Genular: Defining Cellular Identity and Function

Details for: Frk

Gene ID: 14302

Symbol: Frk

Ensembl ID: ENSMUSG00000019779

Description: fyn-related kinase

Associated with

Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Intracellular signaling by second messengers
(R-MMU-9006925)
Neutrophil degranulation
(R-MMU-6798695)
Pip3 activates akt signaling
(R-MMU-1257604)
Pten regulation
(R-MMU-6807070)
Regulation of pten stability and activity
(R-MMU-8948751)
Signal transduction
(R-MMU-162582)
Atp binding
(GO:0005524)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Innate immune response
(GO:0045087)
Kinase activity
(GO:0016301)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Signaling receptor binding
(GO:0005102)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

Tyrosine-protein kinase FRK

Genular Protein ID: 3496387612

Symbol: FRK_MOUSE

Name: Tyrosine-protein kinase FRK

UniProtKB Accession Codes:

Q922K9 Q61364 Q61745

Database IDs:

Citations:

PubMed ID: 7733928

Title: iyk, a novel intracellular protein tyrosine kinase differentially expressed in the mouse mammary gland and intestine.

PubMed ID: 7733928

DOI: 10.1006/bbrc.1995.1540

PubMed ID: 7835707

Title: Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution.

PubMed ID: 7835707

DOI: 10.1016/0378-1119(94)00718-8

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12077350

Title: Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak.

PubMed ID: 12077350

DOI: 10.1128/mcb.22.14.5235-5247.2002

PubMed ID: 15186217

Title: The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity.

PubMed ID: 15186217

DOI: 10.1042/bj20040285

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 512
Mass: 58844
Checksum: B79A0BC07B9EC5F8
Sequence:

MGSVCVRLWA YLQPFLPCWS QEADKSVVIE NPGAFCPPEA PRSQEPERSH GQYFVALFDY 
QARTAEDLSF RAGDKLQVLD TSHEGWWLAR HLEKKGTGLG QQLQGYIPSN YVAEDRSLQA 
EPWFFGAIKR ADAEKQLLYS ENQTGAFLIR ESESQKGDFS LSVLDEGVVK HYRIRRLDEG 
GFFLTRRKVF STLNEFVNYY TTTSDGLCVK LEKPCLKIQV PTPFDLSYKT ADQWEIDRNS 
IQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKS LRHPKLIQLY 
AVCTLEDPIY IITELMRHGS LQEYLQNDGG SKIHLIQQVD MAAQVASGMA YLESQNYIHR 
DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRTNKFSIK 
SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLSQNYRLP QPSNCPQQFY SIMLECWNVE 
PKQRPTFETL HWKLEDYFET DCSYSDTNNF IN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Frk

Associated with

Other Information

iyk, a novel intracellular protein tyrosine kinase differentially expressed in the mouse mammary gland and intestine. PubMed ID: 7733928

Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution. PubMed ID: 7835707

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak. PubMed ID: 12077350

The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity. PubMed ID: 15186217

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079