Genular: Defining Cellular Identity and Function

Details for: Fxn

Gene ID: 14297

Symbol: Fxn

Ensembl ID: ENSMUSG00000059363

Description: frataxin

Associated with

Metabolism
(R-MMU-1430728)
Mitochondrial iron-sulfur cluster biogenesis
(R-MMU-1362409)
Mitochondrial protein import
(R-MMU-1268020)
Protein localization
(R-MMU-9609507)
2 iron, 2 sulfur cluster binding
(GO:0051537)
Adult walking behavior
(GO:0007628)
Aerobic respiration
(GO:0009060)
Cellular response to hydrogen peroxide
(GO:0070301)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Embryo development ending in birth or egg hatching
(GO:0009792)
Enzyme binding
(GO:0019899)
Ferric iron binding
(GO:0008199)
Ferrous iron binding
(GO:0008198)
Ferroxidase activity
(GO:0004322)
Heme biosynthetic process
(GO:0006783)
Intracellular iron ion homeostasis
(GO:0006879)
Iron-sulfur cluster assembly
(GO:0016226)
Iron-sulfur cluster assembly complex
(GO:1990229)
Iron chaperone activity
(GO:0034986)
Iron import into the mitochondrion
(GO:0048250)
Iron incorporation into metallo-sulfur cluster
(GO:0018283)
Iron ion transport
(GO:0006826)
L-cysteine desulfurase complex
(GO:1990221)
Metal ion binding
(GO:0046872)
Mitochondrial iron-sulfur cluster assembly complex
(GO:0099128)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Monoatomic ion transport
(GO:0006811)
Muscle cell cellular homeostasis
(GO:0046716)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of multicellular organism growth
(GO:0040015)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of organ growth
(GO:0046621)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Organ growth
(GO:0035265)
Oxidative phosphorylation
(GO:0006119)
Oxidoreductase activity
(GO:0016491)
Positive regulation of aconitate hydratase activity
(GO:1904234)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of catalytic activity
(GO:0043085)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of lyase activity
(GO:0051349)
Positive regulation of mitochondrial membrane permeability
(GO:0035794)
Positive regulation of succinate dehydrogenase activity
(GO:1904231)
Proprioception
(GO:0019230)
Protein autoprocessing
(GO:0016540)
Regulation of cytosolic calcium ion concentration
(GO:0051480)
Regulation of ferrochelatase activity
(GO:0010722)
Response to iron ion
(GO:0010039)
[2fe-2s] cluster assembly
(GO:0044571)
[4fe-4s] cluster assembly
(GO:0044572)

Other Information

Proteins

Frataxin intermediate form

Genular Protein ID: 3916317979

Symbol: FRDA_MOUSE

Name: Frataxin intermediate form

UniProtKB Accession Codes:

O35943

Database IDs:

Citations:

PubMed ID: 9241270

Title: Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin.

PubMed ID: 9241270

DOI: 10.1038/ng0897-345

PubMed ID: 11823441

Title: Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich ataxia.

PubMed ID: 11823441

DOI: 10.1093/hmg/11.3.217

PubMed ID: 17597094

Title: Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues.

PubMed ID: 17597094

DOI: 10.1093/hmg/ddm163

PubMed ID: 18725397

Title: The in vivo mitochondrial two-step maturation of human frataxin.

PubMed ID: 18725397

DOI: 10.1093/hmg/ddn244

PubMed ID: 19629184

Title: The first cellular models based on frataxin missense mutations that reproduce spontaneously the defects associated with Friedreich ataxia.

PubMed ID: 19629184

DOI: 10.1371/journal.pone.0006379

PubMed ID: 19805308

Title: Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant.

PubMed ID: 19805308

DOI: 10.1073/pnas.0906784106

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21298097

Title: Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex.

PubMed ID: 21298097

DOI: 10.1371/journal.pone.0016199

PubMed ID: 25597503

Title: Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols.

PubMed ID: 25597503

DOI: 10.1038/ncomms6686

Sequence Information:

Length: 207
Mass: 22924
Checksum: C46FD21B44FB26A2
Sequence:

MWAFGGRAAV GLLPRTASRA SAWVGNPRWR EPIVTCGRRG LHVTVNAGAT RHAHLNLHYL 
QILNIKKQSV CVVHLRNLGT LDNPSSLDET AYERLAEETL DSLAEFFEDL ADKPYTLEDY 
DVSFGDGVLT IKLGGDLGTY VINKQTPNKQ IWLSSPSSGP KRYDWTGKNW VYSHDGVSLH 
ELLARELTKA LNTKLDLSSL AYSGKGT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fxn

Associated with

Other Information

Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin. PubMed ID: 9241270

Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich ataxia. PubMed ID: 11823441

Frataxin is essential for extramitochondrial Fe-S cluster proteins in mammalian tissues. PubMed ID: 17597094

The in vivo mitochondrial two-step maturation of human frataxin. PubMed ID: 18725397

The first cellular models based on frataxin missense mutations that reproduce spontaneously the defects associated with Friedreich ataxia. PubMed ID: 19629184

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant. PubMed ID: 19805308

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex. PubMed ID: 21298097

Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols. PubMed ID: 25597503