Details for: Cidec

Gene ID: 14311

Symbol: Cidec

Ensembl ID: ENSMUSG00000030278

Description: cell death-inducing DFFA-like effector c

Associated with

Other Information

Genular Protein ID: 1056888824

Symbol: CIDEC_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1339452

Title: Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C/EBP) and C/EBP-like proteins interact with sequences required for differentiation-dependent expression.

PubMed ID: 1339452

DOI: 10.1016/s0021-9258(19)50555-5

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12910269

Title: Cidea-deficient mice have lean phenotype and are resistant to obesity.

PubMed ID: 12910269

DOI: 10.1038/ng1225

PubMed ID: 18334488

Title: Fat-specific protein 27 regulates storage of triacylglycerol.

PubMed ID: 18334488

DOI: 10.1074/jbc.m708323200

PubMed ID: 18654663

Title: FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets.

PubMed ID: 18654663

DOI: 10.1172/jci34090

PubMed ID: 18682832

Title: Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice.

PubMed ID: 18682832

DOI: 10.1371/journal.pone.0002890

PubMed ID: 18509062

Title: Cidea is associated with lipid droplets and insulin sensitivity in humans.

PubMed ID: 18509062

DOI: 10.1073/pnas.0802063105

PubMed ID: 20089860

Title: Fat-specific protein 27 undergoes ubiquitin-dependent degradation regulated by triacylglycerol synthesis and lipid droplet formation.

PubMed ID: 20089860

DOI: 10.1074/jbc.m109.043786

PubMed ID: 22144693

Title: Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites.

PubMed ID: 22144693

DOI: 10.1083/jcb.201104142

PubMed ID: 22245780

Title: Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.

PubMed ID: 22245780

DOI: 10.1038/nm.2614

PubMed ID: 23233732

Title: Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress.

PubMed ID: 23233732

DOI: 10.1194/jlr.m033365

PubMed ID: 26733203

Title: Differential roles of cell death-inducing DNA fragmentation factor-alpha-like effector (CIDE) proteins in promoting lipid droplet fusion and growth in subpopulations of hepatocytes.

PubMed ID: 26733203

DOI: 10.1074/jbc.m115.701094

PubMed ID: 30361435

Title: Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids.

PubMed ID: 30361435

DOI: 10.1074/jbc.ra118.004892

PubMed ID: 34508658

Title: A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion.

PubMed ID: 34508658

DOI: 10.1016/j.devcel.2021.08.015

PubMed ID: 36477540

Title: CLSTN3beta enforces adipocyte multilocularity to facilitate lipid utilization.

PubMed ID: 36477540

DOI: 10.1038/s41586-022-05507-1

PubMed ID: 24025675

Title: Molecular basis for homo-dimerization of the CIDE domain revealed by the crystal structure of the CIDE-N domain of FSP27.

PubMed ID: 24025675

DOI: 10.1016/j.bbrc.2013.09.018

PubMed ID: 23481402

Title: Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes.

PubMed ID: 23481402

DOI: 10.1038/ncomms2581

Sequence Information:

  • Length: 239
  • Mass: 27324
  • Checksum: 7F4E6C5D2E24A161
  • Sequence:
  • MDYAMKSLSL LYPRSLSRHV AVSTAVVTQQ LVSKPSRETP RARPCRVSTA DRKVRKGIMA 
    HSLEDLLNKV QDILKLKDKP FSLVLEEDGT IVETEEYFQA LAKDTMFMVL LKGQKWKPPS 
    EQRKKRAQLA LSQKPTKKID VARVTFDLYK LNPQDFIGCL NVKATLYDTY SLSYDLHCYK 
    AKRIVKEMLR WTLFSMQATG HMLLGTSSYM QQFLDATEEE QPAKAKPSSL LPACLKMLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.