Details for: PARP4

Gene ID: 143

Symbol: PARP4

Ensembl ID: ENSG00000102699

Description: poly(ADP-ribose) polymerase family member 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.93
    Marker Score: 2600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.71
    Marker Score: 1888
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.59
    Marker Score: 458
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.58
    Marker Score: 1703
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.5
    Marker Score: 1606
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.46
    Marker Score: 1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.42
    Marker Score: 2088
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.34
    Marker Score: 798
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.31
    Marker Score: 1580
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.29
    Marker Score: 1111
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.24
    Marker Score: 727
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.21
    Marker Score: 807
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2
    Marker Score: 21266
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.18
    Marker Score: 7611
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.18
    Marker Score: 585
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.17
    Marker Score: 614
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.16
    Marker Score: 1222
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.15
    Marker Score: 1305
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.14
    Marker Score: 3921
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.14
    Marker Score: 588
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.12
    Marker Score: 2637
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.11
    Marker Score: 4650
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.11
    Marker Score: 4794
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.09
    Marker Score: 17564
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.09
    Marker Score: 2390
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.07
    Marker Score: 27359
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.07
    Marker Score: 399
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.04
    Marker Score: 3273.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.02
    Marker Score: 4266.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.02
    Marker Score: 1967
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.02
    Marker Score: 439
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.01
    Marker Score: 21518
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.01
    Marker Score: 250
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71660
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47883
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.99
    Marker Score: 1003
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30386
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.98
    Marker Score: 3467
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.97
    Marker Score: 5238
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.97
    Marker Score: 1499
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.97
    Marker Score: 196
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.96
    Marker Score: 474
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.95
    Marker Score: 7093
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.95
    Marker Score: 657
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.94
    Marker Score: 1086
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2391
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.94
    Marker Score: 1171
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.93
    Marker Score: 4463
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.91
    Marker Score: 1665
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.91
    Marker Score: 951
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1462
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14083
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2694
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5099
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.89
    Marker Score: 49927
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.89
    Marker Score: 360
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.89
    Marker Score: 882.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.88
    Marker Score: 319.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.88
    Marker Score: 326.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.87
    Marker Score: 7529
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.87
    Marker Score: 10067
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.86
    Marker Score: 314
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.86
    Marker Score: 5499
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.86
    Marker Score: 1216
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.86
    Marker Score: 248
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.86
    Marker Score: 479
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.85
    Marker Score: 1733
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.85
    Marker Score: 413
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.85
    Marker Score: 849
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.85
    Marker Score: 29392
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.85
    Marker Score: 509
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.85
    Marker Score: 1021
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.84
    Marker Score: 657
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.83
    Marker Score: 1453
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.83
    Marker Score: 211
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 474
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.81
    Marker Score: 380
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.81
    Marker Score: 338
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.81
    Marker Score: 233
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.81
    Marker Score: 1576.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.81
    Marker Score: 453
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.8
    Marker Score: 395
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 319
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.79
    Marker Score: 542
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 605
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.79
    Marker Score: 274
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.79
    Marker Score: 953
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.77
    Marker Score: 391
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.77
    Marker Score: 172.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.77
    Marker Score: 995
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.76
    Marker Score: 896
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.76
    Marker Score: 1353
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.76
    Marker Score: 792
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.76
    Marker Score: 222

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Other Information

**Key characteristics:** * PARP4 is a protein of the PARP family of DNA repair proteins. * It is a highly conserved protein with a conserved catalytic domain. * It is a key regulator of DNA repair and is essential for the survival of cells. * It is involved in the repair of double-strand DNA breaks. * It is expressed in a variety of cell types, including epithelial cells, endothelial cells, and immune cells. **Pathways and functions:** * PARP4 is involved in the repair of double-strand DNA breaks. * It is a key regulator of DNA repair and is essential for the survival of cells. * It is involved in the maintenance of genomic integrity. * It is involved in the response to DNA damage. * It is involved in the regulation of cell cycle progression. **Clinical significance:** * Mutations in PARP4 have been linked to a number of human diseases, including cancer and neurodegenerative diseases. * PARP4 inhibitors are being studied as a treatment for these diseases. * PARP4 is a promising target for cancer therapy. **Other relevant information:** * PARP4 is a highly conserved protein with a conserved catalytic domain. * It is a member of the PARP family of DNA repair proteins. * It is a key regulator of DNA repair and is essential for the survival of cells. * It is involved in the repair of double-strand DNA breaks.

Genular Protein ID: 3982475008

Symbol: PARP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UKK3 O75903 Q14682 Q5QNZ9 Q9H1M6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 CarbonylDB 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 4 EPD 1 Ensembl 1 GO 19 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 5 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 6 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10477748

Title: The 193 kDa vault protein, VPARP, is a novel poly(ADP-ribose) polymerase.

PubMed ID: 10477748

DOI: 10.1083/jcb.146.5.917

PubMed ID: 10644454

Title: Identification of a novel gene (ADPRTL1) encoding a potential poly(ADP-ribosyl)transferase protein.

PubMed ID: 10644454

DOI: 10.1006/geno.1999.6024

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 10100603

Title: The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?

PubMed ID: 10100603

DOI: 10.1016/s0014-5793(99)00173-8

PubMed ID: 10551828

Title: Vaults and telomerase share a common subunit, TEP1.

PubMed ID: 10551828

DOI: 10.1074/jbc.274.46.32712

PubMed ID: 15169895

Title: Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo.

PubMed ID: 15169895

DOI: 10.1128/mcb.24.12.5314-5323.2004

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20106667

Title: Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

PubMed ID: 20106667

DOI: 10.1016/j.tibs.2009.12.003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25043379

Title: Family-wide analysis of poly(ADP-ribose) polymerase activity.

PubMed ID: 25043379

DOI: 10.1038/ncomms5426

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 1724
  • Mass: 192595
  • Checksum: DCA1DD4C001EA22F
  • Sequence:
    • MVMGIFANCI FCLKVKYLPQ QQKKKLQTDI KENGGKFSFS LNPQCTHIIL DNADVLSQYQ 
LNSIQKNHVH IANPDFIWKS IREKRLLDVK NYDPYKPLDI TPPPDQKASS SEVKTEGLCP 
DSATEEEDTV ELTEFGMQNV EIPHLPQDFE VAKYNTLEKV GMEGGQEAVV VELQCSRDSR 
DCPFLISSHF LLDDGMETRR QFAIKKTSED ASEYFENYIE ELKKQGFLLR EHFTPEATQL 
ASEQLQALLL EEVMNSSTLS QEVSDLVEMI WAEALGHLEH MLLKPVNRIS LNDVSKAEGI 
LLLVKAALKN GETAEQLQKM MTEFYRLIPH KGTMPKEVNL GLLAKKADLC QLIRDMVNVC 
ETNLSKPNPP SLAKYRALRC KIEHVEQNTE EFLRVRKEVL QNHHSKSPVD VLQIFRVGRV 
NETTEFLSKL GNVRPLLHGS PVQNIVGILC RGLLLPKVVE DRGVQRTDVG NLGSGIYFSD 
SLSTSIKYSH PGETDGTRLL LICDVALGKC MDLHEKDFSL TEAPPGYDSV HGVSQTASVT 
TDFEDDEFVV YKTNQVKMKY IIKFSMPGDQ IKDFHPSDHT ELEEYRPEFS NFSKVEDYQL 
PDAKTSSSTK AGLQDASGNL VPLEDVHIKG RIIDTVAQVI VFQTYTNKSH VPIEAKYIFP 
LDDKAAVCGF EAFINGKHIV GEIKEKEEAQ QEYLEAVTQG HGAYLMSQDA PDVFTVSVGN 
LPPKAKVLIK ITYITELSIL GTVGVFFMPA TVAPWQQDKA LNENLQDTVE KICIKEIGTK 
QSFSLTMSIE MPYVIEFIFS DTHELKQKRT DCKAVISTME GSSLDSSGFS LHIGLSAAYL 
PRMWVEKHPE KESEACMLVF QPDLDVDLPD LASESEVIIC LDCSSSMEGV TFLQAKQIAL 
HALSLVGEKQ KVNIIQFGTG YKELFSYPKH ITSNTMAAEF IMSATPTMGN TDFWKTLRYL 
SLLYPARGSR NILLVSDGHL QDESLTLQLV KRSRPHTRLF ACGIGSTANR HVLRILSQCG 
AGVFEYFNAK SKHSWRKQIE DQMTRLCSPS CHSVSVKWQQ LNPDVPEALQ APAQVPSLFL 
NDRLLVYGFI PHCTQATLCA LIQEKEFRTM VSTTELQKTT GTMIHKLAAR ALIRDYEDGI 
LHENETSHEM KKQTLKSLII KLSKENSLIT QFTSFVAVEK RDENESPFPD IPKVSELIAK 
EDVDFLPYMS WQGEPQEAVR NQSLLASSEW PELRLSKRKH RKIPFSKRKM ELSQPEVSED 
FEEDGLGVLP AFTSNLERGG VEKLLDLSWT ESCKPTATEP LFKKVSPWET STSSFFPILA 
PAVGSYLPPT ARAHSPASLS FASYRQVASF GSAAPPRQFD ASQFSQGPVP GTCADWIPQS 
ASCPTGPPQN PPSSPYCGIV FSGSSLSSAQ SAPLQHPGGF TTRPSAGTFP ELDSPQLHFS 
LPTDPDPIRG FGSYHPSASS PFHFQPSAAS LTANLRLPMA SALPEALCSQ SRTTPVDLCL 
LEESVGSLEG SRCPVFAFQS SDTESDELSE VLQDSCFLQI KCDTKDDSIL CFLEVKEEDE 
IVCIQHWQDA VPWTELLSLQ TEDGFWKLTP ELGLILNLNT NGLHSFLKQK GIQSLGVKGR 
ECLLDLIATM LVLQFIRTRL EKEGIVFKSL MKMDDASISR NIPWAFEAIK QASEWVRRTE 
GQYPSICPRL ELGNDWDSAT KQLLGLQPIS TVSPLHRVLH YSQG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.