cell Significance Index: 5.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2048
    Cell Significance Index: 15.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2030
    Cell Significance Index: 5.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1637
    Cell Significance Index: 31.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1581
    Cell Significance Index: 4.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1561
    Cell Significance Index: 20.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1508
    Cell Significance Index: 66.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1447
    Cell Significance Index: 29.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1388
    Cell Significance Index: 19.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1307
    Cell Significance Index: 9.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1200
    Cell Significance Index: 3.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1109
    Cell Significance Index: 12.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1080
    Cell Significance Index: 18.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1009
    Cell Significance Index: 3.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0949
    Cell Significance Index: 1.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0855
    Cell Significance Index: 0.8900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0815
    Cell Significance Index: 1.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0622
    Cell Significance Index: 22.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0617
    Cell Significance Index: 45.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0469
    Cell Significance Index: 88.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0279
    Cell Significance Index: 17.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0237
    Cell Significance Index: 2.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0234
    Cell Significance Index: 36.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0191
    Cell Significance Index: 8.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0170
    Cell Significance Index: 0.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0162
    Cell Significance Index: 1.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0146
    Cell Significance Index: 0.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0132
    Cell Significance Index: 24.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0128
    Cell Significance Index: 9.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0034
    Cell Significance Index: 4.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0033
    Cell Significance Index: 0.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0025
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0016
    Cell Significance Index: -1.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0060
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0071
    Cell Significance Index: -4.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0085
    Cell Significance Index: -0.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0093
    Cell Significance Index: -0.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0120
    Cell Significance Index: -0.4200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0175
    Cell Significance Index: -0.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0221
    Cell Significance Index: -0.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0250
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0293
    Cell Significance Index: -6.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0310
    Cell Significance Index: -2.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0336
    Cell Significance Index: -2.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0434
    Cell Significance Index: -5.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0501
    Cell Significance Index: -2.2700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0512
    Cell Significance Index: -0.3000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0551
    Cell Significance Index: -0.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0568
    Cell Significance Index: -0.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0709
    Cell Significance Index: -1.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0727
    Cell Significance Index: -1.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0768
    Cell Significance Index: -2.0500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0785
    Cell Significance Index: -0.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0895
    Cell Significance Index: -2.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0948
    Cell Significance Index: -5.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0989
    Cell Significance Index: -1.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1040
    Cell Significance Index: -5.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1042
    Cell Significance Index: -10.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1227
    Cell Significance Index: -7.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1332
    Cell Significance Index: -3.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1346
    Cell Significance Index: -9.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1569
    Cell Significance Index: -4.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1695
    Cell Significance Index: -10.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1822
    Cell Significance Index: -2.6900
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.2097
    Cell Significance Index: -1.0200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2327
    Cell Significance Index: -2.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CRYZ is a homotetrameric protein, composed of four identical subunits, which are arranged in a specific structural configuration. The protein exhibits a high degree of stability and resistance to denaturation, allowing it to maintain its functional integrity under various conditions. CRYZ is primarily expressed in cells of the kidney, reproductive system, and nervous system, where it is involved in maintaining cellular homeostasis and regulating oxidative stress. **Pathways and Functions:** CRYZ is involved in several cellular pathways, including: 1. **NADH and NADPH-dependent reductase activity**: CRYZ exhibits NADH and NADPH-dependent reductase activity, which is essential for maintaining the redox balance within cells. 2. **Protein homotetramerization**: The protein's homotetrameric structure allows it to form oligomers, which play a crucial role in regulating protein function and stability. 3. **Zinc ion binding**: CRYZ binds to zinc ions, which are essential for maintaining its structural integrity and functional activity. 4. **Visual perception**: As a crystallin protein, CRYZ is involved in maintaining the transparency and refractive index of the lens, ensuring clear visual perception. **Clinical Significance:** The dysregulation of CRYZ has been implicated in various diseases, including: 1. **Cataracts**: Mutations in the CRYZ gene have been associated with cataract formation, highlighting the protein's crucial role in maintaining lens transparency. 2. **Ocular diseases**: CRYZ has been linked to other ocular diseases, such as age-related macular degeneration and glaucoma, where its dysregulation contributes to disease progression. 3. **Kidney disorders**: The protein's expression in kidney cells suggests its involvement in maintaining renal homeostasis, and its dysregulation may contribute to kidney diseases, such as nephropathy. In conclusion, CRYZ is a multifunctional protein that plays a vital role in maintaining protein homeostasis, regulating oxidative stress, and ensuring clear visual perception. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the clinical significance of CRYZ in human health and disease.

Genular Protein ID: 3087895683

Symbol: QOR_HUMAN

Name: Quinone oxidoreductase

UniProtKB Accession Codes:

Q08257 A6NN60 D3DQ76 Q53FT0 Q59EU7 Q5HYE7 Q6NSK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 2 EMBL 20 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 8 Rhea 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8466529

Title: Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver.

PubMed ID: 8466529

DOI: 10.1006/bbrc.1993.1302

PubMed ID: 8088825

Title: Organization of the human zeta-crystallin/quinone reductase gene (CRYZ).

PubMed ID: 8088825

DOI: 10.1006/geno.1994.1272

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17497241

Title: Human and yeast zeta-crystallins bind AU-rich elements in RNA.

PubMed ID: 17497241

DOI: 10.1007/s00018-007-7091-1

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20103721

Title: {zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia.

PubMed ID: 20103721

DOI: 10.1096/fj.09-140459

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 329
  • Mass: 35207
  • Checksum: 68C1828911486D4E
  • Sequence:
    • MATGQKLMRA VRVFEFGGPE VLKLRSDIAV PIPKDHQVLI KVHACGVNPV ETYIRSGTYS 
RKPLLPYTPG SDVAGVIEAV GDNASAFKKG DRVFTSSTIS GGYAEYALAA DHTVYKLPEK 
LDFKQGAAIG IPYFTAYRAL IHSACVKAGE SVLVHGASGG VGLAACQIAR AYGLKILGTA 
GTEEGQKIVL QNGAHEVFNH REVNYIDKIK KYVGEKGIDI IIEMLANVNL SKDLSLLSHG 
GRVIVVGSRG TIEINPRDTM AKESSIIGVT LFSSTKEEFQ QYAAALQAGM EIGWLKPVIG 
SQYPLEKVAE AHENIIHGSG ATGKMILLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.