Details for: CS

Gene ID: 1431

Symbol: CS

Ensembl ID: ENSG00000062485

Description: citrate synthase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.95
    Marker Score: 3402
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.49
    Marker Score: 600
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.43
    Marker Score: 523
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.37
    Marker Score: 666
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.3
    Marker Score: 1309
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.28
    Marker Score: 637
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.26
    Marker Score: 22389
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.26
    Marker Score: 3087.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.25
    Marker Score: 3711
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.25
    Marker Score: 3912
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.22
    Marker Score: 1886
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.22
    Marker Score: 44917
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.19
    Marker Score: 73127
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.18
    Marker Score: 3220.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.18
    Marker Score: 1270
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.16
    Marker Score: 25907
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.15
    Marker Score: 779
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.13
    Marker Score: 1181
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.13
    Marker Score: 9684
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.13
    Marker Score: 1658
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.12
    Marker Score: 3012
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.12
    Marker Score: 2668
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.11
    Marker Score: 832
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.11
    Marker Score: 1172
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.1
    Marker Score: 1178
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.1
    Marker Score: 1457
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.09
    Marker Score: 2493
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.09
    Marker Score: 10339
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.08
    Marker Score: 6925
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.08
    Marker Score: 271
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.08
    Marker Score: 406.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.06
    Marker Score: 675.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.06
    Marker Score: 371
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.06
    Marker Score: 9943
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.06
    Marker Score: 339
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.05
    Marker Score: 521
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16386
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.04
    Marker Score: 58120
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.03
    Marker Score: 748
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.02
    Marker Score: 539
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.02
    Marker Score: 1444
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.02
    Marker Score: 502
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.02
    Marker Score: 3927
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.02
    Marker Score: 559
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.02
    Marker Score: 2143
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.01
    Marker Score: 4189
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1
    Marker Score: 4814
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71638
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.99
    Marker Score: 1733
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47860
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30378
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.98
    Marker Score: 972.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.96
    Marker Score: 655
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.96
    Marker Score: 1021
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.96
    Marker Score: 1203
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.96
    Marker Score: 597
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.96
    Marker Score: 224
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.95
    Marker Score: 20381
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.95
    Marker Score: 723
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.94
    Marker Score: 10983
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2387
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.94
    Marker Score: 2330
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.93
    Marker Score: 780
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.93
    Marker Score: 6940
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.93
    Marker Score: 12495
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.93
    Marker Score: 35307
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.93
    Marker Score: 3771.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.92
    Marker Score: 631.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.92
    Marker Score: 973
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.92
    Marker Score: 975
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.92
    Marker Score: 386
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.92
    Marker Score: 13741
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.92
    Marker Score: 483
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.91
    Marker Score: 2147
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5179
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.91
    Marker Score: 507
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.9
    Marker Score: 5499
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2686
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.89
    Marker Score: 648
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.89
    Marker Score: 521
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.89
    Marker Score: 7697
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.89
    Marker Score: 436
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.89
    Marker Score: 215
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.88
    Marker Score: 307
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.88
    Marker Score: 1712
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.88
    Marker Score: 46446
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.88
    Marker Score: 2387
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.87
    Marker Score: 1420
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.87
    Marker Score: 215
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.87
    Marker Score: 930
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.87
    Marker Score: 799
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.87
    Marker Score: 8809
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.87
    Marker Score: 300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.86
    Marker Score: 1805
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.86
    Marker Score: 6621
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.85
    Marker Score: 286

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * Gene Name: CS * Ensembl ID: ENSG00000062485 * Protein: CISY_HUMAN (Citrate synthase, mitochondrial) * Pathway: Citrate (si)-synthase activity, Citrate metabolic process, Citric acid cycle (tca cycle), Metabolism, Metabolism of proteins, Mitochondrial matrix, Mitochondrial protein degradation, Mitochondrial protein import, Mitochondrion, Nucleus, Protein localization * Significantly expressed cells: germ cell, type A enteroendocrine cell, subcutaneous fat cell, epicardial adipocyte, fraction A pre-pro B cell, osteoclast, cortical cell of adrenal gland, glandular epithelial cell, tonsil germinal center B cell, colon epithelial cell **Pathways and functions:** * The citrate synthase gene is involved in the regulation of blood glucose metabolism. * It is highly expressed in germ cell, type A enteroendocrine cells, and other cell types involved in glucose uptake, storage, and metabolism. * It plays a crucial role in maintaining blood glucose homeostasis by regulating the flux of glucose between the blood and cells. * The enzyme is also involved in the regulation of energy production and the detoxification of harmful substances. **Clinical significance:** * Mutations in the CS gene have been linked to several human diseases, including type 2 diabetes, obesity, and metabolic syndrome. * Studies on animal models have shown that targeting CS can ameliorate metabolic abnormalities and improve insulin sensitivity. * Therefore, CS is a potential therapeutic target for the treatment of metabolic disorders.

Genular Protein ID: 1891159060

Symbol: CISY_HUMAN

Name: Citrate synthase, mitochondrial

UniProtKB Accession Codes:

O75390 Q71UT9 Q7KZH0 Q96FZ8 Q9BWN8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 3 CTD 1 CarbonylDB 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 2 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9809442

Title: Cloning and molecular analysis of the human citrate synthase gene.

PubMed ID: 9809442

DOI: 10.1139/g98-074

PubMed ID: 12549038

Title: Cloning and tissue expression pattern analysis of the human citrate synthase cDNA.

PubMed ID: 12549038

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28391595

Title: Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase.

PubMed ID: 28391595

DOI: 10.1002/1873-3468.12649

PubMed ID: 28887308

Title: Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation.

PubMed ID: 28887308

DOI: 10.1074/jbc.m117.808451

Sequence Information:

  • Length: 466
  • Mass: 51712
  • Checksum: 459CB29C0BA06997
  • Sequence:
    • MALLTAAARL LGTKNASCLV LAARHASASS TNLKDILADL IPKEQARIKT FRQQHGKTVV 
GQITVDMMYG GMRGMKGLVY ETSVLDPDEG IRFRGFSIPE CQKLLPKAKG GEEPLPEGLF 
WLLVTGHIPT EEQVSWLSKE WAKRAALPSH VVTMLDNFPT NLHPMSQLSA AVTALNSESN 
FARAYAQGIS RTKYWELIYE DSMDLIAKLP CVAAKIYRNL YREGSGIGAI DSNLDWSHNF 
TNMLGYTDHQ FTELTRLYLT IHSDHEGGNV SAHTSHLVGS ALSDPYLSFA AAMNGLAGPL 
HGLANQEVLV WLTQLQKEVG KDVSDEKLRD YIWNTLNSGR VVPGYGHAVL RKTDPRYTCQ 
REFALKHLPN DPMFKLVAQL YKIVPNVLLE QGKAKNPWPN VDAHSGVLLQ YYGMTEMNYY 
TVLFGVSRAL GVLAQLIWSR ALGFPLERPK SMSTEGLMKF VDSKSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.