Details for: CRYZ

Gene ID: 1429

Symbol: CRYZ

Ensembl ID: ENSG00000116791

Description: crystallin zeta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.29
    Marker Score: 5783
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.97
    Marker Score: 3439
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.88
    Marker Score: 1995
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.86
    Marker Score: 3089
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.85
    Marker Score: 6562
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.73
    Marker Score: 2445
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.72
    Marker Score: 4616
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.67
    Marker Score: 891
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.48
    Marker Score: 5475
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.41
    Marker Score: 349
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.36
    Marker Score: 2223.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.3
    Marker Score: 304
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.28
    Marker Score: 1330
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.21
    Marker Score: 810
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.15
    Marker Score: 1215
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.14
    Marker Score: 1408.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.14
    Marker Score: 4940
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.13
    Marker Score: 620.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.12
    Marker Score: 7181
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.11
    Marker Score: 3637
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.02
    Marker Score: 35402
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.01
    Marker Score: 1029
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1
    Marker Score: 2728
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71736
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47960
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.94
    Marker Score: 1994
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.92
    Marker Score: 4961
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2078
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.86
    Marker Score: 4143.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.86
    Marker Score: 927
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4904
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.86
    Marker Score: 168
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.86
    Marker Score: 2106
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.85
    Marker Score: 1216
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13161
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.82
    Marker Score: 1033.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.82
    Marker Score: 1715
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.81
    Marker Score: 1193
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.79
    Marker Score: 609
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.78
    Marker Score: 290
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.76
    Marker Score: 4916
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.74
    Marker Score: 392
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.74
    Marker Score: 1141
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.73
    Marker Score: 147
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.73
    Marker Score: 455
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.73
    Marker Score: 568
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.72
    Marker Score: 621
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 450
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.7
    Marker Score: 478
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.7
    Marker Score: 1072
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.69
    Marker Score: 2687
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2906
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.69
    Marker Score: 388
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.69
    Marker Score: 827
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.68
    Marker Score: 1093
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.68
    Marker Score: 6827
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 619
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.66
    Marker Score: 2777
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.66
    Marker Score: 630
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.64
    Marker Score: 234
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.64
    Marker Score: 155
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.63
    Marker Score: 182
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.62
    Marker Score: 3945
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.61
    Marker Score: 3221
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.61
    Marker Score: 1067
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.6
    Marker Score: 953
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6
    Marker Score: 3824
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.6
    Marker Score: 179
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.58
    Marker Score: 1282
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.58
    Marker Score: 165
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.57
    Marker Score: 619
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.57
    Marker Score: 1098
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.56
    Marker Score: 951
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.55
    Marker Score: 1258
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.55
    Marker Score: 137
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 330
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.55
    Marker Score: 281
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.54
    Marker Score: 497
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.54
    Marker Score: 283
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.53
    Marker Score: 244
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.53
    Marker Score: 156
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.53
    Marker Score: 378
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.52
    Marker Score: 289
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.52
    Marker Score: 3413
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.52
    Marker Score: 355
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.52
    Marker Score: 512

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Other Information

**Key characteristics** * CRYZ is a protein of approximately 120 kDa. * It is a transmembrane protein that is localized to the plasma membrane. * It is a ubiquitin-dependent protein that is regulated by the cellular redox state. * It is a key regulator of cellular metabolism, and its expression is often upregulated in response to oxidative stress. **Pathways and functions** * CRYZ is involved in the regulation of cellular metabolism. It is a key regulator of the electron transport chain, and its expression is often upregulated in response to oxidative stress. * It is also involved in the regulation of apoptosis. * It is a key regulator of the immune response, and its expression is often upregulated in response to infection. **Clinical significance** CRYZ is a promising target for the treatment of a variety of diseases, including cancer and neurodegenerative diseases. By understanding the role of CRYZ in cellular metabolism and the immune response, it may be possible to develop new treatments for these diseases.

Genular Protein ID: 3087895683

Symbol: QOR_HUMAN

Name: Quinone oxidoreductase

UniProtKB Accession Codes:

Q08257 A6NN60 D3DQ76 Q53FT0 Q59EU7 Q5HYE7 Q6NSK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 2 EMBL 20 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 8 Rhea 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8466529

Title: Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver.

PubMed ID: 8466529

DOI: 10.1006/bbrc.1993.1302

PubMed ID: 8088825

Title: Organization of the human zeta-crystallin/quinone reductase gene (CRYZ).

PubMed ID: 8088825

DOI: 10.1006/geno.1994.1272

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17497241

Title: Human and yeast zeta-crystallins bind AU-rich elements in RNA.

PubMed ID: 17497241

DOI: 10.1007/s00018-007-7091-1

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20103721

Title: {zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia.

PubMed ID: 20103721

DOI: 10.1096/fj.09-140459

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 329
  • Mass: 35207
  • Checksum: 68C1828911486D4E
  • Sequence:
    • MATGQKLMRA VRVFEFGGPE VLKLRSDIAV PIPKDHQVLI KVHACGVNPV ETYIRSGTYS 
RKPLLPYTPG SDVAGVIEAV GDNASAFKKG DRVFTSSTIS GGYAEYALAA DHTVYKLPEK 
LDFKQGAAIG IPYFTAYRAL IHSACVKAGE SVLVHGASGG VGLAACQIAR AYGLKILGTA 
GTEEGQKIVL QNGAHEVFNH REVNYIDKIK KYVGEKGIDI IIEMLANVNL SKDLSLLSHG 
GRVIVVGSRG TIEINPRDTM AKESSIIGVT LFSSTKEEFQ QYAAALQAGM EIGWLKPVIG 
SQYPLEKVAE AHENIIHGSG ATGKMILLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.